Gene info: ID 2556

Gene: GABRA3

GENE ID: 2556

Synonyms: -

Description: gamma-aminobutyric acid type A receptor alpha3 subunit

Gene type: protein-coding

Location: Xq28

dbXrefs: Ensembl:ENSG00000011677 MIM:305660 Vega:OTTHUMG00000024183 UniprotKB:P34903

RefSeq: NG_007102.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
AMPH	0.965
OPCML	0.962
TMEM246	0.961
PCSK2	0.961
PAK1	0.96
INPP4A	0.96
FAXC	0.959
LNX1	0.959
NMNAT2	0.959
GABRB3	0.958

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HEY2	-0.59
YES1	-0.556
RAI14	-0.552
REST	-0.544
RAB13	-0.52
CHST14	-0.518
COPZ2	-0.517
CSAG1	-0.517
CNN2	-0.517
RNF135	-0.511

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00231	Temazepam	Small Molecule	846-50-4	Approved\|Investigational	Target
DB00241	Butalbital	Small Molecule	77-26-9	Approved\|Illicit	Target
DB00306	Talbutal	Small Molecule	115-44-6	Approved\|Illicit	Target
DB00312	Pentobarbital	Small Molecule	76-74-4	Approved\|Investigational	Target
DB00371	Meprobamate	Small Molecule	57-53-4	Approved\|Illicit	Target
DB00402	Eszopiclone	Small Molecule	138729-47-2	Approved\|Investigational	Target
DB00418	Secobarbital	Small Molecule	76-73-3	Approved	Target
DB00425	Zolpidem	Small Molecule	82626-48-0	Approved	Target
DB00463	Metharbital	Small Molecule	50-11-3	Withdrawn	Target
DB00546	Adinazolam	Small Molecule	37115-32-5	Approved	Target
DB00599	Thiopental	Small Molecule	76-75-5	Approved	Target
DB00683	Midazolam	Small Molecule	59467-70-8	Approved\|Illicit	Target
DB00690	Flurazepam	Small Molecule	17617-23-1	Approved\|Illicit\|Investigational	Target
DB00794	Primidone	Small Molecule	125-33-7	Approved	Target
DB00801	Halazepam	Small Molecule	23092-17-3	Approved\|Illicit\|Withdrawn	Target
DB00829	Diazepam	Small Molecule	439-14-5	Approved\|Illicit\|Investigational	Target
DB00842	Oxazepam	Small Molecule	604-75-1	Approved	Target
DB00849	Methylphenobarbital	Small Molecule	115-38-8	Approved	Target
DB00897	Triazolam	Small Molecule	28911-01-5	Approved\|Investigational	Target
DB00898	Ethanol	Small Molecule	64-17-5	Approved	Target
DB01198	Zopiclone	Small Molecule	43200-80-2	Approved	Target
DB01215	Estazolam	Small Molecule	29975-16-4	Approved\|Illicit	Target
DB01351	Amobarbital	Small Molecule	57-43-2	Approved\|Illicit	Target
DB01352	Aprobarbital	Small Molecule	77-02-1	Approved\|Illicit	Target
DB01353	Butethal	Small Molecule	77-28-1	Approved\|Illicit	Target
DB01354	Heptabarbital	Small Molecule	509-86-4	Approved	Target
DB01355	Hexobarbital	Small Molecule	56-29-1	Approved	Target
DB01483	Barbital	Small Molecule	57-44-3	Illicit	Target
DB01496	Barbituric acid derivative	Small Molecule		Experimental\|Illicit	Target
DB01544	Flunitrazepam	Small Molecule	1622-62-4	Approved\|Illicit	Target
DB01558	Bromazepam	Small Molecule	1812-30-2	Approved\|Illicit\|Investigational	Target
DB01559	Clotiazepam	Small Molecule	33671-46-4	Approved\|Illicit	Target
DB01567	Fludiazepam	Small Molecule	3900-31-0	Approved\|Illicit	Target
DB01588	Prazepam	Small Molecule	2955-38-6	Approved\|Illicit	Target
DB01589	Quazepam	Small Molecule	36735-22-5	Approved\|Illicit	Target
DB01594	Cinolazepam	Small Molecule	75696-02-5	Approved	Target
DB01595	Nitrazepam	Small Molecule	146-22-5	Approved	Target
DB04903	Pagoclone	Small Molecule	133737-32-3	Investigational	Target
DB05087	Ganaxolone	Small Molecule	38398-32-2	Investigational	Target
DB09166	Etizolam	Small Molecule	40054-69-1	Approved	Target
DB13872	Lormetazepam	Small Molecule	848-75-9	Approved	Target
DB00186	Lorazepam	Small Molecule	846-49-1	Approved	Target
DB00189	Ethchlorvynol	Small Molecule	113-18-8	Approved\|Illicit\|Withdrawn	Target
DB00228	Enflurane	Small Molecule	13838-16-9	Approved\|Investigational	Target
DB00231	Temazepam	Small Molecule	846-50-4	Approved\|Investigational	Target
DB00237	Butabarbital	Small Molecule	125-40-6	Approved\|Illicit	Target
DB00241	Butalbital	Small Molecule	77-26-9	Approved\|Illicit	Target
DB00273	Topiramate	Small Molecule	97240-79-4	Approved	Target
DB00292	Etomidate	Small Molecule	33125-97-2	Approved	Target
DB00306	Talbutal	Small Molecule	115-44-6	Approved\|Illicit	Target
DB00312	Pentobarbital	Small Molecule	76-74-4	Approved\|Investigational	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00349	Clobazam	Small Molecule	22316-47-8	Approved\|Illicit	Target
DB00371	Meprobamate	Small Molecule	57-53-4	Approved\|Illicit	Target
DB00402	Eszopiclone	Small Molecule	138729-47-2	Approved\|Investigational	Target
DB00404	Alprazolam	Small Molecule	28981-97-7	Approved\|Illicit\|Investigational	Target
DB00463	Metharbital	Small Molecule	50-11-3	Withdrawn	Target
DB00475	Chlordiazepoxide	Small Molecule	58-25-3	Approved\|Illicit\|Investigational	Target
DB00543	Amoxapine	Small Molecule	14028-44-5	Approved	Target
DB00555	Lamotrigine	Small Molecule	84057-84-1	Approved\|Investigational	Target
DB00628	Clorazepate	Small Molecule	23887-31-2	Approved\|Illicit	Target
DB00659	Acamprosate	Small Molecule	77337-76-9	Approved\|Investigational	Target
DB00753	Isoflurane	Small Molecule	26675-46-7	Approved	Target
DB00794	Primidone	Small Molecule	125-33-7	Approved	Target
DB00801	Halazepam	Small Molecule	23092-17-3	Approved\|Illicit\|Withdrawn	Target
DB00818	Propofol	Small Molecule	2078-54-8	Approved\|Investigational	Target
DB00829	Diazepam	Small Molecule	439-14-5	Approved\|Illicit\|Investigational	Target
DB00842	Oxazepam	Small Molecule	604-75-1	Approved	Target
DB00897	Triazolam	Small Molecule	28911-01-5	Approved\|Investigational	Target
DB01028	Methoxyflurane	Small Molecule	76-38-0	Approved\|Investigational	Target
DB01049	Ergoloid mesylate	Small Molecule	8067-24-1	Approved	Target
DB01068	Clonazepam	Small Molecule	1622-61-3	Approved\|Illicit	Target
DB01107	Methyprylon	Small Molecule	125-64-4	Approved\|Illicit\|Withdrawn	Target
DB01159	Halothane	Small Molecule	151-67-7	Approved	Target
DB01189	Desflurane	Small Molecule	57041-67-5	Approved	Target
DB01205	Flumazenil	Small Molecule	78755-81-4	Approved	Target
DB01215	Estazolam	Small Molecule	29975-16-4	Approved\|Illicit	Target
DB01236	Sevoflurane	Small Molecule	28523-86-6	Approved	Target
DB01437	Glutethimide	Small Molecule	77-21-4	Approved\|Illicit	Target
DB01588	Prazepam	Small Molecule	2955-38-6	Approved\|Illicit	Target
DB01589	Quazepam	Small Molecule	36735-22-5	Approved\|Illicit	Target
DB01708	Prasterone	Small Molecule	53-43-0	Approved\|Investigational\|Nutraceutical	Target
DB01956	Taurine	Small Molecule	107-35-7	Approved\|Nutraceutical	Target
DB09118	Stiripentol	Small Molecule	49763-96-4	Approved	Target
DB11582	Thiocolchicoside	Small Molecule	602-41-5	Approved\|Investigational	Target
DB11901	Apalutamide	Small Molecule	956104-40-8	Approved\|Investigational	Target
DB00555	Lamotrigine	Small Molecule	84057-84-1	Approved\|Investigational	Target
DB06579	Adipiplon	Small Molecule	840486-93-3	Investigational	Target
DB13983	5,7,2G??-trihydroxy-6,8-dimethoxyflavone	Small Molecule	159359-22-5	Experimental	Target

ID	Drug Name	Action	PubMed
C006718	1,12-benzoperylene	"1,12-benzoperylene results in increased expression of GABRA3 mRNA"	26377693
C091518	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	"1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRA3 protein"	10698677
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GABRA3 mRNA"	19114083
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GABRA3 mRNA"	28973690
D000082	Acetaminophen	Acetaminophen results in increased expression of GABRA3 mRNA	29067470
D000082	Acetaminophen	GABRA3 mRNA affects the susceptibility to Acetaminophen	27530116
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of GABRA3 gene	27153756
D005680	gamma-Aminobutyric Acid	Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]	15363660
D005680	gamma-Aminobutyric Acid	Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]	15363660
D005680	gamma-Aminobutyric Acid	tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]	15363660
D005680	gamma-Aminobutyric Acid	tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]	15363660
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GABRA3 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of GABRA3 mRNA	24449571
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of GABRA3 mRNA"	19446018
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of GABRA3 mRNA	26377693
D004958	Estradiol	Estradiol results in increased expression of GABRA3 mRNA	16000229
C006780	bisphenol A	bisphenol A affects the expression of GABRA3 mRNA	26950200
C006780	bisphenol A	bisphenol A results in decreased expression of GABRA3 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of GABRA3 gene	28505145
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of GABRA3 mRNA	17484886
C031180	chrysene	chrysene results in increased expression of GABRA3 mRNA	26377693
D003975	Diazepam	Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA3 mRNA]	14684873
D003975	Diazepam	Diazepam results in decreased expression of GABRA3 mRNA	15802192
D003975	Diazepam	Diazepam results in increased activity of GABRA3 protein	15613639
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GABRA3 mRNA	24535843
D000431	Ethanol	Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA3 mRNA]	14684873
D000431	Ethanol	Ethanol deficiency results in increased expression of GABRA3 mRNA	14684873
D000431	Ethanol	Ethanol results in decreased expression of GABRA3 mRNA	14684873
C044610	etizolam	etizolam affects the expression of GABRA3 mRNA	16107249
D015738	Famotidine	Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]	15363660
D015738	Famotidine	Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]	15363660
D005445	Flunitrazepam	Flunitrazepam results in increased activity of GABRA3 protein	16162846
C005499	honokiol	honokiol results in increased activity of [GABRA3 protein binds to GABRB2 protein]	21699169
D017313	Fenretinide	Fenretinide results in increased expression of GABRA3 mRNA	28973697
D008140	Lorazepam	Lorazepam results in increased expression of GABRA3 mRNA	16107249
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GABRA3 mRNA	23519560
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of GABRA3 mRNA	26011545
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GABRA3 mRNA"	19285098
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of GABRA3 mRNA	27935865
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GABRA3 mRNA	24535843
C033457	phenobarbital quinidine	phenobarbital quinidine results in decreased expression of GABRA3 mRNA	15802192
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of GABRA3 mRNA	27935865
D011441	Propylthiouracil	Propylthiouracil results in increased expression of GABRA3 mRNA	24780913
D011929	Razoxane	Razoxane results in decreased expression of GABRA3 mRNA	19915844
D012999	Soman	Soman binds to and affects the activity of GABRA3 protein	22245390
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GABRA3 mRNA	21570461
D013755	Tetradecanoylphorbol Acetate	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GABRA3 mRNA	23519560
C023990	tiotidine	tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]	15363660
C023990	tiotidine	tiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]	15363660
C009495	titanium dioxide	titanium dioxide results in increased expression of GABRA3 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of GABRA3 mRNA	20133372
D014635	Valproic Acid	Valproic Acid results in decreased methylation of GABRA3 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of GABRA3 mRNA	17963808
D014638	Vanadates	Vanadates results in increased expression of GABRA3 mRNA	22714537
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of GABRA3 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004890	GABA-A receptor activity	CONTRIBUTES_TO	IBA	21873635
GO:0005230	extracellular ligand-gated ion channel activity	CONTRIBUTES_TO	IBA	21873635
GO:0005230	extracellular ligand-gated ion channel activity	-	IEA	-
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	-	IBA	21873635
GO:0005254	chloride channel activity	-	IBA	21873635
GO:0005254	chloride channel activity	-	IEA	-
GO:0005515	protein binding	-	IPI	26613940
GO:0008503	benzodiazepine receptor activity	CONTRIBUTES_TO	IBA	21873635
GO:0008503	benzodiazepine receptor activity	-	TAS	8391122
GO:0022851	GABA-gated chloride ion channel activity	-	IBA	21873635
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	IBA	21873635
GO:0007214	gamma-aminobutyric acid signaling pathway	-	IBA	21873635
GO:0007214	gamma-aminobutyric acid signaling pathway	-	IEA	-
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0034220	ion transmembrane transport	-	IBA	21873635
GO:0042391	regulation of membrane potential	-	IBA	21873635
GO:0050877	nervous system process	-	IBA	21873635
GO:0051932	synaptic transmission, GABAergic	-	IBA	21873635
GO:0060078	regulation of postsynaptic membrane potential	-	IBA	21873635
GO:1902476	chloride transmembrane transport	-	IBA	21873635
GO:1902476	chloride transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	TAS	8391122
GO:0030054	cell junction	-	IEA	-
GO:0032590	dendrite membrane	-	IBA	21873635
GO:0034707	chloride channel complex	-	IEA	-
GO:0043005	neuron projection	-	IBA	21873635
GO:0045202	synapse	-	IBA	21873635
GO:0045211	postsynaptic membrane	-	IEA	-
GO:0098794	postsynapse	-	IBA	21873635
GO:1902711	GABA-A receptor complex	-	IBA	21873635

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	IEA
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112315	Transmission across Chemical Synapses	IEA
R-HSA-112316	Neuronal System	TAS
R-HSA-112316	Neuronal System	IEA
R-HSA-977441	GABA A receptor activation	TAS
R-HSA-977443	GABA receptor activation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24273683	Withdrawal from Buprenorphine/Naloxone and Maintenance with a Natural Dopaminergic Agonist: A Cautionary Note. (2013 Apr 23)	Blum K	J Addict Res Ther