Gene: ST6GALNAC3

256435
PRO7177|SIAT7C|ST6GALNACIII|STY
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
protein-coding
1p31.1
Ensembl:ENSG00000184005 MIM:610133 Vega:OTTHUMG00000009615 UniprotKB:Q8NDV1
NC_000001.11
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.489e-1 (AD)  6.818e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12562911chr1:76356915 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24580071chr1:76620271ST6GALNAC3Gene body6.288e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELOVL70.833
PERP0.809
ITGA10.798
CXorf360.795
IL13RA10.793
IQGAP10.79
ELF10.788
GALNT150.786
BNIP20.782
LBR0.781

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GSG1-0.463
SPATA2L-0.463
CRH-0.457
MARCH4-0.445
KCNG1-0.436
GGN-0.436
RTN4R-0.431
ADRA1D-0.429
KCNIP3-0.424
DLK2-0.421

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of ST6GALNAC3 mRNA28522335
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ST6GALNAC3 mRNA"23196670
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of ST6GALNAC3 mRNA16788091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ST6GALNAC3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST6GALNAC3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST6GALNAC3 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ST6GALNAC3 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of ST6GALNAC3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ST6GALNAC3 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ST6GALNAC3 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ST6GALNAC3 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ST6GALNAC3 mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of ST6GALNAC3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ST6GALNAC3 gene28505145
D002220CarbamazepineCarbamazepine affects the expression of ST6GALNAC3 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ST6GALNAC3 mRNA15963342
D002737ChloropreneChloroprene results in decreased expression of ST6GALNAC3 mRNA23125180
D003471CuprizoneCuprizone results in decreased expression of ST6GALNAC3 mRNA27523638
D003561CytarabineCytarabine results in decreased expression of ST6GALNAC3 mRNA21198554
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ST6GALNAC3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ST6GALNAC3 mRNA27392435
D004237DiuronDiuron results in decreased expression of ST6GALNAC3 mRNA21551480
D004317DoxorubicinDoxorubicin affects the methylation of ST6GALNAC3 gene28962528
D005419FlavonoidsFlavonoids results in increased expression of ST6GALNAC3 mRNA18035473
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ST6GALNAC3 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ST6GALNAC3 mRNA26011545
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ST6GALNAC3 mRNA25729387
C046012pentanalpentanal results in increased expression of ST6GALNAC3 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ST6GALNAC3 mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ST6GALNAC3 mRNA19710929
D011441PropylthiouracilPropylthiouracil affects the expression of ST6GALNAC3 mRNA24780913
D011441PropylthiouracilPropylthiouracil results in increased expression of ST6GALNAC3 mRNA18077114
C502851quinocetonequinocetone results in increased expression of ST6GALNAC3 mRNA27046791
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ST6GALNAC3 mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ST6GALNAC3 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST6GALNAC3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ST6GALNAC3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ST6GALNAC3 mRNA23179753|2627250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001665alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity-IBA21873635  
GO:0001665alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity-TAS-  
GO:0008373sialyltransferase activity-IBA21873635  
GO:0008373sialyltransferase activity-IDA17123352  
GO:0047290(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001574ganglioside biosynthetic process-IBA21873635  
GO:0006677glycosylceramide metabolic process-IDA17123352  
GO:0006687glycosphingolipid metabolic process-IDA17123352  
GO:0009100glycoprotein metabolic process-IDA17123352  
GO:0009311oligosaccharide metabolic process-IBA21873635  
GO:0018279protein N-linked glycosylation via asparagine-IBA21873635  
GO:0097503sialylation-IBA21873635  
GO:0097503sialylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005654nucleoplasm-IDA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00604Glycosphingolipid biosynthesis - ganglio series
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4085001Sialic acid metabolismTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-913709O-linked glycosylation of mucinsTAS
R-HSA-977068Termination of O-glycan biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20421487Genome-wide association identifies candidate genes that influence the human electroencephalogram. (2010 May 11)Hodgkinson CAProc Natl Acad Sci U S A