Gene: GABRB2

2561
ICEE2
gamma-aminobutyric acid type A receptor beta2 subunit
protein-coding
5q34
Ensembl:ENSG00000145864 MIM:600232 Vega:OTTHUMG00000130349 UniprotKB:P47870
NG_047050.1
PubMed
ND|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.418e-1 (AD)  2.858e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRA10.982
DLGAP10.98
KCNQ50.978
RBFOX10.978
HCN10.976
CNTNAP20.975
CREG20.974
FGF120.973
PLCB10.972
SCN2A0.971

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.578
WWTR1-0.563
RAB13-0.562
MYL3-0.559
HEY2-0.557
TFPI2-0.553
CNN2-0.55
CMTM3-0.549
RAI14-0.546
RNF135-0.54

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00395CarisoprodolSmall Molecule78-44-4ApprovedTarget
DB00546AdinazolamSmall Molecule37115-32-5ApprovedTarget
DB00683MidazolamSmall Molecule59467-70-8Approved|IllicitTarget
DB00690FlurazepamSmall Molecule17617-23-1Approved|Illicit|InvestigationalTarget
DB00801HalazepamSmall Molecule23092-17-3Approved|Illicit|WithdrawnTarget
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalTarget
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalTarget
DB00842OxazepamSmall Molecule604-75-1ApprovedTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01215EstazolamSmall Molecule29975-16-4Approved|IllicitTarget
DB01381Ginkgo bilobaSmall Molecule-Approved|Investigational|NutraceuticalTarget
DB01558BromazepamSmall Molecule1812-30-2Approved|Illicit|InvestigationalTarget
DB01559ClotiazepamSmall Molecule33671-46-4Approved|IllicitTarget
DB01567FludiazepamSmall Molecule3900-31-0Approved|IllicitTarget
DB01588PrazepamSmall Molecule2955-38-6Approved|IllicitTarget
DB01594CinolazepamSmall Molecule75696-02-5ApprovedTarget
DB01595NitrazepamSmall Molecule146-22-5ApprovedTarget
DB06716FospropofolSmall Molecule258516-89-1Approved|Illicit|InvestigationalTarget
DB00186LorazepamSmall Molecule846-49-1ApprovedTarget
DB00189EthchlorvynolSmall Molecule113-18-8Approved|Illicit|WithdrawnTarget
DB00228EnfluraneSmall Molecule13838-16-9Approved|InvestigationalTarget
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00237ButabarbitalSmall Molecule125-40-6Approved|IllicitTarget
DB00241ButalbitalSmall Molecule77-26-9Approved|IllicitTarget
DB00273TopiramateSmall Molecule97240-79-4ApprovedTarget
DB00292EtomidateSmall Molecule33125-97-2ApprovedTarget
DB00306TalbutalSmall Molecule115-44-6Approved|IllicitTarget
DB00312PentobarbitalSmall Molecule76-74-4Approved|InvestigationalTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00349ClobazamSmall Molecule22316-47-8Approved|IllicitTarget
DB00371MeprobamateSmall Molecule57-53-4Approved|IllicitTarget
DB00402EszopicloneSmall Molecule138729-47-2Approved|InvestigationalTarget
DB00404AlprazolamSmall Molecule28981-97-7Approved|Illicit|InvestigationalTarget
DB00463MetharbitalSmall Molecule50-11-3WithdrawnTarget
DB00475ChlordiazepoxideSmall Molecule58-25-3Approved|Illicit|InvestigationalTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00628ClorazepateSmall Molecule23887-31-2Approved|IllicitTarget
DB00659AcamprosateSmall Molecule77337-76-9Approved|InvestigationalTarget
DB00753IsofluraneSmall Molecule26675-46-7ApprovedTarget
DB00794PrimidoneSmall Molecule125-33-7ApprovedTarget
DB00801HalazepamSmall Molecule23092-17-3Approved|Illicit|WithdrawnTarget
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalTarget
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalTarget
DB00842OxazepamSmall Molecule604-75-1ApprovedTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB01028MethoxyfluraneSmall Molecule76-38-0Approved|InvestigationalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB01068ClonazepamSmall Molecule1622-61-3Approved|IllicitTarget
DB01107MethyprylonSmall Molecule125-64-4Approved|Illicit|WithdrawnTarget
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
DB01189DesfluraneSmall Molecule57041-67-5ApprovedTarget
DB01205FlumazenilSmall Molecule78755-81-4ApprovedTarget
DB01215EstazolamSmall Molecule29975-16-4Approved|IllicitTarget
DB01236SevofluraneSmall Molecule28523-86-6ApprovedTarget
DB01437GlutethimideSmall Molecule77-21-4Approved|IllicitTarget
DB01588PrazepamSmall Molecule2955-38-6Approved|IllicitTarget
DB01589QuazepamSmall Molecule36735-22-5Approved|IllicitTarget
DB01708PrasteroneSmall Molecule53-43-0Approved|Investigational|NutraceuticalTarget
DB01956TaurineSmall Molecule107-35-7Approved|NutraceuticalTarget
DB09118StiripentolSmall Molecule49763-96-4ApprovedTarget
DB11582ThiocolchicosideSmall Molecule602-41-5Approved|InvestigationalTarget
DB11901ApalutamideSmall Molecule956104-40-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0400831-(2-methoxyphenyl)piperazine1-(2-methoxyphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
C0150681-(3-chlorophenyl)piperazine1-(3-chlorophenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
C0150681-(3-chlorophenyl)piperazine"1-(3-chlorophenyl)piperazine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"23266428
C0150681-(3-chlorophenyl)piperazine1-(3-chlorophenyl)piperazine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]23266428
C0150681-(3-chlorophenyl)piperazine1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]23266428
C0150681-(3-chlorophenyl)piperazine"3,4-Methylenedioxyamphetamine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"23266428
C0150681-(3-chlorophenyl)piperazineCocaine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]23266428
C0184061-(3-trifluoromethylphenyl)piperazine1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
C0263861-(4-chlorophenyl)piperazine1-(4-chlorophenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"gamma-Aminobutyric Acid affects the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
C0067371-benzylpiperazine1-benzylpiperazine analog inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
C0067371-benzylpiperazine1-benzylpiperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
C0329042,2',3,5',6-pentachlorobiphenyl"[2,2',3,5',6-pentachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"20819908
C0359762,4,2',4'-tetrachlorobiphenyl"2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"20819908
C0359762,4,2',4'-tetrachlorobiphenyl"[2,4,2',4'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"20819908
C0359762,4,2',4'-tetrachlorobiphenyl"2,4,2',4'-tetrachlorobiphenyl promotes the reaction [3,5-dibromo-2-(2,4-dibromophenoxy)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20861069
C0359762,4,2',4'-tetrachlorobiphenyl"2,4,2',4'-tetrachlorobiphenyl promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20861069
C0359762,4,2',4'-tetrachlorobiphenyl"2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"20861069
C0359762,4,2',4'-tetrachlorobiphenyl"2,4,4'-trichlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20819908
C0359762,4,2',4'-tetrachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20819908
C0359762,4,2',4'-tetrachlorobiphenyl"[3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20861069
C0359762,4,2',4'-tetrachlorobiphenyl"3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20861069
C0359762,4,2',4'-tetrachlorobiphenyl"PCB 180 inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20819908
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"20819908
C0817662,4,4'-trichlorobiphenyl"2,4,4'-trichlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20819908
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20819908
C0094072,5,2',5'-tetrachlorobiphenyl"[2,5,2',5'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"20819908
C5704072,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol"2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"22029276
C0365312,6-xylenol"2,6-xylenol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]"11399263
C0340472-cresol2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]11399263
C0857943,5-dibromo-2-(2,4-dibromophenoxy)phenol"2,4,2',4'-tetrachlorobiphenyl promotes the reaction [3,5-dibromo-2-(2,4-dibromophenoxy)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20861069
C0857943,5-dibromo-2-(2,4-dibromophenoxy)phenol"[3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20861069
C0857943,5-dibromo-2-(2,4-dibromophenoxy)phenol"3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20861069
C0857943,5-dibromo-2-(2,4-dibromophenoxy)phenol"3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20861069
C0857943,5-dibromo-2-(2,4-dibromophenoxy)phenol"3,5-dibromo-2-(2,4-dibromophenoxy)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"20861069
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
C043877acamprosateGABRB2 affects the susceptibility to acamprosate19523047
D020106AcrylamideAcrylamide results in increased expression of GABRB2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GABRB2 gene27153756
C006477alphaxalonealphaxalone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]12939268
C006477alphaxalonealphaxalone promotes the reaction [Muscimol binds to GABRB2 protein]8397295
C006477alphaxalonealphaxalone results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]12939268
C006477alphaxaloneGABRB2 protein affects the susceptibility to alphaxalone12939268
D005680gamma-Aminobutyric Acid1-(2-methoxyphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
D005680gamma-Aminobutyric Acid1-(3-chlorophenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
D005680gamma-Aminobutyric Acid1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
D005680gamma-Aminobutyric Acid1-(4-chlorophenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
D005680gamma-Aminobutyric Acid1-(4-methoxyphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
D005680gamma-Aminobutyric Acid1-benzylpiperazine analog inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
D005680gamma-Aminobutyric Acid1-benzylpiperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
D005680gamma-Aminobutyric Acid1-Butanol affects the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]]11137757
D005680gamma-Aminobutyric Acid"[2,2',3,5',6-pentachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"20819908
D005680gamma-Aminobutyric Acid"[2,4,2',4'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"20819908
D005680gamma-Aminobutyric Acid"2,4,2',4'-tetrachlorobiphenyl promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20861069
D005680gamma-Aminobutyric Acid"[2,4,4'-trichlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"20819908
D005680gamma-Aminobutyric Acid"[2,5,2',5'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"20819908
D005680gamma-Aminobutyric Acid"[3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20861069
D005680gamma-Aminobutyric Acid"3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20861069
D005680gamma-Aminobutyric Acidbeta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15588619
D005680gamma-Aminobutyric AcidBicuculline promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]29038840
D005680gamma-Aminobutyric AcidCamphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15588619
D005680gamma-Aminobutyric Acidcarvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15588619
D005680gamma-Aminobutyric AcidDiazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
D005680gamma-Aminobutyric Acidfipronil promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]29038840
D005680gamma-Aminobutyric AcidFlame Retardants promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]22547355
D005680gamma-Aminobutyric Acidgabazine affects the reaction [tetrabromobisphenol A promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]22547355
D005680gamma-Aminobutyric AcidGABRA5 protein affects the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRB2 protein binds to GABRG2 protein]]10987858
D005680gamma-Aminobutyric Acid"gamma-Aminobutyric Acid affects the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]11812690
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid binds to and results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]11137757
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid promotes the reaction [GABRB2 protein results in increased transport of Chlorides]8161449
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]20861069|2254735
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]29038840
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]29038840
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]29038840
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]29038840
D005680gamma-Aminobutyric Acidisoborneol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15588619
D005680gamma-Aminobutyric Acidloreclezole promotes the reaction [gamma-Aminobutyric Acid promotes the reaction [GABRB2 protein results in increased transport of Chlorides]]8161449
D005680gamma-Aminobutyric AcidMenthol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15588619
D005680gamma-Aminobutyric Acidmenthone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15588619
D005680gamma-Aminobutyric Acidphenylpiperazine analog inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
D005680gamma-Aminobutyric Acidphenylpiperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
D005680gamma-Aminobutyric Acidpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]29038840
D005680gamma-Aminobutyric Acidpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]29038840
D005680gamma-Aminobutyric Acidtetrabromobisphenol A promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]22547355
D005680gamma-Aminobutyric Acidtetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]29038840
D005680gamma-Aminobutyric AcidUrethane promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]11812690
D005680gamma-Aminobutyric Acidbenzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]]18762200
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]18762200
D005680gamma-Aminobutyric Acidalphaxalone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]12939268
D005680gamma-Aminobutyric AcidAnthracenes analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]18275132
D005680gamma-Aminobutyric AcidBicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]27720918
D005680gamma-Aminobutyric AcidBicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein]]]27720918
D005680gamma-Aminobutyric Acidcyclopentaphenanthrene analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]18275132
D005680gamma-Aminobutyric AcidEtomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]12939268
D005680gamma-Aminobutyric AcidFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]15363660
D005680gamma-Aminobutyric AcidFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D005680gamma-Aminobutyric AcidFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15363660
D005680gamma-Aminobutyric AcidFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D005680gamma-Aminobutyric AcidFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]15363660
D005680gamma-Aminobutyric AcidGABRB2 protein affects the susceptibility to gamma-Aminobutyric Acid12939268
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]17054655
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]12939268|1827513
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]11123204
D005680gamma-Aminobutyric Acid[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides11123204
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]11123204
D005680gamma-Aminobutyric Acid[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides11123204
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA4 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]11123204
D005680gamma-Aminobutyric Acid[gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides11123204
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein]27720918
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]11123204
D005680gamma-Aminobutyric Acid[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides11123204
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]11399263
D005680gamma-Aminobutyric Acidmethylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]27720918
D005680gamma-Aminobutyric Acidmethylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein]]27720918
D005680gamma-Aminobutyric AcidNiflumic Acid inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein]]27720918
D005680gamma-Aminobutyric AcidNiflumic Acid promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]27720918
D005680gamma-Aminobutyric AcidPentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]12939268
D005680gamma-Aminobutyric AcidPicrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]17054655
D005680gamma-Aminobutyric Acidpregnenolone sulfate inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]17054655
D005680gamma-Aminobutyric AcidPropofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]12939268
D005680gamma-Aminobutyric AcidSteroids analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]18275132
D005680gamma-Aminobutyric Acidtiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]15363660
D005680gamma-Aminobutyric Acidtiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D005680gamma-Aminobutyric Acidtiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15363660
D005680gamma-Aminobutyric Acidtiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D005680gamma-Aminobutyric Acidtiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]15363660
D005680gamma-Aminobutyric Acidtiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D005680gamma-Aminobutyric Acidtiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]15363660
D005680gamma-Aminobutyric Acidtopiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]11123204
D005680gamma-Aminobutyric Acidtopiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]11123204
D005680gamma-Aminobutyric Acidtopiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]11123204
D005680gamma-Aminobutyric AcidZinc inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]17054655
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GABRB2 mRNA16483693
D000873AnthracenesAnthracenes analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]18275132
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GABRB2 mRNA24449571
C019264avermectinavermectin results in decreased activity of GABRB2 protein10841270
D001418BaclofenBaclofen results in increased expression of GABRB2 protein15236866
D001534BemegrideBemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]19244096
C037689benzamidebenzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]]18762200
C005790beta-thujonebeta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15588619
D001640BicucullineBicuculline promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]29038840
D001640BicucullineBicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]27720918
D001640BicucullineBicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein]]]27720918
C006780bisphenol Abisphenol A affects the expression of GABRB2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of GABRB2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of GABRB2 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of GABRB2 gene28505145
D001761BleomycinBleomycin results in decreased expression of GABRB2 mRNA15808516
C015044bromoformbromoform binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]12505655
D0200011-Butanol1-Butanol affects the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]]11137757
D019256Cadmium ChlorideCadmium Chloride affects the methylation of GABRB2 promoter22457795
D002164CamphorCamphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15588619
D002220CarbamazepineCarbamazepine affects the expression of GABRB2 mRNA25979313
D002328CarisoprodolBemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]19244096
D002328CarisoprodolCarisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]19244096
C006923carvonecarvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15588619
D000068579CelecoxibCelecoxib results in decreased expression of GABRB2 mRNA28201806
D002712ChloridesGABRB2 protein results in increased transport of Chlorides8161449
D002712Chloridesgamma-Aminobutyric Acid promotes the reaction [GABRB2 protein results in increased transport of Chlorides]8161449
D002712Chloridesloreclezole promotes the reaction [gamma-Aminobutyric Acid promotes the reaction [GABRB2 protein results in increased transport of Chlorides]]8161449
D002712ChloridesGABRB2 protein affects the reaction [Muscimol results in increased uptake of Chlorides]12490572
D002712Chlorides[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides11123204
D002712Chlorides[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides11123204
D002712Chlorides[gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides11123204
D002712Chlorides[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides11123204
D002712Chloridestopiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]11123204
D002712Chloridestopiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]11123204
D002712Chloridestopiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]11123204
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GABRB2 mRNA18668222
D003042Cocaine1-(3-chlorophenyl)piperazine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]23266428
D003042Cocaine"3,4-Methylenedioxyamphetamine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"23266428
D003042CocaineCocaine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]23266428
D003042Cocaine"Cocaine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"23266428
D003042CocaineCocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]23266428
C013460cyclopentaphenanthrenecyclopentaphenanthrene analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]18275132
C086916delta-hexachlorocyclohexanedelta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]11156579
C086916delta-hexachlorocyclohexanedelta-hexachlorocyclohexane results in decreased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]11156579
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GABRB2 mRNA]27941970
D003975DiazepamDiazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
D003975DiazepamDiazepam results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]29038840
D003975DiazepamDiazepam results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]29038840
D003975DiazepamDiazepam results in decreased expression of GABRB2 mRNA11804615
D003975Diazepam[Diazepam co-treated with honokiol] results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]21699169
D003975DiazepamDiazepam results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]21699169
C016366dibenzothiophenedibenzothiophene results in decreased expression of GABRB2 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GABRB2 mRNA21266533
D004026DieldrinDieldrin results in decreased expression of GABRB2 mRNA28385952
D004026Dieldrin"Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D004026Dieldrin"Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D004026DieldrinDieldrin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]14637376
D007980LevodopaLevodopa results in decreased expression of GABRB2 mRNA15837143
D004317DoxorubicinDoxorubicin affects the expression of GABRB2 mRNA25529476
C118739entinostatentinostat results in increased expression of GABRB2 mRNA27188386
D000431EthanolGABRB2 protein affects the susceptibility to Ethanol12490572
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GABRB2 mRNA29097150
D005045EtomidateGABRB2 protein affects the susceptibility to Etomidate12490572
D005045EtomidateEtomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]12939268
D005045EtomidateEtomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]12939268
D005045EtomidateGABRB2 protein affects the susceptibility to Etomidate12939268
D015738FamotidineFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]15363660
D015738FamotidineFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D015738FamotidineFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15363660
D015738FamotidineFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D015738FamotidineFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]15363660
C047360felbamatefelbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]17056029
C047360felbamatefelbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]17056029
C082360fipronilfipronil promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]29038840
C082360fipronilfipronil results in decreased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]29038840
C082360fipronilfipronil results in decreased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]29038840
C082360fipronilfipronil results in decreased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form]29038840
D005411Flame RetardantsFlame Retardants promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]22547355
D005411Flame RetardantsFlame Retardants results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]22547355
D005479FlurazepamGABRB2 protein affects the susceptibility to Flurazepam12490572
C049853gabazinegabazine affects the reaction [tetrabromobisphenol A promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]22547355
C015542gaboxadolGABRB2 protein affects the susceptibility to gaboxadol12490572
D006582HexachloropheneHexachlorophene results in increased expression of GABRB2 mRNA29301063
C005499honokiol[Diazepam co-treated with honokiol] results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]21699169
C005499honokiolhonokiol results in increased activity of [GABRA1 protein binds to GABRB2 protein]21699169
C005499honokiolhonokiol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]21699169
C005499honokiolhonokiol results in increased activity of [GABRA2 protein binds to GABRB2 protein]21699169
C005499honokiolhonokiol results in increased activity of [GABRA3 protein binds to GABRB2 protein]21699169
C005499honokiolhonokiol results in increased activity of [GABRA5 protein binds to GABRB2 protein]21699169
C022871isoborneolisoborneol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15588619
C561695(+)-JQ1 compoundGABRB2 promoter modified form results in increased susceptibility to (+)-JQ1 compound26752646
D007649KetamineKetamine results in decreased expression of GABRB2 mRNA20080153
D001556Lindane"Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D001556Lindane"Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GABRB2 mRNA12057914
C066440loreclezoleGABRB2 protein affects the susceptibility to loreclezole10797553
C066440loreclezoleloreclezole promotes the reaction [gamma-Aminobutyric Acid promotes the reaction [GABRB2 protein results in increased transport of Chlorides]]8161449
D008610MentholMenthol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15588619
C019466menthonementhone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15588619
C042720mercuric bromidemercuric bromide results in increased expression of GABRB2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
D0151043,4-Methylenedioxyamphetamine"1-(3-chlorophenyl)piperazine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"23266428
D0151043,4-Methylenedioxyamphetamine"3,4-Methylenedioxyamphetamine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"23266428
D0151043,4-Methylenedioxyamphetamine"3,4-Methylenedioxyamphetamine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"23266428
D0151043,4-Methylenedioxyamphetamine"3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"23266428
D0151043,4-Methylenedioxyamphetamine"Cocaine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"23266428
C004925methylmercuric chlorideBicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]27720918
C004925methylmercuric chlorideBicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein]]]27720918
C004925methylmercuric chloridemethylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]27720918
C004925methylmercuric chloridemethylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein]]27720918
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GABRB2 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]"23266428
D009118MuscimolGABRB2 protein affects the reaction [Muscimol results in increased uptake of Chlorides]12490572
D009118Muscimolalphaxalone promotes the reaction [Muscimol binds to GABRB2 protein]8397295
D009118MuscimolGABRB2 protein binds to Muscimol10591412
D009118MuscimolMuscimol binds to GABRB2 protein8397295
D009118MuscimolPentobarbital affects the reaction [GABRB2 protein binds to Muscimol]10591412
D009118MuscimolPentobarbital promotes the reaction [Muscimol binds to GABRB2 protein]8397295
D009271NaltrexoneGABRB2 affects the susceptibility to Naltrexone19523047
D009532NickelNickel results in decreased expression of GABRB2 mRNA25583101
D009544Niflumic AcidNiflumic Acid inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein]]27720918
D009544Niflumic AcidNiflumic Acid promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]27720918
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of GABRB2 mRNA26272509
C410127PCB 180"PCB 180 inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"20819908
D010424PentobarbitalGABRB2 protein affects the susceptibility to Pentobarbital12939268
D010424PentobarbitalPentobarbital affects the expression of GABRB2 mRNA10591412
D010424PentobarbitalPentobarbital affects the reaction [GABRB2 protein binds to Muscimol]10591412
D010424PentobarbitalPentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]12939268
D010424PentobarbitalPentobarbital promotes the reaction [Muscimol binds to GABRB2 protein]8397295
D010424PentobarbitalPentobarbital results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]12939268
D010433Pentylenetetrazole"Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D010433Pentylenetetrazole"Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D010433PentylenetetrazolePentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]14637376
C052329phaclofenphaclofen results in decreased expression of GABRB2 protein15236866
C031503phenylpiperazinephenylpiperazine analog inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
C031503phenylpiperazinephenylpiperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]26344803
D010852Picrotoxin"Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D010852Picrotoxin"Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
D010852PicrotoxinPicrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]14637376
D010852PicrotoxinPicrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]17054655
D010852PicrotoxinPicrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]17054655
C022961picrotoxininpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]29038840
C022961picrotoxininpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]29038840
C022961picrotoxininGABRB2 protein results in increased susceptibility to picrotoxinin29038840
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of GABRB2 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of GABRB2 mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of GABRB2 mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]20819908
D059808PolyphenolsPolyphenols results in decreased expression of GABRB2 mRNA16293270
D011280PregnanolonePregnanolone results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]29038840
C018370pregnenolone sulfatepregnenolone sulfate inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]17054655
C018370pregnenolone sulfatepregnenolone sulfate results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]17054655
D015742PropofolPropofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]29038840
D015742PropofolPropofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]29038840
D015742PropofolPropofol results in increased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form]29038840
D015742PropofolGABRB2 protein affects the susceptibility to Propofol12939268
D015742PropofolPropofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]12939268
D015742PropofolPropofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]12939268
D015742PropofolPropofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]11399263
D011441PropylthiouracilPropylthiouracil results in decreased expression of GABRB2 mRNA24780913
D013256SteroidsSteroids analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]18275132
C046308tert-butylbicyclo-2-benzoate"tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C046308tert-butylbicyclo-2-benzoate"tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C037476tert-butylbicyclophosphorothionateDieldrin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]14637376
C037476tert-butylbicyclophosphorothionatePentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]14637376
C037476tert-butylbicyclophosphorothionatePicrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]14637376
C037476tert-butylbicyclophosphorothionatetert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]14637376
C037476tert-butylbicyclophosphorothionate"tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C037476tert-butylbicyclophosphorothionate"tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]"14637376
C020806tetrabromobisphenol Agabazine affects the reaction [tetrabromobisphenol A promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]22547355
C020806tetrabromobisphenol Atetrabromobisphenol A binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]22547355
C020806tetrabromobisphenol Atetrabromobisphenol A promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]22547355
C010349tetramethylenedisulfotetramineBicuculline promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]29038840
C010349tetramethylenedisulfotetraminefipronil promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]29038840
C010349tetramethylenedisulfotetraminetetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]29038840
D013806TheophyllineTheophylline results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]11234751
D013943ThymolThymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]11399263
C023990tiotidinetiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]15363660
C023990tiotidinetiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
C023990tiotidinetiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]15363660
C023990tiotidinetiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
C023990tiotidinetiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]15363660
C023990tiotidinetiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
C023990tiotidinetiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]15363660
D014050TolueneToluene affects the expression of GABRB2 mRNA17108153|2182784
C052342topiramatetopiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]11123204
C052342topiramatetopiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]11123204
C052342topiramatetopiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]11123204
D014212TretinoinTretinoin results in increased expression of GABRB2 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of GABRB2 mRNA24935251|2627250
D014520UrethaneUrethane promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]11812690
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GABRB2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GABRB2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of GABRB2 mRNA24896083
D014638VanadatesVanadates results in increased expression of GABRB2 mRNA22714537
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of GABRB2 mRNA25423262
D020888VigabatrinVigabatrin results in decreased expression of GABRB2 mRNA15869561
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB2 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of GABRB2 mRNA26272509|2718838
C085665zaleplonzaleplon deficiency results in decreased expression of GABRB2 mRNA11804615
D015032ZincZinc inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]17054655
D015032ZincZinc results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]17054655
D019287Zinc SulfateZinc Sulfate results in increased expression of GABRB2 mRNA27504894
C049109zolpidemGABRB2 protein affects the susceptibility to zolpidem12490572
C049109zolpidemzolpidem deficiency results in decreased expression of GABRB2 mRNA11804615

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004890GABA-A receptor activityCONTRIBUTES_TOIBA21873635  
GO:0004890GABA-A receptor activity-ISS-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005237inhibitory extracellular ligand-gated ion channel activity-IEA-  
GO:0005254chloride channel activity-ISS-  
GO:0005515protein binding-IPI12819203  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007214gamma-aminobutyric acid signaling pathway-TAS8264558  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007268chemical synaptic transmission-TAS8264558  
GO:0007605sensory perception of sound-IEA-  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0050877nervous system process-IBA21873635  
GO:0051932synaptic transmission, GABAergic-ISS-  
GO:0060119inner ear receptor cell development-IEA-  
GO:0060384innervation-IEA-  
GO:0071420cellular response to histamine-ISS-  
GO:0090102cochlea development-IEA-  
GO:1902476chloride transmembrane transport-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-ISS-  
GO:0030054cell junction-IEA-  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0034707chloride channel complex-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  
GO:1902711GABA-A receptor complex-IBA21873635  
GO:1902711GABA-A receptor complex-ISS-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionIEA
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112315Transmission across Chemical SynapsesIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-977441GABA A receptor activationTAS
R-HSA-977443GABA receptor activationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24136292Association of gamma-aminobutyric acid A receptor alpha2 gene (GABRA2) with alcohol use disorder. (2014 Mar)Li DNeuropsychopharmacology
29032150Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. (2018 Jan 30)Sundararajan TGene
19523047Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators. (2009 Jul)Ooteman WAddict Biol
10195814Association analysis of sequence variants of GABA(A) alpha6, beta2, and gamma2 gene cluster and alcohol dependence. (1999 Mar)Sander TAlcohol Clin Exp Res
15630072Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster. (2005 Jan)Radel MArch Gen Psychiatry
27355804SNPs in NRXN1 and CHRNA5 are associated to smoking and regulation of GABAergic and glutamatergic pathways. (2016 Jul)Perez-Rubio GPharmacogenomics
20166940Primate-accelerated evolutionary genes: novel routes to drug discovery in psychiatric disorders. (2010)Moalic JMCurr Med Chem
15690551No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample. (2005 Jan 5)Dick DMAm J Med Genet B Neuropsychiatr Genet
16766085GABA(A) receptor beta isoform protein expression in human alcoholic brain: interaction with genotype. (2006 Nov)Buckley STNeurochem Int
26561861GABRB2 Haplotype Association with Heroin Dependence in Chinese Population. (2015)Kim YSPLoS One
17440936Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population. (2007 Jun 5)Loh EWAm J Med Genet B Neuropsychiatr Genet