Gene Symbol | Pearson Correlation Coefficient |
---|---|
CHRDL1 | 0.863 |
FAM171B | 0.859 |
AHCYL2 | 0.855 |
HS2ST1 | 0.846 |
TMEM47 | 0.84 |
NADK2 | 0.835 |
NEBL | 0.827 |
ASPH | 0.825 |
AK4 | 0.825 |
LGR4 | 0.822 |
Gene Symbol | Pearson Correlation Coefficient |
---|---|
OR4F5 | -0.497 |
OR4F29 | -0.441 |
GNG8 | -0.322 |
ANXA13 | -0.318 |
TMEM139 | -0.314 |
GRAP2 | -0.311 |
SH2D1A | -0.307 |
SPINK8 | -0.304 |
KEL | -0.304 |
ARHGAP22 | -0.301 |
ID | Drug Name | Drug Type | CAS Num | Status | Role |
---|---|---|---|---|---|
DB00231 | Temazepam | Small Molecule | 846-50-4 | Approved|Investigational | Target |
DB00241 | Butalbital | Small Molecule | 77-26-9 | Approved|Illicit | Target |
DB00306 | Talbutal | Small Molecule | 115-44-6 | Approved|Illicit | Target |
DB00312 | Pentobarbital | Small Molecule | 76-74-4 | Approved|Investigational | Target |
DB00371 | Meprobamate | Small Molecule | 57-53-4 | Approved|Illicit | Target |
DB00402 | Eszopiclone | Small Molecule | 138729-47-2 | Approved|Investigational | Target |
DB00418 | Secobarbital | Small Molecule | 76-73-3 | Approved | Target |
DB00425 | Zolpidem | Small Molecule | 82626-48-0 | Approved | Target |
DB00463 | Metharbital | Small Molecule | 50-11-3 | Withdrawn | Target |
DB00546 | Adinazolam | Small Molecule | 37115-32-5 | Approved | Target |
DB00599 | Thiopental | Small Molecule | 76-75-5 | Approved | Target |
DB00683 | Midazolam | Small Molecule | 59467-70-8 | Approved|Illicit | Target |
DB00690 | Flurazepam | Small Molecule | 17617-23-1 | Approved|Illicit|Investigational | Target |
DB00794 | Primidone | Small Molecule | 125-33-7 | Approved | Target |
DB00801 | Halazepam | Small Molecule | 23092-17-3 | Approved|Illicit|Withdrawn | Target |
DB00829 | Diazepam | Small Molecule | 439-14-5 | Approved|Illicit|Investigational | Target |
DB00842 | Oxazepam | Small Molecule | 604-75-1 | Approved | Target |
DB00849 | Methylphenobarbital | Small Molecule | 115-38-8 | Approved | Target |
DB00897 | Triazolam | Small Molecule | 28911-01-5 | Approved|Investigational | Target |
DB00898 | Ethanol | Small Molecule | 64-17-5 | Approved | Target |
DB01198 | Zopiclone | Small Molecule | 43200-80-2 | Approved | Target |
DB01215 | Estazolam | Small Molecule | 29975-16-4 | Approved|Illicit | Target |
DB01346 | Quinidine barbiturate | Small Molecule | - | Approved | Target |
DB01351 | Amobarbital | Small Molecule | 57-43-2 | Approved|Illicit | Target |
DB01352 | Aprobarbital | Small Molecule | 77-02-1 | Approved|Illicit | Target |
DB01353 | Butethal | Small Molecule | 77-28-1 | Approved|Illicit | Target |
DB01354 | Heptabarbital | Small Molecule | 509-86-4 | Approved | Target |
DB01355 | Hexobarbital | Small Molecule | 56-29-1 | Approved | Target |
DB01483 | Barbital | Small Molecule | 57-44-3 | Illicit | Target |
DB01496 | Barbituric acid derivative | Small Molecule | Experimental|Illicit | Target | |
DB01544 | Flunitrazepam | Small Molecule | 1622-62-4 | Approved|Illicit | Target |
DB01558 | Bromazepam | Small Molecule | 1812-30-2 | Approved|Illicit|Investigational | Target |
DB01559 | Clotiazepam | Small Molecule | 33671-46-4 | Approved|Illicit | Target |
DB01567 | Fludiazepam | Small Molecule | 3900-31-0 | Approved|Illicit | Target |
DB01588 | Prazepam | Small Molecule | 2955-38-6 | Approved|Illicit | Target |
DB01589 | Quazepam | Small Molecule | 36735-22-5 | Approved|Illicit | Target |
DB01594 | Cinolazepam | Small Molecule | 75696-02-5 | Approved | Target |
DB01595 | Nitrazepam | Small Molecule | 146-22-5 | Approved | Target |
DB04903 | Pagoclone | Small Molecule | 133737-32-3 | Investigational | Target |
DB05087 | Ganaxolone | Small Molecule | 38398-32-2 | Investigational | Target |
DB09166 | Etizolam | Small Molecule | 40054-69-1 | Approved | Target |
DB13872 | Lormetazepam | Small Molecule | 848-75-9 | Approved | Target |
DB00186 | Lorazepam | Small Molecule | 846-49-1 | Approved | Target |
DB00189 | Ethchlorvynol | Small Molecule | 113-18-8 | Approved|Illicit|Withdrawn | Target |
DB00228 | Enflurane | Small Molecule | 13838-16-9 | Approved|Investigational | Target |
DB00231 | Temazepam | Small Molecule | 846-50-4 | Approved|Investigational | Target |
DB00237 | Butabarbital | Small Molecule | 125-40-6 | Approved|Illicit | Target |
DB00241 | Butalbital | Small Molecule | 77-26-9 | Approved|Illicit | Target |
DB00273 | Topiramate | Small Molecule | 97240-79-4 | Approved | Target |
DB00292 | Etomidate | Small Molecule | 33125-97-2 | Approved | Target |
DB00306 | Talbutal | Small Molecule | 115-44-6 | Approved|Illicit | Target |
DB00312 | Pentobarbital | Small Molecule | 76-74-4 | Approved|Investigational | Target |
DB00334 | Olanzapine | Small Molecule | 132539-06-1 | Approved|Investigational | Target |
DB00349 | Clobazam | Small Molecule | 22316-47-8 | Approved|Illicit | Target |
DB00371 | Meprobamate | Small Molecule | 57-53-4 | Approved|Illicit | Target |
DB00402 | Eszopiclone | Small Molecule | 138729-47-2 | Approved|Investigational | Target |
DB00404 | Alprazolam | Small Molecule | 28981-97-7 | Approved|Illicit|Investigational | Target |
DB00463 | Metharbital | Small Molecule | 50-11-3 | Withdrawn | Target |
DB00475 | Chlordiazepoxide | Small Molecule | 58-25-3 | Approved|Illicit|Investigational | Target |
DB00543 | Amoxapine | Small Molecule | 14028-44-5 | Approved | Target |
DB00555 | Lamotrigine | Small Molecule | 84057-84-1 | Approved|Investigational | Target |
DB00628 | Clorazepate | Small Molecule | 23887-31-2 | Approved|Illicit | Target |
DB00659 | Acamprosate | Small Molecule | 77337-76-9 | Approved|Investigational | Target |
DB00753 | Isoflurane | Small Molecule | 26675-46-7 | Approved | Target |
DB00794 | Primidone | Small Molecule | 125-33-7 | Approved | Target |
DB00801 | Halazepam | Small Molecule | 23092-17-3 | Approved|Illicit|Withdrawn | Target |
DB00818 | Propofol | Small Molecule | 2078-54-8 | Approved|Investigational | Target |
DB00829 | Diazepam | Small Molecule | 439-14-5 | Approved|Illicit|Investigational | Target |
DB00842 | Oxazepam | Small Molecule | 604-75-1 | Approved | Target |
DB00897 | Triazolam | Small Molecule | 28911-01-5 | Approved|Investigational | Target |
DB01028 | Methoxyflurane | Small Molecule | 76-38-0 | Approved|Investigational | Target |
DB01049 | Ergoloid mesylate | Small Molecule | 8067-24-1 | Approved | Target |
DB01068 | Clonazepam | Small Molecule | 1622-61-3 | Approved|Illicit | Target |
DB01107 | Methyprylon | Small Molecule | 125-64-4 | Approved|Illicit|Withdrawn | Target |
DB01159 | Halothane | Small Molecule | 151-67-7 | Approved | Target |
DB01189 | Desflurane | Small Molecule | 57041-67-5 | Approved | Target |
DB01205 | Flumazenil | Small Molecule | 78755-81-4 | Approved | Target |
DB01215 | Estazolam | Small Molecule | 29975-16-4 | Approved|Illicit | Target |
DB01236 | Sevoflurane | Small Molecule | 28523-86-6 | Approved | Target |
DB01437 | Glutethimide | Small Molecule | 77-21-4 | Approved|Illicit | Target |
DB01588 | Prazepam | Small Molecule | 2955-38-6 | Approved|Illicit | Target |
DB01589 | Quazepam | Small Molecule | 36735-22-5 | Approved|Illicit | Target |
DB01708 | Prasterone | Small Molecule | 53-43-0 | Approved|Investigational|Nutraceutical | Target |
DB01956 | Taurine | Small Molecule | 107-35-7 | Approved|Nutraceutical | Target |
DB09118 | Stiripentol | Small Molecule | 49763-96-4 | Approved | Target |
DB11582 | Thiocolchicoside | Small Molecule | 602-41-5 | Approved|Investigational | Target |
DB11901 | Apalutamide | Small Molecule | 956104-40-8 | Approved|Investigational | Target |
DB00555 | Lamotrigine | Small Molecule | 84057-84-1 | Approved|Investigational | Target |
DB06579 | Adipiplon | Small Molecule | 840486-93-3 | Investigational | Target |
DB13983 | 5,7,2G??-trihydroxy-6,8-dimethoxyflavone | Small Molecule | 159359-22-5 | Experimental | Target |
ID | Drug Name | Action | PubMed |
---|---|---|---|
C091518 | 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane | "1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]" | 14637376 |
C091518 | 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane | "Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]" | 14637376 |
C091518 | 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane | "Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]" | 14637376 |
C091518 | 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane | "Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]" | 14637376 |
C091518 | 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane | "Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]" | 14637376 |
C091518 | 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane | "tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]" | 14637376 |
C091518 | 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane | "tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]" | 14637376 |
C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GABRA2 mRNA" | 27188386 |
C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRA2 mRNA" | 27188386 |
C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GABRA2 mRNA" | 27188386 |
C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRA2 mRNA" | 27188386 |
D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased methylation of GABRA2 gene | 27153756 |
C006477 | alphaxalone | alphaxalone promotes the reaction [Flunitrazepam binds to GABRA2 protein] | 8397295 |
D005680 | gamma-Aminobutyric Acid | Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D005680 | gamma-Aminobutyric Acid | Chloralose promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D005680 | gamma-Aminobutyric Acid | Chlorobutanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D005680 | gamma-Aminobutyric Acid | Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D005680 | gamma-Aminobutyric Acid | Ether promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D005680 | gamma-Aminobutyric Acid | gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein] | 10683198 |
D005680 | gamma-Aminobutyric Acid | gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form] | 29038840 |
D005680 | gamma-Aminobutyric Acid | gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein] | 29038840 |
D005680 | gamma-Aminobutyric Acid | gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] | 29038840 |
D005680 | gamma-Aminobutyric Acid | Isoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D005680 | gamma-Aminobutyric Acid | Methoxyflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D005680 | gamma-Aminobutyric Acid | picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]] | 29038840 |
D005680 | gamma-Aminobutyric Acid | picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein]] | 29038840 |
D005680 | gamma-Aminobutyric Acid | picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]] | 29038840 |
D005680 | gamma-Aminobutyric Acid | sevoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D005680 | gamma-Aminobutyric Acid | tert-Butyl Alcohol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D005680 | gamma-Aminobutyric Acid | tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]] | 29038840 |
D005680 | gamma-Aminobutyric Acid | tribromoethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D005680 | gamma-Aminobutyric Acid | Trifluoroethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D005680 | gamma-Aminobutyric Acid | gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein] | 11123204 |
D005680 | gamma-Aminobutyric Acid | [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides | 11123204 |
D005680 | gamma-Aminobutyric Acid | tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG1 protein]] | 15363660 |
D005680 | gamma-Aminobutyric Acid | tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]] | 15363660 |
D005680 | gamma-Aminobutyric Acid | topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] | 11123204 |
D000639 | Amitriptyline | Amitriptyline results in increased expression of GABRA2 mRNA | 21820738 |
D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of GABRA2 mRNA | 16483693 |
D001280 | Atrazine | Atrazine results in decreased expression of GABRA2 mRNA | 25929836 |
D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of GABRA2 mRNA | 26001963 |
D001640 | Bicuculline | Bicuculline results in decreased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form] | 29038840 |
C006780 | bisphenol A | bisphenol A results in decreased expression of GABRA2 protein | 25112706 |
C006780 | bisphenol A | bisphenol A results in increased expression of GABRA2 protein | 25112706 |
C006780 | bisphenol A | bisphenol A affects the expression of GABRA2 mRNA | 26950200 |
C006780 | bisphenol A | bisphenol A results in decreased expression of GABRA2 mRNA | 25181051 |
C459604 | candoxin | candoxin results in increased expression of GABRA2 mRNA | 16309724 |
D002220 | Carbamazepine | Carbamazepine results in increased activity of GABRA2 protein | 18717705 |
D002330 | Carmustine | Carmustine results in decreased expression of GABRA2 mRNA | 15980968 |
D002330 | Carmustine | GABRA2 mRNA affects the susceptibility to Carmustine | 16365179 |
D002697 | Chloral Hydrate | Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D002698 | Chloralose | Chloralose promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D002698 | Chloralose | Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein] | 10683198 |
D002698 | Chloralose | Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein mutant form] | 10683198 |
D002698 | Chloralose | Chloralose results in increased activity of [GABRA2 protein mutant form binds to GABRB1 protein] | 10683198 |
D002698 | Chloralose | Picrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D002712 | Chlorides | [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides | 11123204 |
D002712 | Chlorides | topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] | 11123204 |
D002724 | Chlorobutanol | Chlorobutanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D003471 | Cuprizone | Cuprizone results in decreased expression of GABRA2 mRNA | 26577399 |
D003975 | Diazepam | Diazepam results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form] | 29038840 |
D003975 | Diazepam | Diazepam results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form] | 29038840 |
D003975 | Diazepam | GABRA2 protein affects the susceptibility to Diazepam | 18313124 |
D003975 | Diazepam | GABRA2 protein results in increased susceptibility to Diazepam | 16284244|2163293 |
D003975 | Diazepam | Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA2 mRNA] | 14684873 |
D003975 | Diazepam | Diazepam results in increased activity of GABRA2 protein | 15613639 |
D004026 | Dieldrin | "Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]" | 14637376 |
D004737 | Enflurane | Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D000431 | Ethanol | Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA2 mRNA] | 14684873 |
D000431 | Ethanol | Ethanol deficiency results in increased expression of GABRA2 mRNA | 14684873 |
D000431 | Ethanol | Ethanol deficiency results in increased expression of GABRA2 protein | 17403139 |
D000431 | Ethanol | Ethanol results in decreased expression of GABRA2 mRNA | 1711815 |
D004986 | Ether | Ether promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
C044610 | etizolam | etizolam affects the expression of GABRA2 mRNA | 16107249 |
C047360 | felbamate | felbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form] | 17056029 |
C047360 | felbamate | felbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] | 17056029 |
C082360 | fipronil | fipronil results in decreased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form] | 29038840 |
C082360 | fipronil | fipronil results in decreased activity of [GABRA2 protein binds to GABRB3] | 29038840 |
C082360 | fipronil | fipronil results in decreased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form] | 29038840 |
D005445 | Flunitrazepam | alphaxalone promotes the reaction [Flunitrazepam binds to GABRA2 protein] | 8397295 |
D005445 | Flunitrazepam | Flunitrazepam binds to GABRA2 protein | 8397295 |
D005445 | Flunitrazepam | Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA2 protein] | 8397295 |
D005445 | Flunitrazepam | Flunitrazepam results in increased activity of GABRA2 protein | 16162846 |
D005492 | Folic Acid | Folic Acid results in increased expression of GABRA2 mRNA | 25006883 |
D004397 | Fonofos | Fonofos results in increased methylation of GABRA2 promoter | 22847954 |
D005557 | Formaldehyde | Formaldehyde results in increased expression of GABRA2 mRNA | 12679049 |
C005499 | honokiol | honokiol results in increased activity of [GABRA2 protein binds to GABRB2 protein] | 21699169 |
D007530 | Isoflurane | Isoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D007854 | Lead | Lead affects the expression of GABRA2 mRNA | 28903495 |
D001556 | Lindane | "Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]" | 14637376 |
D008070 | Lipopolysaccharides | Lipopolysaccharides results in decreased expression of GABRA2 mRNA | 23483921 |
D008140 | Lorazepam | Lorazepam affects the expression of GABRA2 mRNA | 16107249 |
D008733 | Methoxyflurane | Methoxyflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D037742 | Nanotubes, Carbon | "Nanotubes, Carbon results in increased expression of GABRA2 mRNA" | 15585362 |
C036006 | oxcarbazepine | oxcarbazepine results in increased activity of GABRA2 protein | 18717705 |
D010100 | Oxygen | Oxygen deficiency results in increased expression of GABRA2 mRNA | 24236059 |
D010278 | Parathion | Parathion results in increased methylation of GABRA2 promoter | 22847954 |
C086401 | pentabromodiphenyl ether | pentabromodiphenyl ether results in decreased expression of GABRA2 protein | 23916505 |
D010424 | Pentobarbital | GABRA2 protein affects the susceptibility to Pentobarbital | 18313124 |
D010424 | Pentobarbital | Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA2 protein] | 8397295 |
D010433 | Pentylenetetrazole | "Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]" | 14637376 |
D010662 | Phenylmercuric Acetate | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GABRA2 mRNA" | 27188386 |
D010662 | Phenylmercuric Acetate | Phenylmercuric Acetate results in decreased expression of GABRA2 mRNA | 26272509 |
D010852 | Picrotoxin | "Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]" | 14637376 |
D010852 | Picrotoxin | Picrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
C022961 | picrotoxinin | picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]] | 29038840 |
C022961 | picrotoxinin | picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein]] | 29038840 |
C022961 | picrotoxinin | picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]] | 29038840 |
D011280 | Pregnanolone | Pregnanolone results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form] | 29038840 |
D011374 | Progesterone | Progesterone results in increased expression of GABRA2 mRNA | 16000229 |
D015742 | Propofol | Propofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form] | 29038840 |
D015742 | Propofol | Propofol results in increased activity of [GABRA2 protein binds to GABRB3] | 29038840 |
D015742 | Propofol | Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form] | 29038840 |
C042957 | Ro 15-4513 | GABRA2 protein affects the susceptibility to Ro 15-4513 | 15850489 |
C042957 | Ro 15-4513 | Ro 15-4513 binds to and results in increased activity of GABRA2 protein mutant form | 20133874 |
C009250 | sevoflurane | sevoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D012999 | Soman | Soman binds to and affects the activity of GABRA2 protein | 22245390 |
C446685 | systhane | systhane results in decreased expression of GABRA2 mRNA | 16730040 |
C047246 | temozolomide | GABRA2 mRNA affects the susceptibility to temozolomide | 16365179 |
C012568 | terbufos | terbufos results in increased methylation of GABRA2 promoter | 22847954 |
D020002 | tert-Butyl Alcohol | tert-Butyl Alcohol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
C046308 | tert-butylbicyclo-2-benzoate | "tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]" | 14637376 |
C037476 | tert-butylbicyclophosphorothionate | "tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]" | 14637376 |
D043343 | Testosterone Propionate | Testosterone Propionate results in decreased expression of GABRA2 mRNA | 16957604 |
D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of GABRA2 mRNA | 23871856 |
C010349 | tetramethylenedisulfotetramine | GABRA2 protein results in increased susceptibility to tetramethylenedisulfotetramine | 29038840 |
C010349 | tetramethylenedisulfotetramine | tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]] | 29038840 |
C023990 | tiotidine | tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG1 protein]] | 15363660 |
C023990 | tiotidine | tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]] | 15363660 |
D014050 | Toluene | Toluene affects the expression of GABRA2 mRNA | 17108153 |
C052342 | topiramate | topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] | 11123204 |
C032910 | triadimefon | triadimefon results in decreased expression of GABRA2 mRNA | 16730040 |
C062527 | tribromoethanol | tribromoethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D014270 | Trifluoroethanol | Trifluoroethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] | 10683198 |
D014635 | Valproic Acid | "[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRA2 mRNA" | 27188386 |
D014635 | Valproic Acid | Valproic Acid affects the expression of GABRA2 mRNA | 25979313 |
D014635 | Valproic Acid | Valproic Acid results in decreased methylation of GABRA2 gene | 29154799 |
D014635 | Valproic Acid | Valproic Acid results in increased expression of GABRA2 mRNA | 23179753|2438349 |
D014635 | Valproic Acid | Valproic Acid results in decreased expression of GABRA2 mRNA | 24896083 |
GO ID | GO Term | Qualifier | Evidence | PubMed |
---|---|---|---|---|
GO:0004890 | GABA-A receptor activity | CONTRIBUTES_TO | IBA | 21873635 |
GO:0005230 | extracellular ligand-gated ion channel activity | CONTRIBUTES_TO | IBA | 21873635 |
GO:0005237 | inhibitory extracellular ligand-gated ion channel activity | - | IBA | 21873635 |
GO:0005254 | chloride channel activity | - | IBA | 21873635 |
GO:0008503 | benzodiazepine receptor activity | CONTRIBUTES_TO | IBA | 21873635 |
GO:0008503 | benzodiazepine receptor activity | - | IMP | 8391122 |
GO:0022851 | GABA-gated chloride ion channel activity | - | IBA | 21873635 |
GO:0022851 | GABA-gated chloride ion channel activity | - | IDA | 9039914 |
GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | - | IBA | 21873635 |
GO ID | GO Term | Qualifier | Evidence | PubMed |
---|---|---|---|---|
GO:0001505 | regulation of neurotransmitter levels | - | IMP | 8391122 |
GO:0006836 | neurotransmitter transport | - | IMP | 8391122 |
GO:0007165 | signal transduction | - | IBA | 21873635 |
GO:0007214 | gamma-aminobutyric acid signaling pathway | - | IBA | 21873635 |
GO:0007214 | gamma-aminobutyric acid signaling pathway | - | IMP | 8391122 |
GO:0007268 | chemical synaptic transmission | - | IBA | 21873635 |
GO:0034220 | ion transmembrane transport | - | IBA | 21873635 |
GO:0042391 | regulation of membrane potential | - | IBA | 21873635 |
GO:0050877 | nervous system process | - | IBA | 21873635 |
GO:0051932 | synaptic transmission, GABAergic | - | IBA | 21873635 |
GO:0060078 | regulation of postsynaptic membrane potential | - | IBA | 21873635 |
GO:1902476 | chloride transmembrane transport | - | IBA | 21873635 |
GO:1902476 | chloride transmembrane transport | - | IDA | 9039914 |
GO ID | GO Term | Qualifier | Evidence | PubMed |
---|---|---|---|---|
GO:0005886 | plasma membrane | - | TAS | - |
GO:0005887 | integral component of plasma membrane | - | IBA | 21873635 |
GO:0030054 | cell junction | - | IEA | - |
GO:0030285 | integral component of synaptic vesicle membrane | - | IDA | 8391122 |
GO:0032590 | dendrite membrane | - | IBA | 21873635 |
GO:0034707 | chloride channel complex | - | IEA | - |
GO:0043005 | neuron projection | - | IBA | 21873635 |
GO:0045202 | synapse | - | IBA | 21873635 |
GO:0045211 | postsynaptic membrane | - | IEA | - |
GO:0098794 | postsynapse | - | IBA | 21873635 |
GO:1902711 | GABA-A receptor complex | - | IBA | 21873635 |
GO:1902711 | GABA-A receptor complex | - | IDA | 9039914 |
KEGG ID | KEGG Term |
---|---|
hsa04080 | Neuroactive ligand-receptor interaction |
Reactome ID | Reactome Term | Evidence |
---|---|---|
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | TAS |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | IEA |
R-HSA-112315 | Transmission across Chemical Synapses | TAS |
R-HSA-112315 | Transmission across Chemical Synapses | IEA |
R-HSA-112316 | Neuronal System | TAS |
R-HSA-112316 | Neuronal System | IEA |
R-HSA-977441 | GABA A receptor activation | TAS |
R-HSA-977443 | GABA receptor activation | TAS |
PMID | Title (Year) | Author | Journal |
---|---|---|---|
18727688 | The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample. (2008 Oct) | Lind PA | Alcohol Clin Exp Res |
15702134 | GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. (2005 Jun) | Pierucci-Lagha A | Neuropsychopharmacology |
19833324 | The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. (2010 Jan 1) | Enoch MA | Biol Psychiatry |
17982586 | Neurophysiological endophenotypes, CNS disinhibition, and risk for alcohol dependence and related disorders. (2007 Nov 2) | Porjesz B | ScientificWorldJournal |
26116794 | Association of GABAA receptor alpha2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior. (2015 Dec 3) | Strac DS | Prog Neuropsychopharmacol Biol Psychiatry |
26635556 | Motivational Effects of Methylphenidate are Associated with GABRA2 Variants Conferring Addiction Risk. (2015) | Duka T | Front Behav Neurosci |
25399692 | Genetics of alcoholism. (2014 Dec) | Iyer-Eimerbrink PA | Curr Psychiatry Rep |
19536785 | GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. (2010 Mar 5) | Xuei X | Am J Med Genet B Neuropsychiatr Genet |
23692184 | Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood. (2014 Nov) | Dick DM | Addict Biol |
16874763 | Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. (2006 Sep 5) | Enoch MA | Am J Med Genet B Neuropsychiatr Genet |
22555154 | Gamma-aminobutyric acid A receptor, alpha-2 (GABRA2) variants as individual markers for alcoholism: a meta-analysis. (2012 Aug) | Zintzaras E | Psychiatr Genet |
23561058 | How phenotype and developmental stage affect the genes we find: GABRA2 and impulsivity. (2013 Jun) | Dick DM | Twin Res Hum Genet |
28361821 | Candidate genes for alcohol dependence: A genetic association study from India. (2016 Nov) | Malhotra S | Indian J Med Res |
20698837 | A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study. (2010 Dec) | Kareken DA | Alcohol Clin Exp Res |
18482426 | Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study. (2008 Jun) | Agrawal A | Addiction |
20133874 | Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors. (2010 Feb 2) | Dixon CI | Proc Natl Acad Sci U S A |
25307596 | Genetics of alcoholism. (2014) | Edenberg HJ | Handb Clin Neurol |
23566244 | Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems. (2013 Jul) | Villafuerte S | Genes Brain Behav |
22501025 | GABRA2 markers moderate the subjective effects of alcohol. (2013 Mar) | Uhart M | Addict Biol |
17690794 | The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses. (2007 Sep) | Matthews AG | J Stud Alcohol Drugs |
19569404 | Under the influence of genetics: how transdisciplinarity leads us to rethink social pathways to illness. (2008) | Pescosolido BA | AJS |
24091936 | Genetic influences on the development of alcoholism. (2013 Nov) | Enoch MA | Curr Psychiatry Rep |
24975023 | Effect of GABRA2 genotype on development of incentive-motivation circuitry in a sample enriched for alcoholism risk. (2014 Dec) | Heitzeg MM | Neuropsychopharmacology |
15950776 | Alternative splicing and promoter use in the human GABRA2 gene. (2005 Jun 13) | Tian H | Brain Res Mol Brain Res |
24136292 | Association of gamma-aminobutyric acid A receptor alpha2 gene (GABRA2) with alcohol use disorder. (2014 Mar) | Li D | Neuropsychopharmacology |
24692236 | Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. (2014 Jun) | Kos MZ | Am J Med Genet B Neuropsychiatr Genet |
19783384 | Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives. (2010 Jan 15) | Sakai JT | Drug Alcohol Depend |
24557088 | Dutasteride reduces alcohol's sedative effects in men in a human laboratory setting and reduces drinking in the natural environment. (2014 Sep) | Covault J | Psychopharmacology (Berl) |
21683760 | Genetic association study of GABRA2 single nucleotide polymorphisms and electroencephalography in alcohol dependence. (2011 Aug 18) | Lydall GJ | Neurosci Lett |
17949392 | Variation in GABRA2 predicts drinking behavior in project MATCH subjects. (2007 Nov) | Bauer LO | Alcohol Clin Exp Res |
18634760 | Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes. (2008 Oct 15) | Rangaswamy M | Brain Res |
18781239 | Multiple-domain predictors of problematic alcohol use in young adulthood. (2008 Sep) | Kramer JR | J Stud Alcohol Drugs |
16612210 | New findings on the genetic influences on alcohol use and dependence. (2006 May) | Higuchi S | Curr Opin Psychiatry |
17207817 | GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. (2008 Feb) | Soyka M | J Psychiatr Res |
22921455 | alpha2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders. (2012 Nov) | Engin E | Pharmacol Ther |
19207358 | Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerstrom Test for Nicotine Dependence. (2009 Mar) | Agrawal A | Addiction |
21118274 | Role of GABRA2 in moderating subjective responses to alcohol. (2011 Mar) | Roh S | Alcohol Clin Exp Res |
16451705 | Whole-genome association studies of alcoholism with loci linked to schizophrenia susceptibility. (2005 Dec 30) | Namkung J | BMC Genet |
27117237 | Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. (2016 Sep) | Boyd SJ | Alcohol Alcohol |
22978509 | Convergence of genome-wide association and candidate gene studies for alcoholism. (2012 Dec) | Olfson E | Alcohol Clin Exp Res |
18519829 | An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project. (2008 Jun) | Agrawal A | Arch Gen Psychiatry |
20225194 | Analysis of extreme drinking in patients with alcohol dependence using Pareto regression. (2010 May 20) | Das S | Stat Med |
26250693 | GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures. (2015 Sep) | Lieberman R | Alcohol Clin Exp Res |
16395124 | Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis. (2006 Feb) | Fehr C | Psychiatr Genet |
15024690 | Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. (2004 Apr) | Edenberg HJ | Am J Hum Genet |
16961766 | The genetics of alcoholism: identifying specific genes through family studies. (2006 Sep) | Edenberg HJ | Addict Biol |
21483437 | Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. (2012 May) | Villafuerte S | Mol Psychiatry |
23134043 | Identifying genetic variation for alcohol dependence. (2012) | Agrawal A | Alcohol Res |
16557364 | The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. (2006 Jul) | Dick DM | Behav Genet |
25655461 | Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15) | Manzardo AM | Gene |
17507911 | Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene. (2008 Mar) | Covault J | Neuropsychopharmacology |
19487630 | Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. (2009 Jun) | Dick DM | Arch Gen Psychiatry |
19382902 | Altering the relative abundance of GABA A receptor subunits changes GABA- and ethanol-responses in Xenopus oocytes. (2009 Jun) | Hurley JH | Alcohol Clin Exp Res |
25365806 | Genetic variation in GABRA2 moderates peer influence on externalizing behavior in adolescents. (2014) | Villafuerte S | Brain Behav |
15274050 | Allelic and haplotypic association of GABRA2 with alcohol dependence. (2004 Aug 15) | Covault J | Am J Med Genet B Neuropsychiatr Genet |
16894595 | Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. (2006 Dec 5) | Drgon T | Am J Med Genet B Neuropsychiatr Genet |
24220019 | Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism. (2014 Aug) | Enoch MA | Pharmacol Biochem Behav |
20876231 | Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive alpha2-containing GABA(A) receptors. (2011 Jan) | Blednov YA | J Pharmacol Exp Ther |
22882391 | Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. (2012 Sep-Oct) | Smelson D | Am J Addict |
21919924 | GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans. (2012 Apr) | Ittiwut C | Alcohol Clin Exp Res |
20716301 | Obesity, smoking, and frontal brain dysfunction. (2010 Sep-Oct) | Bauer L | Am J Addict |
18818659 | GABRG1 and GABRA2 as independent predictors for alcoholism in two populations. (2009 Apr) | Enoch MA | Neuropsychopharmacology |
24166645 | A GABRA2 variant is associated with increased stimulation and 'high' following alcohol administration. (2014 Jan-Feb) | Arias AJ | Alcohol Alcohol |
26075969 | Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2. (2015 Aug) | Salvatore JE | J Abnorm Psychol |
22662011 | GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects. (2012 May 9) | Grzywacz A | Arch Med Sci |
16562401 | Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction. (2006 Mar) | Dick DM | J Stud Alcohol |
18440057 | The role of GABA(A) receptors in the development of alcoholism. (2008 Jul) | Enoch MA | Pharmacol Biochem Behav |
23712313 | Genetics and alcoholism. (2013 Aug) | Edenberg HJ | Nat Rev Gastroenterol Hepatol |
19672139 | Role of GABRA2 on risk for alcohol, nicotine, and cannabis dependence in the Iowa Adoption Studies. (2009 Apr) | Philibert RA | Psychiatr Genet |
20482509 | Pharmacogenetics of alcohol and alcohol dependence treatment. (2010) | Kranzler HR | Curr Pharm Des |
16341909 | Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism. (2006 Jan) | Dick DM | Behav Genet |
23974430 | Gender-specific gene-environment interaction in alcohol dependence: the impact of daily life events and GABRA2. (2013 Sep) | Perry BL | Behav Genet |
18005236 | Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression. (2008 Jun) | Haughey HM | Genes Brain Behav |
17976953 | Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4. (2008 Jan) | Ittiwut C | Genomics |
18361719 | Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study. (2008 Apr) | Lind PA | Twin Res Hum Genet |
23504072 | Association of VMAT2 gene polymorphisms with alcohol dependence. (2013 Aug) | Fehr C | J Neural Transm (Vienna) |
28847377 | A GABRA2 polymorphism improves a model for prediction of drinking initiation. (2017 Sep) | Kuperman S | Alcohol |
20102561 | GABRA2 and alcohol use disorders: no evidence of an association in an Italian case-control study. (2010 Apr) | Onori N | Alcohol Clin Exp Res |
24687270 | Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study. (2014 Jul) | Melroy WE | Behav Genet |
24548628 | Genetic variation at the CYP2C19 gene associated with metabolic syndrome susceptibility in a South Portuguese population: results from the pilot study of the European Health Examination Survey in Portugal. (2014 Feb 18) | Gaio V | Diabetol Metab Syndr |
15834213 | Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population. (2005 Apr) | Lappalainen J | Alcohol Clin Exp Res |
20202923 | A genome-wide association study of alcohol dependence. (2010 Mar 16) | Bierut LJ | Proc Natl Acad Sci U S A |
26087834 | Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking. (2015 Jul) | Kosobud AE | Alcohol Clin Exp Res |