Gene: GABRD

2563
EIG10|EJM7|GEFSP5
gamma-aminobutyric acid type A receptor delta subunit
protein-coding
1p36.33
Ensembl:ENSG00000187730 MIM:137163 Vega:OTTHUMG00000041064 UniprotKB:O14764
NG_008168.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.090e-1 (AD)  9.422e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04781796chr1:1959747GABRD1.930e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNJ40.973
NGEF0.957
STX1B0.955
DIRAS10.954
CAMKK20.953
EPHB60.953
CACNG80.95
KCNAB20.949
SCAMP50.945
DNM10.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WWTR1-0.564
REST-0.551
RAI14-0.542
KIAA0040-0.531
IGF2BP2-0.529
TFPI2-0.525
YES1-0.524
DNAI2-0.523
SGMS2-0.519
ZNF114-0.518

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00546AdinazolamSmall Molecule37115-32-5ApprovedTarget
DB00683MidazolamSmall Molecule59467-70-8Approved|IllicitTarget
DB00690FlurazepamSmall Molecule17617-23-1Approved|Illicit|InvestigationalTarget
DB00801HalazepamSmall Molecule23092-17-3Approved|Illicit|WithdrawnTarget
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalTarget
DB00842OxazepamSmall Molecule604-75-1ApprovedTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01215EstazolamSmall Molecule29975-16-4Approved|IllicitTarget
DB01558BromazepamSmall Molecule1812-30-2Approved|Illicit|InvestigationalTarget
DB01559ClotiazepamSmall Molecule33671-46-4Approved|IllicitTarget
DB01567FludiazepamSmall Molecule3900-31-0Approved|IllicitTarget
DB01587KetazolamSmall Molecule27223-35-4ApprovedTarget
DB01588PrazepamSmall Molecule2955-38-6Approved|IllicitTarget
DB01589QuazepamSmall Molecule36735-22-5Approved|IllicitTarget
DB01594CinolazepamSmall Molecule75696-02-5ApprovedTarget
DB01595NitrazepamSmall Molecule146-22-5ApprovedTarget
DB00186LorazepamSmall Molecule846-49-1ApprovedTarget
DB00189EthchlorvynolSmall Molecule113-18-8Approved|Illicit|WithdrawnTarget
DB00228EnfluraneSmall Molecule13838-16-9Approved|InvestigationalTarget
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00237ButabarbitalSmall Molecule125-40-6Approved|IllicitTarget
DB00241ButalbitalSmall Molecule77-26-9Approved|IllicitTarget
DB00273TopiramateSmall Molecule97240-79-4ApprovedTarget
DB00292EtomidateSmall Molecule33125-97-2ApprovedTarget
DB00306TalbutalSmall Molecule115-44-6Approved|IllicitTarget
DB00312PentobarbitalSmall Molecule76-74-4Approved|InvestigationalTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00349ClobazamSmall Molecule22316-47-8Approved|IllicitTarget
DB00371MeprobamateSmall Molecule57-53-4Approved|IllicitTarget
DB00402EszopicloneSmall Molecule138729-47-2Approved|InvestigationalTarget
DB00404AlprazolamSmall Molecule28981-97-7Approved|Illicit|InvestigationalTarget
DB00463MetharbitalSmall Molecule50-11-3WithdrawnTarget
DB00475ChlordiazepoxideSmall Molecule58-25-3Approved|Illicit|InvestigationalTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00628ClorazepateSmall Molecule23887-31-2Approved|IllicitTarget
DB00659AcamprosateSmall Molecule77337-76-9Approved|InvestigationalTarget
DB00753IsofluraneSmall Molecule26675-46-7ApprovedTarget
DB00794PrimidoneSmall Molecule125-33-7ApprovedTarget
DB00801HalazepamSmall Molecule23092-17-3Approved|Illicit|WithdrawnTarget
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalTarget
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalTarget
DB00842OxazepamSmall Molecule604-75-1ApprovedTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB01028MethoxyfluraneSmall Molecule76-38-0Approved|InvestigationalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB01068ClonazepamSmall Molecule1622-61-3Approved|IllicitTarget
DB01107MethyprylonSmall Molecule125-64-4Approved|Illicit|WithdrawnTarget
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
DB01189DesfluraneSmall Molecule57041-67-5ApprovedTarget
DB01205FlumazenilSmall Molecule78755-81-4ApprovedTarget
DB01215EstazolamSmall Molecule29975-16-4Approved|IllicitTarget
DB01236SevofluraneSmall Molecule28523-86-6ApprovedTarget
DB01437GlutethimideSmall Molecule77-21-4Approved|IllicitTarget
DB01588PrazepamSmall Molecule2955-38-6Approved|IllicitTarget
DB01589QuazepamSmall Molecule36735-22-5Approved|IllicitTarget
DB01708PrasteroneSmall Molecule53-43-0Approved|Investigational|NutraceuticalTarget
DB01956TaurineSmall Molecule107-35-7Approved|NutraceuticalTarget
DB09118StiripentolSmall Molecule49763-96-4ApprovedTarget
DB11582ThiocolchicosideSmall Molecule602-41-5Approved|InvestigationalTarget
DB11901ApalutamideSmall Molecule956104-40-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GABRD mRNA"19114083
C0006099244-chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide"4-chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]"29038840
D005680gamma-Aminobutyric Acidbenzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]18762200
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]18762200|2903884
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRD protein]29038840
D005680gamma-Aminobutyric Acidtetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]29038840
D005680gamma-Aminobutyric Acidtetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRD protein]]29038840
D005680gamma-Aminobutyric Acidbenzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]]18762200
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]18762200
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GABRD mRNA16483693
C015001arsenitearsenite results in increased methylation of GABRD promoter23974009
C500175bacoside Abacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]20821261
C037689benzamidebenzamide analog binds to and results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]18762200
C037689benzamidebenzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]18762200
C037689benzamidebenzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]]18762200
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GABRD mRNA21839799
C006780bisphenol Abisphenol A affects the expression of GABRD mRNA26950200
C006780bisphenol Abisphenol A results in decreased expression of GABRD mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of GABRD mRNA26079696
D002104CadmiumCadmium results in increased expression of GABRD mRNA24376830
D002220CarbamazepineCarbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]20821261
C009160cyclonitecyclonite results in decreased expression of GABRD mRNA25559034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GABRD mRNA]27941970
D003975DiazepamDiazepam results in increased expression of GABRD mRNA15802192
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GABRD mRNA27392435
D002945CisplatinCisplatin results in increased expression of GABRD mRNA27392435
D004006DichlorvosDichlorvos results in decreased expression of GABRD mRNA19146868
C118739entinostatentinostat results in increased expression of GABRD mRNA27188386
D000431EthanolEthanol results in decreased expression of GABRD protein25456265
D000431EthanolEthanol deficiency results in decreased expression of GABRD mRNA17403139
D018120FinasterideFinasteride inhibits the reaction [Progesterone affects the expression of GABRD mRNA]16879715|1691418
D018120FinasterideFinasteride inhibits the reaction [Progesterone affects the expression of GABRD protein]16879715|1691418
C082360fipronilfipronil results in decreased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]29038840
D005473FluoxetineFluoxetine results in decreased expression of GABRD mRNA17033635
C015542gaboxadolGABRD results in increased susceptibility to gaboxadol17403139
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of GABRD mRNA21782745
D005839GentamicinsGentamicins results in decreased expression of GABRD mRNA22061828
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GABRD mRNA27392435
D007649KetamineKetamine results in increased expression of GABRD mRNA20080153
C029891lead chloridelead chloride results in increased expression of GABRD mRNA19651682
D008727MethotrexateMethotrexate results in decreased expression of GABRD mRNA24449571
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of GABRD mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GABRD mRNA19651682
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GABRD mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of GABRD mRNA24810058
D009020MorphineMorphine results in increased expression of GABRD mRNA15183518
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of GABRD mRNA17616710
D010269ParaquatParaquat results in decreased expression of GABRD mRNA19146868
D010278ParathionParathion results in decreased expression of GABRD mRNA19146868
D010424PentobarbitalGABRD protein affects the susceptibility to Pentobarbital15201633
D010424PentobarbitalPentobarbital results in increased expression of GABRD mRNA8848253
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GABRD mRNA20136073
C033457phenobarbital quinidinephenobarbital quinidine results in increased expression of GABRD mRNA15802192
D010862PilocarpinePilocarpine results in decreased expression of GABRD protein15456836
D010862Pilocarpinebacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]20821261
D010862PilocarpineCarbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]20821261
D010862PilocarpinePilocarpine results in decreased expression of GABRD mRNA20821261
C006253pirinixic acidpirinixic acid results in increased expression of GABRD mRNA20813756
D059808PolyphenolsPolyphenols results in decreased expression of GABRD mRNA16293270
D011280PregnanolonePregnanolone results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]29038840
D011280PregnanolonePregnanolone results in decreased expression of GABRD protein16914187
D011374ProgesteroneFinasteride inhibits the reaction [Progesterone affects the expression of GABRD mRNA]16879715|1691418
D011374ProgesteroneFinasteride inhibits the reaction [Progesterone affects the expression of GABRD protein]16879715|1691418
D011374ProgesteroneProgesterone affects the expression of GABRD mRNA16879715|1691418
D011374ProgesteroneProgesterone affects the expression of GABRD protein15834956|1687971
D011374ProgesteroneProgesterone metabolite affects the expression of GABRD mRNA16879715
D011374ProgesteroneProgesterone results in decreased expression of GABRD protein16914187
D011441PropylthiouracilPropylthiouracil results in decreased expression of GABRD mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of GABRD mRNA27029645
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GABRD mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GABRD mRNA21570461
C009413tetrahydrodeoxycorticosteronetetrahydrodeoxycorticosterone results in decreased expression of GABRD protein16914187
C010349tetramethylenedisulfotetraminetetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]29038840
C010349tetramethylenedisulfotetraminetetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRD protein]]29038840
D014050TolueneToluene affects the expression of GABRD mRNA17108153
C040533trimethyltin chloridetrimethyltin chloride results in decreased expression of GABRD mRNA19651682
D014635Valproic AcidValproic Acid results in increased expression of GABRD mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of GABRD gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of GABRD mRNA19651682
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GABRD gene25560391
D015032ZincZinc affects the expression of GABRD mRNA16413754

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004890GABA-A receptor activityCONTRIBUTES_TOIBA21873635  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005230extracellular ligand-gated ion channel activity-IEA-  
GO:0005254chloride channel activity-IEA-  
GO:0005515protein binding-IPI16189514  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-TAS2176788  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007268chemical synaptic transmission-IEA-  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO:1902476chloride transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS2176788  
GO:0030054cell junction-IEA-  
GO:0034707chloride channel complex-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:1902711GABA-A receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29156239Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. (2018 Feb)Lieberman RAlcohol