Gene info: ID 2567

Gene: GABRG3

GENE ID: 2567

Synonyms: -

Description: gamma-aminobutyric acid type A receptor gamma3 subunit

Gene type: protein-coding

Location: 15q12

dbXrefs: Ensembl:ENSG00000182256 MIM:600233 Vega:OTTHUMG00000044462 UniprotKB:Q99928

RefSeq: NG_032887.1

Retrived from: PubMed|SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: CD|AD

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.613e-1 (AD) 6.208e-2 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs28668284	chr15:27364047 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs10083616	chr15:27364025 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs9707971	chr15:27363004 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ARHGAP20	0.914
PCDHAC2	0.896
XKR4	0.894
IL12RB2	0.892
SCN8A	0.885
TRPC5	0.884
NBEA	0.883
FAM78B	0.882
PPM1E	0.881
KCNH1	0.881

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RAB13	-0.634
COPZ2	-0.629
ROM1	-0.626
STON2	-0.622
AGTRAP	-0.618
IMPA2	-0.613
CHST14	-0.61
RNF135	-0.603
HVCN1	-0.598
FCGRT	-0.597

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00231	Temazepam	Small Molecule	846-50-4	Approved\|Investigational	Target
DB00546	Adinazolam	Small Molecule	37115-32-5	Approved	Target
DB00683	Midazolam	Small Molecule	59467-70-8	Approved\|Illicit	Target
DB00690	Flurazepam	Small Molecule	17617-23-1	Approved\|Illicit\|Investigational	Target
DB00801	Halazepam	Small Molecule	23092-17-3	Approved\|Illicit\|Withdrawn	Target
DB00829	Diazepam	Small Molecule	439-14-5	Approved\|Illicit\|Investigational	Target
DB00842	Oxazepam	Small Molecule	604-75-1	Approved	Target
DB00897	Triazolam	Small Molecule	28911-01-5	Approved\|Investigational	Target
DB00898	Ethanol	Small Molecule	64-17-5	Approved	Target
DB01215	Estazolam	Small Molecule	29975-16-4	Approved\|Illicit	Target
DB01558	Bromazepam	Small Molecule	1812-30-2	Approved\|Illicit\|Investigational	Target
DB01559	Clotiazepam	Small Molecule	33671-46-4	Approved\|Illicit	Target
DB01567	Fludiazepam	Small Molecule	3900-31-0	Approved\|Illicit	Target
DB01588	Prazepam	Small Molecule	2955-38-6	Approved\|Illicit	Target
DB01589	Quazepam	Small Molecule	36735-22-5	Approved\|Illicit	Target
DB01594	Cinolazepam	Small Molecule	75696-02-5	Approved	Target
DB01595	Nitrazepam	Small Molecule	146-22-5	Approved	Target
DB00186	Lorazepam	Small Molecule	846-49-1	Approved	Target
DB00189	Ethchlorvynol	Small Molecule	113-18-8	Approved\|Illicit\|Withdrawn	Target
DB00228	Enflurane	Small Molecule	13838-16-9	Approved\|Investigational	Target
DB00231	Temazepam	Small Molecule	846-50-4	Approved\|Investigational	Target
DB00237	Butabarbital	Small Molecule	125-40-6	Approved\|Illicit	Target
DB00241	Butalbital	Small Molecule	77-26-9	Approved\|Illicit	Target
DB00273	Topiramate	Small Molecule	97240-79-4	Approved	Target
DB00292	Etomidate	Small Molecule	33125-97-2	Approved	Target
DB00306	Talbutal	Small Molecule	115-44-6	Approved\|Illicit	Target
DB00312	Pentobarbital	Small Molecule	76-74-4	Approved\|Investigational	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00349	Clobazam	Small Molecule	22316-47-8	Approved\|Illicit	Target
DB00371	Meprobamate	Small Molecule	57-53-4	Approved\|Illicit	Target
DB00402	Eszopiclone	Small Molecule	138729-47-2	Approved\|Investigational	Target
DB00404	Alprazolam	Small Molecule	28981-97-7	Approved\|Illicit\|Investigational	Target
DB00463	Metharbital	Small Molecule	50-11-3	Withdrawn	Target
DB00475	Chlordiazepoxide	Small Molecule	58-25-3	Approved\|Illicit\|Investigational	Target
DB00543	Amoxapine	Small Molecule	14028-44-5	Approved	Target
DB00555	Lamotrigine	Small Molecule	84057-84-1	Approved\|Investigational	Target
DB00628	Clorazepate	Small Molecule	23887-31-2	Approved\|Illicit	Target
DB00659	Acamprosate	Small Molecule	77337-76-9	Approved\|Investigational	Target
DB00753	Isoflurane	Small Molecule	26675-46-7	Approved	Target
DB00794	Primidone	Small Molecule	125-33-7	Approved	Target
DB00801	Halazepam	Small Molecule	23092-17-3	Approved\|Illicit\|Withdrawn	Target
DB00818	Propofol	Small Molecule	2078-54-8	Approved\|Investigational	Target
DB00829	Diazepam	Small Molecule	439-14-5	Approved\|Illicit\|Investigational	Target
DB00842	Oxazepam	Small Molecule	604-75-1	Approved	Target
DB00897	Triazolam	Small Molecule	28911-01-5	Approved\|Investigational	Target
DB01028	Methoxyflurane	Small Molecule	76-38-0	Approved\|Investigational	Target
DB01049	Ergoloid mesylate	Small Molecule	8067-24-1	Approved	Target
DB01068	Clonazepam	Small Molecule	1622-61-3	Approved\|Illicit	Target
DB01107	Methyprylon	Small Molecule	125-64-4	Approved\|Illicit\|Withdrawn	Target
DB01159	Halothane	Small Molecule	151-67-7	Approved	Target
DB01189	Desflurane	Small Molecule	57041-67-5	Approved	Target
DB01205	Flumazenil	Small Molecule	78755-81-4	Approved	Target
DB01215	Estazolam	Small Molecule	29975-16-4	Approved\|Illicit	Target
DB01236	Sevoflurane	Small Molecule	28523-86-6	Approved	Target
DB01437	Glutethimide	Small Molecule	77-21-4	Approved\|Illicit	Target
DB01588	Prazepam	Small Molecule	2955-38-6	Approved\|Illicit	Target
DB01589	Quazepam	Small Molecule	36735-22-5	Approved\|Illicit	Target
DB01708	Prasterone	Small Molecule	53-43-0	Approved\|Investigational\|Nutraceutical	Target
DB01956	Taurine	Small Molecule	107-35-7	Approved\|Nutraceutical	Target
DB09118	Stiripentol	Small Molecule	49763-96-4	Approved	Target
DB11582	Thiocolchicoside	Small Molecule	602-41-5	Approved\|Investigational	Target
DB11901	Apalutamide	Small Molecule	956104-40-8	Approved\|Investigational	Target
DB00555	Lamotrigine	Small Molecule	84057-84-1	Approved\|Investigational	Target
DB06579	Adipiplon	Small Molecule	840486-93-3	Investigational	Target
DB13983	5,7,2G??-trihydroxy-6,8-dimethoxyflavone	Small Molecule	159359-22-5	Experimental	Target

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GABRG3 mRNA"	19114083
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GABRG3 mRNA	16483693
D001280	Atrazine	Atrazine results in decreased expression of GABRG3 mRNA	25929836
C006780	bisphenol A	bisphenol A affects the expression of GABRG3 mRNA	26950200
C006780	bisphenol A	bisphenol A results in decreased expression of GABRG3 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of GABRG3 mRNA	25270620
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GABRG3 gene	20938992
D003300	Copper	Copper deficiency results in increased expression of GABRG3 mRNA	26033743
C121718	dicyclanil	dicyclanil results in increased expression of GABRG3 mRNA	15664270
D004041	Dietary Fats	Dietary Fats results in increased expression of GABRG3 mRNA	25016146
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of GABRG3 mRNA	26033743
C118739	entinostat	entinostat results in increased expression of GABRG3 mRNA	27188386
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GABRG3 gene	20938992
D007854	Lead	Lead affects the expression of GABRG3 mRNA	28903495
D008694	Methamphetamine	Methamphetamine results in increased expression of GABRG3 mRNA	15644446
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GABRG3 gene	20938992
D011374	Progesterone	Progesterone results in increased expression of GABRG3 mRNA	16000229
C045950	propiconazole	propiconazole results in increased expression of GABRG3 mRNA	16643972
C089730	rosiglitazone	rosiglitazone results in increased expression of GABRG3 mRNA	21515302
D012524	Sarin	Sarin results in increased expression of GABRG3 mRNA	19522546
D012834	Silver	Silver results in increased expression of GABRG3 mRNA	27131904
C446685	systhane	systhane results in increased expression of GABRG3 mRNA	16643972
C501413	tesaglitazar	tesaglitazar results in increased expression of GABRG3 mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GABRG3 mRNA	21570461
D014050	Toluene	Toluene affects the expression of GABRG3 mRNA	17108153
C032910	triadimefon	triadimefon results in increased expression of GABRG3 mRNA	16643972
C057693	troglitazone	troglitazone results in increased expression of GABRG3 mRNA	21515302
D014635	Valproic Acid	Valproic Acid results in decreased methylation of GABRG3 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of GABRG3 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004890	GABA-A receptor activity	CONTRIBUTES_TO	IBA	21873635
GO:0004890	GABA-A receptor activity	-	IEA	-
GO:0005230	extracellular ligand-gated ion channel activity	CONTRIBUTES_TO	IBA	21873635
GO:0005230	extracellular ligand-gated ion channel activity	-	IEA	-
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	-	IBA	21873635
GO:0005254	chloride channel activity	-	IBA	21873635
GO:0005254	chloride channel activity	-	IEA	-
GO:0008503	benzodiazepine receptor activity	CONTRIBUTES_TO	IBA	21873635
GO:0022851	GABA-gated chloride ion channel activity	-	IBA	21873635
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	IBA	21873635
GO:0007214	gamma-aminobutyric acid signaling pathway	-	IBA	21873635
GO:0007214	gamma-aminobutyric acid signaling pathway	-	IEA	-
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0034220	ion transmembrane transport	-	IBA	21873635
GO:0042391	regulation of membrane potential	-	IBA	21873635
GO:0042493	response to drug	-	IEA	-
GO:0050877	nervous system process	-	IBA	21873635
GO:0051932	synaptic transmission, GABAergic	-	IBA	21873635
GO:0060078	regulation of postsynaptic membrane potential	-	IBA	21873635
GO:1902476	chloride transmembrane transport	-	IBA	21873635
GO:1902476	chloride transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0030054	cell junction	-	IEA	-
GO:0032590	dendrite membrane	-	IBA	21873635
GO:0034707	chloride channel complex	-	IEA	-
GO:0043005	neuron projection	-	IBA	21873635
GO:0045202	synapse	-	IBA	21873635
GO:0045211	postsynaptic membrane	-	IEA	-
GO:0098794	postsynapse	-	IBA	21873635
GO:1902711	GABA-A receptor complex	-	IBA	21873635

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	IEA
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112315	Transmission across Chemical Synapses	IEA
R-HSA-112316	Neuronal System	TAS
R-HSA-112316	Neuronal System	IEA
R-HSA-977441	GABA A receptor activation	TAS
R-HSA-977443	GABA receptor activation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22072270	Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. (2012 Apr)	Wang KS	J Neural Transm (Vienna)
14745296	Association of GABRG3 with alcohol dependence. (2004 Jan)	Dick DM	Alcohol Clin Exp Res
25921801	Eye color: A potential indicator of alcohol dependence risk in European Americans. (2015 Jul)	Sulovari A	Am J Med Genet B Neuropsychiatr Genet
16961766	The genetics of alcoholism: identifying specific genes through family studies. (2006 Sep)	Edenberg HJ	Addict Biol
19382902	Altering the relative abundance of GABA A receptor subunits changes GABA- and ethanol-responses in Xenopus oocytes. (2009 Jun)	Hurley JH	Alcohol Clin Exp Res