Gene: GABRB3

2562
ECA5|EIEE43
gamma-aminobutyric acid type A receptor beta3 subunit
protein-coding
15q12
Ensembl:ENSG00000166206 MIM:137192 Vega:OTTHUMG00000129231 UniprotKB:P28472
NG_012836.1
PubMed|SNP Mapped
CD|ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.354e-1 (AD)  4.259e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10519567chr15:26738703 (GRCh38.p7)G>A / G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNKSR20.982
SCN2A0.981
ST8SIA30.977
ATP2B10.972
FGF140.971
TMEM2460.971
GRIA10.97
NCEH10.97
PCSK20.969
MYT1L0.969

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.56
HEY2-0.545
MYL3-0.544
RAI14-0.534
TFPI2-0.53
FZD10-0.526
CNN2-0.525
RNF135-0.524
RUNX3-0.52
YES1-0.518

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00425ZolpidemSmall Molecule82626-48-0ApprovedTarget
DB00431LindaneSmall Molecule58-89-9Approved|WithdrawnTarget
DB00546AdinazolamSmall Molecule37115-32-5ApprovedTarget
DB00592PiperazineSmall Molecule110-85-0ApprovedTarget
DB00602IvermectinSmall Molecule70288-86-7Approved|InvestigationalTarget
DB00683MidazolamSmall Molecule59467-70-8Approved|IllicitTarget
DB00690FlurazepamSmall Molecule17617-23-1Approved|Illicit|InvestigationalTarget
DB00801HalazepamSmall Molecule23092-17-3Approved|Illicit|WithdrawnTarget
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalTarget
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalTarget
DB00842OxazepamSmall Molecule604-75-1ApprovedTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01215EstazolamSmall Molecule29975-16-4Approved|IllicitTarget
DB01544FlunitrazepamSmall Molecule1622-62-4Approved|IllicitTarget
DB01558BromazepamSmall Molecule1812-30-2Approved|Illicit|InvestigationalTarget
DB01559ClotiazepamSmall Molecule33671-46-4Approved|IllicitTarget
DB01567FludiazepamSmall Molecule3900-31-0Approved|IllicitTarget
DB01588PrazepamSmall Molecule2955-38-6Approved|IllicitTarget
DB01589QuazepamSmall Molecule36735-22-5Approved|IllicitTarget
DB01594CinolazepamSmall Molecule75696-02-5ApprovedTarget
DB01595NitrazepamSmall Molecule146-22-5ApprovedTarget
DB06716FospropofolSmall Molecule258516-89-1Approved|Illicit|InvestigationalTarget
DB12458MuscimolSmall Molecule2763-96-4InvestigationalTarget
DB00186LorazepamSmall Molecule846-49-1ApprovedTarget
DB00189EthchlorvynolSmall Molecule113-18-8Approved|Illicit|WithdrawnTarget
DB00228EnfluraneSmall Molecule13838-16-9Approved|InvestigationalTarget
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00237ButabarbitalSmall Molecule125-40-6Approved|IllicitTarget
DB00241ButalbitalSmall Molecule77-26-9Approved|IllicitTarget
DB00273TopiramateSmall Molecule97240-79-4ApprovedTarget
DB00292EtomidateSmall Molecule33125-97-2ApprovedTarget
DB00306TalbutalSmall Molecule115-44-6Approved|IllicitTarget
DB00312PentobarbitalSmall Molecule76-74-4Approved|InvestigationalTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00349ClobazamSmall Molecule22316-47-8Approved|IllicitTarget
DB00371MeprobamateSmall Molecule57-53-4Approved|IllicitTarget
DB00402EszopicloneSmall Molecule138729-47-2Approved|InvestigationalTarget
DB00404AlprazolamSmall Molecule28981-97-7Approved|Illicit|InvestigationalTarget
DB00463MetharbitalSmall Molecule50-11-3WithdrawnTarget
DB00475ChlordiazepoxideSmall Molecule58-25-3Approved|Illicit|InvestigationalTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00628ClorazepateSmall Molecule23887-31-2Approved|IllicitTarget
DB00659AcamprosateSmall Molecule77337-76-9Approved|InvestigationalTarget
DB00753IsofluraneSmall Molecule26675-46-7ApprovedTarget
DB00794PrimidoneSmall Molecule125-33-7ApprovedTarget
DB00801HalazepamSmall Molecule23092-17-3Approved|Illicit|WithdrawnTarget
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalTarget
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalTarget
DB00842OxazepamSmall Molecule604-75-1ApprovedTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB01028MethoxyfluraneSmall Molecule76-38-0Approved|InvestigationalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB01068ClonazepamSmall Molecule1622-61-3Approved|IllicitTarget
DB01107MethyprylonSmall Molecule125-64-4Approved|Illicit|WithdrawnTarget
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
DB01189DesfluraneSmall Molecule57041-67-5ApprovedTarget
DB01205FlumazenilSmall Molecule78755-81-4ApprovedTarget
DB01215EstazolamSmall Molecule29975-16-4Approved|IllicitTarget
DB01236SevofluraneSmall Molecule28523-86-6ApprovedTarget
DB01437GlutethimideSmall Molecule77-21-4Approved|IllicitTarget
DB01588PrazepamSmall Molecule2955-38-6Approved|IllicitTarget
DB01589QuazepamSmall Molecule36735-22-5Approved|IllicitTarget
DB01708PrasteroneSmall Molecule53-43-0Approved|Investigational|NutraceuticalTarget
DB01956TaurineSmall Molecule107-35-7Approved|NutraceuticalTarget
DB09118StiripentolSmall Molecule49763-96-4ApprovedTarget
DB11582ThiocolchicosideSmall Molecule602-41-5Approved|InvestigationalTarget
DB11901ApalutamideSmall Molecule956104-40-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to and results in decreased activity of GABRB3 protein"21111751
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB3 protein]"21111751
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein"11312652|1148935
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRB3 protein binds to GABRB1 protein]"21111751
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Endosulfan inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]"11312652
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Etomidate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]"21111751
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"fipronil inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]"11312652
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"gamma-Aminobutyric Acid promotes the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB3 protein]]"21111751
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]"11312652
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in increased expression of GABRB3 mRNA27417517
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GABRB3 mRNA"21394737
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GABRB3 mRNA"19114083
C5704072,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol"2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]"22029276
C5704072,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol"2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]"22029276
C0981233,3-bis(trifluoromethyl)bicyclo(2.2.1)heptane-2,2-dicarbonitrile"3,3-bis(trifluoromethyl)bicyclo(2.2.1)heptane-2,2-dicarbonitrile binds to GABRB3 protein"16537435
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C0006099244-chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide"4-chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]"29038840
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
D019342Acetic AcidAcetic Acid affects the expression of GABRB3 protein21296659
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of GABRB3 mRNA28522335
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C006477alphaxalonealphaxalone promotes the reaction [Muscimol binds to GABRB3 protein]8397295
D005680gamma-Aminobutyric Acidalpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D005680gamma-Aminobutyric Acidbenzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]18762200
D005680gamma-Aminobutyric Acid[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D005680gamma-Aminobutyric Acid[delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D005680gamma-Aminobutyric Aciddelta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
D005680gamma-Aminobutyric Aciddelta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
D005680gamma-Aminobutyric Aciddelta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D005680gamma-Aminobutyric Aciddelta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D005680gamma-Aminobutyric AcidFlumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]8632757
D005680gamma-Aminobutyric Acid"gamma-Aminobutyric Acid promotes the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB3 protein]]"21111751
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid promotes the reaction [GABRB3 protein results in increased transport of Chlorides]8161449
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]9316872
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]29038840
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein]29038840
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]29038840
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]18762200|2903884
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]29038840
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRD protein]29038840
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG1 protein]29038840
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]9316872
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]29038840
D005680gamma-Aminobutyric AcidLanthanum promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D005680gamma-Aminobutyric AcidLindane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
D005680gamma-Aminobutyric AcidLindane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D005680gamma-Aminobutyric AcidLindane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D005680gamma-Aminobutyric AcidLindane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
D005680gamma-Aminobutyric AcidLindane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
D005680gamma-Aminobutyric Acidloreclezole promotes the reaction [gamma-Aminobutyric Acid promotes the reaction [GABRB3 protein results in increased transport of Chlorides]]8161449
D005680gamma-Aminobutyric Acidloreclezole promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D005680gamma-Aminobutyric AcidPentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D005680gamma-Aminobutyric AcidPicrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D005680gamma-Aminobutyric Acidpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D005680gamma-Aminobutyric Acidpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein]]29038840
D005680gamma-Aminobutyric Acidpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D005680gamma-Aminobutyric Acidpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D005680gamma-Aminobutyric Acidpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D005680gamma-Aminobutyric Acid[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D005680gamma-Aminobutyric AcidPropofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D005680gamma-Aminobutyric AcidRo 15-4513 promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]8632757
D005680gamma-Aminobutyric Acidtetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D005680gamma-Aminobutyric Acidtetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D005680gamma-Aminobutyric Acidtetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]29038840
D005680gamma-Aminobutyric Acidtetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRD protein]]29038840
D005680gamma-Aminobutyric Acidtetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D000639AmitriptylineAmitriptyline results in increased expression of GABRB3 mRNA21820738
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GABRB3 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of GABRB3 mRNA26705709
D001280AtrazineAtrazine results in decreased expression of GABRB3 mRNA22378314
C487081belinostatbelinostat results in increased expression of GABRB3 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C037689benzamidebenzamide analog binds to and results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]18762200
C037689benzamidebenzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]18762200
D004958EstradiolEstradiol results in increased expression of GABRB3 mRNA16000229
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of GABRB3 mRNA19833106
D001640BicucullineBicuculline results in decreased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D001640BicucullineBicuculline results in decreased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D001640BicucullineBicuculline results in decreased expression of GABRB3 mRNA9600394
C006780bisphenol Abisphenol A results in decreased expression of GABRB3 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of GABRB3 mRNA29097150
C054626bretazenilbretazenil binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]8632757
C054626bretazenilbretazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]8632757
C099813bromochloroacetic acidbromochloroacetic acid affects the expression of GABRB3 protein21296659
C018475butyraldehydebutyraldehyde results in decreased expression of GABRB3 mRNA26079696
D002104CadmiumCadmium results in increased expression of GABRB3 mRNA23369406
C084597chlorcyclizinechlorcyclizine results in increased expression of GABRB3 mRNA21058326
D002712ChloridesGABRB3 protein results in increased transport of Chlorides8161449
D002712Chloridesgamma-Aminobutyric Acid promotes the reaction [GABRB3 protein results in increased transport of Chlorides]8161449
D002712Chloridesloreclezole promotes the reaction [gamma-Aminobutyric Acid promotes the reaction [GABRB3 protein results in increased transport of Chlorides]]8161449
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of GABRB3 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GABRB3 mRNA20938992
C021604CL 218872CL 218872 binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]8632757
D003024ClozapineClozapine results in increased expression of GABRB3 mRNA18923069
D003042CocaineCocaine affects the expression of GABRB3 mRNA20187946
D003042CocaineCocaine affects the phosphorylation of and affects the expression of GABRB3 protein20826313
D019327Copper SulfateCopper Sulfate results in decreased expression of GABRB3 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of GABRB3 mRNA26577399
C086916delta-hexachlorocyclohexane[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C086916delta-hexachlorocyclohexane[delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C086916delta-hexachlorocyclohexanedelta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
C086916delta-hexachlorocyclohexanedelta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
C086916delta-hexachlorocyclohexanedelta-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C086916delta-hexachlorocyclohexanedelta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C086916delta-hexachlorocyclohexanedelta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C086916delta-hexachlorocyclohexanedelta-hexachlorocyclohexane results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]9316872
C086916delta-hexachlorocyclohexanedelta-hexachlorocyclohexane results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]9316872
C086916delta-hexachlorocyclohexaneLindane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
D003907DexamethasoneDexamethasone results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]9316872
D003975DiazepamDiazepam results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D003975DiazepamDiazepam results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D003975DiazepamDiazepam results in increased expression of GABRB3 mRNA15802192
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of GABRB3 mRNA28962523
D004026DieldrinDieldrin results in decreased expression of GABRB3 mRNA9600394
D004026DieldrinDieldrin results in increased expression of GABRB3 mRNA9302086
D004726EndosulfanEndosulfan binds to GABRB3 protein11489356|1653743
D004726Endosulfan"Endosulfan inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]"11312652
C118739entinostatentinostat results in decreased expression of GABRB3 mRNA27188386
C118739entinostatentinostat results in increased expression of GABRB3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
D000431EthanolEthanol results in increased expression of GABRB3 mRNA28069986
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GABRB3 mRNA29097150
D005045Etomidate"Etomidate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]"21111751
D005045EtomidateGABRB3 protein results in increased susceptibility to Etomidate9523823
C047360felbamatefelbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]17056029
C047360felbamatefelbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]17056029
C047360felbamatefelbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]17056029
C047360felbamatefelbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]17056029
C082360fipronilfipronil binds to GABRB3 protein11489356|1653743
C082360fipronil"fipronil inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]"11312652
C082360fipronilfipronil results in decreased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
C082360fipronilfipronil results in decreased activity of [GABRA2 protein binds to GABRB3]29038840
C082360fipronilfipronil results in decreased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
C082360fipronilfipronil results in decreased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]29038840
C082360fipronilfipronil results in decreased activity of [GABRA4 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
C082360fipronilfipronil results in decreased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D005442FlumazenilFlumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]8632757
D005442FlumazenilFlumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]8632757
D005442FlumazenilFlumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]8632757
D005445Flunitrazepam"2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]"22029276
D005445FlunitrazepamFlunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]8632757
D005445FlunitrazepamFlunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]22029276
D005445FlunitrazepamPropofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]22029276
D005472FluorouracilFluorouracil results in increased expression of GABRB3 protein21296659
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GABRB3 mRNA20938992
D018682GABA AgentsGABA Agents binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]8632757
D018682GABA AgentsGABA Agents binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]8632757
D006220HaloperidolHaloperidol results in increased expression of GABRB3 mRNA18923069
C005499honokiolhonokiol results in increased activity of [GABRA1 protein binds to GABRB3 protein]21699169
D007608Kainic AcidKainic Acid results in increased expression of GABRB3 mRNA27386150
D007608Kainic AcidQuercetin inhibits the reaction [Kainic Acid results in increased expression of GABRB3 mRNA]27386150
D048628KetolidesKetolides analog results in increased expression of GABRB3 mRNA24967691
C063822L 663581L 663581 binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]8632757
C063822L 663581L 663581 binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]8632757
D007811Lanthanum[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D007811LanthanumLanthanum promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D001556LindaneLindane binds to GABRB3 protein11489356|1653743
D001556Lindane"Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]"11312652
D001556LindaneLindane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
D001556LindaneLindane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D001556LindaneLindane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D001556LindaneLindane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
D001556LindaneLindane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D001556LindaneLindane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
D001556LindaneLindane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C066440loreclezole[delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C066440loreclezoleGABRB3 protein affects the susceptibility to loreclezole10797553
C066440loreclezoleloreclezole promotes the reaction [gamma-Aminobutyric Acid promotes the reaction [GABRB3 protein results in increased transport of Chlorides]]8161449
C066440loreclezoleloreclezole promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C042720mercuric bromidemercuric bromide results in increased expression of GABRB3 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
D008627Mercuric Chloride"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GABRB3 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GABRB3 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
D008874MidazolamGABRB3 protein results in increased susceptibility to Midazolam9523823
D009118Muscimol"2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]"22029276
D009118MuscimolMuscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]22029276
D009118MuscimolPropofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]22029276
D009118Muscimolalphaxalone promotes the reaction [Muscimol binds to GABRB3 protein]8397295
D009118MuscimolMuscimol binds to GABRB3 protein8397295
D009118MuscimolPentobarbital promotes the reaction [Muscimol binds to GABRB3 protein]8397295
C066471NCS 382NCS 382 results in increased expression of GABRB3 mRNA29031482
C029407oleylamideGABRB3 gene mutant form results in decreased susceptibility to oleylamide11742254
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of GABRB3 mRNA26272509
D052638Particulate MatterParticulate Matter affects the methylation of GABRB3 promoter28153600
D052638Particulate MatterParticulate Matter results in decreased expression of GABRB3 mRNA28153600
D010424PentobarbitalLindane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
D010424PentobarbitalLindane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D010424PentobarbitalPentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D010424PentobarbitalPentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]9316872
D010424Pentobarbital[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D010424PentobarbitalPentobarbital promotes the reaction [Muscimol binds to GABRB3 protein]8397295
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of GABRB3 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of GABRB3 mRNA19482888
C033457phenobarbital quinidinephenobarbital quinidine results in increased expression of GABRB3 mRNA15802192
D019800PhenolPhenol results in decreased phosphorylation of GABRB3 protein28964900
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GABRB3 mRNA26272509
D010852Picrotoxindelta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
D010852PicrotoxinLindane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
D010852PicrotoxinPicrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C022961picrotoxininGABRB3 protein results in increased susceptibility to picrotoxinin29038840
C022961picrotoxininpicrotoxinin binds to GABRB3 protein16537435
C022961picrotoxininpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
C022961picrotoxininpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein]]29038840
C022961picrotoxininpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
C022961picrotoxininpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
C022961picrotoxininpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D011280PregnanolonePregnanolone results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D011280PregnanolonePregnanolone results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D011280PregnanolonePregnanolone results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]29038840
D011280PregnanolonePregnanolone results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of GABRB3 mRNA19833106
D015742Propofoldelta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]9316872
D015742PropofolPropofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]22029276
D015742PropofolPropofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]22029276
D015742Propofol[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D015742PropofolPropofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
D015742PropofolPropofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D015742PropofolPropofol results in increased activity of [GABRA2 protein binds to GABRB3]29038840
D015742PropofolPropofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D015742PropofolPropofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]29038840
D011794QuercetinQuercetin inhibits the reaction [Kainic Acid results in increased expression of GABRB3 mRNA]27386150
C042957Ro 15-4513Ro 15-4513 binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]8632757
C042957Ro 15-4513Ro 15-4513 promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]8632757
C017947sodium arsenitesodium arsenite affects the methylation of GABRB3 gene28589171
D017693Sodium Bicarbonate[Sodium Chloride co-treated with Sodium Bicarbonate] results in decreased phosphorylation of GABRB3 protein28964900
D012965Sodium Chloride[Sodium Chloride co-treated with Sodium Bicarbonate] results in decreased phosphorylation of GABRB3 protein28964900
C037476tert-butylbicyclophosphorothionatealpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C037476tert-butylbicyclophosphorothionatedelta-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C037476tert-butylbicyclophosphorothionateLindane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]9316872
C037476tert-butylbicyclophosphorothionatetert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]9316872
C037476tert-butylbicyclophosphorothionatetert-butylbicyclophosphorothionate binds to GABRB3 protein16537435
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GABRB3 mRNA21570461|2637764
C010349tetramethylenedisulfotetramineGABRB3 protein results in increased susceptibility to tetramethylenedisulfotetramine29038840
C010349tetramethylenedisulfotetraminetetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
C010349tetramethylenedisulfotetraminetetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
C010349tetramethylenedisulfotetraminetetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]29038840
C010349tetramethylenedisulfotetraminetetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRD protein]]29038840
C010349tetramethylenedisulfotetraminetetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]29038840
D014050TolueneToluene affects the expression of GABRB3 mRNA17108153
D014212TretinoinTretinoin results in decreased expression of GABRB3 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of GABRB3 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABRB3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GABRB3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GABRB3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of GABRB3 gene29154799
D014640VancomycinVancomycin results in increased expression of GABRB3 mRNA18930951
D014801Vitamin AVitamin A results in increased expression of GABRB3 mRNA17225872
C111237vorinostatvorinostat results in decreased expression of GABRB3 mRNA27188386
C111237vorinostatvorinostat results in increased expression of GABRB3 mRNA26272509
C049109zolpidemzolpidem binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]8632757

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004890GABA-A receptor activityCONTRIBUTES_TOIBA21873635  
GO:0004890GABA-A receptor activity-IMP22303015  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0022851GABA-gated chloride ion channel activity-IDA9039914  
GO:0022851GABA-gated chloride ion channel activity-IMP22303015  26950270  
GO:0022851GABA-gated chloride ion channel activity-ISS-  
GO:0042802identical protein binding-IPI16537435  24909990  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-TAS1664410  
GO:0007214gamma-aminobutyric acid signaling pathway-IMP26950270  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007605sensory perception of sound-IEA-  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0050877nervous system process-IBA21873635  
GO:0060021roof of mouth development-ISS-  
GO:0060080inhibitory postsynaptic potential-IEA-  
GO:0060119inner ear receptor cell development-IEA-  
GO:0060384innervation-IEA-  
GO:0071420cellular response to histamine-IDA18281286  
GO:0090102cochlea development-IEA-  
GO:1902476chloride transmembrane transport-IDA9039914  
GO:1902476chloride transmembrane transport-IMP22303015  
GO:1902476chloride transmembrane transport-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA26950270  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IMP22303015  
GO:0030054cell junction-IEA-  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0034707chloride channel complex-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:1902711GABA-A receptor complex-IBA21873635  
GO:1902711GABA-A receptor complex-IDA9039914  26950270  
GO:1902711GABA-A receptor complex-IMP22303015  
GO:1902711GABA-A receptor complex-ISS-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionIEA
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112315Transmission across Chemical SynapsesIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-977441GABA A receptor activationTAS
R-HSA-977443GABA receptor activationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
9858031D2 dopamine receptor and GABA(A) receptor beta3 subunit genes and alcoholism. (1998 Nov 16)Noble EPPsychiatry Res
12555233Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting. (2003 Feb)Song JAm J Med Genet B Neuropsychiatr Genet
14745296Association of GABRG3 with alcohol dependence. (2004 Jan)Dick DMAlcohol Clin Exp Res
22924764Array-based profiling of DNA methylation changes associated with alcohol dependence. (2013 Jan)Zhang HAlcohol Clin Exp Res
26277529Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry. (2016 Jan 4)Levran OProg Neuropsychopharmacol Biol Psychiatry
15296817Alcohol-related expectancies are associated with the D2 dopamine receptor and GABAA receptor beta3 subunit genes. (2004 Jul 15)Young RMPsychiatry Res
25921801Eye color: A potential indicator of alcohol dependence risk in European Americans. (2015 Jul)Sulovari AAm J Med Genet B Neuropsychiatr Genet
10374739Chromosome Workshop: chromosomes 11, 14, and 15. (1999 Jun 18)Craddock NAm J Med Genet
2571316815q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers. (2015 Feb 23)Leng SJ Natl Cancer Inst