Gene: GAD1

2571
CPSQ1|GAD|SCP
glutamate decarboxylase 1
protein-coding
2q31.1
Ensembl:ENSG00000128683 MIM:605363 Vega:OTTHUMG00000044175 UniprotKB:Q99259
NG_021477.1
PubMed|SNP Mapped
CD|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.050e-1 (AD)  6.107e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3791853chr2:170838560 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GAD20.959
NRIP30.94
BTBD110.939
PCP4L10.931
ENTPD30.929
VWC20.925
SLC32A10.922
FGF130.917
ZNF385D0.911
FGF120.909

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDA-0.543
TGIF1-0.517
AGTRAP-0.517
REST-0.516
ATOH8-0.5
ROM1-0.497
CSAG1-0.489
MAGEA12-0.488
WDR38-0.487
HVCN1-0.487

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in decreased expression of GAD1 mRNA27417517
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of GAD1 mRNA"19095052
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GAD1 mRNA"27291303
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of GAD1 mRNA"25710175
C4118272,5-dihydro-2,4,5-trimethylthiazoline"GAD1 affects the reaction [2,5-dihydro-2,4,5-trimethylthiazoline results in increased secretion of Corticosterone]"21219938
C0125873,5,6-trichloro-2-pyridinol"3,5,6-trichloro-2-pyridinol results in decreased activity of GAD1 protein"15541749
C0108353-acetylpyridine3-acetylpyridine results in increased expression of GAD1 mRNA8774452
C0108353-acetylpyridineAmphetamine inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]8774452
C0108353-acetylpyridineClenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]8774452
C0108353-acetylpyridinePropranolol inhibits the reaction [Amphetamine inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]]8774452
C0108353-acetylpyridinePropranolol inhibits the reaction [Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]]8774452
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GAD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C0248364-nitrophenol4-nitrophenol results in decreased activity of GAD1 protein15541749
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GAD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of GAD1 mRNA]]19660528
D000082AcetaminophenAcetaminophen affects the expression of GAD1 mRNA17562736
D019342Acetic AcidAcetic Acid results in increased expression of GAD1 mRNA17065238
C056165acetovanilloneacetovanillone inhibits the reaction [Ketamine results in decreased expression of GAD1 protein]18063801
D000447AldehydesAldehydes results in increased expression of GAD1 mRNA25014914
C069206alpha helical corticotropin-releasing hormonealpha helical corticotropin-releasing hormone results in increased expression of GAD1 protein15486230
C010845aluminum chloridealuminum chloride results in increased activity of GAD1 protein11696403
D005680gamma-Aminobutyric AcidGAD1 protein results in increased chemical synthesis of gamma-Aminobutyric Acid11875278|9634146
D005680gamma-Aminobutyric AcidGAD1 protein results in increased chemical synthesis of gamma-Aminobutyric Acid15571623
D005680gamma-Aminobutyric AcidGAD1 protein results in increased chemical synthesis of gamma-Aminobutyric Acid12376704|1536853
D000640Amitrole"Amitrole promotes the reaction [Sodium Chloride, Dietary results in decreased expression of GAD1 protein]"25891026
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GAD1 mRNA16483693
D000661AmphetamineAmphetamine affects the expression of GAD1 protein19059431
D000661AmphetamineAmphetamine results in increased expression of GAD1 mRNA23660488
D000661AmphetamineAmphetamine inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]8774452
D000661AmphetamineAmphetamine results in increased expression of GAD1 mRNA18312583
D000661AmphetamineAmphetamine results in increased expression of GAD1 protein14725721
D000661AmphetaminePropranolol inhibits the reaction [Amphetamine inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]]8774452
D014150Antipsychotic AgentsAntipsychotic Agents results in increased expression of GAD1 mRNA18923069
C027423aroclor 1242[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of GAD1 protein17324953
C028617aroclor 1248[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of GAD1 protein17324953
C026987aroclor 1260[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of GAD1 protein17324953
D001152ArsenicalsArsenicals results in decreased methylation of GAD1 promoter23315758
D001280AtrazineAtrazine results in decreased expression of GAD1 mRNA25929836
C487081belinostatbelinostat results in increased expression of GAD1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GAD1 mRNA20106945|2163298
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of GAD1 mRNA]24758408
D004958EstradiolEstradiol results in increased expression of GAD1 mRNA24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of GAD1 mRNA19833106
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of GAD1 mRNA22154832
D004958EstradiolEstradiol results in increased expression of GAD1 mRNA22154832
D004958EstradiolEstradiol results in increased expression of GAD1 mRNA15677881
C006780bisphenol Abisphenol A affects the expression of GAD1 mRNA25181051|2695020
C006780bisphenol Abisphenol A results in decreased expression of GAD1 mRNA18180321|2379145
C006780bisphenol Abisphenol A results in increased methylation of GAD1 gene28505145
C006780bisphenol Adecitabine inhibits the reaction [bisphenol A results in decreased expression of GAD1 mRNA]23791455
C018475butyraldehydebutyraldehyde results in increased expression of GAD1 mRNA26079696
D002087ButyratesGAD1 protein results in decreased susceptibility to Butyrates15369822
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GAD1 mRNA12160620
D002220CarbamazepineCarbamazepine affects the expression of GAD1 mRNA25979313
C070295catalase-polyethylene glycol"catalase-polyethylene glycol inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of GAD1 protein]"25891026
D020111Chlorodiphenyl (54% Chlorine)[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of GAD1 protein17324953
D002746ChlorpromazineChlorpromazine results in decreased methylation of GAD1 promoter19110320
D002746ChlorpromazineValproic Acid promotes the reaction [Chlorpromazine results in decreased methylation of GAD1 promoter]19110320
D002976ClenbuterolClenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]8774452
D002976ClenbuterolClenbuterol inhibits the reaction [Reserpine results in increased expression of GAD1 mRNA]8774452
D002976ClenbuterolPropranolol inhibits the reaction [Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]]8774452
D003024ClozapineClozapine results in increased expression of GAD1 mRNA17942719
D003024ClozapineClozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]17942719
D003024ClozapineClozapine results in decreased methylation of GAD1 promoter18757738
D003024ClozapineValproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]18757738
D003024ClozapineClozapine results in increased expression of GAD1 mRNA12887421|1506124
C018021cobaltous chloridecobaltous chloride results in decreased expression of GAD1 mRNA22941251
D003042CocaineCocaine results in decreased expression of GAD1 mRNA12629581
D003042CocaineCocaine results in increased expression of GAD1 protein15295023|1861141
D003345Corticosterone"GAD1 affects the reaction [2,5-dihydro-2,4,5-trimethylthiazoline results in increased secretion of Corticosterone]"21219938
D016578Crack CocaineCrack Cocaine results in increased expression of GAD1 mRNA12629581
C029892cupric chloridecupric chloride results in decreased expression of GAD1 mRNA24650576
D003471CuprizoneCuprizone results in increased expression of GAD1 mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA]23267840
D016572CyclosporineCyclosporine results in decreased expression of GAD1 mRNA27989131
C093628cyproconazolecyproconazole results in decreased expression of GAD1 mRNA25182419
C014347decitabinedecitabine inhibits the reaction [bisphenol A results in decreased expression of GAD1 mRNA]23791455
D003975DiazepamDiazepam results in decreased expression of GAD1 mRNA15802192
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GAD1 mRNA15620428
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GAD1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of GAD1 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of GAD1 mRNA25016146
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of GAD1 mRNA17065238
D007980LevodopaLevodopa results in increased expression of GAD1 mRNA14622157
D007980Levodopa6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of GAD1 mRNA]]19660528
D007980LevodopaLevodopa inhibits the reaction [Oxidopamine results in increased expression of GAD1 mRNA]17241287
D007980LevodopaLevodopa promotes the reaction [Oxidopamine results in increased expression of GAD1 mRNA]19660528
D007980LevodopaLevodopa results in increased expression of GAD1 mRNA15837143
D018492Dopamine AntagonistsDopamine Antagonists results in increased expression of GAD1 mRNA15044549
D004317DoxorubicinDoxorubicin results in increased expression of GAD1 mRNA17065238
D015773EnalaprilatEnalaprilat inhibits the reaction [AGT protein modified form results in decreased expression of GAD1]24342267
D004726EndosulfanEndosulfan results in increased expression of GAD1 mRNA21036383
C118739entinostatentinostat results in increased expression of GAD1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of GAD1 protein27659729
D000431EthanolEthanol results in increased expression of GAD1 mRNA15729141
D005033EthylmaleimideEthylmaleimide results in decreased activity of GAD1 protein15836621
C045989eticloprideeticlopride results in increased expression of GAD1 mRNA15044549
C540355fenamidonefenamidone results in decreased expression of GAD1 mRNA27029645
D005473FluoxetineFluoxetine results in increased expression of GAD1 mRNA17033635
D016666Fluvoxamine[Haloperidol co-treated with Fluvoxamine] affects the expression of GAD1 protein15967061
D004397FonofosFonofos results in increased methylation of GAD1 promoter22847954
C039281furanfuran results in increased methylation of GAD1 gene22079235
D005665FurosemideFurosemide results in decreased expression of GAD1 mRNA14596865
D019833GenisteinGenistein results in decreased expression of GAD1 mRNA21782745
D005947GlucoseGlucose promotes the reaction [[IPF1 protein binds to GAD1 promoter] which results in increased expression of GAD1 mRNA]12150938|1215093
D005947GlucoseGlucose results in increased expression of GAD1 mRNA12150938
D005947GlucoseGAD1 protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency]25966616
D006220Haloperidol[Haloperidol co-treated with Fluvoxamine] affects the expression of GAD1 protein15967061
D006220HaloperidolHaloperidol results in decreased expression of GAD1 mRNA14519413
D006220HaloperidolHaloperidol results in decreased expression of GAD1 protein19359144
D006220HaloperidolHaloperidol results in increased expression of GAD1 mRNA12887421|1506124
D006854HydrocortisoneHydrocortisone results in increased expression of GAD1 protein15531528
D006861Hydrogen PeroxideGAD1 protein results in decreased susceptibility to Hydrogen Peroxide15369822
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of GAD1 mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of GAD1 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GAD1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of GAD1 mRNA27392435
D007608Kainic AcidKainic Acid results in increased expression of GAD1 mRNA16797850
D007649Ketamineacetovanillone inhibits the reaction [Ketamine results in decreased expression of GAD1 protein]18063801
D007649KetamineKetamine results in decreased expression of GAD118063801
D007649KetamineKetamine results in increased expression of GAD1 mRNA23660488
D007854LeadLead affects the expression of GAD1 mRNA28903495
D007854LeadLead results in decreased expression of GAD1 protein15149801
C045463leflunomideleflunomide results in increased expression of GAD1 mRNA28988120
C025340manganese chloridemanganese chloride results in decreased expression of GAD1 mRNA12106697
D0150973-Mercaptopropionic Acid3-Mercaptopropionic Acid results in decreased activity of GAD1 protein4154755
D008715MethionineMethionine promotes the reaction [MECP2 binds to GAD1 promoter]16113080
D008715MethionineMethionine results in decreased expression of GAD120442623
D008715MethionineMethionine results in decreased expression of GAD1 mRNA15671176
D008715MethionineMethionine results in decreased expression of GAD1 protein16113080
D008715MethionineValproic Acid inhibits the reaction [Methionine results in decreased expression of GAD1 protein]20442623
D008727MethotrexateGAD1 protein affects the susceptibility to Methotrexate16217747
D008727MethotrexateMethotrexate results in decreased expression of GAD1 mRNA24449571
C030667methylazoxymethanolmethylazoxymethanol results in decreased expression of GAD1 mRNA23932495
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GAD1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GAD1 mRNA21385734
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GAD1 mRNA"15363887
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GAD1 protein"15882945
D009020MorphineMorphine results in increased expression of GAD1 mRNA15673448|1831258
D009151Mustard GasMustard Gas results in increased expression of GAD1 mRNA15674844
C029938nickel sulfatenickel sulfate results in increased expression of GAD1 mRNA22714537
D009538NicotineNicotine results in increased expression of GAD1 mRNA18312583
C025256nonylphenolnonylphenol results in increased expression of GAD1 mRNA15620428
D016627OxidopamineOxidopamine results in increased expression of GAD1 mRNA14622157
D016627Oxidopamine6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of GAD1 mRNA]]19660528
D016627OxidopamineLevodopa inhibits the reaction [Oxidopamine results in increased expression of GAD1 mRNA]17241287
D016627OxidopamineLevodopa promotes the reaction [Oxidopamine results in increased expression of GAD1 mRNA]19660528
D016627OxidopamineOxidopamine results in increased expression of GAD1 mRNA12077209|1504454
C076029olanzapineolanzapine results in decreased expression of GAD1 mRNA14519413
C076029olanzapineolanzapine results in decreased expression of GAD1 protein19359144
D010100OxygenOxygen deficiency results in increased expression of GAD1 mRNA26516004
D010100OxygenGAD1 protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency]25966616
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of GAD1 mRNA26272509
D010269ParaquatParaquat results in decreased expression of GAD1 mRNA17493592
D010278ParathionParathion results in increased methylation of GAD1 promoter22847954
D052638Particulate MatterParticulate Matter results in increased expression of GAD1 mRNA22178795
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of GAD1 protein23916505
C046012pentanalpentanal results in increased expression of GAD1 mRNA26079696
D010433Pentylenetetrazole[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of GAD1 mRNA21503142
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GAD1 mRNA23978341
C023036perfluorooctanoic acid[perfluorooctanoic acid co-treated with PPARA] results in increased expression of GAD1 mRNA20118188
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of GAD1 mRNA20118188
C000593032PGW5 compoundPGW5 compound affects the expression of GAD1 protein24389121
C033457phenobarbital quinidinephenobarbital quinidine results in decreased expression of GAD1 mRNA15802192
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GAD1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GAD1 mRNA26272509
D010852PicrotoxinPicrotoxin results in increased expression of GAD1 mRNA15170462
D010862PilocarpinePilocarpine results in increased expression of GAD1 mRNA16797850
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of GAD1 mRNA19833106
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of GAD1 mRNA22154832
C005556propionaldehydepropionaldehyde results in increased expression of GAD1 mRNA26079696
D011433PropranololPropranolol inhibits the reaction [Amphetamine inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]]8774452
D011433PropranololPropranolol inhibits the reaction [Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]]8774452
D011441PropylthiouracilPropylthiouracil results in increased expression of GAD1 mRNA24780913
D011732Pyridoxal PhosphatePyridoxal Phosphate binds to GAD1 protein modified form15686475
D011732Pyridoxal PhosphatePyridoxal Phosphate results in increased activity of GAD1 protein171340
D011732Pyridoxal PhosphatePyridoxal Phosphate results in decreased activity of GAD1 protein7463050
C003257pyridoxal phosphate gamma-glutamyl hydrazonepyridoxal phosphate gamma-glutamyl hydrazone results in decreased activity of GAD1 protein171340
D011794QuercetinQuercetin results in increased expression of GAD1 mRNA21632981
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GAD1 mRNA19059307
D012110ReserpineClenbuterol inhibits the reaction [Reserpine results in increased expression of GAD1 mRNA]8774452
D012110ReserpineReserpine results in increased expression of GAD1 mRNA8774452
C017947sodium arsenitesodium arsenite results in increased expression of GAD1 mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of GAD1 mRNA20376865
D017673Sodium Chloride, Dietary"Amitrole promotes the reaction [Sodium Chloride, Dietary results in decreased expression of GAD1 protein]"25891026
D017673Sodium Chloride, Dietary"catalase-polyethylene glycol inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of GAD1 protein]"25891026
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in decreased expression of GAD1 protein"25891026
D018038Sodium SeleniteSodium Selenite results in decreased expression of GAD1 mRNA23274088
C049985staurosporine aglyconestaurosporine aglycone results in decreased expression of GAD1 mRNA12859332
C049985staurosporine aglyconestaurosporine aglycone results in decreased expression of GAD1 protein12859332
D013311StreptozocinCurcumin inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA]23267840
D013311StreptozocinINS1 protein inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA]23267840
D013311StreptozocinStreptozocin results in decreased expression of GAD1 mRNA23267840
D013469SulpirideSulpiride results in decreased methylation of GAD1 promoter18757738
D013469SulpirideValproic Acid promotes the reaction [Sulpiride results in decreased methylation of GAD1 promoter]18757738
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of GAD1 mRNA19059307
C012568terbufosterbufos results in increased methylation of GAD1 promoter22847954
D013739TestosteroneTestosterone results in increased expression of GAD1 mRNA21281643
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GAD1 mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GAD1 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GAD1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GAD1 mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GAD1 mRNA12060831
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of GAD1 mRNA"14622157
D014050TolueneToluene affects the expression of GAD1 mRNA21827849
D014212TretinoinTretinoin results in decreased expression of GAD1 mRNA21934132
D014212TretinoinTretinoin results in increased expression of GAD1 mRNA11841568|2246660
D014212TretinoinTretinoin results in increased expression of GAD1 protein alternative form11841568
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of GAD1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GAD1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of GAD1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GAD1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid inhibits the reaction [MECP2 binds to GAD1 promoter]16113080
D014635Valproic AcidValproic Acid inhibits the reaction [Methionine results in decreased expression of GAD1 protein]20442623
D014635Valproic AcidValproic Acid promotes the reaction [Chlorpromazine results in decreased methylation of GAD1 promoter]19110320
D014635Valproic AcidValproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]18757738
D014635Valproic AcidValproic Acid promotes the reaction [Sulpiride results in decreased methylation of GAD1 promoter]18757738
D014635Valproic AcidValproic Acid results in decreased expression of GAD1 mRNA24896083
D014635Valproic AcidValproic Acid results in decreased methylation of GAD1 promoter20716949
D014635Valproic AcidValproic Acid results in increased expression of GAD1 mRNA15737665
D014635Valproic AcidValproic Acid results in increased expression of GAD1 protein15379904
D014635Valproic AcidValproic Acid results in increased expression of GAD120716949
D020888Vigabatrin[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of GAD1 mRNA21503142
D020888VigabatrinVigabatrin results in increased expression of GAD1 protein11673025
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAD1 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of GAD1 mRNA26272509
D015032ZincZinc deficiency results in increased expression of GAD1 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004351glutamate decarboxylase activity-IDA10671565  
GO:0004351glutamate decarboxylase activity-TAS-  
GO:0005515protein binding-IPI10671565  16189514  17474147  21516116  25416956  26871637  
27107014  
GO:0016595glutamate binding-IEA-  
GO:0030170pyridoxal phosphate binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:0047485protein N-terminus binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006538glutamate catabolic process-TAS10671565  
GO:0006540glutamate decarboxylation to succinate-TAS1549570  
GO:0007268chemical synaptic transmission-TAS8954991  
GO:0009449gamma-aminobutyric acid biosynthetic process-IEA-  
GO:0018352protein-pyridoxal-5-phosphate linkage-TAS10671565  
GO:0035176social behavior-IEA-  
GO:0035641locomotory exploration behavior-IEA-  
GO:0042493response to drug-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA10671565  
GO:0005886plasma membrane-TAS-  
GO:0005938cell cortex-IEA-  
GO:0012506vesicle membrane-NAS10671565  
GO:0043679axon terminus-IEA-  
GO:0048786presynaptic active zone-IEA-  
GO:0060077inhibitory synapse-IEA-  
GO:0061202clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane-TAS-  
KEGG ID KEGG Term
hsa00250Alanine, aspartate and glutamate metabolism
hsa00410beta-Alanine metabolism
hsa00430Taurine and hypotaurine metabolism
hsa00650Butanoate metabolism
hsa01100Metabolic pathways
hsa04940Type I diabetes mellitus
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-888568GABA synthesisTAS
R-HSA-888590GABA synthesis, release, reuptake and degradationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17067345Glutamate decarboxylase genes and alcoholism in Han Taiwanese men. (2006 Nov)Loh el-WAlcohol Clin Exp Res
23857790Genome-wide DNA methylation patterns in discordant sib pairs with alcohol dependence. (2013 Mar)Zhao RAsia Pac Psychiatry
26277529Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry. (2016 Jan 4)Levran OProg Neuropsychopharmacol Biol Psychiatry
25655461Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)Manzardo AMGene
9133412Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. (1997 May 15)Buck KJJ Neurosci
19111404Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence. (2009 Apr 1)Kuo PHDrug Alcohol Depend