Gene: FAM133B

257415
-
family with sequence similarity 133 member B
protein-coding
7q21.2
Ensembl:ENSG00000234545 Vega:OTTHUMG00000155863 UniprotKB:Q5BKY9
NC_000007.14
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.589e-1 (AD)  7.150e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6964507chr7:92581624 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6465363chr7:92577956 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGFG10.894
ZBTB110.891
FGFR1OP20.889
RSBN1L0.888
KRIT10.886
CDC5L0.885
CCDC470.885
ATF20.885
RPE0.882
APPBP20.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.557
OR4F29-0.529
MTRNR2L10-0.343
MTRNR2L6-0.329
MTRNR2L9-0.316
MTRNR2L3-0.303
MTRNR2L8-0.292
RSPO1-0.289
KLRB1-0.286
MTRNR2L2-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FAM133B mRNA"19114083
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FAM133B gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FAM133B mRNA19770486
D000452AldrinAldrin results in decreased expression of FAM133B mRNA18579281
D001151ArsenicArsenic affects the methylation of FAM133B gene25304211
D001280AtrazineAtrazine results in increased expression of FAM133B mRNA23358194
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FAM133B mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FAM133B mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of FAM133B mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FAM133B mRNA27858113
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FAM133B mRNA"26238291
C044887beta-methylcholinebeta-methylcholine affects the expression of FAM133B mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FAM133B mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of FAM133B mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of FAM133B mRNA25270620
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FAM133B mRNA27858113
D003033Coal TarCoal Tar results in decreased expression of FAM133B mRNA27858113
C018021cobaltous chloridecobaltous chloride results in increased expression of FAM133B mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of FAM133B mRNA25270620
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FAM133B mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FAM133B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of FAM133B mRNA27392435
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FAM133B mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FAM133B mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FAM133B mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FAM133B mRNA27392435
C544151jinfukangjinfukang results in decreased expression of FAM133B mRNA27392435
C410337K 7174K 7174 results in increased expression of FAM133B mRNA24086573
D008777MethyltestosteroneMethyltestosterone results in decreased expression of FAM133B mRNA29191790
C568376MT19c compoundMT19c compound results in increased expression of FAM133B mRNA21781307
C017557nickel subsulfidenickel subsulfide results in increased expression of FAM133B mRNA21086188
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of FAM133B mRNA27153767
D010936Plant ExtractsPlant Extracts results in increased expression of FAM133B mRNA23557933
D012834SilverSilver results in increased expression of FAM133B mRNA27131904
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FAM133B mRNA25613284
C012589trichostatin Atrichostatin A results in increased expression of FAM133B mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of FAM133B mRNA27188386
D014635Valproic AcidValproic Acid results in decreased methylation of FAM133B gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FAM133B gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal