Gene: GCA

25801
GCL
grancalcin
protein-coding
2q24.2
Ensembl:ENSG00000115271 MIM:607030 Vega:OTTHUMG00000132057 UniprotKB:P28676
NC_000002.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND
36   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.812e-1 (AD)  1.849e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3788964chr2:162350970 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C5orf150.881
RARS20.87
POT10.846
DIMT10.845
MBD40.843
CHMP2B0.842
GOLGA50.842
MARCH10.84
RNF130.838
LIPA0.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.488
OR4F29-0.476
WNT7B-0.346
SALL3-0.33
ADAMTSL5-0.325
HES5-0.323
NWD1-0.322
PTGDR2-0.318
ARSF-0.308
EYA2-0.298

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTarget
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTarget
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of GCA mRNA"26377693
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of GCA mRNA16788091
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GCA mRNA23630614
D000393Air PollutantsAir Pollutants analog results in decreased expression of GCA mRNA21757418
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of GCA mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GCA mRNA24449571
D001379AzathioprineAzathioprine results in decreased expression of GCA mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GCA mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GCA mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of GCA mRNA21932408
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of GCA gene28505145
C006780bisphenol Abisphenol A results in increased expression of GCA mRNA25181051
C584509C646 compoundC646 compound results in increased expression of GCA mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of GCA mRNA25979313
D019327Copper SulfateCopper Sulfate results in decreased expression of GCA mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of GCA mRNA25562108
D003561CytarabineCytarabine results in decreased expression of GCA mRNA21198554
C000944dicrotophosdicrotophos results in decreased expression of GCA mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GCA mRNA24535843
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of GCA mRNA27638505
D004237DiuronDiuron results in decreased expression of GCA mRNA21551480
C118739entinostatentinostat results in increased expression of GCA mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GCA mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GCA mRNA23649840
C039281furanfuran results in increased expression of GCA mRNA27387713
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of GCA gene28505145
D006046GoldGold results in decreased expression of GCA mRNA25523186
D017313FenretinideFenretinide results in decreased expression of GCA mRNA28973697
C492448ICG 001ICG 001 results in increased expression of GCA mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GCA mRNA25613284
D007529IsoflavonesIsoflavones results in increased expression of GCA mRNA17374662
D007649KetamineKetamine results in decreased expression of GCA mRNA20080153
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GCA mRNA26378955
D008727MethotrexateMethotrexate results in decreased expression of GCA mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GCA mRNA23179753|2718838
C523799MRK 003GCA results in decreased susceptibility to MRK 00319903844
C568376MT19c compoundMT19c compound results in increased expression of GCA mRNA21781307
D009532NickelNickel results in decreased expression of GCA mRNA23195993
D009532NickelNickel results in increased expression of GCA mRNA24768652|2558310
D010416PentachlorophenolPentachlorophenol results in increased expression of GCA mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of GCA mRNA19159669
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GCA mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of GCA mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of GCA mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GCA mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GCA mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GCA mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of GCA mRNA23018184
C045950propiconazolepropiconazole results in increased expression of GCA mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of GCA mRNA24780913
D011794QuercetinQuercetin results in decreased expression of GCA mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GCA mRNA25895662
D012834SilverSilver results in decreased expression of GCA mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of GCA mRNA22714537
C016104sodium bichromatesodium bichromate affects the expression of GCA mRNA22110744
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GCA mRNA26378955
C061133tamibarotenetamibarotene results in increased expression of GCA mRNA15498508
D013629TamoxifenTamoxifen affects the expression of GCA mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GCA mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GCA mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GCA mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GCA mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of GCA mRNA23411599
D019772TopotecanGCA protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in increased expression of GCA mRNA15498508|1589460
D014212TretinoinTretinoin results in increased expression of GCA mRNA16788091
C012589trichostatin Atrichostatin A affects the expression of GCA mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GCA mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of GCA mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of GCA gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GCA mRNA23179753|2718838
D014638VanadatesVanadates results in decreased expression of GCA mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of GCA gene25560391
C025643vinclozolinvinclozolin results in increased expression of GCA mRNA20566332
C111237vorinostatvorinostat results in increased expression of GCA mRNA27188386
D015032ZincZinc deficiency results in increased expression of GCA mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IDA11717497  
GO:0005515protein binding-IPI25416956  
GO:0042803protein homodimerization activity-IPI11717497  
GO:0046982protein heterodimerization activity-IPI12804766  
GO ID GO Term Qualifier Evidence PubMed
GO:0043312neutrophil degranulation-TAS-  
GO:0061025membrane fusion-TAS1530588  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0035578azurophil granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21779349Smoking and COX-2 functional polymorphisms interact to increase the risk of gastric cardia adenocarcinoma in Chinese population. (2011)Zhang XMPLoS One
28457683[Epidemiology and natural history of giant cell arteritis]. (2017 Oct)Mahr ARev Med Interne
23507055Cardiovascular disease due to accelerated atherosclerosis in systemic vasculitides. (2013 Feb)Cohen Tervaert JWBest Pract Res Clin Rheumatol
18046624An investigation on the polymorphisms of two DNA repair genes and susceptibility to ESCC and GCA of high-incidence region in northern China. (2009 Feb)Wang NMol Biol Rep
26485766Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population. (2015 Dec 15)Qiu LXOncotarget
26770518Genetic variations in MTHFR and gastric cardia adenocarcinoma susceptibility in the Chinese Han population. (2015)Wang YInt J Clin Exp Med
26203295Altered placental DNA methylation patterns associated with maternal smoking: current perspectives. (2015 May 7)Maccani JZAdv Genomics Genet
15319302The functional SNP in the matrix metalloproteinase-3 promoter modifies susceptibility and lymphatic metastasis in esophageal squamous cell carcinoma but not in gastric cardiac adenocarcinoma. (2004 Dec)Zhang JCarcinogenesis
16480585[Association of polymorphisms of p21cip1 and p27kip1 genes with susceptibilities of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. (2006 Feb)Guo WAi Zheng
26617241N-Acetyltransferase 2 (NAT2) genetic variation and the susceptibility to noncardiac gastric adenocarcinoma in Taiwan. (2016 Mar)Chang CHJ Chin Med Assoc
25476857Associations between polymorphisms of HOTAIR and risk of gastric cardia adenocarcinoma in a population of north China. (2015 Apr)Guo WTumour Biol
21940365Functional polymorphisms in FAS/FASL system contribute to the risk of occurrence but not progression of gastric cardiac adenocarcinoma. (2012 Jan-Feb)Zhang WHepatogastroenterology
17094900[Correlation of p73 polymorphisms to genetic susceptibilities to esophageal carcinoma and gastric cardiac carcinoma]. (2006 Nov)Ge HAi Zheng
12854127NQO1 C609T polymorphism associated with esophageal cancer and gastric cardiac carcinoma in North China. (2003 Jul)Zhang JHWorld J Gastroenterol
25837767Association between catalase gene polymorphisms and risk of chronic hepatitis B, hepatitis B virus-related liver cirrhosis and hepatocellular carcinoma in Guangxi population: a case-control study. (2015 Apr)Liu YMedicine (Baltimore)
19125794PTEN polymorphisms and the risk of esophageal carcinoma and gastric cardiac carcinoma in a high incidence region of China. (2008)Ge HDis Esophagus
17138534[The association of MMP-13 polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. (2006 Dec)Zhang XJYi Chuan
15930031The functional polymorphism in the matrix metalloproteinase-7 promoter increases susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma. (2005 Oct)Zhang JCarcinogenesis
23991993B-cell Lymphoma 2 rs17757541 C>G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population. (2013)Li QAsian Pac J Cancer Prev
26221374Programmed death-1 (PD-1) polymorphism is associated with gastric cardia adenocarcinoma. (2015)Tang WInt J Clin Exp Med
21148629Association of candidate genetic variations with gastric cardia adenocarcinoma in Chinese population: a multiple interaction analysis. (2011 Mar)Liu LCarcinogenesis
15962389Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China. (2005 Jun 21)Wang YMWorld J Gastroenterol
16536979[Correlations between serine hydroxymethyltransferase1 C1420T polymorphisms and susceptibilities to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. (2006 Mar)Wang YMAi Zheng
29588230Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning. (2018 May)Dozmorov MGBrain Behav Immun
17355791[Correlations of XRCC5 polymorphisms to genetic susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a high incidence region]. (2007 Mar)Dong XJAi Zheng
27105532Genetic variant of miR-146a rs2910164 C>G and gastric cancer susceptibility. (2016 Jun 7)Xia ZGOncotarget
16965652[Correlation of XPC Ala499Val and Lys939Gln polymorphisms to risks of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. (2006 Sep)Zhou RMAi Zheng
22161620Diabetes and risk of esophageal and gastric adenocarcinomas. (2012 Sep 15)Jiang XInt J Cancer
15832405No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China. (2005 Apr 28)Jin XWorld J Gastroenterol
26154995Esophageal Squamous Cell Carcinoma and Gastric Cardia Adenocarcinoma Shared Susceptibility Locus in C20orf54: Evidence from Published Studies. (2015 Jul 8)Duan FSci Rep
17927872[Correlation of 53BP1 and p53 polymorphisms to susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. (2007 Oct)Cao YYAi Zheng
26910281Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population. (2016 Mar 29)Qiu LXOncotarget
15682481Interleukin-10 -1082 promoter polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a population of high-incidence region of north China. (2005 Feb 14)Guo WWorld J Gastroenterol
21105043Serum thyroglobulin, a biomarker for iodine deficiency, is not associated with increased risk of upper gastrointestinal cancers in a large Chinese cohort. (2011 Nov 1)Lin SWInt J Cancer
6946753Effect of cigarette smoking on duodenogastric reflux of bile acids. (1981 Aug)Yeomans NDAust N Z J Med
15890089[Correlation of E-cadherin polymorphisms to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. (2005 May)Zhang XFAi Zheng