Gene: PRPF40B

25766
HYPC
pre-mRNA processing factor 40 homolog B
protein-coding
12q13.12
Ensembl:ENSG00000110844 Vega:OTTHUMG00000169568 UniprotKB:Q6NWY9
NG_032901.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.368e-1 (AD)  9.458e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP3K120.94
DPH10.924
SUGP20.914
MYBBP1A0.912
KIAA0895L0.912
ZMYM30.908
FAM160B20.907
PKD10.904
L3MBTL10.904
GGT70.904

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.511
OR4F29-0.469
MTRNR2L6-0.424
MTRNR2L9-0.415
MTRNR2L10-0.405
PPBP-0.388
CLEC2B-0.371
LRRIQ1-0.361
CST7-0.352
RAB13-0.351

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of PRPF40B mRNA"23829299
C547126AZM551248AZM551248 results in decreased expression of PRPF40B mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of PRPF40B mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PRPF40B mRNA26377693
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of PRPF40B mRNA]22228805
C006780bisphenol Abisphenol A results in increased expression of PRPF40B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PRPF40B gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PRPF40B mRNA28628672
D016572CyclosporineCyclosporine results in increased expression of PRPF40B mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PRPF40B mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PRPF40B mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of PRPF40B mRNA18042831
C118739entinostatentinostat results in increased expression of PRPF40B mRNA27188386
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PRPF40B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PRPF40B mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PRPF40B mRNA27392435
C544151jinfukangjinfukang results in increased expression of PRPF40B mRNA27392435
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PRPF40B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PRPF40B mRNA"25554681
D000073878Palm OilPalm Oil results in decreased expression of PRPF40B mRNA18042831
D010936Plant ExtractsPlant Extracts results in decreased expression of PRPF40B mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRPF40B mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRPF40B mRNA21570461
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PRPF40B mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of PRPF40B mRNA25979313

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000398mRNA splicing, via spliceosome-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005685U1 snRNP-IBA21873635  
GO:0016607nuclear speck-IEA-  
GO:0071004U2-type prespliceosome-IBA21873635  
KEGG ID KEGG Term
hsa03040Spliceosome
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26498691SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer. (2015 Nov 10)Tian JOncotarget