Gene info: ID 2564

Gene: GABRE

GENE ID: 2564

Synonyms: -

Description: gamma-aminobutyric acid type A receptor epsilon subunit

Gene type: protein-coding

Location: Xq28

dbXrefs: Ensembl:ENSG00000102287 MIM:300093 Vega:OTTHUMG00000024176 UniprotKB:P78334

RefSeq: NG_012511.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ADAMTS9	0.859
MPZL2	0.853
C1R	0.846
STC1	0.846
CASP4	0.844
PDLIM1	0.833
OSMR	0.829
COL4A1	0.818
IL1R1	0.816
PLSCR1	0.811

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNIP3	-0.56
MARCH4	-0.559
KIT	-0.54
NEUROD6	-0.54
NOG	-0.539
CRH	-0.532
WNT7A	-0.531
CPLX3	-0.531
F7	-0.529
SLC32A1	-0.528

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00231	Temazepam	Small Molecule	846-50-4	Approved\|Investigational	Target
DB00546	Adinazolam	Small Molecule	37115-32-5	Approved	Target
DB00683	Midazolam	Small Molecule	59467-70-8	Approved\|Illicit	Target
DB00690	Flurazepam	Small Molecule	17617-23-1	Approved\|Illicit\|Investigational	Target
DB00801	Halazepam	Small Molecule	23092-17-3	Approved\|Illicit\|Withdrawn	Target
DB00829	Diazepam	Small Molecule	439-14-5	Approved\|Illicit\|Investigational	Target
DB00842	Oxazepam	Small Molecule	604-75-1	Approved	Target
DB00897	Triazolam	Small Molecule	28911-01-5	Approved\|Investigational	Target
DB00898	Ethanol	Small Molecule	64-17-5	Approved	Target
DB01215	Estazolam	Small Molecule	29975-16-4	Approved\|Illicit	Target
DB01558	Bromazepam	Small Molecule	1812-30-2	Approved\|Illicit\|Investigational	Target
DB01559	Clotiazepam	Small Molecule	33671-46-4	Approved\|Illicit	Target
DB01567	Fludiazepam	Small Molecule	3900-31-0	Approved\|Illicit	Target
DB01587	Ketazolam	Small Molecule	27223-35-4	Approved	Target
DB01588	Prazepam	Small Molecule	2955-38-6	Approved\|Illicit	Target
DB01589	Quazepam	Small Molecule	36735-22-5	Approved\|Illicit	Target
DB01594	Cinolazepam	Small Molecule	75696-02-5	Approved	Target
DB01595	Nitrazepam	Small Molecule	146-22-5	Approved	Target
DB00186	Lorazepam	Small Molecule	846-49-1	Approved	Target
DB00189	Ethchlorvynol	Small Molecule	113-18-8	Approved\|Illicit\|Withdrawn	Target
DB00228	Enflurane	Small Molecule	13838-16-9	Approved\|Investigational	Target
DB00231	Temazepam	Small Molecule	846-50-4	Approved\|Investigational	Target
DB00237	Butabarbital	Small Molecule	125-40-6	Approved\|Illicit	Target
DB00241	Butalbital	Small Molecule	77-26-9	Approved\|Illicit	Target
DB00273	Topiramate	Small Molecule	97240-79-4	Approved	Target
DB00292	Etomidate	Small Molecule	33125-97-2	Approved	Target
DB00306	Talbutal	Small Molecule	115-44-6	Approved\|Illicit	Target
DB00312	Pentobarbital	Small Molecule	76-74-4	Approved\|Investigational	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00349	Clobazam	Small Molecule	22316-47-8	Approved\|Illicit	Target
DB00371	Meprobamate	Small Molecule	57-53-4	Approved\|Illicit	Target
DB00402	Eszopiclone	Small Molecule	138729-47-2	Approved\|Investigational	Target
DB00404	Alprazolam	Small Molecule	28981-97-7	Approved\|Illicit\|Investigational	Target
DB00463	Metharbital	Small Molecule	50-11-3	Withdrawn	Target
DB00475	Chlordiazepoxide	Small Molecule	58-25-3	Approved\|Illicit\|Investigational	Target
DB00543	Amoxapine	Small Molecule	14028-44-5	Approved	Target
DB00555	Lamotrigine	Small Molecule	84057-84-1	Approved\|Investigational	Target
DB00628	Clorazepate	Small Molecule	23887-31-2	Approved\|Illicit	Target
DB00659	Acamprosate	Small Molecule	77337-76-9	Approved\|Investigational	Target
DB00753	Isoflurane	Small Molecule	26675-46-7	Approved	Target
DB00794	Primidone	Small Molecule	125-33-7	Approved	Target
DB00801	Halazepam	Small Molecule	23092-17-3	Approved\|Illicit\|Withdrawn	Target
DB00818	Propofol	Small Molecule	2078-54-8	Approved\|Investigational	Target
DB00829	Diazepam	Small Molecule	439-14-5	Approved\|Illicit\|Investigational	Target
DB00842	Oxazepam	Small Molecule	604-75-1	Approved	Target
DB00897	Triazolam	Small Molecule	28911-01-5	Approved\|Investigational	Target
DB01028	Methoxyflurane	Small Molecule	76-38-0	Approved\|Investigational	Target
DB01049	Ergoloid mesylate	Small Molecule	8067-24-1	Approved	Target
DB01068	Clonazepam	Small Molecule	1622-61-3	Approved\|Illicit	Target
DB01107	Methyprylon	Small Molecule	125-64-4	Approved\|Illicit\|Withdrawn	Target
DB01159	Halothane	Small Molecule	151-67-7	Approved	Target
DB01189	Desflurane	Small Molecule	57041-67-5	Approved	Target
DB01205	Flumazenil	Small Molecule	78755-81-4	Approved	Target
DB01215	Estazolam	Small Molecule	29975-16-4	Approved\|Illicit	Target
DB01236	Sevoflurane	Small Molecule	28523-86-6	Approved	Target
DB01437	Glutethimide	Small Molecule	77-21-4	Approved\|Illicit	Target
DB01588	Prazepam	Small Molecule	2955-38-6	Approved\|Illicit	Target
DB01589	Quazepam	Small Molecule	36735-22-5	Approved\|Illicit	Target
DB01708	Prasterone	Small Molecule	53-43-0	Approved\|Investigational\|Nutraceutical	Target
DB01956	Taurine	Small Molecule	107-35-7	Approved\|Nutraceutical	Target
DB09118	Stiripentol	Small Molecule	49763-96-4	Approved	Target
DB11582	Thiocolchicoside	Small Molecule	602-41-5	Approved\|Investigational	Target
DB11901	Apalutamide	Small Molecule	956104-40-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of GABRE mRNA	21641981
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of GABRE gene	27153756
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of GABRE mRNA	21757418
D005680	gamma-Aminobutyric Acid	Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]	10049148
D005680	gamma-Aminobutyric Acid	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]	10049148
D005680	gamma-Aminobutyric Acid	Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]	10049148
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GABRE mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of GABRE mRNA	22521957
D001379	Azathioprine	Azathioprine results in increased expression of GABRE mRNA	22623647
D001569	Benzodiazepines	GABRE protein results in decreased susceptibility to Benzodiazepines	11691872
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GABRE mRNA	20106945\|2163298
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of GABRE mRNA	20660070
D004958	Estradiol	Estradiol results in increased expression of GABRE mRNA	16000229
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GABRE mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of GABRE mRNA	26950200
C018475	butyraldehyde	butyraldehyde results in decreased expression of GABRE mRNA	26079696
D002707	Chlordiazepoxide	GABRE protein results in decreased susceptibility to Chlordiazepoxide	11691872
D019327	Copper Sulfate	Copper Sulfate results in increased expression of GABRE mRNA	19549813
C029892	cupric chloride	cupric chloride results in increased expression of GABRE mRNA	17211630
D016572	Cyclosporine	Cyclosporine results in decreased expression of GABRE mRNA	20106945\|2798913
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of GABRE mRNA	23640034
D003907	Dexamethasone	Dexamethasone results in decreased expression of GABRE mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GABRE mRNA	28628672
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of GABRE mRNA	27392435
C000944	dicrotophos	dicrotophos results in increased expression of GABRE mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of GABRE mRNA	25016146
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GABRE mRNA	22079256
D005045	Etomidate	Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]	10049148
C039281	furan	furan results in increased methylation of GABRE gene	22079235
D019833	Genistein	Genistein results in decreased expression of GABRE mRNA	26865667
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GABRE mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GABRE mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of GABRE mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of GABRE mRNA	24231268
D008713	Methimazole	Methimazole results in increased expression of GABRE mRNA	22504374
C034818	methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate	"GABRE protein results in decreased susceptibility to methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate"	11691872
D008874	Midazolam	GABRE protein results in decreased susceptibility to Midazolam	11691872
C028007	nickel monoxide	nickel monoxide results in increased expression of GABRE mRNA	19167457
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of GABRE mRNA	18593933
D010424	Pentobarbital	Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]	10049148
D010424	Pentobarbital	Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]	10049148
D010424	Pentobarbital	GABRE protein results in decreased susceptibility to Pentobarbital	9039914
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GABRE mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of GABRE mRNA	17950772
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of GABRE mRNA]	17950772
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of GABRE mRNA	21334430
D059808	Polyphenols	Polyphenols results in decreased expression of GABRE mRNA	16293270
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GABRE mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of GABRE mRNA	22079256\|2271453
D011280	Pregnanolone	GABRE protein results in decreased susceptibility to Pregnanolone	9039914
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of GABRE mRNA	20660070
D015742	Propofol	Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]	10049148
D015742	Propofol	GABRE protein results in decreased susceptibility to Propofol	9039914
D011441	Propylthiouracil	Propylthiouracil results in increased expression of GABRE mRNA	22504374
D011794	Quercetin	Quercetin results in increased expression of GABRE mRNA	21632981
D012834	Silver	Silver results in increased expression of GABRE mRNA	26014281
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GABRE mRNA	12377990
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of GABRE gene	25560391
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of GABRE mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004890	GABA-A receptor activity	CONTRIBUTES_TO	IBA	21873635
GO:0004890	GABA-A receptor activity	-	IEA	-
GO:0005230	extracellular ligand-gated ion channel activity	CONTRIBUTES_TO	IBA	21873635
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	-	IBA	21873635
GO:0005254	chloride channel activity	-	IBA	21873635
GO:0008503	benzodiazepine receptor activity	CONTRIBUTES_TO	IBA	21873635
GO:0022851	GABA-gated chloride ion channel activity	-	IBA	21873635
GO:0022851	GABA-gated chloride ion channel activity	-	IDA	9039914
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	IBA	21873635
GO:0007165	signal transduction	-	IEA	-
GO:0007214	gamma-aminobutyric acid signaling pathway	-	IBA	21873635
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0034220	ion transmembrane transport	-	IBA	21873635
GO:0042391	regulation of membrane potential	-	IBA	21873635
GO:0050877	nervous system process	-	IBA	21873635
GO:0051932	synaptic transmission, GABAergic	-	IBA	21873635
GO:0060078	regulation of postsynaptic membrane potential	-	IBA	21873635
GO:1902476	chloride transmembrane transport	-	IBA	21873635
GO:1902476	chloride transmembrane transport	-	IEA	-
GO:2001226	negative regulation of chloride transport	-	IDA	9039914

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0030054	cell junction	-	IEA	-
GO:0032590	dendrite membrane	-	IBA	21873635
GO:0034707	chloride channel complex	-	IEA	-
GO:0043005	neuron projection	-	IBA	21873635
GO:0045202	synapse	-	IBA	21873635
GO:0045211	postsynaptic membrane	-	IEA	-
GO:0098794	postsynapse	-	IBA	21873635
GO:1902711	GABA-A receptor complex	-	IBA	21873635
GO:1902711	GABA-A receptor complex	-	IDA	9039914

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18482426	Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study. (2008 Jun)	Agrawal A	Addiction