Gene: STEAP1B

256227
-
STEAP family member 1B
protein-coding
7p15.3
Ensembl:ENSG00000105889 Vega:OTTHUMG00000152529 UniprotKB:Q6NZ63
NC_000007.14
SNP Mapped
1   ANCO-SNPs
AD
0   
9.143e-1 (AD)  5.296e-1 (ND)   (Frontal_Cortex)
5.975e-1 (AD)  2.167e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3114717chr7:22452771 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLHL40.675
SPTLC20.654
SLC6A90.651
TMEM2060.637
EDIL30.636
PLCL10.633
SLCO3A10.632
AFMID0.631
FAM124A0.62
CNTNAP40.619

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GLI3-0.403
SLC13A5-0.398
HKDC1-0.382
EYA1-0.376
RNF43-0.376
CABLES1-0.37
SALL3-0.369
ATP13A5-0.366
ZIC5-0.361
IGFN1-0.355

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP1B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP1B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP1B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP1B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP1B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP1B mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of STEAP1B gene27153756
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP1B mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of STEAP1B mRNA26272509
D000069439DasatinibDasatinib results in decreased expression of STEAP1B mRNA20579391
C118739entinostatentinostat results in increased expression of STEAP1B mRNA27188386
C492448ICG 001ICG 001 results in increased expression of STEAP1B mRNA26191083
D010100OxygenOxygen deficiency results in decreased expression of STEAP1B mRNA26516004
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP1B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of STEAP1B mRNA26272509
D012822Silicon DioxideSilicon Dioxide results in increased expression of STEAP1B mRNA25351596
C017947sodium arsenitesodium arsenite affects the methylation of STEAP1B gene28589171
C012589trichostatin Atrichostatin A results in increased expression of STEAP1B mRNA24935251
D017973Tungsten CompoundsTungsten Compounds results in increased expression of STEAP1B mRNA28666766
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP1B mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of STEAP1B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of STEAP1B mRNA23179753|2438349
C111237vorinostatvorinostat results in increased expression of STEAP1B mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008823cupric reductase activity-IBA21873635  
GO:0052851ferric-chelate reductase (NADPH) activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0015677copper ion import-IBA21873635  
GO:0055114oxidation-reduction process-IBA21873635  
GO:0098706ferric iron import across plasma membrane-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal