Gene: GALC

2581
-
galactosylceramidase
protein-coding
14q31.3
Ensembl:ENSG00000054983 MIM:606890 Vega:OTTHUMG00000028646 UniprotKB:P54803
NG_011853.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.948e-1 (AD)  5.729e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LMBRD10.9
APH1B0.892
NCSTN0.887
SCARB20.878
SLC35A50.877
OSGEPL10.871
CLIP40.869
PTCD30.866
HSD17B40.863
UBXN40.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.656
OR4F29-0.615
MTRNR2L6-0.267
HMHB1-0.246
RNF223-0.246
IFNG-0.244
MTRNR2L9-0.243
TTLL10-0.235
FCER2-0.234
MTRNR2L10-0.231

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALC mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALC mRNA"27188386
D001104ArbutinArbutin results in increased expression of GALC mRNA17103032
C547126AZM551248AZM551248 results in decreased expression of GALC mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GALC mRNA22228805
D004958EstradiolEstradiol results in decreased expression of GALC mRNA21185374
C006780bisphenol Abisphenol A results in decreased expression of GALC mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of GALC mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GALC gene20938992
D003520CyclophosphamideGALC protein affects the susceptibility to Cyclophosphamide16217747
C014347decitabinedecitabine results in decreased methylation of GALC gene27923600
D013759DronabinolDronabinol results in decreased expression of GALC mRNA18584336
D004041Dietary FatsDietary Fats results in increased expression of GALC mRNA25016146
C118739entinostatentinostat results in decreased expression of GALC mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALC mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GALC mRNA17555576
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GALC gene20938992
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of GALC mRNA24297863
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GALC mRNA23086925|2675264
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GALC gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GALC mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GALC mRNA"20188158
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of GALC mRNA25380136
C029938nickel sulfatenickel sulfate results in decreased expression of GALC mRNA22714537
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GALC mRNA22714537
C017947sodium arsenitesodium arsenite affects the methylation of GALC gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of GALC mRNA28595984
D013629TamoxifenTamoxifen affects the expression of GALC mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GALC promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GALC mRNA19465110
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GALC mRNA20133372
D014415TunicamycinTunicamycin results in increased expression of GALC mRNA17127020
D014635Valproic AcidValproic Acid affects the expression of GALC mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GALC mRNA23179753|2493525
C066075vanadium pentoxidevanadium pentoxide affects the expression of GALC mRNA26210822
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GALC gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of GALC mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004336galactosylceramidase activity-ISS-  
GO:0004336galactosylceramidase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006683galactosylceramide catabolic process-ISS-  
GO:0006687glycosphingolipid metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-TAS7601472  
GO:0043202lysosomal lumen-TAS-  
KEGG ID KEGG Term
hsa00600Sphingolipid metabolism
hsa01100Metabolic pathways
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1660662Glycosphingolipid metabolismTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25101718IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. (2015 Mar)Lee JHAm J Respir Cell Mol Biol