Gene: GABRA4

2557
-
gamma-aminobutyric acid type A receptor alpha4 subunit
protein-coding
4p12
Ensembl:ENSG00000109158 MIM:137141 Vega:OTTHUMG00000099431 UniprotKB:P48169
NG_011809.1
PubMed
0   ANCO-SNPs
ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.128e-1 (AD)  6.352e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DGKB0.95
CACNB40.948
CSRNP30.948
SCAI0.947
CLVS20.947
ELMOD10.947
AKAP50.946
SLC2A130.945
NDST30.945
GABRB30.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.616
MYL3-0.589
HEY2-0.538
CNN2-0.524
COPZ2-0.522
RAB13-0.518
FLT3LG-0.515
RNF135-0.515
MAGEA12-0.511
SNHG18-0.511

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00241ButalbitalSmall Molecule77-26-9Approved|IllicitTarget
DB00306TalbutalSmall Molecule115-44-6Approved|IllicitTarget
DB00312PentobarbitalSmall Molecule76-74-4Approved|InvestigationalTarget
DB00371MeprobamateSmall Molecule57-53-4Approved|IllicitTarget
DB00418SecobarbitalSmall Molecule76-73-3ApprovedTarget
DB00463MetharbitalSmall Molecule50-11-3WithdrawnTarget
DB00599ThiopentalSmall Molecule76-75-5ApprovedTarget
DB00683MidazolamSmall Molecule59467-70-8Approved|IllicitTarget
DB00690FlurazepamSmall Molecule17617-23-1Approved|Illicit|InvestigationalTarget
DB00794PrimidoneSmall Molecule125-33-7ApprovedTarget
DB00842OxazepamSmall Molecule604-75-1ApprovedTarget
DB00849MethylphenobarbitalSmall Molecule115-38-8ApprovedTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01351AmobarbitalSmall Molecule57-43-2Approved|IllicitTarget
DB01352AprobarbitalSmall Molecule77-02-1Approved|IllicitTarget
DB01353ButethalSmall Molecule77-28-1Approved|IllicitTarget
DB01354HeptabarbitalSmall Molecule509-86-4ApprovedTarget
DB01355HexobarbitalSmall Molecule56-29-1ApprovedTarget
DB01483BarbitalSmall Molecule57-44-3IllicitTarget
DB01496Barbituric acid derivativeSmall MoleculeExperimental|IllicitTarget
DB01544FlunitrazepamSmall Molecule1622-62-4Approved|IllicitTarget
DB01558BromazepamSmall Molecule1812-30-2Approved|Illicit|InvestigationalTarget
DB01595NitrazepamSmall Molecule146-22-5ApprovedTarget
DB05087GanaxoloneSmall Molecule38398-32-2InvestigationalTarget
DB00186LorazepamSmall Molecule846-49-1ApprovedTarget
DB00189EthchlorvynolSmall Molecule113-18-8Approved|Illicit|WithdrawnTarget
DB00228EnfluraneSmall Molecule13838-16-9Approved|InvestigationalTarget
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00237ButabarbitalSmall Molecule125-40-6Approved|IllicitTarget
DB00241ButalbitalSmall Molecule77-26-9Approved|IllicitTarget
DB00273TopiramateSmall Molecule97240-79-4ApprovedTarget
DB00292EtomidateSmall Molecule33125-97-2ApprovedTarget
DB00306TalbutalSmall Molecule115-44-6Approved|IllicitTarget
DB00312PentobarbitalSmall Molecule76-74-4Approved|InvestigationalTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00349ClobazamSmall Molecule22316-47-8Approved|IllicitTarget
DB00371MeprobamateSmall Molecule57-53-4Approved|IllicitTarget
DB00402EszopicloneSmall Molecule138729-47-2Approved|InvestigationalTarget
DB00404AlprazolamSmall Molecule28981-97-7Approved|Illicit|InvestigationalTarget
DB00463MetharbitalSmall Molecule50-11-3WithdrawnTarget
DB00475ChlordiazepoxideSmall Molecule58-25-3Approved|Illicit|InvestigationalTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00628ClorazepateSmall Molecule23887-31-2Approved|IllicitTarget
DB00659AcamprosateSmall Molecule77337-76-9Approved|InvestigationalTarget
DB00753IsofluraneSmall Molecule26675-46-7ApprovedTarget
DB00794PrimidoneSmall Molecule125-33-7ApprovedTarget
DB00801HalazepamSmall Molecule23092-17-3Approved|Illicit|WithdrawnTarget
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalTarget
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalTarget
DB00842OxazepamSmall Molecule604-75-1ApprovedTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB01028MethoxyfluraneSmall Molecule76-38-0Approved|InvestigationalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB01068ClonazepamSmall Molecule1622-61-3Approved|IllicitTarget
DB01107MethyprylonSmall Molecule125-64-4Approved|Illicit|WithdrawnTarget
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
DB01189DesfluraneSmall Molecule57041-67-5ApprovedTarget
DB01205FlumazenilSmall Molecule78755-81-4ApprovedTarget
DB01215EstazolamSmall Molecule29975-16-4Approved|IllicitTarget
DB01236SevofluraneSmall Molecule28523-86-6ApprovedTarget
DB01437GlutethimideSmall Molecule77-21-4Approved|IllicitTarget
DB01588PrazepamSmall Molecule2955-38-6Approved|IllicitTarget
DB01589QuazepamSmall Molecule36735-22-5Approved|IllicitTarget
DB01708PrasteroneSmall Molecule53-43-0Approved|Investigational|NutraceuticalTarget
DB01956TaurineSmall Molecule107-35-7Approved|NutraceuticalTarget
DB09118StiripentolSmall Molecule49763-96-4ApprovedTarget
DB11582ThiocolchicosideSmall Molecule602-41-5Approved|InvestigationalTarget
DB11901ApalutamideSmall Molecule956104-40-8Approved|InvestigationalTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB06579AdipiplonSmall Molecule840486-93-3InvestigationalTarget
DB139835,7,2G??-trihydroxy-6,8-dimethoxyflavoneSmall Molecule159359-22-5ExperimentalTarget
ID Drug Name Action PubMed
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of GABRA4 mRNA"20206263
C0006099244-chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide"4-chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]"29038840
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GABRA4 mRNA25607892
D005680gamma-Aminobutyric Acidbenzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]18762200
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]29038840
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]29038840
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]18762200|2903884
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]29038840
D005680gamma-Aminobutyric Acidpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D005680gamma-Aminobutyric Acidtetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]29038840
D005680gamma-Aminobutyric Acidbenzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]]18762200
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]18762200
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA4 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]11123204
D005680gamma-Aminobutyric Acid[gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides11123204
D000639AmitriptylineAmitriptyline results in increased expression of GABRA4 mRNA21820738
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GABRA4 mRNA16483693
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GABRA4 mRNA25607892
C015001arsenitearsenite results in increased methylation of GABRA4 promoter23974009
D001280AtrazineAtrazine results in increased expression of GABRA4 mRNA22378314
C037689benzamidebenzamide analog binds to and results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]18762200
C037689benzamidebenzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]18762200
C037689benzamidebenzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]]18762200
D004958EstradiolEstradiol affects the expression of GABRA4 mRNA16000229
D004958Estradiol[Estradiol co-treated with Progesterone] affects the expression of GABRA4 mRNA19833106
D004958EstradiolEstradiol results in decreased expression of GABRA4 mRNA19833106
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of GABRA4 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GABRA4 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of GABRA4 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of GABRA4 mRNA25181051
D001761BleomycinBleomycin results in decreased expression of GABRA4 mRNA15808516
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of GABRA4 mRNA22079614
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GABRA4 mRNA25607892
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GABRA4 mRNA12832660
D002712Chlorides[gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides11123204
D003471CuprizoneCuprizone results in decreased expression of GABRA4 mRNA26577399
C086916delta-hexachlorocyclohexanedelta-hexachlorocyclohexane results in decreased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]11156579
D003975DiazepamDiazepam deficiency results in increased expression of GABRA4 mRNA11804615
D003975DiazepamDiazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 mRNA]14684873
D003975DiazepamDiazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 protein]14684873
D003975DiazepamDiazepam results in increased expression of GABRA4 mRNA15802192
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GABRA4 mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GABRA4 mRNA25607892
D004041Dietary FatsDietary Fats results in increased expression of GABRA4 mRNA25016146
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GABRA4 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GABRA4 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GABRA4 mRNA25607892
C074283estradiol 3-benzoate[Progesterone co-treated with estradiol 3-benzoate] results in decreased expression of GABRA4 mRNA19394921
D000431EthanolDiazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 mRNA]14684873
D000431EthanolDiazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 protein]14684873
D000431EthanolEthanol deficiency results in increased expression of GABRA4 mRNA14684873|1740313
D000431EthanolEthanol deficiency results in increased expression of GABRA4 protein14684873|1740313
D000431EthanolFlumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 mRNA]17403139
D000431EthanolFlumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 protein]17403139
C047360felbamatefelbamate results in decreased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]17056029
C047360felbamatefelbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]17056029
C082360fipronilfipronil results in decreased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]29038840
C082360fipronilfipronil results in decreased activity of [GABRA4 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D005442FlumazenilFlumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 mRNA]17403139
D005442FlumazenilFlumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 protein]17403139
D005665FurosemideFurosemide results in decreased activity of GABRA4 protein15613639
D007530IsofluraneGABRA4 affects the susceptibility to Isoflurane19923508
D007530Isoflurane[Isoflurane co-treated with Nitrous Oxide] affects the expression of GABRA4 mRNA16733821
D007657Ketone BodiesKetone Bodies results in decreased expression of GABRA4 mRNA15469884
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GABRA4 mRNA25607892
D008140LorazepamGABRA4 protein affects the susceptibility to Lorazepam12522171
D008140LorazepamLorazepam affects the expression of GABRA4 mRNA16107249
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GABRA4 mRNA21385734
D008874MidazolamMidazolam results in increased expression of GABRA4 mRNA16733821
D009020MorphineMorphine results in increased expression of GABRA4 mRNA21178816
D009609Nitrous Oxide[Isoflurane co-treated with Nitrous Oxide] affects the expression of GABRA4 mRNA16733821
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of GABRA4 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of GABRA4 mRNA27935865
C000589285NP260NP260 binds to and results in decreased activity of GABRA4 protein24699182
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GABRA4 mRNA25607892
D010269ParaquatParaquat results in increased expression of GABRA4 mRNA18198484
D010424PentobarbitalPentobarbital results in increased expression of GABRA4 mRNA16733821
C033457phenobarbital quinidinephenobarbital quinidine results in increased expression of GABRA4 mRNA15802192
C022961picrotoxininpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D010862PilocarpinePilocarpine results in increased expression of GABRA4 protein15456836
D010862PilocarpinePilocarpine promotes the reaction [EGR3 protein binds to GABRA4 promoter]16091474
D010862PilocarpinePilocarpine results in increased expression of GABRA4 mRNA16091474
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of GABRA4 mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of GABRA4 mRNA12832660
D010936Plant ExtractsPlant Extracts results in decreased expression of GABRA4 mRNA23557933
D011280PregnanolonePregnanolone results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]29038840
D011280PregnanolonePregnanolone deficiency results in increased expression of GABRA4 mRNA9651210
D011280PregnanolonePregnanolone deficiency results in increased expression of GABRA4 protein9651210
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GABRA4 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GABRA4 mRNA25607892
D011374Progesterone[Estradiol co-treated with Progesterone] affects the expression of GABRA4 mRNA19833106
D011374ProgesteroneGABRA4 protein affects the susceptibility to Progesterone12522171
D011374ProgesteroneProgesterone affects the expression of GABRA4 protein12522171|1583495
D011374Progesterone[Progesterone co-treated with estradiol 3-benzoate] results in decreased expression of GABRA4 mRNA19394921
D015742PropofolPropofol results in increased expression of GABRA4 mRNA16733821
D011441PropylthiouracilPropylthiouracil results in decreased expression of GABRA4 mRNA24780913
D011929RazoxaneRazoxane results in decreased expression of GABRA4 mRNA19915844
D015474IsotretinoinIsotretinoin results in decreased expression of GABRA4 mRNA20436886
C042957Ro 15-4513Ro 15-4513 results in increased activity of GABRA4 protein16162846
D013619TacrineTacrine results in increased expression of GABRA4 mRNA12832660
D043343Testosterone PropionateTestosterone Propionate results in increased expression of GABRA4 mRNA16957604
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate promotes the reaction [EGR3 protein binds to GABRA4 promoter]16091474
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of GABRA4 mRNA16091474
C010349tetramethylenedisulfotetraminetetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]29038840
D014050TolueneToluene affects the expression of GABRA4 mRNA17108153
D014241TrichloroethyleneTrichloroethylene results in decreased expression of GABRA4 mRNA26745549
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GABRA4 gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GABRA4 mRNA25607892
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of GABRA4 mRNA27935865
C085665zaleplonzaleplon deficiency results in increased expression of GABRA4 mRNA11804615
C049109zolpidemzolpidem deficiency results in increased expression of GABRA4 mRNA11804615

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004890GABA-A receptor activityCONTRIBUTES_TOIBA21873635  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005230extracellular ligand-gated ion channel activity-IEA-  
GO:0005237inhibitory extracellular ligand-gated ion channel activity-IBA21873635  
GO:0005254chloride channel activity-IBA21873635  
GO:0005254chloride channel activity-IEA-  
GO:0008503benzodiazepine receptor activityCONTRIBUTES_TOIBA21873635  
GO:0008503benzodiazepine receptor activity-TAS8719416  
GO:0022851GABA-gated chloride ion channel activity-IBA21873635  
GO:1904315transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007214gamma-aminobutyric acid signaling pathway-IBA21873635  
GO:0007214gamma-aminobutyric acid signaling pathway-IEA-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007417central nervous system development-IEA-  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO:0051932synaptic transmission, GABAergic-IBA21873635  
GO:0060078regulation of postsynaptic membrane potential-IBA21873635  
GO:1902476chloride transmembrane transport-IBA21873635  
GO:1902476chloride transmembrane transport-IEA-  
GO:2001023regulation of response to drug-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS8719416  
GO:0030054cell junction-IEA-  
GO:0032590dendrite membrane-IBA21873635  
GO:0034707chloride channel complex-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:0098794postsynapse-IBA21873635  
GO:1902711GABA-A receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionIEA
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112315Transmission across Chemical SynapsesIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-977441GABA A receptor activationTAS
R-HSA-977443GABA receptor activationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15024690Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. (2004 Apr)Edenberg HJAm J Hum Genet
17135278Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. (2007 Jan 1)Saccone SFHum Mol Genet
26250693GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures. (2015 Sep)Lieberman RAlcohol Clin Exp Res
26455281Novel candidate genes for alcoholism--transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring rats. (2015 Dec)Stankiewicz AMPharmacol Biochem Behav
27355804SNPs in NRXN1 and CHRNA5 are associated to smoking and regulation of GABAergic and glutamatergic pathways. (2016 Jul)Perez-Rubio GPharmacogenomics
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