Gene: SLC24A2

25769
NCKX2
solute carrier family 24 member 2
protein-coding
9p22.1-p21.3
Ensembl:ENSG00000155886 MIM:609838 Vega:OTTHUMG00000019646 UniprotKB:Q9UI40
NG_029734.1
SNP Mapped
0   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.022e-1 (AD)  8.404e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTPRD0.937
PEX5L0.933
DIRAS20.932
DNM30.929
MFSD60.922
SLITRK10.918
RASGRP10.918
B3GALT20.916
WDR70.916
HECW20.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHOD-0.514
LRAT-0.506
RNF135-0.495
GJB2-0.493
RAB13-0.492
ASB4-0.484
RREB1-0.479
EMP3-0.478
PDZK1IP1-0.476
CYP11A1-0.47

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLC24A2 mRNA"19114083
C5736932-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in decreased expression of SLC24A2 mRNA22193206
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC24A2 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC24A2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC24A2 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC24A2 mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of SLC24A2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC24A2 gene28505145
D002118CalciumSLC24A2 protein results in increased uptake of Calcium14660663
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SLC24A2 mRNA18668222
C039671ciglitazoneciglitazone results in decreased expression of SLC24A2 mRNA22193206
D003042CocaineCocaine affects the expression of SLC24A2 mRNA20187946
D003300CopperCopper deficiency results in increased expression of SLC24A2 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of SLC24A2 mRNA26577399
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SLC24A2 mRNA]27941970
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC24A2 mRNA22129741
D002117CalcitriolCalcitriol results in decreased expression of SLC24A2 mRNA26485663
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of SLC24A2 mRNA22193206
D005419FlavonoidsFlavonoids results in decreased expression of SLC24A2 mRNA18035473
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC24A2 mRNA22129741
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC24A2 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SLC24A2 mRNA26011545
C500085muraglitazarmuraglitazar results in decreased expression of SLC24A2 mRNA21515302
C046012pentanalpentanal results in increased expression of SLC24A2 mRNA26079696
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SLC24A2 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC24A2 mRNA24780913
C089730rosiglitazonerosiglitazone results in decreased expression of SLC24A2 mRNA21515302
D053260SootSoot results in decreased expression of SLC24A2 mRNA26551751
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SLC24A2 mRNA"18579281
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC24A2 mRNA16267337
D013853ThioacetamideThioacetamide results in decreased expression of SLC24A2 mRNA23411599
C057693troglitazonetroglitazone results in decreased expression of SLC24A2 mRNA21515302
D014635Valproic AcidValproic Acid affects the expression of SLC24A2 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005262calcium channel activity-IBA21873635  
GO:0008273calcium, potassium:sodium antiporter activity-IBA21873635  
GO:0008273calcium, potassium:sodium antiporter activity-IDA18166528  
GO:0008273calcium, potassium:sodium antiporter activity-TAS-  
GO:0015293symporter activity-IEA-  
GO:0046983protein dimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006811ion transport-TAS-  
GO:0006813potassium ion transport-IEA-  
GO:0006874cellular calcium ion homeostasis-IBA21873635  
GO:0007601visual perception-IEA-  
GO:0007612learning-IEA-  
GO:0007613memory-IEA-  
GO:0034220ion transmembrane transport-IDA18166528  
GO:0035725sodium ion transmembrane transport-IEA-  
GO:0050896response to stimulus-IEA-  
GO:0060291long-term synaptic potentiation-IBA21873635  
GO:0060292long term synaptic depression-IBA21873635  
GO:0070588calcium ion transmembrane transport-IBA21873635  
GO:0070588calcium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425561Sodium/Calcium exchangersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal