Gene: GAK

2580
DNAJ26|DNAJC26
cyclin G associated kinase
protein-coding
4p16.3
Ensembl:ENSG00000178950 MIM:602052 Vega:OTTHUMG00000088301 UniprotKB:O14976
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.140e-1 (AD)  9.987e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01552919chr4:901847GAK2.100e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATG4B0.951
MED150.949
ATP13A10.944
HGS0.944
EDC40.941
ZNF5980.94
UNC45A0.94
TRMT10.938
PHRF10.935
CTSA0.935

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.703
OR4F29-0.659
MTRNR2L9-0.294
KLRB1-0.292
TRDN-0.289
MTRNR2L6-0.278
MTRNR2L10-0.277
GSDMC-0.269
TTLL10-AS1-0.268
KLRC2-0.267

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of GAK mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GAK mRNA"19114083
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of GAK mRNA12419474
D000082AcetaminophenAcetaminophen affects the expression of GAK mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GAK gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GAK mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GAK mRNA24449571
D001151ArsenicArsenic affects the expression of GAK mRNA25304211
D001151ArsenicArsenic affects the methylation of GAK gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of GAK mRNA20458559
D001205Ascorbic Acid[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of GAK mRNA16443354
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GAK mRNA"19150397
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GAK mRNA28628672
C006780bisphenol Abisphenol A affects the expression of GAK mRNA23557687
C006780bisphenol Abisphenol A results in increased expression of GAK mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GAK gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GAK mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of GAK mRNA12419474
D002101Cacodylic AcidCacodylic Acid results in increased expression of GAK mRNA16122865
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of GAK promoter22457795
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GAK gene20938992
D016572CyclosporineCyclosporine results in increased expression of GAK mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GAK mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GAK mRNA28628672
D003976DiazinonDiazinon results in decreased expression of GAK mRNA21968025
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of GAK mRNA27638505
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GAK protein23301498
D005473FluoxetineFluoxetine results in decreased expression of GAK mRNA21852994
D005485FlutamideFlutamide results in increased expression of GAK mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GAK gene20938992
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GAK mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GAK mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GAK mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GAK mRNA28628672
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GAK gene20938992
C028577monobutyl phthalatemonobutyl phthalate affects the expression of GAK mRNA20864626
C022838nickel chloridenickel chloride affects the expression of GAK mRNA22546817
D010269ParaquatParaquat results in increased expression of GAK mRNA18198484
C017947sodium arsenitesodium arsenite results in decreased expression of GAK protein21925251
D012969Sodium FluorideSodium Fluoride results in decreased expression of GAK protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of GAK mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GAK mRNA21570461
D014212Tretinoin[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of GAK mRNA16443354
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GAK mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of GAK mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GAK gene25560391
C025643vinclozolinvinclozolin results in decreased expression of GAK mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of GAK mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0005515protein binding-IPI22645275  24510904  24947832  29568061  
GO:0005524ATP binding-IEA-  
GO:0030276clathrin binding-IBA21873635  
GO:0030332cyclin binding-ISS-  
GO:0051087chaperone binding-TAS26345367  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO:0006898receptor-mediated endocytosis-IBA21873635  
GO:0006898receptor-mediated endocytosis-IMP16155256  
GO:0007029endoplasmic reticulum organization-ISS-  
GO:0007030Golgi organization-IMP16155256  24510904  
GO:0007049cell cycle-IEA-  
GO:0010977negative regulation of neuron projection development-IDA24510904  
GO:0016191synaptic vesicle uncoating-ISS20160091  
GO:0034067protein localization to Golgi apparatus-IMP16155256  
GO:0051085chaperone cofactor-dependent protein refolding-TAS26345367  
GO:0061024membrane organization-TAS-  
GO:0072318clathrin coat disassembly-IBA21873635  
GO:0072318clathrin coat disassembly-IMP16155256  
GO:0072583clathrin-dependent endocytosis-IBA21873635  
GO:0072583clathrin-dependent endocytosis-IMP16155256  
GO:0072659protein localization to plasma membrane-IMP16155256  
GO:0090160Golgi to lysosome transport-IMP16155256  
GO:1905224clathrin-coated pit assembly-IMP16155256  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005794Golgi apparatus-IDA16155256  
GO:0005829cytosol-TAS-  
GO:0005925focal adhesion-IEA-  
GO:0016020membrane-HDA19946888  
GO:0031982vesicle-IBA21873635  
GO:0031982vesicle-IDA24510904  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045202synapse-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-199992trans-Golgi Network Vesicle BuddingTAS
R-HSA-421837Clathrin derived vesicle buddingTAS
R-HSA-432722Golgi Associated Vesicle BiogenesisTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26318431Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma. (2016 Feb)Sun WTumour Biol