Gene: AMBN

258
AI1F
ameloblastin
protein-coding
4q13.3
Ensembl:ENSG00000178522 MIM:601259 Vega:OTTHUMG00000129913 UniprotKB:Q9NP70
NG_042078.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.746e-1 (AD)  1.624e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR1010.967
DGKK0.966
DRD30.962
ENTHD10.96
SAG0.954
SLC18A30.941
SLC35D30.94
GPR10.933
CHAT0.926
ZBED20.92

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.445
SYTL2-0.374
NEUROD2-0.369
TNNT2-0.367
SOHLH1-0.365
GALNT9-0.364
NANOS3-0.351
NXPH3-0.342
ALDH1A1-0.337
TBR1-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of AMBN mRNA"23829299
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AMBN mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of AMBN mRNA24465770
C006780bisphenol A[bisphenol A co-treated with Sodium Fluoride] results in decreased expression of AMBN mRNA27257137
C006780bisphenol Abisphenol A results in decreased expression of AMBN mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of AMBN promoter22457795
C070609EMD 53998EMD 53998 analog results in decreased expression of AMBN mRNA24977338
C069837fullerene C60fullerene C60 results in decreased expression of AMBN mRNA19167457
D012969Sodium Fluoride[bisphenol A co-treated with Sodium Fluoride] results in decreased expression of AMBN mRNA27257137
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to AMBN promoter]19654925
C009495titanium dioxidetitanium dioxide affects the expression of AMBN mRNA17656681
D014635Valproic AcidValproic Acid affects the expression of AMBN mRNA25979313
D015032ZincZinc deficiency results in decreased expression of AMBN mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25789606  
GO:0008083growth factor activity-IBA21873635  
GO:0008083growth factor activity-ISS-  
GO:0030345structural constituent of tooth enamel-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IBA21873635  
GO:0007155cell adhesion-ISS-  
GO:0008283cell proliferation-IBA21873635  
GO:0008283cell proliferation-ISS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0031214biomineral tissue development-IEA-  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28266114Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases. (2017 Mar)Chapple ILJ Clin Periodontol