Gene: GALR1

2587
GALNR|GALNR1
galanin receptor 1
protein-coding
18q23
Ensembl:ENSG00000166573 MIM:600377 Vega:OTTHUMG00000132875 UniprotKB:P47211
NG_009223.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.709e-1 (AD)  1.940e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF170.784
MROH50.782
CTHRC10.776
DPPA40.769
FER1L60.759
TBX210.754
GADL10.749
FCRL30.744
COL15A10.736
C2orf830.732

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CABLES1-0.474
TPCN1-0.423
FUT9-0.419
ADCY2-0.414
TMEM221-0.408
CYP46A1-0.408
LGI1-0.405
CDH20-0.404
CNTFR-0.4
NDP-0.4

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GALR1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GALR1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GALR1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GALR1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GALR1 mRNA"25510870
C0174872-mercaptoacetate2-mercaptoacetate results in increased expression of GALR1 mRNA9858361|9928191
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALR1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GALR1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of GALR1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of GALR1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GALR1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GALR1 mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of GALR1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of GALR1 mRNA22079614
D002713ChlorineChlorine results in decreased expression of GALR1 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of GALR1 mRNA18636392
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of GALR1 mRNA24317228
D003847DeoxyglucoseDeoxyglucose results in increased expression of GALR1 mRNA9858361|9928191
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GALR1 mRNA15620428
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of GALR1 mRNA28085963
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GALR1 mRNA15620428
C024629dimethyl phthalatedimethyl phthalate affects the expression of GALR1 mRNA26924002
D004397FonofosFonofos results in increased methylation of GALR1 promoter22847954
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of GALR1 mRNA21782745
C008261lead acetatelead acetate results in decreased expression of GALR1 mRNA22609695
C008261lead acetatelead acetate results in decreased expression of GALR1 mRNA22641619
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GALR1 mRNA12057914
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of GALR1 mRNA21782745
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of GALR1 mRNA24810058
C517284monomethyl phthalatemonomethyl phthalate affects the expression of GALR1 mRNA26924002
C025256nonylphenolnonylphenol results in decreased expression of GALR1 mRNA15620428
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of GALR1 mRNA18636392
D010278ParathionParathion results in increased methylation of GALR1 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GALR1 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALR1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GALR1 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of GALR1 mRNA23557933
C017947sodium arsenitesodium arsenite results in increased expression of GALR1 mRNA12760830
C012568terbufosterbufos results in increased methylation of GALR1 promoter22847954

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004966galanin receptor activity-IBA21873635  
GO:0004966galanin receptor activity-IDA24517231  
GO:0005515protein binding-IPI23597562  25691535  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO:0017046peptide hormone binding-IDA24517231  
GO:0042923neuropeptide binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0007194negative regulation of adenylate cyclase activity-IEA-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007218neuropeptide signaling pathway-TAS7524088  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA24517231  
GO:0051464positive regulation of cortisol secretion-IMP17982695  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-TAS7524088  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21955024Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala. (2012 Jul)Bajo MAddict Biol
23639882The role of galanin system in modulating depression, anxiety, and addiction-like behaviors after chronic restraint stress. (2013 Aug 29)Zhao XNeuroscience
17083333Alcoholism is associated with GALR3 but not two other galanin receptor genes. (2007 Jul)Belfer IGenes Brain Behav
21969124Galanin negatively modulates opiate withdrawal via galanin receptor 1. (2012 Apr)Holmes FEPsychopharmacology (Berl)
22373943Pharmacogenetic association of the galanin receptor (GALR1) SNP rs2717162 with smoking cessation. (2012 Jun)Gold ABNeuropsychopharmacology
21796100The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence. (2011 Oct)Jackson KJNeuropsychopharmacology
25657825Identification and validation of the methylation biomarkers of non-small cell lung cancer (NSCLC). (2015)Guo SClin Epigenetics
24766650Drug addiction and stress-response genetic variability: association study in African Americans. (2014 Jul)Levran OAnn Hum Genet