Gene info: ID 2570

Gene: GABRR2

GENE ID: 2570

Synonyms: -

Description: gamma-aminobutyric acid type A receptor rho2 subunit

Gene type: protein-coding

Location: 6q15

dbXrefs: Ensembl:ENSG00000111886 MIM:137162 Vega:OTTHUMG00000015198 UniprotKB:P28476

RefSeq: NG_033977.2

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.784e-1 (AD) 8.111e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4707535	chr6:89268187 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NFATC3	0.635
BACE2	0.627
NFKB1	0.619
CD180	0.618
TICAM2	0.611
POU4F1	0.606
STAB1	0.596
ZC3HAV1	0.586
CHRNB4	0.586
KDM5A	0.583

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SPDEF	-0.347
ZSCAN1	-0.341
C12orf54	-0.329
PRSS27	-0.313
MYCNOS	-0.312
SAPCD2	-0.308
DHRS12	-0.299
CRH	-0.295
CHST8	-0.294
LYRM9	-0.288

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00231	Temazepam	Small Molecule	846-50-4	Approved\|Investigational	Target
DB00546	Adinazolam	Small Molecule	37115-32-5	Approved	Target
DB00683	Midazolam	Small Molecule	59467-70-8	Approved\|Illicit	Target
DB00690	Flurazepam	Small Molecule	17617-23-1	Approved\|Illicit\|Investigational	Target
DB00801	Halazepam	Small Molecule	23092-17-3	Approved\|Illicit\|Withdrawn	Target
DB00829	Diazepam	Small Molecule	439-14-5	Approved\|Illicit\|Investigational	Target
DB00842	Oxazepam	Small Molecule	604-75-1	Approved	Target
DB00897	Triazolam	Small Molecule	28911-01-5	Approved\|Investigational	Target
DB01215	Estazolam	Small Molecule	29975-16-4	Approved\|Illicit	Target
DB01558	Bromazepam	Small Molecule	1812-30-2	Approved\|Illicit\|Investigational	Target
DB01559	Clotiazepam	Small Molecule	33671-46-4	Approved\|Illicit	Target
DB01567	Fludiazepam	Small Molecule	3900-31-0	Approved\|Illicit	Target
DB01588	Prazepam	Small Molecule	2955-38-6	Approved\|Illicit	Target
DB01589	Quazepam	Small Molecule	36735-22-5	Approved\|Illicit	Target
DB01594	Cinolazepam	Small Molecule	75696-02-5	Approved	Target
DB01595	Nitrazepam	Small Molecule	146-22-5	Approved	Target

ID	Drug Name	Action	PubMed
D000082	Acetaminophen	Acetaminophen affects the expression of GABRR2 mRNA	17562736
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GABRR2 mRNA	16483693
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of GABRR2 mRNA	15912405
C006780	bisphenol A	bisphenol A results in increased methylation of GABRR2 gene	28505145
C010059	carbamylhydrazine	carbamylhydrazine analog results in decreased expression of GABRR2 mRNA	28834696
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of GABRR2 mRNA	19784758
D003907	Dexamethasone	Dexamethasone results in increased expression of GABRR2 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of GABRR2 mRNA]	20032058
C121718	dicyclanil	dicyclanil results in increased expression of GABRR2 mRNA	15664270
D006861	Hydrogen Peroxide	[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GABRR2 protein	18951874
D007854	Lead	Lead results in decreased expression of GABRR2 mRNA	19921347
D008743	Methyl Parathion	Methyl Parathion results in increased expression of GABRR2 mRNA	19784758
D010278	Parathion	Parathion results in increased expression of GABRR2 mRNA	19784758
C006253	pirinixic acid	pirinixic acid results in decreased expression of GABRR2 mRNA	17950772
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of GABRR2 mRNA	23608068
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of GABRR2 mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GABRR2 mRNA	26377647
D013806	Theophylline	[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GABRR2 protein	18951874
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of GABRR2 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004890	GABA-A receptor activity	CONTRIBUTES_TO	IBA	21873635
GO:0005230	extracellular ligand-gated ion channel activity	CONTRIBUTES_TO	IBA	21873635
GO:0005230	extracellular ligand-gated ion channel activity	-	IEA	-
GO:0005254	chloride channel activity	-	IEA	-
GO:0019904	protein domain specific binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	IBA	21873635
GO:0007165	signal transduction	-	TAS	1315307
GO:0007214	gamma-aminobutyric acid signaling pathway	-	IEA	-
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0007268	chemical synaptic transmission	-	TAS	1315307
GO:0007601	visual perception	-	IEA	-
GO:0034220	ion transmembrane transport	-	IBA	21873635
GO:0042391	regulation of membrane potential	-	IBA	21873635
GO:0050877	nervous system process	-	IBA	21873635
GO:1902476	chloride transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	TAS	1315307
GO:0030054	cell junction	-	IEA	-
GO:0034707	chloride channel complex	-	IEA	-
GO:0043005	neuron projection	-	IBA	21873635
GO:0045202	synapse	-	IBA	21873635
GO:0045211	postsynaptic membrane	-	IEA	-
GO:1902711	GABA-A receptor complex	-	IBA	21873635

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-977442	GABA A (rho) receptor activation	TAS
R-HSA-977443	GABA receptor activation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19536785	GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. (2010 Mar 5)	Xuei X	Am J Med Genet B Neuropsychiatr Genet