Gene: PRKD2

25865
HSPC187|PKD2|nPKC-D2
protein kinase D2
protein-coding
19q13.32
Ensembl:ENSG00000105287 MIM:607074 Vega:OTTHUMG00000183431 UniprotKB:Q9BZL6
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
9.869e-1 (AD)  8.245e-1 (ND)   (Frontal_Cortex)
6.255e-1 (AD)  8.713e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10412340chr19:46718501 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTBP10.754
PRICKLE30.753
NFKB20.748
SCARF10.74
RELA0.737
HDAC70.736
TOR4A0.735
FERMT30.731
VASP0.73
PPP1R180.728

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.389
SMIM18-0.361
CNTN6-0.36
PPEF1-0.357
SPHKAP-0.351
AARD-0.348
GRIN3A-0.345
KNCN-0.338
FSTL5-0.337
DRD5-0.335

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PRKD2 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PRKD2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PRKD2 mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PRKD2 mRNA19770486
D001151ArsenicArsenic affects the expression of PRKD2 mRNA18414638
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRKD2 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRKD2 mRNA21569818|2222880
C044887beta-methylcholinebeta-methylcholine affects the expression of PRKD2 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of PRKD2 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of PRKD2 mRNA25979313
D016572CyclosporineCyclosporine results in increased expression of PRKD2 mRNA25562108
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of PRKD2 protein23811945
D003976DiazinonDiazinon results in decreased methylation of PRKD2 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PRKD2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PRKD2 mRNA27594783
D002945CisplatinCisplatin results in increased expression of PRKD2 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of PRKD2 mRNA28302478
D004317DoxorubicinDoxorubicin results in increased expression of PRKD2 mRNA25896364
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PRKD2 mRNA23649840
C069837fullerene C60fullerene C60 results in increased expression of PRKD2 mRNA19167457
D017313FenretinideFenretinide results in increased expression of PRKD2 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRKD2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PRKD2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PRKD2 mRNA23086925
D008694MethamphetamineMethamphetamine results in increased expression of PRKD2 mRNA19564919
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PRKD2 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PRKD2 mRNA24810058
C437683motexafin gadoliniummotexafin gadolinium results in decreased expression of PRKD2 mRNA16357179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PRKD2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PRKD2 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of PRKD2 mRNA19167457
D010126OzoneOzone results in decreased expression of PRKD2 mRNA12763052
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of PRKD2 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of PRKD2 mRNA23892564
D012643SeleniumSelenium results in increased expression of PRKD2 mRNA19244175
D012969Sodium FluorideSodium Fluoride results in decreased expression of PRKD2 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRKD2 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRKD2 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of PRKD2 mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of PRKD2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PRKD2 mRNA28111298
C057693troglitazonetroglitazone results in decreased expression of PRKD2 mRNA28973697
D014520UrethaneUrethane results in increased expression of PRKD2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of PRKD2 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of PRKD2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of PRKD2 mRNA17292431
C111237vorinostatvorinostat results in increased expression of PRKD2 mRNA22083351
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of PRKD2 mRNA18593933
D019345Zinc AcetateZinc Acetate results in decreased expression of PRKD2 mRNA16357179

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA17077180  
GO:0004674protein serine/threonine kinase activity-IDA18440775  
GO:0004674protein serine/threonine kinase activity-IMP28428613  
GO:0004674protein serine/threonine kinase activity-NAS11062248  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004697protein kinase C activity-IEA-  
GO:0005080protein kinase C binding-IPI28428613  
GO:0005515protein binding-IPI17962809  19192391  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001938positive regulation of endothelial cell proliferation-IGI20497126  
GO:0001938positive regulation of endothelial cell proliferation-IMP19001381  
GO:0002250adaptive immune response-IEA-  
GO:0006468protein phosphorylation-IDA22228765  
GO:0006468protein phosphorylation-NAS11062248  
GO:0007155cell adhesion-IEA-  
GO:0008219cell death-IMP17077180  
GO:0010595positive regulation of endothelial cell migration-IMP19001381  
GO:0018105peptidyl-serine phosphorylation-IDA18440775  
GO:0018105peptidyl-serine phosphorylation-IMP28428613  
GO:0018107peptidyl-threonine phosphorylation-IMP28428613  
GO:0030148sphingolipid biosynthetic process-TAS-  
GO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway-IMP19001381  
GO:0032743positive regulation of interleukin-2 production-ISS-  
GO:0032757positive regulation of interleukin-8 production-IMP16928771  
GO:0032793positive regulation of CREB transcription factor activity-IGI20497126  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IGI20497126  
GO:0035556intracellular signal transduction-IMP18059339  18440775  
GO:0035924cellular response to vascular endothelial growth factor stimulus-IGI20497126  
GO:0035924cellular response to vascular endothelial growth factor stimulus-IMP18059339  18440775  
GO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway-IGI20497126  
GO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway-IMP18440775  
GO:0043536positive regulation of blood vessel endothelial cell migration-IGI20497126  
GO:0043536positive regulation of blood vessel endothelial cell migration-IMP18440775  
GO:0045743positive regulation of fibroblast growth factor receptor signaling pathway-IMP19001381  
GO:0045766positive regulation of angiogenesis-IGI20497126  
GO:0045766positive regulation of angiogenesis-IMP18440775  19001381  
GO:0045785positive regulation of cell adhesion-IMP17951978  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA17077180  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP18059339  
GO:0046777protein autophosphorylation-IDA17077180  
GO:0046777protein autophosphorylation-TAS21488147  
GO:0048010vascular endothelial growth factor receptor signaling pathway-IMP18059339  
GO:0050852T cell receptor signaling pathway-IDA17077180  
GO:0050862positive regulation of T cell receptor signaling pathway-ISS-  
GO:0051091positive regulation of DNA-binding transcription factor activity-IMP19192391  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IMP15604256  16928771  28428613  
GO:0061154endothelial tube morphogenesis-TAS21488147  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS-  
GO:0089700protein kinase D signaling-IBA21873635  
GO:0089700protein kinase D signaling-IGI20497126  
GO:1901727positive regulation of histone deacetylase activity-IGI20497126  
GO:1902533positive regulation of intracellular signal transduction-IMP18440775  
GO:2000573positive regulation of DNA biosynthetic process-ISS-  
GO:2001028positive regulation of endothelial cell chemotaxis-IMP18440775  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA17077180  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA17077180  
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1660661Sphingolipid de novo biosynthesisTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal