Gene: GABRR1

2569
-
gamma-aminobutyric acid type A receptor rho1 subunit
protein-coding
6q15
Ensembl:ENSG00000146276 MIM:137161 Vega:OTTHUMG00000015195 UniprotKB:P24046
NC_000006.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.881e-1 (AD)  7.153e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRTAP19-50.468
RFPL4A0.445
HIC10.445
ADAMTS70.44
LINC004790.439
OR4D110.439
EPGN0.439
MRGPRX20.435
OR8I20.434
LCE4A0.431

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C10orf82-0.343
AARD-0.336
SPHKAP-0.335
NMU-0.333
FSTL5-0.33
GRIN3A-0.329
MYO5B-0.323
HMGCLL1-0.321
KIAA1024-0.311
CCDC113-0.31

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00431LindaneSmall Molecule58-89-9Approved|WithdrawnTarget
DB00466PicrotoxinSmall Molecule124-87-8ExperimentalTarget
DB00546AdinazolamSmall Molecule37115-32-5ApprovedTarget
DB00683MidazolamSmall Molecule59467-70-8Approved|IllicitTarget
DB00690FlurazepamSmall Molecule17617-23-1Approved|Illicit|InvestigationalTarget
DB00801HalazepamSmall Molecule23092-17-3Approved|Illicit|WithdrawnTarget
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalTarget
DB00842OxazepamSmall Molecule604-75-1ApprovedTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB01215EstazolamSmall Molecule29975-16-4Approved|IllicitTarget
DB01558BromazepamSmall Molecule1812-30-2Approved|Illicit|InvestigationalTarget
DB01559ClotiazepamSmall Molecule33671-46-4Approved|IllicitTarget
DB01567FludiazepamSmall Molecule3900-31-0Approved|IllicitTarget
DB01588PrazepamSmall Molecule2955-38-6Approved|IllicitTarget
DB01589QuazepamSmall Molecule36735-22-5Approved|IllicitTarget
DB01594CinolazepamSmall Molecule75696-02-5ApprovedTarget
DB01595NitrazepamSmall Molecule146-22-5ApprovedTarget
ID Drug Name Action PubMed
C04159712-ketoendrin12-ketoendrin binds to GABRR1 protein11879973
C0915181-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane"1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRR1 protein"11879973
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GABRR1 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GABRR1 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of GABRR1 mRNA17562736
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of GABRR1 protein12106692
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRR1 protein binds to GABRG2 protein]12106692
D005680gamma-Aminobutyric AcidPentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRR1 protein binds to GABRG2 protein]]12106692
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GABRR1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of GABRR1 mRNA26705709
D001280AtrazineAtrazine results in decreased expression of GABRR1 mRNA25929836
C006780bisphenol Abisphenol A results in increased expression of GABRR1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of GABRR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GABRR1 gene28505145
D001761BleomycinBleomycin results in decreased expression of GABRR1 mRNA15808516
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of GABRR1 promoter22457795
C010059carbamylhydrazinecarbamylhydrazine analog results in decreased expression of GABRR1 mRNA28834696
C121718dicyclanildicyclanil results in increased expression of GABRR1 mRNA15664270
D004026DieldrinDieldrin binds to GABRR1 protein11879973
D004041Dietary FatsDietary Fats results in decreased expression of GABRR1 mRNA18042831
D004726EndosulfanEndosulfan binds to GABRR1 protein11879973
C008261lead acetatelead acetate results in decreased expression of GABRR1 mRNA22641619
D001556LindaneLindane binds to GABRR1 protein11879973
D000073878Palm OilPalm Oil results in decreased expression of GABRR1 mRNA18042831
D010424PentobarbitalPentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRR1 protein binds to GABRG2 protein]]12106692
D010852PicrotoxinPicrotoxin results in decreased activity of [GABRR1 protein binds to GABRG2 protein]12106692
D020849Raloxifene HydrochlorideESR2 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of GABRR1 mRNA]14699072
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of GABRR1 mRNA14699072
D012524SarinSarin results in decreased expression of GABRR1 mRNA19522546
D012834SilverSilver results in decreased expression of GABRR1 mRNA27131904
D012834SilverSilver results in increased expression of GABRR1 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GABRR1 mRNA21570461
D013849ThimerosalThimerosal results in increased expression of GABRR1 mRNA27188386
D014212TretinoinTretinoin results in increased expression of GABRR1 mRNA21934132
C032910triadimefontriadimefon results in increased expression of GABRR1 mRNA26705709
C012589trichostatin Atrichostatin A results in decreased expression of GABRR1 mRNA26705709
D014635Valproic AcidValproic Acid results in decreased expression of GABRR1 mRNA24896083
D015032ZincZinc results in decreased activity of [GABRR1 protein binds to GABRG2 protein]12106692

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004890GABA-A receptor activityCONTRIBUTES_TOIBA21873635  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005230extracellular ligand-gated ion channel activity-IEA-  
GO:0005254chloride channel activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007214gamma-aminobutyric acid signaling pathway-TAS10779366  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007268chemical synaptic transmission-TAS1849271  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO:1902476chloride transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS10779366  
GO:0030054cell junction-IEA-  
GO:0034707chloride channel complex-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:1902711GABA-A receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-977442GABA A (rho) receptor activationTAS
R-HSA-977443GABA receptor activationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19536785GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. (2010 Mar 5)Xuei XAm J Med Genet B Neuropsychiatr Genet