Gene: PRDX5

25824
ACR1|AOEB166|B166|HEL-S-55|PLP|PMP20|PRDX6|PRXV|SBBI10|prx-V
peroxiredoxin 5
protein-coding
11q13.1
Ensembl:ENSG00000126432 MIM:606583 Vega:OTTHUMG00000168805 UniprotKB:P30044
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.991e-1 (AD)  1.685e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDUFB100.972
MEA10.965
NDUFB110.963
UQCRH0.962
CUEDC20.96
MRPS210.96
GPX40.959
NDUFA80.958
ATP6V1F0.958
CUTA0.957

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.851
OR4F29-0.832
IL18RAP-0.274
KCNJ15-0.274
CXCR2-0.269
MTRNR2L6-0.26
CXCR1-0.255
FCGR3B-0.245
MMP9-0.245
VNN3-0.244

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PRDX5 mRNA"23962555
C0821644-methoxycinnamate methyl ester4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA]19442820
D000082AcetaminophenAcetaminophen results in decreased expression of PRDX5 mRNA25704631
D000117AcetylglucosamineAcetylglucosamine results in increased expression of PRDX5 mRNA18047607
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRDX5 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PRDX5 mRNA24449571
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"[arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide co-treated with Herbicides] results in increased expression of PRDX5 mRNA"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"[arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide co-treated with triclopyr] results in increased expression of PRDX5 mRNA"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Herbicides results in decreased expression of PRDX5 mRNA]"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX5 mRNA]"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide results in increased expression of PRDX5 mRNA"21318024
D001151ArsenicArsenic results in increased expression of PRDX5 protein19818359
C006632arsenic trioxidearsenic trioxide results in increased expression of PRDX5 mRNA25258189
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRDX5 mRNA22228805
D004958EstradiolEstradiol results in increased expression of PRDX5 protein22070562
D004958Estradiol[Medroxyprogesterone Acetate co-treated with Estradiol] affects the expression of PRDX521159850
C006780bisphenol Abisphenol A results in increased expression of PRDX5 protein25772901
C006780bisphenol Abisphenol A affects the expression of PRDX5 mRNA25181051
D002065BuspironeBuspirone results in increased expression of PRDX5 mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PRDX5 mRNA14729362
C037123cadmium sulfatecadmium sulfate results in increased expression of PRDX5 mRNA17328222
C040048caffeic acidcaffeic acid promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA]19442820
D002220CarbamazepineCarbamazepine affects the expression of PRDX5 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PRDX5 mRNA25471833
D002251Carbon TetrachlorideQuercetin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PRDX5 mRNA]25471833
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of PRDX5 mRNA28954213
C100187chloropicrinchloropicrin affects the expression of PRDX5 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PRDX5 gene20938992
D002995Clofibric AcidClofibric Acid affects the expression of PRDX5 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in increased expression of PRDX5 mRNA24386269
D003042CocaineCocaine affects the expression of PRDX5 protein19393250
D019327Copper SulfateCopper Sulfate results in decreased expression of PRDX5 mRNA19789285
D016572CyclosporineCyclosporine results in decreased expression of PRDX5 mRNA25562108
C017160cypermethrincypermethrin results in increased expression of PRDX5 mRNA21142847
C014347decitabinedecitabine affects the expression of PRDX5 mRNA23300844
C014347decitabinedecitabine results in increased expression of PRDX5 mRNA20231622
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PRDX5 mRNA28659758
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PRDX5 mRNA]27941970
C492519diarylpropionitrilediarylpropionitrile results in increased expression of PRDX5 protein22070562
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PRDX5 mRNA21266533
D002945CisplatinCisplatin affects the expression of PRDX5 mRNA23300844
D002945CisplatinCisplatin results in increased expression of PRDX5 protein22023808
D004317DoxorubicinDoxorubicin results in decreased expression of PRDX5 protein21251210
D004317DoxorubicinDoxorubicin results in increased expression of PRDX5 mRNA21463615
D004317DoxorubicinDoxorubicin results in increased expression of PRDX5 protein21463615
D004317DoxorubicinMT1 affects the reaction [Doxorubicin results in increased expression of PRDX5 mRNA]21463615
D004317DoxorubicinMT1 affects the reaction [Doxorubicin results in increased expression of PRDX5 protein]21463615
D004317DoxorubicinMT2 affects the reaction [Doxorubicin results in increased expression of PRDX5 mRNA]21463615
D004317DoxorubicinMT2 affects the reaction [Doxorubicin results in increased expression of PRDX5 protein]21463615
D004317Doxorubicinsodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of PRDX5 protein]21251210
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA]"19442820
D005419FlavonoidsFlavonoids results in decreased expression of PRDX5 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PRDX5 gene20938992
C435770gambierol[Okadaic Acid co-treated with gambierol] results in decreased expression of PRDX5 protein19397276
D006108GraphiteGraphite results in increased expression of PRDX5 protein22157353
D006540Herbicides"[arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide co-treated with Herbicides] results in increased expression of PRDX5 mRNA"21318024
D006540Herbicides"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Herbicides results in decreased expression of PRDX5 mRNA]"21318024
D006540HerbicidesHerbicides results in decreased expression of PRDX5 mRNA21318024
D006540HerbicidesHerbicides results in increased expression of PRDX5 mRNA21318024
D006861Hydrogen PeroxidePRDX5 protein affects the susceptibility to Hydrogen Peroxide21051700
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PRDX5 mRNA14729362
C492448ICG 001ICG 001 results in increased expression of PRDX5 mRNA26191083
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of PRDX5 mRNA28954213
D008094LithiumLithium results in increased expression of PRDX5 protein18296634
D014975LuteinLutein results in decreased expression of PRDX5 mRNA24865317
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate affects the expression of PRDX521159850
D017258Medroxyprogesterone Acetate[Medroxyprogesterone Acetate co-treated with Estradiol] affects the expression of PRDX521159850
D008694MethamphetamineMethamphetamine results in increased expression of PRDX5 mRNA19149911
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PRDX5 gene20938992
D0156551-Methyl-4-phenylpyridiniumPRDX5 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium18262354
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of PRDX5 protein20600802
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PRDX5 protein"22157353
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PRDX5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PRDX5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PRDX5 mRNA"19836432
C051752nefazodonenefazodone results in increased expression of PRDX5 mRNA24136188
C028007nickel monoxidenickel monoxide results in increased expression of PRDX5 mRNA19167457
C012655nimesulidenimesulide results in increased expression of PRDX5 mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of PRDX5 protein19716841
D019319Okadaic Acid[Okadaic Acid co-treated with gambierol] results in decreased expression of PRDX5 protein19397276
D019319Okadaic AcidOkadaic Acid results in decreased expression of PRDX5 protein19397276
D010269ParaquatParaquat results in increased expression of PRDX5 mRNA22996356
D010269Paraquat[Quercetin co-treated with Paraquat] results in increased expression of PRDX5 mRNA22996356
D010416PentachlorophenolPentachlorophenol results in decreased expression of PRDX5 mRNA24642059
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of PRDX5 mRNA21984479
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PRDX5 protein26178269
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PRDX5 mRNA28659758
D010695PhlorhizinPhlorhizin results in decreased expression of PRDX5 mRNA22538082
D010846Picloram"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX5 mRNA]"21318024
D010846PicloramPicloram results in decreased expression of PRDX5 mRNA21318024
C006253pirinixic acidpirinixic acid results in increased expression of PRDX5 mRNA23517768
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of PRDX5 mRNA27989595
D011374ProgesteroneProgesterone results in decreased expression of PRDX5 mRNA23018184
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PRDX5 mRNA28659758
D011791QuartzQuartz affects the expression of PRDX5 mRNA19836432
D011794Quercetin[Quercetin co-treated with Paraquat] results in increased expression of PRDX5 mRNA22996356
D011794QuercetinQuercetin results in increased expression of PRDX5 mRNA21051700|2299635
D011794QuercetinQuercetin results in increased expression of PRDX5 protein21051700
D011794QuercetinQuercetin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PRDX5 mRNA]25471833
D012834SilverSilver results in decreased expression of PRDX5 mRNA22576574
C031618sodium nitratesodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of PRDX5 protein]21251210
C031618sodium nitratesodium nitrate results in increased expression of PRDX5 protein22484629
D018038Sodium SeleniteSodium Selenite results in increased expression of PRDX5 mRNA18175754
D013311StreptozocinPRDX4 protein inhibits the reaction [Streptozocin results in decreased expression of PRDX5 mRNA]20446767
D013311StreptozocinStreptozocin results in decreased expression of PRDX5 mRNA20446767
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRDX5 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRDX5 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of PRDX5 mRNA28973375
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of PRDX5 protein"25852303
D019284Thapsigargin4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA]19442820
D019284Thapsigargincaffeic acid promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA]19442820
D019284Thapsigargin"Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA]"19442820
D019284ThapsigarginThapsigargin results in decreased expression of PRDX5 mRNA19442820
D019284ThapsigarginThapsigargin results in increased expression of PRDX5 mRNA22378314
D014050TolueneToluene affects the expression of PRDX5 mRNA21827849
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PRDX5 mRNA28973375
C032742triclopyr"[arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide co-treated with triclopyr] results in increased expression of PRDX5 mRNA"21318024
C032742triclopyrtriclopyr results in increased expression of PRDX5 mRNA21318024
D014415TunicamycinTunicamycin results in increased expression of PRDX5 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of PRDX5 mRNA25979313
C025643vinclozolinvinclozolin results in decreased expression of PRDX5 mRNA23555832
C025643vinclozolinvinclozolin results in increased expression of PRDX5 mRNA22570695
C111237vorinostatvorinostat results in increased expression of PRDX5 protein20543569

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001016RNA polymerase III regulatory region DNA binding-IDA10095767  
GO:0004601peroxidase activity-IDA10521424  
GO:0005102signaling receptor binding-IPI20178365  
GO:0008379thioredoxin peroxidase activity-EXP10514471  10521424  10751410  15280035  17519234  17707404  
21385867  
GO:0008379thioredoxin peroxidase activity-IBA21873635  
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process-IMP18262354  
GO:0046983protein dimerization activity-IDA15046979  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0006954inflammatory response-TAS10521424  
GO:0006979response to oxidative stress-IDA10521424  
GO:0016480negative regulation of transcription by RNA polymerase III-IDA10095767  
GO:0034599cellular response to oxidative stress-IBA21873635  
GO:0034599cellular response to oxidative stress-TAS-  
GO:0034614cellular response to reactive oxygen species-IMP18262354  
GO:0042744hydrogen peroxide catabolic process-IBA21873635  
GO:0043066negative regulation of apoptotic process-IMP18262354  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0045454cell redox homeostasis-IBA21873635  
GO:0045454cell redox homeostasis-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA23580065  
GO:0005634nucleus-IDA10095767  15785239  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA15785239  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA10521424  10751410  18262354  
GO:0005759mitochondrial matrix-TAS-  
GO:0005777peroxisome-IBA21873635  
GO:0005777peroxisome-IDA10521424  
GO:0005782peroxisomal matrix-IEA-  
GO:0005829cytosol-IDA18262354  
GO:0005829cytosol-TAS-  
GO:0031410cytoplasmic vesicle-IDA10095767  
GO:0043231intracellular membrane-bounded organelle-IDA15785239  
GO:0048471perinuclear region of cytoplasm-IDA10095767  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
KEGG ID KEGG Term
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3299685Detoxification of Reactive Oxygen SpeciesTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22387199Genetic variation in antioxidant enzymes and lung function. (2012 May 1)Bentley ARFree Radic Biol Med