Gene info: ID 2554

Gene: GABRA1

GENE ID: 2554

Synonyms: ECA4|EIEE19|EJM|EJM5

Description: gamma-aminobutyric acid type A receptor alpha1 subunit

Gene type: protein-coding

Location: 5q34

dbXrefs: Ensembl:ENSG00000022355 MIM:137160 Vega:OTTHUMG00000163586 UniprotKB:P14867

RefSeq: NG_011548.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 14

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.393e-1 (AD) 3.191e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg01069159	chr5:161275865	GABRA1	Promoter	3.598e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GABRB2	0.982
PRKCE	0.977
SYT1	0.977
RGS4	0.977
DLGAP1	0.976
HCN1	0.976
PLCB1	0.975
SYT13	0.975
CDK14	0.973
CAP2	0.973

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CSAG1	-0.578
MYL3	-0.551
CNN2	-0.549
WWTR1	-0.547
HEY2	-0.547
RAB13	-0.547
ARHGEF5	-0.542
RAI14	-0.542
RNF135	-0.541
REST	-0.54

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00231	Temazepam	Small Molecule	846-50-4	Approved\|Investigational	Target
DB00241	Butalbital	Small Molecule	77-26-9	Approved\|Illicit	Target
DB00273	Topiramate	Small Molecule	97240-79-4	Approved	Target
DB00292	Etomidate	Small Molecule	33125-97-2	Approved	Target
DB00306	Talbutal	Small Molecule	115-44-6	Approved\|Illicit	Target
DB00312	Pentobarbital	Small Molecule	76-74-4	Approved\|Investigational	Target
DB00371	Meprobamate	Small Molecule	57-53-4	Approved\|Illicit	Target
DB00395	Carisoprodol	Small Molecule	78-44-4	Approved	Target
DB00402	Eszopiclone	Small Molecule	138729-47-2	Approved\|Investigational	Target
DB00418	Secobarbital	Small Molecule	76-73-3	Approved	Target
DB00425	Zolpidem	Small Molecule	82626-48-0	Approved	Target
DB00463	Metharbital	Small Molecule	50-11-3	Withdrawn	Target
DB00466	Picrotoxin	Small Molecule	124-87-8	Experimental	Target
DB00474	Methohexital	Small Molecule	151-83-7	Approved	Target
DB00543	Amoxapine	Small Molecule	14028-44-5	Approved	Target
DB00546	Adinazolam	Small Molecule	37115-32-5	Approved	Target
DB00599	Thiopental	Small Molecule	76-75-5	Approved	Target
DB00683	Midazolam	Small Molecule	59467-70-8	Approved\|Illicit	Target
DB00690	Flurazepam	Small Molecule	17617-23-1	Approved\|Illicit\|Investigational	Target
DB00753	Isoflurane	Small Molecule	26675-46-7	Approved	Target
DB00794	Primidone	Small Molecule	125-33-7	Approved	Target
DB00801	Halazepam	Small Molecule	23092-17-3	Approved\|Illicit\|Withdrawn	Target
DB00829	Diazepam	Small Molecule	439-14-5	Approved\|Illicit\|Investigational	Target
DB00837	Progabide	Small Molecule	62666-20-0	Approved\|Investigational	Target
DB00842	Oxazepam	Small Molecule	604-75-1	Approved	Target
DB00849	Methylphenobarbital	Small Molecule	115-38-8	Approved	Target
DB00897	Triazolam	Small Molecule	28911-01-5	Approved\|Investigational	Target
DB00898	Ethanol	Small Molecule	64-17-5	Approved	Target
DB00962	Zaleplon	Small Molecule	151319-34-5	Approved\|Illicit\|Investigational	Target
DB01028	Methoxyflurane	Small Molecule	76-38-0	Approved\|Investigational	Target
DB01107	Methyprylon	Small Molecule	125-64-4	Approved\|Illicit\|Withdrawn	Target
DB01154	Thiamylal	Small Molecule	77-27-0	Approved	Target
DB01159	Halothane	Small Molecule	151-67-7	Approved	Target
DB01174	Phenobarbital	Small Molecule	50-06-6	Approved\|Investigational	Target
DB01198	Zopiclone	Small Molecule	43200-80-2	Approved	Target
DB01205	Flumazenil	Small Molecule	78755-81-4	Approved	Target
DB01215	Estazolam	Small Molecule	29975-16-4	Approved\|Illicit	Target
DB01236	Sevoflurane	Small Molecule	28523-86-6	Approved	Target
DB01341	Dihydroquinidine barbiturate	Small Molecule	-	Experimental	Target
DB01346	Quinidine barbiturate	Small Molecule	-	Approved	Target
DB01351	Amobarbital	Small Molecule	57-43-2	Approved\|Illicit	Target
DB01352	Aprobarbital	Small Molecule	77-02-1	Approved\|Illicit	Target
DB01353	Butethal	Small Molecule	77-28-1	Approved\|Illicit	Target
DB01354	Heptabarbital	Small Molecule	509-86-4	Approved	Target
DB01355	Hexobarbital	Small Molecule	56-29-1	Approved	Target
DB01381	Ginkgo biloba	Small Molecule	-	Approved\|Investigational\|Nutraceutical	Target
DB01437	Glutethimide	Small Molecule	77-21-4	Approved\|Illicit	Target
DB01483	Barbital	Small Molecule	57-44-3	Illicit	Target
DB01496	Barbituric acid derivative	Small Molecule		Experimental\|Illicit	Target
DB01544	Flunitrazepam	Small Molecule	1622-62-4	Approved\|Illicit	Target
DB01558	Bromazepam	Small Molecule	1812-30-2	Approved\|Illicit\|Investigational	Target
DB01559	Clotiazepam	Small Molecule	33671-46-4	Approved\|Illicit	Target
DB01567	Fludiazepam	Small Molecule	3900-31-0	Approved\|Illicit	Target
DB01587	Ketazolam	Small Molecule	27223-35-4	Approved	Target
DB01588	Prazepam	Small Molecule	2955-38-6	Approved\|Illicit	Target
DB01589	Quazepam	Small Molecule	36735-22-5	Approved\|Illicit	Target
DB01594	Cinolazepam	Small Molecule	75696-02-5	Approved	Target
DB01595	Nitrazepam	Small Molecule	146-22-5	Approved	Target
DB05087	Ganaxolone	Small Molecule	38398-32-2	Investigational	Target
DB06470	clomethiazole	Small Molecule		Investigational	Target
DB09166	Etizolam	Small Molecule	40054-69-1	Approved	Target
DB12458	Muscimol	Small Molecule	2763-96-4	Investigational	Target
DB13872	Lormetazepam	Small Molecule	848-75-9	Approved	Target
DB00186	Lorazepam	Small Molecule	846-49-1	Approved	Target
DB00189	Ethchlorvynol	Small Molecule	113-18-8	Approved\|Illicit\|Withdrawn	Target
DB00228	Enflurane	Small Molecule	13838-16-9	Approved\|Investigational	Target
DB00231	Temazepam	Small Molecule	846-50-4	Approved\|Investigational	Target
DB00237	Butabarbital	Small Molecule	125-40-6	Approved\|Illicit	Target
DB00241	Butalbital	Small Molecule	77-26-9	Approved\|Illicit	Target
DB00273	Topiramate	Small Molecule	97240-79-4	Approved	Target
DB00292	Etomidate	Small Molecule	33125-97-2	Approved	Target
DB00306	Talbutal	Small Molecule	115-44-6	Approved\|Illicit	Target
DB00312	Pentobarbital	Small Molecule	76-74-4	Approved\|Investigational	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00349	Clobazam	Small Molecule	22316-47-8	Approved\|Illicit	Target
DB00371	Meprobamate	Small Molecule	57-53-4	Approved\|Illicit	Target
DB00402	Eszopiclone	Small Molecule	138729-47-2	Approved\|Investigational	Target
DB00404	Alprazolam	Small Molecule	28981-97-7	Approved\|Illicit\|Investigational	Target
DB00463	Metharbital	Small Molecule	50-11-3	Withdrawn	Target
DB00475	Chlordiazepoxide	Small Molecule	58-25-3	Approved\|Illicit\|Investigational	Target
DB00543	Amoxapine	Small Molecule	14028-44-5	Approved	Target
DB00555	Lamotrigine	Small Molecule	84057-84-1	Approved\|Investigational	Target
DB00628	Clorazepate	Small Molecule	23887-31-2	Approved\|Illicit	Target
DB00659	Acamprosate	Small Molecule	77337-76-9	Approved\|Investigational	Target
DB00753	Isoflurane	Small Molecule	26675-46-7	Approved	Target
DB00794	Primidone	Small Molecule	125-33-7	Approved	Target
DB00801	Halazepam	Small Molecule	23092-17-3	Approved\|Illicit\|Withdrawn	Target
DB00818	Propofol	Small Molecule	2078-54-8	Approved\|Investigational	Target
DB00829	Diazepam	Small Molecule	439-14-5	Approved\|Illicit\|Investigational	Target
DB00842	Oxazepam	Small Molecule	604-75-1	Approved	Target
DB00897	Triazolam	Small Molecule	28911-01-5	Approved\|Investigational	Target
DB01028	Methoxyflurane	Small Molecule	76-38-0	Approved\|Investigational	Target
DB01049	Ergoloid mesylate	Small Molecule	8067-24-1	Approved	Target
DB01068	Clonazepam	Small Molecule	1622-61-3	Approved\|Illicit	Target
DB01107	Methyprylon	Small Molecule	125-64-4	Approved\|Illicit\|Withdrawn	Target
DB01159	Halothane	Small Molecule	151-67-7	Approved	Target
DB01189	Desflurane	Small Molecule	57041-67-5	Approved	Target
DB01205	Flumazenil	Small Molecule	78755-81-4	Approved	Target
DB01215	Estazolam	Small Molecule	29975-16-4	Approved\|Illicit	Target
DB01236	Sevoflurane	Small Molecule	28523-86-6	Approved	Target
DB01437	Glutethimide	Small Molecule	77-21-4	Approved\|Illicit	Target
DB01588	Prazepam	Small Molecule	2955-38-6	Approved\|Illicit	Target
DB01589	Quazepam	Small Molecule	36735-22-5	Approved\|Illicit	Target
DB01708	Prasterone	Small Molecule	53-43-0	Approved\|Investigational\|Nutraceutical	Target
DB01956	Taurine	Small Molecule	107-35-7	Approved\|Nutraceutical	Target
DB09118	Stiripentol	Small Molecule	49763-96-4	Approved	Target
DB11582	Thiocolchicoside	Small Molecule	602-41-5	Approved\|Investigational	Target
DB11901	Apalutamide	Small Molecule	956104-40-8	Approved\|Investigational	Target
DB00555	Lamotrigine	Small Molecule	84057-84-1	Approved\|Investigational	Target
DB06579	Adipiplon	Small Molecule	840486-93-3	Investigational	Target
DB13983	5,7,2G??-trihydroxy-6,8-dimethoxyflavone	Small Molecule	159359-22-5	Experimental	Target

ID	Drug Name	Action	PubMed
C024566	1,1,1-trichloroethane	"1,1,1-trichloroethane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]"	10825391
C040083	1-(2-methoxyphenyl)piperazine	1-(2-methoxyphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
C015068	1-(3-chlorophenyl)piperazine	1-(3-chlorophenyl)piperazine affects the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]	21729720
C015068	1-(3-chlorophenyl)piperazine	1-(3-chlorophenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
C015068	1-(3-chlorophenyl)piperazine	"1-(3-chlorophenyl)piperazine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	23266428
C015068	1-(3-chlorophenyl)piperazine	1-(3-chlorophenyl)piperazine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	23266428
C015068	1-(3-chlorophenyl)piperazine	1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	23266428
C015068	1-(3-chlorophenyl)piperazine	"3,4-Methylenedioxyamphetamine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	23266428
C015068	1-(3-chlorophenyl)piperazine	Cocaine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	23266428
C018406	1-(3-trifluoromethylphenyl)piperazine	1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
C026386	1-(4-chlorophenyl)piperazine	1-(4-chlorophenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
C091518	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	"1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB1 protein]"	21111751
C091518	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	"1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	14637376
C091518	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	"1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB3 protein]"	21111751
C091518	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	"Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
C091518	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	"gamma-Aminobutyric Acid affects the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
C091518	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	"gamma-Aminobutyric Acid promotes the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB1 protein]]"	21111751
C091518	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	"gamma-Aminobutyric Acid promotes the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB3 protein]]"	21111751
C091518	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	"Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
C091518	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	"Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
C091518	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	"Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
C091518	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	"tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
C091518	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	"tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
C490166	1-(4-methoxyphenyl)piperazine	1-(4-methoxyphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
C006737	1-benzylpiperazine	1-benzylpiperazine analog inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
C006737	1-benzylpiperazine	1-benzylpiperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
C118559	1-bromopropane	1-bromopropane results in decreased expression of GABRA1 mRNA	19576243
C038844	1-octen-3-ol	1-octen-3-ol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
C038844	1-octen-3-ol	1-octen-3-ol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]	16569037
C032904	2,2',3,5',6-pentachlorobiphenyl	"[2,2',3,5',6-pentachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	20819908
C035976	2,4,2',4'-tetrachlorobiphenyl	"2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	20819908
C035976	2,4,2',4'-tetrachlorobiphenyl	"[2,4,2',4'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	20819908
C035976	2,4,2',4'-tetrachlorobiphenyl	"2,4,2',4'-tetrachlorobiphenyl promotes the reaction [3,5-dibromo-2-(2,4-dibromophenoxy)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20861069
C035976	2,4,2',4'-tetrachlorobiphenyl	"2,4,2',4'-tetrachlorobiphenyl promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20861069
C035976	2,4,2',4'-tetrachlorobiphenyl	"2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	20861069
C035976	2,4,2',4'-tetrachlorobiphenyl	"2,4,4'-trichlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20819908
C035976	2,4,2',4'-tetrachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20819908
C035976	2,4,2',4'-tetrachlorobiphenyl	"[3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20861069
C035976	2,4,2',4'-tetrachlorobiphenyl	"3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20861069
C035976	2,4,2',4'-tetrachlorobiphenyl	"PCB 180 inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20819908
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	20819908
C081766	2,4,4'-trichlorobiphenyl	"2,4,4'-trichlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20819908
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20819908
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,5,2',5'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	20819908
C570407	2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol	"2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]"	22029276
C570407	2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol	"2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]"	22029276
C570407	2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol	"2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	22029276
C036531	2,6-xylenol	"2,6-xylenol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]"	11399263
C034047	2-cresol	2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]	11399263
C085794	3,5-dibromo-2-(2,4-dibromophenoxy)phenol	"2,4,2',4'-tetrachlorobiphenyl promotes the reaction [3,5-dibromo-2-(2,4-dibromophenoxy)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20861069
C085794	3,5-dibromo-2-(2,4-dibromophenoxy)phenol	"[3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20861069
C085794	3,5-dibromo-2-(2,4-dibromophenoxy)phenol	"3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20861069
C085794	3,5-dibromo-2-(2,4-dibromophenoxy)phenol	"3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20861069
C085794	3,5-dibromo-2-(2,4-dibromophenoxy)phenol	"3,5-dibromo-2-(2,4-dibromophenoxy)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	20861069
C054511	4,5-dimethyl-3-hydroxy-2(5H)-furanone	"4,5-dimethyl-3-hydroxy-2(5H)-furanone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]"	14664509
C534316	7-hydroxy-7-methyl-3-methylene-1-octene	7-hydroxy-7-methyl-3-methylene-1-octene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]	16569037
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of GABRA1 gene	27153756
D000481	Allantoin	Allantoin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in decreased expression of GABRA1 mRNA	17785943
C006477	alphaxalone	alphaxalone promotes the reaction [Flunitrazepam binds to GABRA1 protein]	8397295
C006477	alphaxalone	alphaxalone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	12939268
C006477	alphaxalone	alphaxalone results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	12939268
D005680	gamma-Aminobutyric Acid	1-octen-3-ol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D005680	gamma-Aminobutyric Acid	1-octen-3-ol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]	16569037
D005680	gamma-Aminobutyric Acid	"4,5-dimethyl-3-hydroxy-2(5H)-furanone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]"	14664509
D005680	gamma-Aminobutyric Acid	7-hydroxy-7-methyl-3-methylene-1-octene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]	16569037
D005680	gamma-Aminobutyric Acid	Allantoin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D005680	gamma-Aminobutyric Acid	benzothiazole promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D005680	gamma-Aminobutyric Acid	catechol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D005680	gamma-Aminobutyric Acid	Chlorogenic Acid inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D005680	gamma-Aminobutyric Acid	Coffee inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D005680	gamma-Aminobutyric Acid	Ethanol analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	12926865
D005680	gamma-Aminobutyric Acid	geraniol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]	16569037
D005680	gamma-Aminobutyric Acid	Guaiacol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D005680	gamma-Aminobutyric Acid	linalool promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]	16569037
D005680	gamma-Aminobutyric Acid	maltol inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D005680	gamma-Aminobutyric Acid	Theobromine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D005680	gamma-Aminobutyric Acid	Theophylline inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D005680	gamma-Aminobutyric Acid	"1,1,1-trichloroethane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]"	10825391
D005680	gamma-Aminobutyric Acid	1-(2-methoxyphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
D005680	gamma-Aminobutyric Acid	1-(3-chlorophenyl)piperazine affects the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]	21729720
D005680	gamma-Aminobutyric Acid	1-(3-chlorophenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
D005680	gamma-Aminobutyric Acid	1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
D005680	gamma-Aminobutyric Acid	1-(4-chlorophenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
D005680	gamma-Aminobutyric Acid	1-(4-methoxyphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
D005680	gamma-Aminobutyric Acid	1-benzylpiperazine analog inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
D005680	gamma-Aminobutyric Acid	1-benzylpiperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
D005680	gamma-Aminobutyric Acid	1-Butanol affects the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]]	11137757
D005680	gamma-Aminobutyric Acid	"[2,2',3,5',6-pentachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	20819908
D005680	gamma-Aminobutyric Acid	"[2,4,2',4'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	20819908
D005680	gamma-Aminobutyric Acid	"2,4,2',4'-tetrachlorobiphenyl promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20861069
D005680	gamma-Aminobutyric Acid	"[2,4,4'-trichlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	20819908
D005680	gamma-Aminobutyric Acid	"[2,5,2',5'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	20819908
D005680	gamma-Aminobutyric Acid	"3,4-Methylenedioxyamphetamine affects the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]"	21729720
D005680	gamma-Aminobutyric Acid	"[3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20861069
D005680	gamma-Aminobutyric Acid	"3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20861069
D005680	gamma-Aminobutyric Acid	alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D005680	gamma-Aminobutyric Acid	Amphetamine promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]	21729720
D005680	gamma-Aminobutyric Acid	beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15588619
D005680	gamma-Aminobutyric Acid	Bicuculline promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]	29038840
D005680	gamma-Aminobutyric Acid	Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15588619
D005680	gamma-Aminobutyric Acid	carvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15588619
D005680	gamma-Aminobutyric Acid	[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D005680	gamma-Aminobutyric Acid	[delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D005680	gamma-Aminobutyric Acid	delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
D005680	gamma-Aminobutyric Acid	delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
D005680	gamma-Aminobutyric Acid	delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]	11156579
D005680	gamma-Aminobutyric Acid	delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D005680	gamma-Aminobutyric Acid	Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
D005680	gamma-Aminobutyric Acid	Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]]	10825391
D005680	gamma-Aminobutyric Acid	Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]	10049148
D005680	gamma-Aminobutyric Acid	Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]	10049148
D005680	gamma-Aminobutyric Acid	fipronil promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]	29038840
D005680	gamma-Aminobutyric Acid	Flame Retardants promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	22547355
D005680	gamma-Aminobutyric Acid	gabazine affects the reaction [tetrabromobisphenol A promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]	22547355
D005680	gamma-Aminobutyric Acid	GABRA1 protein results in increased susceptibility to gamma-Aminobutyric Acid	15765150
D005680	gamma-Aminobutyric Acid	"gamma-Aminobutyric Acid affects the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	11812690
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid binds to and results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]	11137757
D005680	gamma-Aminobutyric Acid	"gamma-Aminobutyric Acid promotes the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB1 protein]]"	21111751
D005680	gamma-Aminobutyric Acid	"gamma-Aminobutyric Acid promotes the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB3 protein]]"	21111751
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]	10825391
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]	29038840
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	20861069\|2254735
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]	29038840
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]	9316872
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]	29038840
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]	21729720
D005680	gamma-Aminobutyric Acid	isoborneol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15588619
D005680	gamma-Aminobutyric Acid	Lanthanum promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D005680	gamma-Aminobutyric Acid	Lindane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
D005680	gamma-Aminobutyric Acid	Lindane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]	11156579
D005680	gamma-Aminobutyric Acid	Lindane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D005680	gamma-Aminobutyric Acid	Lindane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
D005680	gamma-Aminobutyric Acid	Lindane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
D005680	gamma-Aminobutyric Acid	loreclezole promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D005680	gamma-Aminobutyric Acid	Menthol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15588619
D005680	gamma-Aminobutyric Acid	menthone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15588619
D005680	gamma-Aminobutyric Acid	Methamphetamine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]	21729720
D005680	gamma-Aminobutyric Acid	methylone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]	21729720
D005680	gamma-Aminobutyric Acid	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]	10049148
D005680	gamma-Aminobutyric Acid	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]	10049148
D005680	gamma-Aminobutyric Acid	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D005680	gamma-Aminobutyric Acid	phenylpiperazine analog inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
D005680	gamma-Aminobutyric Acid	phenylpiperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
D005680	gamma-Aminobutyric Acid	Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D005680	gamma-Aminobutyric Acid	picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]	29038840
D005680	gamma-Aminobutyric Acid	picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]	29038840
D005680	gamma-Aminobutyric Acid	[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D005680	gamma-Aminobutyric Acid	Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]	10049148
D005680	gamma-Aminobutyric Acid	Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]	10049148
D005680	gamma-Aminobutyric Acid	Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D005680	gamma-Aminobutyric Acid	tetrabromobisphenol A promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	22547355
D005680	gamma-Aminobutyric Acid	tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]	29038840
D005680	gamma-Aminobutyric Acid	tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]	29038840
D005680	gamma-Aminobutyric Acid	Toluene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	10825391
D005680	gamma-Aminobutyric Acid	Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	10825391
D005680	gamma-Aminobutyric Acid	Urethane promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	11812690
D005680	gamma-Aminobutyric Acid	Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]	1712603
D005680	gamma-Aminobutyric Acid	Ethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]	1712603
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]	1712603
D005680	gamma-Aminobutyric Acid	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]	1712603
D005680	gamma-Aminobutyric Acid	alphaxalone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	12939268
D005680	gamma-Aminobutyric Acid	Anthracenes analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	18275132
D005680	gamma-Aminobutyric Acid	Bicuculline inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	1977069
D005680	gamma-Aminobutyric Acid	Bicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]	27720918
D005680	gamma-Aminobutyric Acid	cyclopentaphenanthrene analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	18275132
D005680	gamma-Aminobutyric Acid	Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	12939268
D005680	gamma-Aminobutyric Acid	Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]	15363660
D005680	gamma-Aminobutyric Acid	Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]	15363660
D005680	gamma-Aminobutyric Acid	Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15363660
D005680	gamma-Aminobutyric Acid	Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	1977069
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	17054655
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]	1977069
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	12939268\|1827513
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]	11123204
D005680	gamma-Aminobutyric Acid	[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides	11123204
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]	11399263
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB1 protein]	2165521
D005680	gamma-Aminobutyric Acid	"methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]"	1977069
D005680	gamma-Aminobutyric Acid	methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	27720918
D005680	gamma-Aminobutyric Acid	Niflumic Acid promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	27720918
D005680	gamma-Aminobutyric Acid	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	1977069
D005680	gamma-Aminobutyric Acid	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	12939268
D005680	gamma-Aminobutyric Acid	Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	17054655
D005680	gamma-Aminobutyric Acid	pregnenolone sulfate inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	17054655
D005680	gamma-Aminobutyric Acid	Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	12939268
D005680	gamma-Aminobutyric Acid	Steroids analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	18275132
D005680	gamma-Aminobutyric Acid	tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]	15363660
D005680	gamma-Aminobutyric Acid	tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]	15363660
D005680	gamma-Aminobutyric Acid	tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15363660
D005680	gamma-Aminobutyric Acid	topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]	11123204
D005680	gamma-Aminobutyric Acid	Zinc inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	17054655
D000639	Amitriptyline	Amitriptyline results in decreased expression of GABRA1 mRNA	22341215
D000639	Amitriptyline	Amitriptyline results in increased expression of GABRA1 mRNA	21820738
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GABRA1 mRNA	16483693
D000661	Amphetamine	Amphetamine promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]	21729720
D000873	Anthracenes	Anthracenes analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	18275132
D000873	Anthracenes	GABRA1 protein mutant form results in decreased susceptibility to Anthracenes analog	18275132
C016986	apraclonidine	apraclonidine binds to and affects the activity of GABRA1 protein	17496723
D001151	Arsenic	Arsenic affects the methylation of GABRA1 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in increased expression of GABRA1 mRNA	20458559
C500175	bacoside A	bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA]	20821261
D001534	Bemegride	Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	19244096
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GABRA1 mRNA	26001963
C005465	benzothiazole	benzothiazole promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D004958	Estradiol	[Estradiol co-treated with Progesterone] affects the expression of GABRA1 mRNA	19833106
D004958	Estradiol	Estradiol results in decreased expression of GABRA1 mRNA	19833106
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of GABRA1 mRNA	26496021
C005790	beta-thujone	beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15588619
D001640	Bicuculline	Bicuculline inhibits the reaction [Ethanol analog results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]	16569037
D001640	Bicuculline	Bicuculline promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]	29038840
D001640	Bicuculline	Bicuculline results in decreased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]	29038840
D001640	Bicuculline	Bicuculline inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	1977069
D001640	Bicuculline	Bicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]	27720918
D001640	Bicuculline	Bicuculline results in decreased expression of GABRA1 mRNA	9600394
C006780	bisphenol A	bisphenol A results in decreased expression of GABRA1 mRNA	24465770
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of GABRA1 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of GABRA1 mRNA	25181051
C054626	bretazenil	bretazenil binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]	8632757
C015044	bromoform	bromoform binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	12505655
D020001	1-Butanol	1-Butanol affects the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]]	11137757
D020001	1-Butanol	1-Butanol results in increased activity of GABRA1 protein	16807363
D002164	Camphor	Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15588619
D002220	Carbamazepine	Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA]	20821261
D002220	Carbamazepine	Carbamazepine results in increased activity of GABRA1 protein	18717705
D002328	Carisoprodol	Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	19244096
D002328	Carisoprodol	Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	19244096
C006923	carvone	carvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15588619
C034221	catechol	catechol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D002712	Chlorides	GABRA1 protein affects the reaction [Muscimol results in increased uptake of Chlorides]	12490572
D002712	Chlorides	[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides	11123204
D002712	Chlorides	topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]	11123204
D002726	Chlorogenic Acid	Chlorogenic Acid inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
C021604	CL 218872	CL 218872 binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]	8632757
C021604	CL 218872	CL 218872 binds to and results in increased activity of GABRA1 protein	16378217
D003000	Clonidine	Clonidine binds to and affects the activity of GABRA1 protein	17496723
D003024	Clozapine	Clozapine results in increased expression of GABRA1 mRNA	17266109
D003042	Cocaine	1-(3-chlorophenyl)piperazine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	23266428
D003042	Cocaine	"3,4-Methylenedioxyamphetamine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	23266428
D003042	Cocaine	Cocaine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	23266428
D003042	Cocaine	"Cocaine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	23266428
D003042	Cocaine	Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	23266428
D003042	Cocaine	Cocaine affects the expression of GABRA1 protein	20826313
D003069	Coffee	Coffee inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D005576	Colforsin	Colforsin results in increased expression of GABRA1	9147380
D003471	Cuprizone	Cuprizone results in decreased expression of GABRA1 mRNA	26577399
D003474	Curcumin	Curcumin results in decreased expression of GABRA1 mRNA	18299980
C013460	cyclopentaphenanthrene	cyclopentaphenanthrene analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	18275132
C013460	cyclopentaphenanthrene	GABRA1 protein mutant form results in decreased susceptibility to cyclopentaphenanthrene analog	18275132
C017160	cypermethrin	cypermethrin promotes the reaction [cypermethrin results in decreased expression of GABRA1 mRNA]	25288152
C017160	cypermethrin	cypermethrin promotes the reaction [cypermethrin results in decreased expression of GABRA1 protein]	25288152
C017160	cypermethrin	cypermethrin results in decreased expression of GABRA1 mRNA	25288152
C017160	cypermethrin	cypermethrin results in decreased expression of GABRA1 protein	25288152
C086916	delta-hexachlorocyclohexane	[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
C086916	delta-hexachlorocyclohexane	[delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
C086916	delta-hexachlorocyclohexane	delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
C086916	delta-hexachlorocyclohexane	delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
C086916	delta-hexachlorocyclohexane	delta-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
C086916	delta-hexachlorocyclohexane	delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]	11156579
C086916	delta-hexachlorocyclohexane	delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
C086916	delta-hexachlorocyclohexane	delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]	11156579
C086916	delta-hexachlorocyclohexane	delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]	11156579
C086916	delta-hexachlorocyclohexane	delta-hexachlorocyclohexane results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]	9316872
C086916	delta-hexachlorocyclohexane	Lindane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
D003907	Dexamethasone	Dexamethasone results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]	9316872
D003975	Diazepam	Diazepam affects the activity of GABRA1 protein	15864560
D003975	Diazepam	Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
D003975	Diazepam	Diazepam results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]	29038840
D003975	Diazepam	Diazepam results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]	29038840
D003975	Diazepam	Diazepam results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]	29038840
D003975	Diazepam	Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]	1712603
D003975	Diazepam	Diazepam promotes the reaction [Ethanol deficiency results in decreased expression of GABRA1 mRNA]	14684873
D003975	Diazepam	Diazepam results in decreased expression of GABRA1 mRNA	11804615\|1580219
D003975	Diazepam	Diazepam results in increased activity of GABRA1 protein	15613639
D003975	Diazepam	[Diazepam co-treated with honokiol] results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	21699169
D003975	Diazepam	Diazepam results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	21699169
C016366	dibenzothiophene	dibenzothiophene results in decreased expression of GABRA1 mRNA	23656968
D004026	Dieldrin	"Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
D004026	Dieldrin	Dieldrin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	14637376
D004026	Dieldrin	Dieldrin results in decreased expression of GABRA1 mRNA	9600394
D007980	Levodopa	Levodopa results in decreased expression of GABRA1 mRNA	15837143
D007980	Levodopa	Levodopa results in decreased expression of GABRA1 protein	15837143
D004737	Enflurane	Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]]	10825391
D000431	Ethanol	Bicuculline inhibits the reaction [Ethanol analog results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]	16569037
D000431	Ethanol	Ethanol analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	12926865
D000431	Ethanol	Ethanol analog results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]	16569037
D000431	Ethanol	Ethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]	1712603
D000431	Ethanol	Ethanol results in decreased expression of GABRA1 protein	25456265
D000431	Ethanol	Ethanol results in increased activity of GABRA1 protein	16807363
D000431	Ethanol	GABRA1 protein affects the susceptibility to Ethanol	12490572
D000431	Ethanol	Diazepam promotes the reaction [Ethanol deficiency results in decreased expression of GABRA1 mRNA]	14684873
D000431	Ethanol	Ethanol affects the localization of GABRA1 protein	25456265
D000431	Ethanol	Ethanol deficiency results in decreased expression of GABRA1 mRNA	14684873\|1740313
D000431	Ethanol	Ethanol results in decreased expression of GABRA1 mRNA	14684873\|1711815
D000431	Ethanol	Flumazenil inhibits the reaction [Ethanol deficiency results in decreased expression of GABRA1 mRNA]	17403139
D005045	Etomidate	Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]	10049148
D005045	Etomidate	Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]	10049148
D005045	Etomidate	Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	12939268
D005045	Etomidate	Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	12939268
D015738	Famotidine	Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]	15363660
D015738	Famotidine	Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]	15363660
D015738	Famotidine	Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15363660
C047360	felbamate	felbamate results in decreased activity of [GABRA1 protein binds to GABRB1 protein]	17056029
C047360	felbamate	felbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]	17056029
C047360	felbamate	felbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]	17056029
C047360	felbamate	felbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]	17056029
C082360	fipronil	fipronil promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]	29038840
C082360	fipronil	fipronil results in decreased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]	29038840
C082360	fipronil	fipronil results in decreased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]	29038840
C082360	fipronil	fipronil results in decreased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]	29038840
D005411	Flame Retardants	Flame Retardants promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	22547355
D005411	Flame Retardants	Flame Retardants results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	22547355
D005442	Flumazenil	Flumazenil inhibits the reaction [Ethanol deficiency results in decreased expression of GABRA1 mRNA]	17403139
D005442	Flumazenil	Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	1977069
D005445	Flunitrazepam	Flunitrazepam binds to GABRA1 protein	17496723
D005445	Flunitrazepam	"2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]"	22029276
D005445	Flunitrazepam	Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]	8632757
D005445	Flunitrazepam	Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]	22029276
D005445	Flunitrazepam	Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	22029276
D005445	Flunitrazepam	alphaxalone promotes the reaction [Flunitrazepam binds to GABRA1 protein]	8397295
D005445	Flunitrazepam	Flunitrazepam binds to GABRA1 protein	8397295
D005445	Flunitrazepam	Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA1 protein]	8397295
D005479	Flurazepam	Flurazepam binds to and affects the activity of GABRA1 protein	17496723
D005479	Flurazepam	GABRA1 protein affects the susceptibility to Flurazepam	12490572
D005481	Flurothyl	Flurothyl results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]	11090101
D018682	GABA Agents	GABA Agents binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]	8632757
C049853	gabazine	gabazine affects the reaction [tetrabromobisphenol A promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]	22547355
C015542	gaboxadol	GABRA1 protein affects the susceptibility to gaboxadol	12490572
C007836	geraniol	geraniol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]	16569037
D006139	Guaiacol	Guaiacol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D006220	Haloperidol	Haloperidol results in decreased expression of GABRA1 mRNA	18797397
D006582	Hexachlorophene	Hexachlorophene affects the expression of GABRA1 mRNA	29301063
C005499	honokiol	[Diazepam co-treated with honokiol] results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	21699169
C005499	honokiol	honokiol results in increased activity of [GABRA1 protein binds to GABRB2 protein]	21699169
C005499	honokiol	honokiol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	21699169
C005499	honokiol	honokiol results in increased activity of [GABRA1 protein binds to GABRB3 protein]	21699169
D007501	Iron	[Iron deficiency co-treated with manganese chloride] results in increased expression of GABRA1 protein	18771689
D007501	Iron	Iron deficiency results in decreased expression of GABRA1 mRNA	18771689
D007501	Iron	Iron deficiency results in increased expression of GABRA1 protein	18771689
C022871	isoborneol	isoborneol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15588619
D007530	Isoflurane	Isoflurane results in increased activity of GABRA1 protein	16807363
C063822	L 663581	L 663581 binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]	8632757
D007811	Lanthanum	[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D007811	Lanthanum	Lanthanum promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D007854	Lead	Lead affects the expression of GABRA1 mRNA	28903495
D007854	Lead	Lead results in increased expression of GABRA1 mRNA	19921347
C008261	lead acetate	lead acetate affects the expression of GABRA1 mRNA	24875535
C018584	linalool	linalool promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]	16569037
D001556	Lindane	"Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
D001556	Lindane	Lindane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
D001556	Lindane	Lindane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]	11156579
D001556	Lindane	Lindane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D001556	Lindane	Lindane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
D001556	Lindane	Lindane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D001556	Lindane	Lindane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
D001556	Lindane	Lindane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D001556	Lindane	Lindane results in increased expression of GABRA1 mRNA	25572523
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of GABRA1 mRNA	12057914
D008140	Lorazepam	Lorazepam results in decreased expression of GABRA1 mRNA	16107249
C066440	loreclezole	[delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
C066440	loreclezole	loreclezole promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
C008316	maltol	maltol inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
C025340	manganese chloride	[Iron deficiency co-treated with manganese chloride] results in increased expression of GABRA1 protein	18771689
C025340	manganese chloride	manganese chloride results in decreased expression of GABRA1 mRNA	18771689
C025340	manganese chloride	manganese chloride results in increased expression of GABRA1 protein	18771689
D008610	Menthol	Menthol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15588619
C019466	menthone	menthone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15588619
D008694	Methamphetamine	Methamphetamine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]	21729720
C034818	methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate	"methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]"	1977069
D015104	3,4-Methylenedioxyamphetamine	"1-(3-chlorophenyl)piperazine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	23266428
D015104	3,4-Methylenedioxyamphetamine	"3,4-Methylenedioxyamphetamine affects the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]"	21729720
D015104	3,4-Methylenedioxyamphetamine	"3,4-Methylenedioxyamphetamine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	23266428
D015104	3,4-Methylenedioxyamphetamine	"3,4-Methylenedioxyamphetamine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	23266428
D015104	3,4-Methylenedioxyamphetamine	"3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	23266428
D015104	3,4-Methylenedioxyamphetamine	"Cocaine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	23266428
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of GABRA1 mRNA	21385734
C004925	methylmercuric chloride	Bicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]	27720918
C004925	methylmercuric chloride	methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	27720918
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"	23266428
C400939	methylone	methylone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]	21729720
C043243	methyl tert-butyl ether	methyl tert-butyl ether results in increased expression of GABRA1 mRNA	19344668
C043243	methyl tert-butyl ether	methyl tert-butyl ether results in increased expression of GABRA1 protein	19344668
D009020	Morphine	Morphine results in decreased expression of GABRA1 mRNA	15183518
D009020	Morphine	Morphine results in increased expression of GABRA1 mRNA	15183518
D009118	Muscimol	"2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]"	22029276
D009118	Muscimol	Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]	22029276
D009118	Muscimol	Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	22029276
D009118	Muscimol	GABRA1 protein affects the reaction [Muscimol results in increased uptake of Chlorides]	12490572
D009544	Niflumic Acid	Niflumic Acid promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	27720918
C036006	oxcarbazepine	oxcarbazepine results in increased activity of GABRA1 protein	18717705
C410127	PCB 180	"PCB 180 inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	20819908
D010424	Pentobarbital	Pentobarbital binds to and affects the activity of GABRA1 protein	17496723
D010424	Pentobarbital	Lindane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
D010424	Pentobarbital	Lindane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D010424	Pentobarbital	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]	10049148
D010424	Pentobarbital	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]	10049148
D010424	Pentobarbital	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D010424	Pentobarbital	Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]	10049148
D010424	Pentobarbital	Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]	10049148
D010424	Pentobarbital	Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]	9316872
D010424	Pentobarbital	[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D010424	Pentobarbital	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]	1712603
D010424	Pentobarbital	Pentobarbital affects the expression of GABRA1 mRNA	8787126
D010424	Pentobarbital	Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA1 protein]	8397295
D010424	Pentobarbital	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	1977069
D010424	Pentobarbital	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	12939268
D010424	Pentobarbital	Pentobarbital results in decreased expression of GABRA1 mRNA	8207435
D010424	Pentobarbital	Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	12939268
D010424	Pentobarbital	Pentobarbital results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB1 protein]	2165521
D010433	Pentylenetetrazole	"Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
D010433	Pentylenetetrazole	Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	14637376
D010622	Phencyclidine	Phencyclidine results in increased expression of GABRA1 mRNA	17266109
C033457	phenobarbital quinidine	phenobarbital quinidine results in decreased expression of GABRA1 mRNA	15802192
C031503	phenylpiperazine	phenylpiperazine analog inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
C031503	phenylpiperazine	phenylpiperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	26344803
D010852	Picrotoxin	delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
D010852	Picrotoxin	Lindane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
D010852	Picrotoxin	"Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
D010852	Picrotoxin	Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D010852	Picrotoxin	Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	14637376
D010852	Picrotoxin	Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	17054655
D010852	Picrotoxin	Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	17054655
C022961	picrotoxinin	picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]	29038840
C022961	picrotoxinin	picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]	29038840
D010862	Pilocarpine	bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA]	20821261
D010862	Pilocarpine	Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA]	20821261
D010862	Pilocarpine	Pilocarpine results in decreased expression of GABRA1 mRNA	20821261
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	20819908
D011280	Pregnanolone	Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]	29038840
D011280	Pregnanolone	Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]	29038840
D011280	Pregnanolone	Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]	29038840
C018370	pregnenolone sulfate	pregnenolone sulfate inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	17054655
C018370	pregnenolone sulfate	pregnenolone sulfate results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	17054655
D011374	Progesterone	[Estradiol co-treated with Progesterone] affects the expression of GABRA1 mRNA	19833106
D015742	Propofol	delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]	9316872
D015742	Propofol	Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	22029276
D015742	Propofol	Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	22029276
D015742	Propofol	[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D015742	Propofol	Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]	10049148
D015742	Propofol	Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]	10049148
D015742	Propofol	Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
D015742	Propofol	Propofol results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]	29038840
D015742	Propofol	Propofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]	29038840
D015742	Propofol	Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]	29038840
D015742	Propofol	Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	12939268
D015742	Propofol	Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	12939268
D015742	Propofol	Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]	11399263
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of GABRA1 mRNA	24780913
D012999	Soman	Soman binds to and affects the activity of GABRA1 protein	22245390
D013256	Steroids	GABRA1 protein mutant form results in decreased susceptibility to Steroids analog	18275132
D013256	Steroids	Steroids analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	18275132
C043232	tert-butyl beta-carboline-3-carboxylate	tert-butyl beta-carboline-3-carboxylate binds to and results in decreased activity of GABRA1 protein	15698896
C043232	tert-butyl beta-carboline-3-carboxylate	[tert-butyl beta-carboline-3-carboxylate binds to and results in decreased activity of GABRA1 protein] which results in decreased susceptibility to tert-butyl beta-carboline-3-carboxylate	15698896
C043232	tert-butyl beta-carboline-3-carboxylate	[tert-butyl beta-carboline-3-carboxylate binds to and results in decreased activity of GABRA1 protein] which results in decreased susceptibility to zolpidem	15698896
C046308	tert-butylbicyclo-2-benzoate	"tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
C037476	tert-butylbicyclophosphorothionate	alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
C037476	tert-butylbicyclophosphorothionate	delta-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
C037476	tert-butylbicyclophosphorothionate	Dieldrin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	14637376
C037476	tert-butylbicyclophosphorothionate	Lindane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]	9316872
C037476	tert-butylbicyclophosphorothionate	Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	14637376
C037476	tert-butylbicyclophosphorothionate	Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	14637376
C037476	tert-butylbicyclophosphorothionate	tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	14637376
C037476	tert-butylbicyclophosphorothionate	tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]	9316872
C037476	tert-butylbicyclophosphorothionate	"tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"	14637376
D043343	Testosterone Propionate	Testosterone Propionate results in decreased expression of GABRA1 mRNA	16957604
C020806	tetrabromobisphenol A	gabazine affects the reaction [tetrabromobisphenol A promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]	22547355
C020806	tetrabromobisphenol A	tetrabromobisphenol A binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	22547355
C020806	tetrabromobisphenol A	tetrabromobisphenol A promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	22547355
C010349	tetramethylenedisulfotetramine	Bicuculline promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]	29038840
C010349	tetramethylenedisulfotetramine	fipronil promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]	29038840
C010349	tetramethylenedisulfotetramine	tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]	29038840
C010349	tetramethylenedisulfotetramine	tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]	29038840
D013805	Theobromine	Theobromine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D013806	Theophylline	Theophylline inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	14664509
D013806	Theophylline	Theophylline results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	11234751
D013849	Thimerosal	Thimerosal results in increased expression of GABRA1 mRNA	27188386
D013943	Thymol	Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]	11399263
C023990	tiotidine	tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]	15363660
C023990	tiotidine	tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]	15363660
C023990	tiotidine	tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	15363660
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of GABRA1 mRNA	28111298
D014050	Toluene	Toluene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	10825391
D014050	Toluene	Toluene affects the expression of GABRA1 mRNA	17108153\|2182784
C052342	topiramate	topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]	11123204
D014241	Trichloroethylene	Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]]	10825391
D014241	Trichloroethylene	Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]	10825391
C012589	trichostatin A	trichostatin A results in increased expression of GABRA1 mRNA	24935251
D014520	Urethane	Urethane promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	11812690
D014635	Valproic Acid	Valproic Acid results in decreased methylation of GABRA1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of GABRA1 mRNA	24935251
D014635	Valproic Acid	Valproic Acid results in decreased expression of GABRA1 mRNA	24896083
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of GABRA1 gene	25560391
D015016	Yohimbine	Yohimbine binds to and affects the activity of GABRA1 protein	17496723
C085665	zaleplon	zaleplon binds to and results in increased activity of GABRA1 protein	16378217
C085665	zaleplon	zaleplon deficiency results in decreased expression of GABRA1 mRNA	11804615
D015032	Zinc	Zinc inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]	17054655
D015032	Zinc	Zinc results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]	17054655
C049109	zolpidem	zolpidem binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]	8632757
C049109	zolpidem	zolpidem binds to and results in increased activity of GABRA1 protein	16378217
C049109	zolpidem	GABRA1 protein affects the susceptibility to zolpidem	12490572
C049109	zolpidem	GABRA1 protein results in increased susceptibility to zolpidem	16630580
C049109	zolpidem	[tert-butyl beta-carboline-3-carboxylate binds to and results in decreased activity of GABRA1 protein] which results in decreased susceptibility to zolpidem	15698896
C049109	zolpidem	zolpidem binds to and results in increased activity of GABRA1 protein	15698896
C049109	zolpidem	zolpidem deficiency results in decreased expression of GABRA1 mRNA	11804615
C049109	zolpidem	zolpidem results in increased activity of GABRA1 protein	16162846

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004890	GABA-A receptor activity	CONTRIBUTES_TO	IBA	21873635
GO:0005230	extracellular ligand-gated ion channel activity	CONTRIBUTES_TO	IBA	21873635
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	-	IBA	21873635
GO:0005254	chloride channel activity	-	IBA	21873635
GO:0008144	drug binding	-	ISS	-
GO:0008503	benzodiazepine receptor activity	CONTRIBUTES_TO	IBA	21873635
GO:0016917	GABA receptor activity	contributes_to	ISS	-
GO:0022851	GABA-gated chloride ion channel activity	-	IBA	21873635
GO:0022851	GABA-gated chloride ion channel activity	-	IDA	9039914
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	-	IBA	21873635
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	IBA	21873635
GO:0007214	gamma-aminobutyric acid signaling pathway	-	IBA	21873635
GO:0007214	gamma-aminobutyric acid signaling pathway	-	IEA	-
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0034220	ion transmembrane transport	-	IBA	21873635
GO:0042391	regulation of membrane potential	-	IBA	21873635
GO:0050877	nervous system process	-	IBA	21873635
GO:0051932	synaptic transmission, GABAergic	-	IBA	21873635
GO:0051932	synaptic transmission, GABAergic	-	ISS	-
GO:0060078	regulation of postsynaptic membrane potential	-	IBA	21873635
GO:0060078	regulation of postsynaptic membrane potential	-	IEA	-
GO:0071420	cellular response to histamine	-	IEA	-
GO:1902476	chloride transmembrane transport	-	IBA	21873635
GO:1902476	chloride transmembrane transport	-	IDA	9039914

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	ISS	-
GO:0030054	cell junction	-	IEA	-
GO:0030659	cytoplasmic vesicle membrane	-	IEA	-
GO:0032590	dendrite membrane	-	IBA	21873635
GO:0034707	chloride channel complex	-	IEA	-
GO:0043005	neuron projection	-	IBA	21873635
GO:0045202	synapse	-	IBA	21873635
GO:0045211	postsynaptic membrane	-	IEA	-
GO:0098794	postsynapse	-	IBA	21873635
GO:1902710	GABA receptor complex	-	ISS	-
GO:1902711	GABA-A receptor complex	-	IBA	21873635
GO:1902711	GABA-A receptor complex	-	IDA	9039914

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	IEA
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112315	Transmission across Chemical Synapses	IEA
R-HSA-112316	Neuronal System	TAS
R-HSA-112316	Neuronal System	IEA
R-HSA-977441	GABA A receptor activation	TAS
R-HSA-977443	GABA receptor activation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22072270	Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. (2012 Apr)	Wang KS	J Neural Transm (Vienna)
24136292	Association of gamma-aminobutyric acid A receptor alpha2 gene (GABRA2) with alcohol use disorder. (2014 Mar)	Li D	Neuropsychopharmacology
29032150	Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. (2018 Jan 30)	Sundararajan T	Gene
25191505	GABA Receptors Genes Polymorphisms and Alcohol Dependence: No Evidence of an Association in an Italian Male Population. (2014 Aug)	Terranova C	Clin Psychopharmacol Neurosci
29156239	Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. (2018 Feb)	Lieberman R	Alcohol
15690551	No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample. (2005 Jan 5)	Dick DM	Am J Med Genet B Neuropsychiatr Genet
16451705	Whole-genome association studies of alcoholism with loci linked to schizophrenia susceptibility. (2005 Dec 30)	Namkung J	BMC Genet
29520058	Histone deacetylases mediate GABAA receptor expression, physiology, and behavioral maladaptations in rat models of alcohol dependence. (2018 Jun)	Bohnsack JP	Neuropsychopharmacology
16792556	Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample. (2006 Jul)	Dick DM	Alcohol Clin Exp Res
25655461	Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)	Manzardo AM	Gene
12555233	Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting. (2003 Feb)	Song J	Am J Med Genet B Neuropsychiatr Genet
17440936	Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population. (2007 Jun 5)	Loh EW	Am J Med Genet B Neuropsychiatr Genet
28798030	Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons. (2017 Oct)	Bohnsack JP	J Pharmacol Exp Ther
28361821	Candidate genes for alcohol dependence: A genetic association study from India. (2016 Nov)	Malhotra S	Indian J Med Res