Gene: GABRA2

2555
-
gamma-aminobutyric acid type A receptor alpha2 subunit
protein-coding
4p12
Ensembl:ENSG00000151834 MIM:137140 Vega:OTTHUMG00000044266 UniprotKB:P47869
NG_012835.2
PubMed
CD|OD|ND|AD
83   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.291e-2 (AD)  4.397e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRDL10.863
FAM171B0.859
AHCYL20.855
HS2ST10.846
TMEM470.84
NADK20.835
NEBL0.827
ASPH0.825
AK40.825
LGR40.822

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.497
OR4F29-0.441
GNG8-0.322
ANXA13-0.318
TMEM139-0.314
GRAP2-0.311
SH2D1A-0.307
SPINK8-0.304
KEL-0.304
ARHGAP22-0.301

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00241ButalbitalSmall Molecule77-26-9Approved|IllicitTarget
DB00306TalbutalSmall Molecule115-44-6Approved|IllicitTarget
DB00312PentobarbitalSmall Molecule76-74-4Approved|InvestigationalTarget
DB00371MeprobamateSmall Molecule57-53-4Approved|IllicitTarget
DB00402EszopicloneSmall Molecule138729-47-2Approved|InvestigationalTarget
DB00418SecobarbitalSmall Molecule76-73-3ApprovedTarget
DB00425ZolpidemSmall Molecule82626-48-0ApprovedTarget
DB00463MetharbitalSmall Molecule50-11-3WithdrawnTarget
DB00546AdinazolamSmall Molecule37115-32-5ApprovedTarget
DB00599ThiopentalSmall Molecule76-75-5ApprovedTarget
DB00683MidazolamSmall Molecule59467-70-8Approved|IllicitTarget
DB00690FlurazepamSmall Molecule17617-23-1Approved|Illicit|InvestigationalTarget
DB00794PrimidoneSmall Molecule125-33-7ApprovedTarget
DB00801HalazepamSmall Molecule23092-17-3Approved|Illicit|WithdrawnTarget
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalTarget
DB00842OxazepamSmall Molecule604-75-1ApprovedTarget
DB00849MethylphenobarbitalSmall Molecule115-38-8ApprovedTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01198ZopicloneSmall Molecule43200-80-2ApprovedTarget
DB01215EstazolamSmall Molecule29975-16-4Approved|IllicitTarget
DB01346Quinidine barbiturateSmall Molecule-ApprovedTarget
DB01351AmobarbitalSmall Molecule57-43-2Approved|IllicitTarget
DB01352AprobarbitalSmall Molecule77-02-1Approved|IllicitTarget
DB01353ButethalSmall Molecule77-28-1Approved|IllicitTarget
DB01354HeptabarbitalSmall Molecule509-86-4ApprovedTarget
DB01355HexobarbitalSmall Molecule56-29-1ApprovedTarget
DB01483BarbitalSmall Molecule57-44-3IllicitTarget
DB01496Barbituric acid derivativeSmall MoleculeExperimental|IllicitTarget
DB01544FlunitrazepamSmall Molecule1622-62-4Approved|IllicitTarget
DB01558BromazepamSmall Molecule1812-30-2Approved|Illicit|InvestigationalTarget
DB01559ClotiazepamSmall Molecule33671-46-4Approved|IllicitTarget
DB01567FludiazepamSmall Molecule3900-31-0Approved|IllicitTarget
DB01588PrazepamSmall Molecule2955-38-6Approved|IllicitTarget
DB01589QuazepamSmall Molecule36735-22-5Approved|IllicitTarget
DB01594CinolazepamSmall Molecule75696-02-5ApprovedTarget
DB01595NitrazepamSmall Molecule146-22-5ApprovedTarget
DB04903PagocloneSmall Molecule133737-32-3InvestigationalTarget
DB05087GanaxoloneSmall Molecule38398-32-2InvestigationalTarget
DB09166EtizolamSmall Molecule40054-69-1ApprovedTarget
DB13872LormetazepamSmall Molecule848-75-9ApprovedTarget
DB00186LorazepamSmall Molecule846-49-1ApprovedTarget
DB00189EthchlorvynolSmall Molecule113-18-8Approved|Illicit|WithdrawnTarget
DB00228EnfluraneSmall Molecule13838-16-9Approved|InvestigationalTarget
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00237ButabarbitalSmall Molecule125-40-6Approved|IllicitTarget
DB00241ButalbitalSmall Molecule77-26-9Approved|IllicitTarget
DB00273TopiramateSmall Molecule97240-79-4ApprovedTarget
DB00292EtomidateSmall Molecule33125-97-2ApprovedTarget
DB00306TalbutalSmall Molecule115-44-6Approved|IllicitTarget
DB00312PentobarbitalSmall Molecule76-74-4Approved|InvestigationalTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00349ClobazamSmall Molecule22316-47-8Approved|IllicitTarget
DB00371MeprobamateSmall Molecule57-53-4Approved|IllicitTarget
DB00402EszopicloneSmall Molecule138729-47-2Approved|InvestigationalTarget
DB00404AlprazolamSmall Molecule28981-97-7Approved|Illicit|InvestigationalTarget
DB00463MetharbitalSmall Molecule50-11-3WithdrawnTarget
DB00475ChlordiazepoxideSmall Molecule58-25-3Approved|Illicit|InvestigationalTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00628ClorazepateSmall Molecule23887-31-2Approved|IllicitTarget
DB00659AcamprosateSmall Molecule77337-76-9Approved|InvestigationalTarget
DB00753IsofluraneSmall Molecule26675-46-7ApprovedTarget
DB00794PrimidoneSmall Molecule125-33-7ApprovedTarget
DB00801HalazepamSmall Molecule23092-17-3Approved|Illicit|WithdrawnTarget
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalTarget
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalTarget
DB00842OxazepamSmall Molecule604-75-1ApprovedTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB01028MethoxyfluraneSmall Molecule76-38-0Approved|InvestigationalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB01068ClonazepamSmall Molecule1622-61-3Approved|IllicitTarget
DB01107MethyprylonSmall Molecule125-64-4Approved|Illicit|WithdrawnTarget
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
DB01189DesfluraneSmall Molecule57041-67-5ApprovedTarget
DB01205FlumazenilSmall Molecule78755-81-4ApprovedTarget
DB01215EstazolamSmall Molecule29975-16-4Approved|IllicitTarget
DB01236SevofluraneSmall Molecule28523-86-6ApprovedTarget
DB01437GlutethimideSmall Molecule77-21-4Approved|IllicitTarget
DB01588PrazepamSmall Molecule2955-38-6Approved|IllicitTarget
DB01589QuazepamSmall Molecule36735-22-5Approved|IllicitTarget
DB01708PrasteroneSmall Molecule53-43-0Approved|Investigational|NutraceuticalTarget
DB01956TaurineSmall Molecule107-35-7Approved|NutraceuticalTarget
DB09118StiripentolSmall Molecule49763-96-4ApprovedTarget
DB11582ThiocolchicosideSmall Molecule602-41-5Approved|InvestigationalTarget
DB11901ApalutamideSmall Molecule956104-40-8Approved|InvestigationalTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB06579AdipiplonSmall Molecule840486-93-3InvestigationalTarget
DB139835,7,2G??-trihydroxy-6,8-dimethoxyflavoneSmall Molecule159359-22-5ExperimentalTarget
ID Drug Name Action PubMed
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GABRA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GABRA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRA2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GABRA2 gene27153756
C006477alphaxalonealphaxalone promotes the reaction [Flunitrazepam binds to GABRA2 protein]8397295
D005680gamma-Aminobutyric AcidChloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D005680gamma-Aminobutyric AcidChloralose promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D005680gamma-Aminobutyric AcidChlorobutanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D005680gamma-Aminobutyric AcidEnflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D005680gamma-Aminobutyric AcidEther promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]10683198
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]29038840
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein]29038840
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]29038840
D005680gamma-Aminobutyric AcidIsoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D005680gamma-Aminobutyric AcidMethoxyflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D005680gamma-Aminobutyric Acidpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]29038840
D005680gamma-Aminobutyric Acidpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein]]29038840
D005680gamma-Aminobutyric Acidpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D005680gamma-Aminobutyric Acidsevoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D005680gamma-Aminobutyric Acidtert-Butyl Alcohol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D005680gamma-Aminobutyric Acidtetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D005680gamma-Aminobutyric Acidtribromoethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D005680gamma-Aminobutyric AcidTrifluoroethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]11123204
D005680gamma-Aminobutyric Acid[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides11123204
D005680gamma-Aminobutyric Acidtiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D005680gamma-Aminobutyric Acidtiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]15363660
D005680gamma-Aminobutyric Acidtopiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]11123204
D000639AmitriptylineAmitriptyline results in increased expression of GABRA2 mRNA21820738
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GABRA2 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of GABRA2 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GABRA2 mRNA26001963
D001640BicucullineBicuculline results in decreased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
C006780bisphenol Abisphenol A results in decreased expression of GABRA2 protein25112706
C006780bisphenol Abisphenol A results in increased expression of GABRA2 protein25112706
C006780bisphenol Abisphenol A affects the expression of GABRA2 mRNA26950200
C006780bisphenol Abisphenol A results in decreased expression of GABRA2 mRNA25181051
C459604candoxincandoxin results in increased expression of GABRA2 mRNA16309724
D002220CarbamazepineCarbamazepine results in increased activity of GABRA2 protein18717705
D002330CarmustineCarmustine results in decreased expression of GABRA2 mRNA15980968
D002330CarmustineGABRA2 mRNA affects the susceptibility to Carmustine16365179
D002697Chloral HydrateChloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D002698ChloraloseChloralose promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D002698ChloraloseChloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]10683198
D002698ChloraloseChloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein mutant form]10683198
D002698ChloraloseChloralose results in increased activity of [GABRA2 protein mutant form binds to GABRB1 protein]10683198
D002698ChloralosePicrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D002712Chlorides[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides11123204
D002712Chloridestopiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]11123204
D002724ChlorobutanolChlorobutanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D003471CuprizoneCuprizone results in decreased expression of GABRA2 mRNA26577399
D003975DiazepamDiazepam results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]29038840
D003975DiazepamDiazepam results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D003975DiazepamGABRA2 protein affects the susceptibility to Diazepam18313124
D003975DiazepamGABRA2 protein results in increased susceptibility to Diazepam16284244|2163293
D003975DiazepamDiazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA2 mRNA]14684873
D003975DiazepamDiazepam results in increased activity of GABRA2 protein15613639
D004026Dieldrin"Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D004737EnfluraneEnflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D000431EthanolDiazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA2 mRNA]14684873
D000431EthanolEthanol deficiency results in increased expression of GABRA2 mRNA14684873
D000431EthanolEthanol deficiency results in increased expression of GABRA2 protein17403139
D000431EthanolEthanol results in decreased expression of GABRA2 mRNA1711815
D004986EtherEther promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
C044610etizolametizolam affects the expression of GABRA2 mRNA16107249
C047360felbamatefelbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]17056029
C047360felbamatefelbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]17056029
C082360fipronilfipronil results in decreased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]29038840
C082360fipronilfipronil results in decreased activity of [GABRA2 protein binds to GABRB3]29038840
C082360fipronilfipronil results in decreased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D005445Flunitrazepamalphaxalone promotes the reaction [Flunitrazepam binds to GABRA2 protein]8397295
D005445FlunitrazepamFlunitrazepam binds to GABRA2 protein8397295
D005445FlunitrazepamPentobarbital promotes the reaction [Flunitrazepam binds to GABRA2 protein]8397295
D005445FlunitrazepamFlunitrazepam results in increased activity of GABRA2 protein16162846
D005492Folic AcidFolic Acid results in increased expression of GABRA2 mRNA25006883
D004397FonofosFonofos results in increased methylation of GABRA2 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of GABRA2 mRNA12679049
C005499honokiolhonokiol results in increased activity of [GABRA2 protein binds to GABRB2 protein]21699169
D007530IsofluraneIsoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D007854LeadLead affects the expression of GABRA2 mRNA28903495
D001556Lindane"Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of GABRA2 mRNA23483921
D008140LorazepamLorazepam affects the expression of GABRA2 mRNA16107249
D008733MethoxyfluraneMethoxyflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GABRA2 mRNA"15585362
C036006oxcarbazepineoxcarbazepine results in increased activity of GABRA2 protein18717705
D010100OxygenOxygen deficiency results in increased expression of GABRA2 mRNA24236059
D010278ParathionParathion results in increased methylation of GABRA2 promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of GABRA2 protein23916505
D010424PentobarbitalGABRA2 protein affects the susceptibility to Pentobarbital18313124
D010424PentobarbitalPentobarbital promotes the reaction [Flunitrazepam binds to GABRA2 protein]8397295
D010433Pentylenetetrazole"Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GABRA2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GABRA2 mRNA26272509
D010852Picrotoxin"Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D010852PicrotoxinPicrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
C022961picrotoxininpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]29038840
C022961picrotoxininpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein]]29038840
C022961picrotoxininpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D011280PregnanolonePregnanolone results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D011374ProgesteroneProgesterone results in increased expression of GABRA2 mRNA16000229
D015742PropofolPropofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]29038840
D015742PropofolPropofol results in increased activity of [GABRA2 protein binds to GABRB3]29038840
D015742PropofolPropofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
C042957Ro 15-4513GABRA2 protein affects the susceptibility to Ro 15-451315850489
C042957Ro 15-4513Ro 15-4513 binds to and results in increased activity of GABRA2 protein mutant form20133874
C009250sevofluranesevoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D012999SomanSoman binds to and affects the activity of GABRA2 protein22245390
C446685systhanesysthane results in decreased expression of GABRA2 mRNA16730040
C047246temozolomideGABRA2 mRNA affects the susceptibility to temozolomide16365179
C012568terbufosterbufos results in increased methylation of GABRA2 promoter22847954
D020002tert-Butyl Alcoholtert-Butyl Alcohol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
C046308tert-butylbicyclo-2-benzoate"tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C037476tert-butylbicyclophosphorothionate"tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D043343Testosterone PropionateTestosterone Propionate results in decreased expression of GABRA2 mRNA16957604
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GABRA2 mRNA23871856
C010349tetramethylenedisulfotetramineGABRA2 protein results in increased susceptibility to tetramethylenedisulfotetramine29038840
C010349tetramethylenedisulfotetraminetetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
C023990tiotidinetiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
C023990tiotidinetiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]15363660
D014050TolueneToluene affects the expression of GABRA2 mRNA17108153
C052342topiramatetopiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]11123204
C032910triadimefontriadimefon results in decreased expression of GABRA2 mRNA16730040
C062527tribromoethanoltribromoethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D014270TrifluoroethanolTrifluoroethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]10683198
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRA2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GABRA2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of GABRA2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GABRA2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of GABRA2 mRNA24896083

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004890GABA-A receptor activityCONTRIBUTES_TOIBA21873635  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005237inhibitory extracellular ligand-gated ion channel activity-IBA21873635  
GO:0005254chloride channel activity-IBA21873635  
GO:0008503benzodiazepine receptor activityCONTRIBUTES_TOIBA21873635  
GO:0008503benzodiazepine receptor activity-IMP8391122  
GO:0022851GABA-gated chloride ion channel activity-IBA21873635  
GO:0022851GABA-gated chloride ion channel activity-IDA9039914  
GO:1904315transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001505regulation of neurotransmitter levels-IMP8391122  
GO:0006836neurotransmitter transport-IMP8391122  
GO:0007165signal transduction-IBA21873635  
GO:0007214gamma-aminobutyric acid signaling pathway-IBA21873635  
GO:0007214gamma-aminobutyric acid signaling pathway-IMP8391122  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO:0051932synaptic transmission, GABAergic-IBA21873635  
GO:0060078regulation of postsynaptic membrane potential-IBA21873635  
GO:1902476chloride transmembrane transport-IBA21873635  
GO:1902476chloride transmembrane transport-IDA9039914  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0030054cell junction-IEA-  
GO:0030285integral component of synaptic vesicle membrane-IDA8391122  
GO:0032590dendrite membrane-IBA21873635  
GO:0034707chloride channel complex-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:0098794postsynapse-IBA21873635  
GO:1902711GABA-A receptor complex-IBA21873635  
GO:1902711GABA-A receptor complex-IDA9039914  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionIEA
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112315Transmission across Chemical SynapsesIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-977441GABA A receptor activationTAS
R-HSA-977443GABA receptor activationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18727688The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample. (2008 Oct)Lind PAAlcohol Clin Exp Res
15702134GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. (2005 Jun)Pierucci-Lagha ANeuropsychopharmacology
19833324The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. (2010 Jan 1)Enoch MABiol Psychiatry
17982586Neurophysiological endophenotypes, CNS disinhibition, and risk for alcohol dependence and related disorders. (2007 Nov 2)Porjesz BScientificWorldJournal
26116794Association of GABAA receptor alpha2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior. (2015 Dec 3)Strac DSProg Neuropsychopharmacol Biol Psychiatry
26635556Motivational Effects of Methylphenidate are Associated with GABRA2 Variants Conferring Addiction Risk. (2015)Duka TFront Behav Neurosci
25399692Genetics of alcoholism. (2014 Dec)Iyer-Eimerbrink PACurr Psychiatry Rep
19536785GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. (2010 Mar 5)Xuei XAm J Med Genet B Neuropsychiatr Genet
23692184Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood. (2014 Nov)Dick DMAddict Biol
16874763Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. (2006 Sep 5)Enoch MAAm J Med Genet B Neuropsychiatr Genet
22555154Gamma-aminobutyric acid A receptor, alpha-2 (GABRA2) variants as individual markers for alcoholism: a meta-analysis. (2012 Aug)Zintzaras EPsychiatr Genet
23561058How phenotype and developmental stage affect the genes we find: GABRA2 and impulsivity. (2013 Jun)Dick DMTwin Res Hum Genet
28361821Candidate genes for alcohol dependence: A genetic association study from India. (2016 Nov)Malhotra SIndian J Med Res
20698837A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study. (2010 Dec)Kareken DAAlcohol Clin Exp Res
18482426Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study. (2008 Jun)Agrawal AAddiction
20133874Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors. (2010 Feb 2)Dixon CIProc Natl Acad Sci U S A
25307596Genetics of alcoholism. (2014)Edenberg HJHandb Clin Neurol
23566244Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems. (2013 Jul)Villafuerte SGenes Brain Behav
22501025GABRA2 markers moderate the subjective effects of alcohol. (2013 Mar)Uhart MAddict Biol
17690794The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses. (2007 Sep)Matthews AGJ Stud Alcohol Drugs
19569404Under the influence of genetics: how transdisciplinarity leads us to rethink social pathways to illness. (2008)Pescosolido BAAJS
24091936Genetic influences on the development of alcoholism. (2013 Nov)Enoch MACurr Psychiatry Rep
24975023Effect of GABRA2 genotype on development of incentive-motivation circuitry in a sample enriched for alcoholism risk. (2014 Dec)Heitzeg MMNeuropsychopharmacology
15950776Alternative splicing and promoter use in the human GABRA2 gene. (2005 Jun 13)Tian HBrain Res Mol Brain Res
24136292Association of gamma-aminobutyric acid A receptor alpha2 gene (GABRA2) with alcohol use disorder. (2014 Mar)Li DNeuropsychopharmacology
24692236Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. (2014 Jun)Kos MZAm J Med Genet B Neuropsychiatr Genet
19783384Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives. (2010 Jan 15)Sakai JTDrug Alcohol Depend
24557088Dutasteride reduces alcohol's sedative effects in men in a human laboratory setting and reduces drinking in the natural environment. (2014 Sep)Covault JPsychopharmacology (Berl)
21683760Genetic association study of GABRA2 single nucleotide polymorphisms and electroencephalography in alcohol dependence. (2011 Aug 18)Lydall GJNeurosci Lett
17949392Variation in GABRA2 predicts drinking behavior in project MATCH subjects. (2007 Nov)Bauer LOAlcohol Clin Exp Res
18634760Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes. (2008 Oct 15)Rangaswamy MBrain Res
18781239Multiple-domain predictors of problematic alcohol use in young adulthood. (2008 Sep)Kramer JRJ Stud Alcohol Drugs
16612210New findings on the genetic influences on alcohol use and dependence. (2006 May)Higuchi SCurr Opin Psychiatry
17207817GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. (2008 Feb)Soyka MJ Psychiatr Res
22921455alpha2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders. (2012 Nov)Engin EPharmacol Ther
19207358Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerstrom Test for Nicotine Dependence. (2009 Mar)Agrawal AAddiction
21118274Role of GABRA2 in moderating subjective responses to alcohol. (2011 Mar)Roh SAlcohol Clin Exp Res
16451705Whole-genome association studies of alcoholism with loci linked to schizophrenia susceptibility. (2005 Dec 30)Namkung JBMC Genet
27117237Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. (2016 Sep)Boyd SJAlcohol Alcohol
22978509Convergence of genome-wide association and candidate gene studies for alcoholism. (2012 Dec)Olfson EAlcohol Clin Exp Res
18519829An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project. (2008 Jun)Agrawal AArch Gen Psychiatry
20225194Analysis of extreme drinking in patients with alcohol dependence using Pareto regression. (2010 May 20)Das SStat Med
26250693GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures. (2015 Sep)Lieberman RAlcohol Clin Exp Res
16395124Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis. (2006 Feb)Fehr CPsychiatr Genet
15024690Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. (2004 Apr)Edenberg HJAm J Hum Genet
16961766The genetics of alcoholism: identifying specific genes through family studies. (2006 Sep)Edenberg HJAddict Biol
21483437Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. (2012 May)Villafuerte SMol Psychiatry
23134043Identifying genetic variation for alcohol dependence. (2012)Agrawal AAlcohol Res
16557364The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. (2006 Jul)Dick DMBehav Genet
25655461Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)Manzardo AMGene
17507911Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene. (2008 Mar)Covault JNeuropsychopharmacology
19487630Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. (2009 Jun)Dick DMArch Gen Psychiatry
19382902Altering the relative abundance of GABA A receptor subunits changes GABA- and ethanol-responses in Xenopus oocytes. (2009 Jun)Hurley JHAlcohol Clin Exp Res
25365806Genetic variation in GABRA2 moderates peer influence on externalizing behavior in adolescents. (2014)Villafuerte SBrain Behav
15274050Allelic and haplotypic association of GABRA2 with alcohol dependence. (2004 Aug 15)Covault JAm J Med Genet B Neuropsychiatr Genet
16894595Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. (2006 Dec 5)Drgon TAm J Med Genet B Neuropsychiatr Genet
24220019Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism. (2014 Aug)Enoch MAPharmacol Biochem Behav
20876231Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive alpha2-containing GABA(A) receptors. (2011 Jan)Blednov YAJ Pharmacol Exp Ther
22882391Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. (2012 Sep-Oct)Smelson DAm J Addict
21919924GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans. (2012 Apr)Ittiwut CAlcohol Clin Exp Res
20716301Obesity, smoking, and frontal brain dysfunction. (2010 Sep-Oct)Bauer LAm J Addict
18818659GABRG1 and GABRA2 as independent predictors for alcoholism in two populations. (2009 Apr)Enoch MANeuropsychopharmacology
24166645A GABRA2 variant is associated with increased stimulation and 'high' following alcohol administration. (2014 Jan-Feb)Arias AJAlcohol Alcohol
26075969Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2. (2015 Aug)Salvatore JEJ Abnorm Psychol
22662011GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects. (2012 May 9)Grzywacz AArch Med Sci
16562401Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction. (2006 Mar)Dick DMJ Stud Alcohol
18440057The role of GABA(A) receptors in the development of alcoholism. (2008 Jul)Enoch MAPharmacol Biochem Behav
23712313Genetics and alcoholism. (2013 Aug)Edenberg HJNat Rev Gastroenterol Hepatol
19672139Role of GABRA2 on risk for alcohol, nicotine, and cannabis dependence in the Iowa Adoption Studies. (2009 Apr)Philibert RAPsychiatr Genet
20482509Pharmacogenetics of alcohol and alcohol dependence treatment. (2010)Kranzler HRCurr Pharm Des
16341909Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism. (2006 Jan)Dick DMBehav Genet
23974430Gender-specific gene-environment interaction in alcohol dependence: the impact of daily life events and GABRA2. (2013 Sep)Perry BLBehav Genet
18005236Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression. (2008 Jun)Haughey HMGenes Brain Behav
17976953Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4. (2008 Jan)Ittiwut CGenomics
18361719Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study. (2008 Apr)Lind PATwin Res Hum Genet
23504072Association of VMAT2 gene polymorphisms with alcohol dependence. (2013 Aug)Fehr CJ Neural Transm (Vienna)
28847377A GABRA2 polymorphism improves a model for prediction of drinking initiation. (2017 Sep)Kuperman SAlcohol
20102561GABRA2 and alcohol use disorders: no evidence of an association in an Italian case-control study. (2010 Apr)Onori NAlcohol Clin Exp Res
24687270Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study. (2014 Jul)Melroy WEBehav Genet
24548628Genetic variation at the CYP2C19 gene associated with metabolic syndrome susceptibility in a South Portuguese population: results from the pilot study of the European Health Examination Survey in Portugal. (2014 Feb 18)Gaio VDiabetol Metab Syndr
15834213Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population. (2005 Apr)Lappalainen JAlcohol Clin Exp Res
20202923A genome-wide association study of alcohol dependence. (2010 Mar 16)Bierut LJProc Natl Acad Sci U S A
26087834Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking. (2015 Jul)Kosobud AEAlcohol Clin Exp Res