Gene: COL6A5

256076
COL29A1|VWA4
collagen type VI alpha 5 chain
protein-coding
3q22.1
Ensembl:ENSG00000172752 MIM:611916 Vega:OTTHUMG00000159712 UniprotKB:A8TX70
NG_021424.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.847e-1 (AD)  7.227e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAX0.739
LRRC150.684
DMBX10.63
POU4F10.622
CHRNB40.615
ITK0.612
PLEKHS10.612
TNFSF180.608
TAS2R600.607
BTN1A10.584

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALDH1A1-0.257
RNF182-0.23
GLI1-0.214
TMEM221-0.212
RAB41-0.208
PYGM-0.202
HMGN5-0.196
HPSE2-0.193
MYBPC1-0.19
TPSD1-0.189

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of COL6A5 mRNA26690555
C006780bisphenol Abisphenol A results in decreased expression of COL6A5 mRNA25181051
D002994ClofibrateClofibrate results in decreased expression of COL6A5 mRNA22300585
D003471CuprizoneCuprizone results in decreased expression of COL6A5 mRNA26577399
C568376MT19c compoundMT19c compound results in decreased expression of COL6A5 mRNA21781307
D009532NickelNickel results in increased expression of COL6A5 mRNA24768652|2558310
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of COL6A5 mRNA27935865
C025589ochratoxin Aochratoxin A results in decreased methylation of COL6A5 gene26431795
D010795Phthalic AcidsPhthalic Acids results in increased expression of COL6A5 mRNA21061450
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of COL6A5 mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of COL6A5 mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in increased expression of COL6A5 mRNA23608068
D011441PropylthiouracilPropylthiouracil affects the expression of COL6A5 mRNA24780913

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19478074  
GO:0030020extracellular matrix structural constituent conferring tensile strength-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA18400749  
GO:0005576extracellular region-TAS-  
GO:0005581collagen trimer-IEA-  
GO:0062023collagen-containing extracellular matrixcolocalizes_withISS22261194  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474290Collagen formationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-2022090Assembly of collagen fibrils and other multimeric structuresTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-3000178ECM proteoglycansTAS
R-HSA-3000178ECM proteoglycansIEA
R-HSA-375165NCAM signaling for neurite out-growthTAS
R-HSA-419037NCAM1 interactionsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-8948216Collagen chain trimerizationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29217820Longitudinal exome-wide association study to identify genetic susceptibility loci for hypertension in a Japanese population. (2017 Dec 8)Yasukochi YExp Mol Med