Gene: NPB

256933
L7|PPL7|PPNPB
neuropeptide B
protein-coding
17q25.3
Ensembl:ENSG00000183979 MIM:607996 Vega:OTTHUMG00000177983 UniprotKB:Q8NG41
NC_000017.11
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.157e-1 (AD)  7.769e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of NPB mRNA"22698814
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NPB mRNA"25614096
D000082AcetaminophenAcetaminophen results in decreased expression of NPB mRNA22230336
D020106AcrylamideAcrylamide affects the expression of NPB mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NPB mRNA16483693
D001280AtrazineAtrazine results in decreased expression of NPB mRNA27655631
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NPB mRNA19770486|2196490
C006780bisphenol Abisphenol A affects the expression of NPB mRNA25181051
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of NPB mRNA24763279
D003471CuprizoneCuprizone results in decreased expression of NPB mRNA26577399
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NPB mRNA27392435
D002945CisplatinCisplatin results in decreased expression of NPB mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NPB mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of NPB mRNA25016146
C024629dimethyl phthalatedimethyl phthalate affects the expression of NPB mRNA26924002
D005419FlavonoidsFlavonoids results in decreased expression of NPB mRNA18035473
C039281furanfuran results in increased expression of NPB mRNA27387713
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of NPB mRNA24763279
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NPB mRNA27392435
C544151jinfukangjinfukang results in increased expression of NPB mRNA27392435
D007854LeadLead affects the expression of NPB mRNA28903495
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NPB mRNA"25620056
C006253pirinixic acidpirinixic acid results in increased expression of NPB mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of NPB mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of NPB mRNA24780913
D012969Sodium FluorideSodium Fluoride results in increased expression of NPB mRNA27862939
D014635Valproic AcidValproic Acid results in decreased expression of NPB mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of NPB gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IEA-  
GO:0005515protein binding-IPI12118011  12401809  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IDA12118011  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007218neuropeptide signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22463586Pioglitazone prevents smoking carcinogen-induced lung tumor development in mice. (2012 Jul)Li MYCurr Cancer Drug Targets
25719459The number of divergent purging behaviors is associated with histories of trauma, PTSD, and comorbidity in a national sample of women. (2015)Brewerton TDEat Disord
28137364Nucleoplasmic bridges as a biomarker of DNA damage exposed to radon. (2017 Feb)Meenakshi CMutat Res