Gene: RASGRP3

25780
GRP3
RAS guanyl releasing protein 3
protein-coding
2p22.3
Ensembl:ENSG00000152689 MIM:609531 Vega:OTTHUMG00000152124 UniprotKB:Q8IV61
NG_053077.1
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.353e-1 (AD)  8.972e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7561821chr2:33490675 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FRMD4B0.903
FAM107B0.899
PRR5L0.895
VRK20.886
ST180.885
TMCC30.881
ASPA0.873
ERMN0.87
PLD10.868
FOLH10.865

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.55
PCDH8-0.509
CDH22-0.485
GRB14-0.485
POU3F1-0.485
CALB2-0.464
CNGB1-0.463
HCN4-0.46
KCNQ4-0.455
ASB2-0.454

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of RASGRP3 mRNA"26377693
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of RASGRP3 mRNA19933214
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RASGRP3 mRNA"18648102
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of RASGRP3 mRNA19191707
D020106AcrylamideAcrylamide results in decreased expression of RASGRP3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RASGRP3 mRNA27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of RASGRP3 mRNA28522335
D018501Antirheumatic Agents[Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of RASGRP3 mRNA16817978
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RASGRP3 mRNA24449571
D001151ArsenicArsenic affects the methylation of RASGRP3 gene25304211
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RASGRP3 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RASGRP3 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of RASGRP3 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RASGRP3 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RASGRP3 mRNA22228805|2261060
C006780bisphenol Abisphenol A results in decreased expression of RASGRP3 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of RASGRP3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RASGRP3 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of RASGRP3 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of RASGRP3 mRNA26079696
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of RASGRP3 mRNA24763279
D002737ChloropreneChloroprene results in decreased expression of RASGRP3 mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RASGRP3 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of RASGRP3 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of RASGRP3 mRNA24386269
D003471CuprizoneCuprizone results in decreased expression of RASGRP3 mRNA27523638
C089595cylindrospermopsincylindrospermopsin results in increased expression of RASGRP3 mRNA24921660
D003907DexamethasoneDexamethasone results in decreased expression of RASGRP3 mRNA21356098
D003907DexamethasoneDexamethasone promotes the reaction [Lipopolysaccharides results in decreased expression of RASGRP3 mRNA]22185406
D003907DexamethasoneDexamethasone results in decreased expression of RASGRP3 mRNA22185406
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RASGRP3 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of RASGRP3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of RASGRP3 mRNA27392435
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RASGRP3 mRNA22079256
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of RASGRP3 mRNA24763279
D017313FenretinideFenretinide results in increased expression of RASGRP3 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RASGRP3 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of RASGRP3 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of RASGRP3 mRNA27392435
D048628KetolidesKetolides analog results in increased expression of RASGRP3 mRNA24967691
D008070LipopolysaccharidesDexamethasone promotes the reaction [Lipopolysaccharides results in decreased expression of RASGRP3 mRNA]22185406
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of RASGRP3 mRNA22185406
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of RASGRP3 mRNA]22185406
D008070Lipopolysaccharides"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of RASGRP3 mRNA]"22185406
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RASGRP3 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of RASGRP3 mRNA26378955
D008694MethamphetamineMethamphetamine results in increased expression of RASGRP3 mRNA25290377
D008727Methotrexate[Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of RASGRP3 mRNA16817978
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RASGRP3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RASGRP3 mRNA"25554681
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in decreased expression of RASGRP3 mRNA24888373
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of RASGRP3 mRNA25729387
C046012pentanalpentanal results in decreased expression of RASGRP3 mRNA26079696
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RASGRP3 mRNA19710929
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in decreased expression of RASGRP3 mRNA24888373
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RASGRP3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RASGRP3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of RASGRP3 mRNA22714537
C513428pyrachlostrobinpyrachlostrobin results in increased expression of RASGRP3 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of RASGRP3 mRNA21356098
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of RASGRP3 mRNA]22185406
D011794QuercetinQuercetin results in decreased expression of RASGRP3 mRNA22185406
D011794QuercetinQuercetin affects the expression of RASGRP3 mRNA18178720
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RASGRP3 mRNA25895662
D012834SilverSilver results in increased expression of RASGRP3 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of RASGRP3 mRNA25879800
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RASGRP3 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of RASGRP3 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RASGRP3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RASGRP3 mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RASGRP3 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of RASGRP3 mRNA23557971
C082097tocotrienol, delta"tocotrienol, delta results in decreased expression of RASGRP3 mRNA"21356098
C082097tocotrienol, delta"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of RASGRP3 mRNA]"22185406
C082097tocotrienol, delta"tocotrienol, delta results in decreased expression of RASGRP3 mRNA"22185406
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of RASGRP3 mRNA25729387
D019772TopotecanTopotecan results in increased expression of RASGRP3 mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of RASGRP3 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of RASGRP3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RASGRP3 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of RASGRP3 gene29154799
D014638VanadatesVanadates results in increased expression of RASGRP3 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RASGRP3 gene25560391
D012256RiboflavinRiboflavin results in decreased expression of RASGRP3 mRNA21356098

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005096GTPase activator activity-IDA10934204  
GO:0005509calcium ion binding-NAS10934204  
GO:0005515protein binding-IPI25416956  27107014  
GO:0019900kinase binding-IEA-  
GO:0019992diacylglycerol binding-NAS10934204  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-NAS10934204  
GO:0000165MAPK cascade-TAS-  
GO:0007264small GTPase mediated signal transduction-TAS10934204  
GO:0007265Ras protein signal transduction-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS10934204  
GO:0032045guanyl-nucleotide exchange factor complex-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04662B cell receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)IEA
R-HSA-1169092Activation of RAS in B cellsTAS
R-HSA-1169092Activation of RAS in B cellsIEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24890784Exon microarray analysis of human dorsolateral prefrontal cortex in alcoholism. (2014 Jun)Manzardo AMAlcohol Clin Exp Res