Gene: TNFAIP8

25816
GG2-1|MDC-3.13|NDED|SCC-S2|SCCS2
TNF alpha induced protein 8
protein-coding
5q23.1
Ensembl:ENSG00000145779 MIM:612111 Vega:OTTHUMG00000162949 UniprotKB:O95379
NC_000005.10
SNP Mapped
3   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.249e-1 (AD)  1.775e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3813301chr5:119339551 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs17164572chr5:119338002 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs7704398chr5:119331947 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23985447chr5:118691066TNFAIP8Promoter2.810e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DAPP10.893
SPTLC30.886
FAM20A0.884
BNC20.876
VEGFC0.876
TFPI0.875
PLCG20.872
ADPRH0.869
FAM129A0.867
TRIM380.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.533
BDH1-0.532
TMEM179-0.522
CYP46A1-0.522
MYADML2-0.52
LRTM2-0.52
KCNIP3-0.515
BCL11A-0.512
CHRNA4-0.509
KCNK4-0.508

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of TNFAIP8 mRNA19933214
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TNFAIP8 mRNA"17547211
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TNFAIP8 mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of TNFAIP8 mRNA19191707
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of TNFAIP8 mRNA19191707
D000082AcetaminophenAcetaminophen affects the expression of TNFAIP8 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TNFAIP8 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TNFAIP8 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TNFAIP8 mRNA27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TNFAIP8 mRNA24449571
D001151ArsenicArsenic affects the methylation of TNFAIP8 gene25304211
C058317arsenic disulfidearsenic disulfide results in increased expression of TNFAIP8 mRNA16918137
C006632arsenic trioxidearsenic trioxide results in increased expression of TNFAIP8 mRNA17547211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of TNFAIP8 mRNA"24160326
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of TNFAIP8 mRNA"25757056
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNFAIP8 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNFAIP8 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNFAIP8 mRNA"19150397
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of TNFAIP8 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of TNFAIP8 mRNA23019147
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TNFAIP8 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of TNFAIP8 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TNFAIP8 promoter23359474
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TNFAIP8 mRNA28628672
C018475butyraldehydebutyraldehyde results in increased expression of TNFAIP8 mRNA26079696
D002104CadmiumCadmium results in increased expression of TNFAIP8 mRNA23369406
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TNFAIP8 mRNA27339419
D002746ChlorpromazineChlorpromazine results in increased expression of TNFAIP8 mRNA25596134
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TNFAIP820938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TNFAIP8 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFAIP8 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of TNFAIP8 mRNA18353800
D004002Clodronic AcidClodronic Acid results in increased expression of TNFAIP8 mRNA25596134
D016572CyclosporineCyclosporine results in decreased expression of TNFAIP8 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased expression of TNFAIP8 mRNA25562108
D003907DexamethasoneDexamethasone results in increased expression of TNFAIP8 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TNFAIP8 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TNFAIP8 mRNA28628672
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TNFAIP8 promoter23359474
D002945CisplatinCisplatin results in increased expression of TNFAIP8 mRNA25596134|2739243
D002945CisplatinTNFAIP8 results in decreased susceptibility to Cisplatin21969086
D002945CisplatinCisplatin results in increased expression of TNFAIP8 mRNA21151649
C000944dicrotophosdicrotophos results in decreased expression of TNFAIP8 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TNFAIP8 mRNA26924002
D004026DieldrinDieldrin affects the expression of TNFAIP8 mRNA22546817
D004041Dietary FatsDietary Fats results in decreased expression of TNFAIP8 mRNA18042831
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TNFAIP8 promoter23359474
D002117CalcitriolCalcitriol results in increased expression of TNFAIP8 mRNA16002434
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TNFAIP8 mRNA17547211
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TNFAIP8 mRNA25380136
D004237DiuronDiuron results in decreased expression of TNFAIP8 mRNA21551480
D004317DoxorubicinDoxorubicin results in decreased expression of TNFAIP8 mRNA25896364
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TNFAIP8 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TNFAIP8 mRNA17351261
C082360fipronilfipronil results in increased expression of TNFAIP8 mRNA23962444
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TNFAIP820938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TNFAIP8 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFAIP8 mRNA20938992
D019833GenisteinGenistein results in decreased expression of TNFAIP8 mRNA15378649
D005839GentamicinsGentamicins results in increased expression of TNFAIP8 mRNA22061828
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of TNFAIP8 mRNA17183730
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TNFAIP8 protein18951874
D007052IbuprofenIbuprofen results in decreased expression of TNFAIP8 mRNA25596134
D007069IfosfamideIfosfamide results in increased expression of TNFAIP8 mRNA25596134
C016517indole-3-carbinolindole-3-carbinol affects the expression of TNFAIP8 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TNFAIP8 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TNFAIP8 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TNFAIP8 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TNFAIP8 mRNA28628672
C410337K 7174K 7174 results in increased expression of TNFAIP8 mRNA24086573
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TNFAIP8 mRNA26378955
D008628MercuryMercury results in increased expression of TNFAIP8 mRNA17547211
D008628MercuryMercury results in decreased expression of TNFAIP8 mRNA22688007
D008687MetforminMetformin results in increased expression of TNFAIP8 mRNA25596134
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TNFAIP820938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TNFAIP8 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFAIP8 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of TNFAIP8 mRNA17400583
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TNFAIP8 mRNA26924002
C437683motexafin gadoliniummotexafin gadolinium results in decreased expression of TNFAIP8 mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFAIP8 mRNA16357179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TNFAIP8 mRNA"25554681
C022838nickel chloridenickel chloride results in increased expression of TNFAIP8 mRNA17312168|1754721
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TNFAIP8 mRNA"12756304
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TNFAIP8 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of TNFAIP8 mRNA25596134
D010100OxygenOxygen deficiency results in increased expression of TNFAIP8 mRNA24205000
D000073878Palm OilPalm Oil results in decreased expression of TNFAIP8 mRNA18042831
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of TNFAIP8 mRNA28973697
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TNFAIP8 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TNFAIP8 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TNFAIP8 mRNA22079256|2271453
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of TNFAIP8 mRNA20660070
D011441PropylthiouracilPropylthiouracil affects the expression of TNFAIP8 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TNFAIP8 mRNA27029645
D011794QuercetinQuercetin results in increased expression of TNFAIP8 mRNA21632981
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the expression of TNFAIP8 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TNFAIP8 mRNA19073995
D012822Silicon DioxideSilicon Dioxide results in increased expression of TNFAIP8 mRNA23221170
D012999SomanSoman results in decreased expression of TNFAIP8 mRNA19281266
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TNFAIP8 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNFAIP8 mRNA21570461
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TNFAIP8 protein18951874
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TNFAIP8 mRNA22363418
C066340tolcaponetolcapone binds to TNFAIP8 protein19783845
D019772TopotecanTNFAIP8 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TNFAIP8 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of TNFAIP8 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased methylation of TNFAIP8 gene27618143
C012589trichostatin Atrichostatin A affects the expression of TNFAIP8 mRNA28542535
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TNFAIP8 mRNA29024780
D014520UrethaneUrethane results in decreased expression of TNFAIP8 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of TNFAIP8 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of TNFAIP8 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TNFAIP8 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of TNFAIP8 mRNA19101580
D014640VancomycinVancomycin results in increased expression of TNFAIP8 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TNFAIP8 gene25487561
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TNFAIP8 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of TNFAIP8 mRNA26682919
D014800VitalliumVitallium analog results in increased expression of TNFAIP8 mRNA23825117
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFAIP8 mRNA16357179
D019345Zinc AcetateZinc Acetate results in decreased expression of TNFAIP8 mRNA16357179
C088658zoledronic acidzoledronic acid results in increased expression of TNFAIP8 mRNA24714768|2559613

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  21516116  25416956  
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process-IBA21873635  
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process-IMP10644768  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0043065positive regulation of apoptotic process-IMP10644768  
GO:0043066negative regulation of apoptotic process-TAS10644768  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA14724590  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483255PI MetabolismTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal