Gene: COL24A1

255631
-
collagen type XXIV alpha 1 chain
protein-coding
1p22.3
Ensembl:ENSG00000171502 MIM:610025 Vega:OTTHUMG00000010629 UniprotKB:Q17RW2
NG_053093.1
SNP Mapped
1   ANCO-SNPs
AD
0   
4.193e-1 (AD)  2.637e-2 (ND)   (Frontal_Cortex)
6.307e-1 (AD)  4.457e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17128651chr1:86000053 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FRAS10.847
CACNA1D0.833
DNAJC5G0.823
GPR610.822
RNF2070.82
L3MBTL10.82
VWA70.82
SH3D210.819
DRP20.817
TMEM2410.814

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.626
ROM1-0.586
TMEM176A-0.574
GNG12-0.571
MYL3-0.571
CHST14-0.57
HEBP2-0.566
YES1-0.557
COPZ2-0.556
EMP3-0.554

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COL24A1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COL24A1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COL24A1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COL24A1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COL24A1 mRNA"25510870
D000082AcetaminophenAcetaminophen results in increased expression of COL24A1 mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of COL24A1 mRNA28959563
D001151ArsenicArsenic affects the methylation of COL24A1 gene25304211
D001151ArsenicArsenic results in increased methylation of COL24A1 promoter21291286
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COL24A1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COL24A1 mRNA22300585
C006780bisphenol Abisphenol A results in decreased expression of COL24A1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of COL24A1 mRNA26079696
D002994ClofibrateClofibrate results in decreased expression of COL24A1 mRNA22300585
D003471CuprizoneCuprizone results in decreased expression of COL24A1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of COL24A1 mRNA25596134
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of COL24A1 mRNA]27941970
C011890kojic acidkojic acid results in decreased expression of COL24A1 mRNA16595896
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COL24A1 mRNA"25510870
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of COL24A1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of COL24A1 mRNA23806026
C017947sodium arsenitesodium arsenite results in increased expression of and affects the splicing of COL24A1 mRNA25879800
D013629TamoxifenTamoxifen results in increased expression of COL24A1 mRNA25123088
D014212TretinoinTretinoin results in increased expression of COL24A1 mRNA21934132
D014635Valproic AcidValproic Acid affects the expression of COL24A1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of COL24A1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-IBA21873635  
GO:0005201extracellular matrix structural constituent-IEA-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0002244hematopoietic progenitor cell differentiation-IEA-  
GO:0030198extracellular matrix organization-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005581collagen trimer-IEA-  
GO:0005615extracellular space-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-2022090Assembly of collagen fibrils and other multimeric structuresTAS
R-HSA-6806834Signaling by METTAS
R-HSA-8874081MET activates PTK2 signalingTAS
R-HSA-8875878MET promotes cell motilityTAS
R-HSA-8948216Collagen chain trimerizationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal