Gene: NPNT

255743
EGFL6L|POEM
nephronectin
protein-coding
4q24
Ensembl:ENSG00000168743 MIM:610306 Vega:OTTHUMG00000161189 UniprotKB:Q6UXI9
NC_000004.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.223e-1 (AD)  5.219e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTGIS0.673
ABI3BP0.662
SCARA50.657
TSPAN20.655
PTGFR0.649
SLC9A20.649
SRL0.644
UTRN0.643
AMOTL10.636
PKP20.634

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IGFALS-0.318
RHCG-0.313
IZUMO4-0.305
SLC14A1-0.299
KRTAP5-8-0.284
CDKN2C-0.284
NTN5-0.273
KIAA1755-0.268
PLIN4-0.264
HPN-0.258

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NPNT mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NPNT mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of NPNT mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NPNT gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NPNT mRNA24449571
D001151ArsenicArsenic affects the methylation of NPNT gene25304211
D001280AtrazineAtrazine results in decreased expression of NPNT mRNA25929836
D001379AzathioprineAzathioprine results in decreased expression of NPNT mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NPNT mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NPNT mRNA20713471
D004958EstradiolEstradiol results in decreased expression of NPNT mRNA21185374
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NPNT mRNA26314618
D002994ClofibrateClofibrate results in decreased expression of NPNT mRNA22300585
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of NPNT mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of NPNT mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NPNT mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of NPNT mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of NPNT mRNA25562108
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of NPNT mRNA28962523
D004041Dietary FatsDietary Fats results in increased expression of NPNT mRNA25016146
D005047EtoposideEtoposide results in increased expression of NPNT mRNA25270620
C000625835HFPO2 compoundHFPO2 compound results in increased expression of NPNT mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of NPNT mRNA27553808
D017313FenretinideFenretinide results in increased expression of NPNT mRNA28973697
C008261lead acetatelead acetate results in decreased expression of NPNT mRNA22613225
C042720mercuric bromidemercuric bromide results in increased expression of NPNT mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NPNT mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NPNT mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in decreased expression of NPNT mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NPNT mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NPNT mRNA"25554681
D009532NickelNickel results in decreased expression of NPNT mRNA24768652
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of NPNT mRNA20971185
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of NPNT mRNA26272509
D052638Particulate MatterParticulate Matter results in decreased expression of NPNT mRNA28341207
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of NPNT mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of NPNT mRNA19429403
D010705PhosgenePhosgene affects the expression of NPNT mRNA16300373
C006253pirinixic acidpirinixic acid results in increased expression of NPNT mRNA18301758|1844570
D010936Plant ExtractsPlant Extracts results in decreased expression of NPNT mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of NPNT mRNA23608068
C005556propionaldehydepropionaldehyde results in decreased expression of NPNT mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NPNT mRNA25895662
D053260SootSoot results in decreased expression of NPNT mRNA26551751
D014284TriiodothyronineTriiodothyronine results in increased expression of NPNT mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NPNT mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NPNT mRNA26377647|2892240
C009495titanium dioxidetitanium dioxide results in increased expression of NPNT mRNA23557971
D014212TretinoinTretinoin results in increased expression of NPNT mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of NPNT mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NPNT mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of NPNT mRNA29024780
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of NPNT mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of NPNT gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of NPNT mRNA24896083
C029297vinylidene chloridevinylidene chloride results in decreased expression of NPNT mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-ISS15754038  
GO:0005178integrin binding-NAS11470831  
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001657ureteric bud development-ISS15754038  
GO:0001658branching involved in ureteric bud morphogenesis-ISS15754038  
GO:0007160cell-matrix adhesion-ISS15754038  
GO:0010694positive regulation of alkaline phosphatase activity-IEA-  
GO:0010811positive regulation of cell-substrate adhesion-ISS15754038  
GO:0030198extracellular matrix organization-ISS15754038  
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway-IEA-  
GO:0033631cell-cell adhesion mediated by integrin-ISS15754038  
GO:0045184establishment of protein localization-IEA-  
GO:0045669positive regulation of osteoblast differentiation-ISS15754038  
GO:0045987positive regulation of smooth muscle contraction-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS15754038  
GO:0071356cellular response to tumor necrosis factor-ISS15754038  
GO:0097195pilomotor reflex-IEA-  
GO:2000721positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-ISS15754038  
GO:0005604basement membrane-IEA-  
GO:0030485smooth muscle contractile fiber-IEA-  
GO:0034678integrin alpha8-beta1 complex-IEA-  
GO:0062023collagen-containing extracellular matrix-ISS-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26986948An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma. (2016)Accordini SPLoS One
26423011Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. (2015 Oct)Wain LVLancet Respir Med