Gene: ANKK1

255239
DRD2|PKK2
ankyrin repeat and kinase domain containing 1
protein-coding
11q23.2
Ensembl:ENSG00000170209 MIM:608774 Vega:OTTHUMG00000167715 UniprotKB:Q8NFD2
NG_012976.1
PubMed
CD|OD|ND|AD
61   
NA (AD)  9.516e-1 (ND)   (Frontal_Cortex)
6.157e-2 (AD)  8.597e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DRD20.612
TNK10.58
IL11RA0.564
TRAIP0.562
RGS90.554
B3GALT50.553
ZMYND100.55
OTOF0.549
TTC21A0.548
FER1L50.544

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB39A-0.28
BEND4-0.242
MORC1-0.225
TTLL10-0.223
UNC45B-0.22
SUCNR1-0.22
FAM216B-0.216
NPR3-0.213
CCDC60-0.21
IBSP-0.207

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C496492abrineabrine results in decreased expression of ANKK1 mRNA22595364
D000082AcetaminophenAcetaminophen results in increased expression of ANKK1 mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of ANKK1 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ANKK1 mRNA21298039
D001151ArsenicArsenic results in increased methylation of ANKK1 gene24525453
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ANKK1 mRNA23735875
C006780bisphenol Abisphenol A results in decreased expression of ANKK1 mRNA25181051
D003300CopperCopper deficiency results in increased expression of ANKK1 mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of ANKK1 mRNA19549813
D019422Dietary SucroseDietary Sucrose results in increased expression of ANKK1 mRNA26033743
C028007nickel monoxidenickel monoxide results in decreased expression of ANKK1 mRNA19167457
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ANKK1 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of ANKK1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ANKK1 mRNA23806026
C017947sodium arsenitesodium arsenite results in increased expression of ANKK1 mRNA25879800
C032910triadimefontriadimefon results in decreased expression of ANKK1 mRNA26790661
D014635Valproic AcidValproic Acid results in decreased expression of ANKK1 mRNA23527032

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18828801Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. (2008 Dec)Yang BZAlcohol Clin Exp Res
18690118Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood. (2008 Sep)Perkins KABehav Pharmacol
26410615An initial investigation of associations between dopamine-linked genetic variation and smoking motives in African Americans. (2015 Nov)Bidwell LCPharmacol Biochem Behav
25273375NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence. (2015 Apr)Bidwell LCPsychopharmacology (Berl)
17850642Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. (2007 Oct)Dick DMAlcohol Clin Exp Res
22232963[Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome]. (2011 May-Jun)Grochans EPsychiatr Pol
23635803ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. (2013 Jul)Spellicy CJPharmacogenet Genomics
23153044A prospective study of the effects of the DRD2/ANKK1 TaqIA polymorphism and impulsivity on smoking initiation. (2013 Jan)Doran NSubst Use Misuse
25545355Genetic variants and early cigarette smoking and nicotine dependence phenotypes in adolescents. (2014)O'Loughlin JPLoS One
15146457Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. (2004 Jun)Neville MJHum Mutat
25875614Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans. (2015 May)Levran OAnn Hum Genet
21244814Waterpipe Smoking And The DRD2/ANKK1 Genotype. (2010)Radwan GNJ Egypt Public Health Assoc
22949583Pharmacogenetic smoking cessation intervention in a health care setting: a pilot feasibility study. (2013 Feb)McClure JBNicotine Tob Res
17948892The association between DRD2/ANKK1, 5-HTTLPR gene, and specific personality trait on antisocial alcoholism among Han Chinese in Taiwan. (2008 Jun 5)Wu CYAm J Med Genet B Neuropsychiatr Genet
21663922Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium. (2011 Aug 15)McGuire VJ Neurol Sci
19526298The ANKK1 kinase gene and psychiatric disorders. (2009 Jul)Ponce GNeurotox Res
29275025[Genetic factors in alcohol dependence]. (2017 Dec 20)Ramoz NPresse Med
27490263The association of dopamine pathway gene score, nicotine dependence and smoking cessation in a rural male population of Shandong, China. (2016 Sep)Li SAm J Addict
19283474Cortical NMDA receptor expression in human chronic alcoholism: influence of the TaqIA allele of ANKK1. (2009 Oct)Ridge JPNeurochem Res
23558112The association of DRD2 -141C and ANKK1 TaqIA polymorphisms with alcohol dependence in Korean population classified by the Lesch typology. (2013 Jul-Aug)Lee SHAlcohol Alcohol
21997315ANKK1/DRD2 locus variants are associated with rimonabant efficacy in aiding smoking cessation: pilot data. (2011 Dec)Wilcox CSJ Investig Med
19914044Effect of the TaqIA polymorphism on ethanol response in the brain. (2009 Dec 30)London EDPsychiatry Res
19796663Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients. (2010 Feb 1)Lucht MProg Neuropsychopharmacol Biol Psychiatry
22509987COMT Val158Met modulates the effect of childhood adverse experiences on the risk of alcohol dependence. (2013 Mar)Schellekens AFAddict Biol
20350135Prospective association of dopamine-related polymorphisms with smoking cessation in general care. (2010 Apr)Breitling LPPharmacogenomics
29749891The DRD2/ANKK1 Taq1A polymorphism is associated with smoking cessation failure in patients with coronary heart disease. (2015 Sep)Mayer O JrPer Med
21403585Lack of allelic association between markers at the DRD2 and ANKK1 gene loci with the alcohol-dependence syndrome and criminal activity. (2011 Dec)Kasiakogia-Worlley KPsychiatr Genet
24444411Pharmacogenetics of nicotine addiction: role of dopamine. (2014 Feb)Herman AIPharmacogenomics
26153084CYP2B6 rs2279343 polymorphism is associated with smoking cessation success in bupropion therapy. (2015 Sep)Tomaz PREur J Clin Pharmacol
23443985DRD2 and ANKK1 gene polymorphisms and alcohol dependence: a case-control study among a Mendelian population of East Asian ancestry. (2013 Jul-Aug)Suraj Singh HAlcohol Alcohol
27180960Case control study of ANKK1 Taq 1A polymorphism in patients with alcohol dependence classified according to Lesch's typology. (2016 May 4)Samochowiec APostepy Hig Med Dosw (Online)
25526961Genetic influence of dopamine receptor, dopamine transporter, and nicotine metabolism on smoking cessation and nicotine dependence in a Japanese population. (2014 Dec 20)Ohmoto MBMC Genet
18354387Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample. (2009 Jan)Huang WNeuropsychopharmacology
23941313Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion. (2013 Dec)David SPAddiction
20554694Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (2010 Jul-Aug)Kovanen LAlcohol Alcohol
18669994DRD2 and ANKK1 genotype in alcohol-dependent patients with psychopathic traits: association and interaction study. (2008 Aug)Ponce GBr J Psychiatry
18690117Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers. (2008 Sep)Perkins KABehav Pharmacol
27613936High Prevalence of Smoking in the Roma Population Seems to Have No Genetic Background. (2016 Dec)Fiatal SNicotine Tob Res
22970887The association between DRD2/ANKK1 and genetically informed measures of alcohol use and problems. (2013 May)Meyers JLAddict Biol
23691092Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language. (2013)Eicher JDPLoS One
26624925The significant association of Taq1A genotypes in DRD2/ANKK1 with smoking cessation in a large-scale meta-analysis of Caucasian populations. (2015 Dec 1)Ma YTransl Psychiatry
17085484Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. (2006 Dec 15)Gelernter JHum Mol Genet
22046326'Smoking genes': a genetic association study. (2011)Verde ZPLoS One
23303482ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. (2013 Mar)Nelson ECJAMA Psychiatry
22698582DRD2/ANKK1 TaqIA and SLC6A3 VNTR polymorphisms in alcohol dependence: association and gene-gene interaction study in a population of Central Italy. (2012 Aug 1)Mignini FNeurosci Lett
20133381Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans. (2010 Mar)David SPNicotine Tob Res
24065931The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers. (2013)Robinson JDFront Psychiatry
23203481A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence. (2013 Mar)Wang FHum Genet
21070510Interaction between ALDH2*1*1 and DRD2/ANKK1 TaqI A1A1 genes may be associated with antisocial personality disorder not co-morbid with alcoholism. (2012 Sep)Lu RBAddict Biol
25139281Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions. (2015 Feb)Ma YMol Neurobiol
22722500Association study of 27 annotated genes for clozapine pharmacogenetics: validation of preexisting studies and identification of a new candidate gene, ABCB1, for treatment response. (2012 Aug)Lee STJ Clin Psychopharmacol
18058350DRD2/ANKK1 TaqI polymorphism and smoking behavior of Egyptian male cigarette smokers. (2007 Dec)Radwan GNNicotine Tob Res
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (2011 May)Kendler KSAlcohol Clin Exp Res
25415204Suicidal behavior and haplotypes of the dopamine receptor gene (DRD2) and ANKK1 gene polymorphisms in patients with alcohol dependence--preliminary report. (2014)Jasiewicz APLoS One
23128675Genetic analysis of polymorphisms in dopamine receptor and transporter genes for association with smoking among cancer patients. (2013)Gordiev MEur Addict Res
19373123Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution. (2009 Jun)Doehring APharmacogenet Genomics
24629326Impulsivity-related cognition in alcohol dependence: Is it moderated by DRD2/ANKK1 gene status and executive dysfunction? (2014 Nov)Gullo MJAddict Behav
22382052A DRD2 and ANKK1 haplotype is associated with nicotine dependence. (2012 Apr 30)Voisey JPsychiatry Res
23238469Influence of DRD2 and ANKK1 polymorphisms on the manifestation of withdrawal syndrome symptoms in alcohol addiction. (2012)Grzywacz APharmacol Rep
21168125TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. (2011 Apr 1)Ducci FBiol Psychiatry
17761687Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. (2007 Dec 1)Yang BZHum Mol Genet