Gene: FAM19A5

25817
QLLK5208|TAFA-5|TAFA5|UNQ5208
family with sequence similarity 19 member A5, C-C motif chemokine like
protein-coding
22q13.32
Ensembl:ENSG00000219438 MIM:617499 Vega:OTTHUMG00000150308 UniprotKB:Q7Z5A7
NC_000022.11
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.711e-1 (AD)  2.275e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs5771934chr22:48673638 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs16999684chr22:48671066 (GRCh38.p7)A>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00481629chr22:48972850FAM19A52.600e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXW50.918
DDA10.914
CKB0.914
POLR3H0.906
LRP30.901
LRRC4B0.9
MLST80.899
UBXN60.899
MAP2K20.898
AES0.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.772
OR4F29-0.731
KCNJ15-0.419
TNFAIP8-0.4
C2orf83-0.397
TFPI2-0.394
PZP-0.393
SLC16A12-0.389
FOLR3-0.388
LILRB2-0.385

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM19A5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM19A5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM19A5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM19A5 mRNA"27188386
D001151ArsenicArsenic affects the methylation of FAM19A5 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of FAM19A5 mRNA20458559
D001280AtrazineAtrazine results in decreased expression of FAM19A5 mRNA25929836
D001379AzathioprineAzathioprine results in decreased expression of FAM19A5 mRNA21621594
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FAM19A5 mRNA20106945|2163298
C006780bisphenol Abisphenol A results in decreased expression of FAM19A5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FAM19A5 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of FAM19A5 mRNA22079614
D019327Copper SulfateCopper Sulfate results in decreased expression of FAM19A5 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in increased expression of FAM19A5 mRNA21621594
D016572CyclosporineCyclosporine results in decreased expression of FAM19A5 mRNA25562108
D016572CyclosporineCyclosporine results in decreased methylation of FAM19A5 promoter27989131
D016572CyclosporineCyclosporine results in increased expression of FAM19A5 mRNA21621594
D003907DexamethasoneDexamethasone results in increased expression of FAM19A5 mRNA21621594
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FAM19A5 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FAM19A5 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of FAM19A5 mRNA27392435
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FAM19A5 mRNA27392435
C410337K 7174K 7174 results in decreased expression of FAM19A5 mRNA24086573
D008694MethamphetamineMethamphetamine results in decreased expression of FAM19A5 mRNA26307267
D008727MethotrexateMethotrexate results in decreased expression of FAM19A5 mRNA21621594
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FAM19A5 mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM19A5 mRNA"27188386
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of FAM19A5 mRNA24810058
D009532NickelNickel results in decreased expression of FAM19A5 mRNA25583101
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM19A5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of FAM19A5 mRNA26272509
D011239PrednisolonePrednisolone results in increased expression of FAM19A5 mRNA21621594
D011794QuercetinQuercetin results in decreased expression of FAM19A5 mRNA21632981
C031389resorcinolresorcinol results in increased expression of FAM19A5 mRNA22623647
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FAM19A5 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FAM19A5 mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAM19A5 mRNA26377647
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of FAM19A5 gene26756918
D014212TretinoinTretinoin results in decreased expression of FAM19A5 mRNA21934132
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FAM19A5 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of FAM19A5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FAM19A5 mRNA19101580|2915479
D014635Valproic AcidValproic Acid results in increased methylation of FAM19A5 gene29154799
C025643vinclozolinvinclozolin affects the expression of FAM19A5 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal