Gene: GABRG1

2565
-
gamma-aminobutyric acid type A receptor gamma1 subunit
protein-coding
4p12
Ensembl:ENSG00000163285 MIM:137166 Vega:OTTHUMG00000128609 UniprotKB:Q8N1C3
NG_046964.1
PubMed
0   ANCO-SNPs
ND|AD
15   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.364e-1 (AD)  1.734e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPON10.912
NTRK20.912
SLC1A20.899
GJA10.893
TMEM470.887
GPAM0.882
SLC39A120.882
METTL7A0.881
ETNPPL0.874
SLC4A40.872

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FER1L6-0.459
CD163L1-0.45
GADL1-0.434
CD244-0.409
L1TD1-0.408
SCARA5-0.395
SLC47A1-0.392
FCER2-0.387
KLHDC7B-0.386
GALR1-0.384

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00546AdinazolamSmall Molecule37115-32-5ApprovedTarget
DB00683MidazolamSmall Molecule59467-70-8Approved|IllicitTarget
DB00690FlurazepamSmall Molecule17617-23-1Approved|Illicit|InvestigationalTarget
DB00801HalazepamSmall Molecule23092-17-3Approved|Illicit|WithdrawnTarget
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalTarget
DB00842OxazepamSmall Molecule604-75-1ApprovedTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01215EstazolamSmall Molecule29975-16-4Approved|IllicitTarget
DB01558BromazepamSmall Molecule1812-30-2Approved|Illicit|InvestigationalTarget
DB01559ClotiazepamSmall Molecule33671-46-4Approved|IllicitTarget
DB01567FludiazepamSmall Molecule3900-31-0Approved|IllicitTarget
DB01587KetazolamSmall Molecule27223-35-4ApprovedTarget
DB01588PrazepamSmall Molecule2955-38-6Approved|IllicitTarget
DB01589QuazepamSmall Molecule36735-22-5Approved|IllicitTarget
DB01594CinolazepamSmall Molecule75696-02-5ApprovedTarget
DB01595NitrazepamSmall Molecule146-22-5ApprovedTarget
DB00186LorazepamSmall Molecule846-49-1ApprovedTarget
DB00189EthchlorvynolSmall Molecule113-18-8Approved|Illicit|WithdrawnTarget
DB00228EnfluraneSmall Molecule13838-16-9Approved|InvestigationalTarget
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00237ButabarbitalSmall Molecule125-40-6Approved|IllicitTarget
DB00241ButalbitalSmall Molecule77-26-9Approved|IllicitTarget
DB00273TopiramateSmall Molecule97240-79-4ApprovedTarget
DB00292EtomidateSmall Molecule33125-97-2ApprovedTarget
DB00306TalbutalSmall Molecule115-44-6Approved|IllicitTarget
DB00312PentobarbitalSmall Molecule76-74-4Approved|InvestigationalTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00349ClobazamSmall Molecule22316-47-8Approved|IllicitTarget
DB00371MeprobamateSmall Molecule57-53-4Approved|IllicitTarget
DB00402EszopicloneSmall Molecule138729-47-2Approved|InvestigationalTarget
DB00404AlprazolamSmall Molecule28981-97-7Approved|Illicit|InvestigationalTarget
DB00463MetharbitalSmall Molecule50-11-3WithdrawnTarget
DB00475ChlordiazepoxideSmall Molecule58-25-3Approved|Illicit|InvestigationalTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00628ClorazepateSmall Molecule23887-31-2Approved|IllicitTarget
DB00659AcamprosateSmall Molecule77337-76-9Approved|InvestigationalTarget
DB00753IsofluraneSmall Molecule26675-46-7ApprovedTarget
DB00794PrimidoneSmall Molecule125-33-7ApprovedTarget
DB00801HalazepamSmall Molecule23092-17-3Approved|Illicit|WithdrawnTarget
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalTarget
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalTarget
DB00842OxazepamSmall Molecule604-75-1ApprovedTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB01028MethoxyfluraneSmall Molecule76-38-0Approved|InvestigationalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB01068ClonazepamSmall Molecule1622-61-3Approved|IllicitTarget
DB01107MethyprylonSmall Molecule125-64-4Approved|Illicit|WithdrawnTarget
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
DB01189DesfluraneSmall Molecule57041-67-5ApprovedTarget
DB01205FlumazenilSmall Molecule78755-81-4ApprovedTarget
DB01215EstazolamSmall Molecule29975-16-4Approved|IllicitTarget
DB01236SevofluraneSmall Molecule28523-86-6ApprovedTarget
DB01437GlutethimideSmall Molecule77-21-4Approved|IllicitTarget
DB01588PrazepamSmall Molecule2955-38-6Approved|IllicitTarget
DB01589QuazepamSmall Molecule36735-22-5Approved|IllicitTarget
DB01708PrasteroneSmall Molecule53-43-0Approved|Investigational|NutraceuticalTarget
DB01956TaurineSmall Molecule107-35-7Approved|NutraceuticalTarget
DB09118StiripentolSmall Molecule49763-96-4ApprovedTarget
DB11582ThiocolchicosideSmall Molecule602-41-5Approved|InvestigationalTarget
DB11901ApalutamideSmall Molecule956104-40-8Approved|InvestigationalTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB06579AdipiplonSmall Molecule840486-93-3InvestigationalTarget
DB139835,7,2G??-trihydroxy-6,8-dimethoxyflavoneSmall Molecule159359-22-5ExperimentalTarget
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GABRG1 gene27153756
D019386AlendronateAlendronate affects the expression of GABRG1 mRNA16079270
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of GABRG1 mRNA28522335
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG1 protein]29038840
D005680gamma-Aminobutyric AcidFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D005680gamma-Aminobutyric AcidFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D005680gamma-Aminobutyric Acidtiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D005680gamma-Aminobutyric Acidtiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D005680gamma-Aminobutyric Acidtiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GABRG1 mRNA16483693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GABRG1 mRNA18164116
D001640BicucullineBicuculline results in decreased expression of GABRG1 mRNA9600394
C006780bisphenol Abisphenol A results in decreased expression of GABRG1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of GABRG1 mRNA29097150
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of GABRG1 mRNA22079614
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GABRG1 mRNA12734012
D003471CuprizoneCuprizone results in decreased expression of GABRG1 mRNA27523638
D004026DieldrinDieldrin results in decreased expression of GABRG1 mRNA9600394
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GABRG1 mRNA18164116
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GABRG1 mRNA16079270
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GABRG1 mRNA29097150
D015738FamotidineFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D015738FamotidineFamotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D005419FlavonoidsFlavonoids results in increased expression of GABRG1 mRNA18035473
C006253pirinixic acidpirinixic acid results in increased expression of GABRG1 mRNA23811191
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of GABRG1 mRNA16079270
C023990tiotidinetiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
C023990tiotidinetiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
C023990tiotidinetiotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]15363660
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of GABRG1 gene27618143
D014635Valproic AcidValproic Acid results in decreased methylation of GABRG1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GABRG1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004890GABA-A receptor activityCONTRIBUTES_TOIBA21873635  
GO:0004890GABA-A receptor activity-IEA-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005230extracellular ligand-gated ion channel activity-IEA-  
GO:0005237inhibitory extracellular ligand-gated ion channel activity-IBA21873635  
GO:0005254chloride channel activity-IBA21873635  
GO:0005254chloride channel activity-IEA-  
GO:0008503benzodiazepine receptor activityCONTRIBUTES_TOIBA21873635  
GO:0022851GABA-gated chloride ion channel activity-IBA21873635  
GO:0050811GABA receptor binding-IEA-  
GO:1904315transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007214gamma-aminobutyric acid signaling pathway-IBA21873635  
GO:0007214gamma-aminobutyric acid signaling pathway-IEA-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007268chemical synaptic transmission-IEA-  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO:0051932synaptic transmission, GABAergic-IBA21873635  
GO:0060078regulation of postsynaptic membrane potential-IBA21873635  
GO:1902476chloride transmembrane transport-IBA21873635  
GO:1902476chloride transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0030054cell junction-IEA-  
GO:0032590dendrite membrane-IBA21873635  
GO:0034707chloride channel complex-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043235receptor complex-IEA-  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:0098794postsynapse-IBA21873635  
GO:1902711GABA-A receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22384067Transcriptome-wide survey of mouse CNS-derived cells reveals monoallelic expression within novel gene families. (2012)Li SMPLoS One
15024690Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. (2004 Apr)Edenberg HJAm J Hum Genet
22662011GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects. (2012 May 9)Grzywacz AArch Med Sci
21919924GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans. (2012 Apr)Ittiwut CAlcohol Clin Exp Res
1321425Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome. (1992 Jul 1)Wilcox ASProc Natl Acad Sci U S A
17507911Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene. (2008 Mar)Covault JNeuropsychopharmacology
18818659GABRG1 and GABRA2 as independent predictors for alcoholism in two populations. (2009 Apr)Enoch MANeuropsychopharmacology
22072270Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. (2012 Apr)Wang KSJ Neural Transm (Vienna)
26250693GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures. (2015 Sep)Lieberman RAlcohol Clin Exp Res
24166645A GABRA2 variant is associated with increased stimulation and 'high' following alcohol administration. (2014 Jan-Feb)Arias AJAlcohol Alcohol
25655461Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)Manzardo AMGene
26087834Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking. (2015 Jul)Kosobud AEAlcohol Clin Exp Res
17976953Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4. (2008 Jan)Ittiwut CGenomics
27355804SNPs in NRXN1 and CHRNA5 are associated to smoking and regulation of GABAergic and glutamatergic pathways. (2016 Jul)Perez-Rubio GPharmacogenomics
19426171Associations among GABRG1, level of response to alcohol, and drinking behaviors. (2009 Aug)Ray LAAlcohol Clin Exp Res