Gene: KLK5

25818
KLK-L2|KLKL2|SCTE
kallikrein related peptidase 5
protein-coding
19q13.41
Ensembl:ENSG00000167754 MIM:605643 Vega:OTTHUMG00000183097 UniprotKB:Q9Y337
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
4.842e-1 (AD)  9.229e-2 (ND)   (Frontal_Cortex)
6.029e-1 (AD)  8.911e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLK70.737
MCHR10.717
ABCC120.689
LRRC730.685
KCNK30.683
PRSS120.674
NREP0.664
ZNRF10.663
CGREF10.661
RGS60.661

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.568
OTUD7B-0.521
CPM-0.517
YES1-0.51
ACTL6A-0.5
ZHX2-0.497
HEY2-0.491
SEPT10-0.491
CHST14-0.49
HVCN1-0.49

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of KLK5 mRNA17562736
D002922CiguatoxinsCiguatoxins affects the expression of KLK5 mRNA18353800
D019343Citric AcidCitric Acid results in increased activity of KLK5 protein16517595
C018021cobaltous chloridecobaltous chloride results in increased expression of KLK5 mRNA21139344
D019327Copper SulfateCopper Sulfate results in increased expression of KLK5 mRNA19549813
D003976DiazinonDiazinon results in increased methylation of KLK5 gene22964155
D002945CisplatinKLK5 protein affects the susceptibility to Cisplatin16217747
D002117CalcitriolCalcitriol results in increased expression of KLK5 mRNA26485663
D009538NicotineNicotine results in increased expression of KLK5 mRNA23825647
C046012pentanalpentanal results in decreased expression of KLK5 mRNA26079696
D011374Progesterone[Progesterone results in increased activity of PGR protein] which results in increased expression of KLK5 mRNA15845616
D012906SmokeSmoke results in decreased expression of KLK5 mRNA21095227
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of KLK5 mRNA27480279
D014635Valproic AcidValproic Acid results in increased methylation of KLK5 gene29154799
D015032ZincSEMG1 protein inhibits the reaction [Zinc results in decreased activity of KLK5 protein]16517595
D015032ZincSEMG2 protein inhibits the reaction [Zinc results in decreased activity of KLK5 protein]16517595
D015032ZincZinc results in decreased activity of KLK5 protein16517595

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activity-TAS-  
GO:0004252serine-type endopeptidase activity-EXP16885167  
GO:0004252serine-type endopeptidase activity-IDA16885167  
GO:0004252serine-type endopeptidase activity-NAS11054574  
GO:0005515protein binding-IPI19194479  23629652  
GO:0008233peptidase activity-IMP17012259  
GO:0008236serine-type peptidase activity-TAS10514489  
GO ID GO Term Qualifier Evidence PubMed
GO:0002803positive regulation of antibacterial peptide production-IBA21873635  
GO:0002803positive regulation of antibacterial peptide production-IMP17012259  
GO:0006508proteolysis-IEA-  
GO:0008544epidermis development-TAS10514489  
GO:0022617extracellular matrix disassembly-IBA21873635  
GO:0045745positive regulation of G-protein coupled receptor protein signaling pathway-IDA16885167  
GO:0070268cornification-TAS-  
GO:0097186amelogenesis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IMP17012259  
GO:0005829cytosol-TAS-  
GO:0030141secretory granule-IBA21873635  
GO:0097209epidermal lamellar body-IDA15675955  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-6805567KeratinizationTAS
R-HSA-6805567KeratinizationIEA
R-HSA-6809371Formation of the cornified envelopeTAS
R-HSA-6809371Formation of the cornified envelopeIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18316555A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. (2008 Mar 1)Planque CClin Cancer Res