Gene: MXRA5

25878
-
matrix remodeling associated 5
protein-coding
Xp22.33
Ensembl:ENSG00000101825 MIM:300938 Vega:OTTHUMG00000021083 UniprotKB:Q9NR99
NG_021336.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL15A10.666
FER1L60.658
PZP0.655
PLA2R10.653
LAMC30.651
HMCN10.644
ANO10.641
PROM10.638
IL2RB0.635
NMUR10.624

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BGLAP-0.376
GKAP1-0.364
FAM43B-0.362
NRN1L-0.356
RAB41-0.355
NTSR2-0.351
CLDND2-0.347
C19orf25-0.341
GDF9-0.337
HIST3H2A-0.337

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MXRA5 mRNA"25614096
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of MXRA5 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MXRA5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MXRA5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MXRA5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MXRA5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MXRA5 mRNA26690555
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of MXRA5 mRNA"25351596
D001379AzathioprineAzathioprine results in increased expression of MXRA5 mRNA19192274
C547126AZM551248AZM551248 results in increased expression of MXRA5 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of MXRA5 gene25435355
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of MXRA5 mRNA20660070
C006780bisphenol Abisphenol A affects the expression of MXRA5 mRNA20170705
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MXRA5 mRNA28628672
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MXRA5 mRNA28628672
C584509C646 compoundC646 compound results in increased expression of MXRA5 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of MXRA5 mRNA25979313
C023676chloroquine diphosphatechloroquine diphosphate results in increased expression of MXRA5 mRNA19192274
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MXRA5 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MXRA5 mRNA28628672
D002117CalcitriolCalcitriol results in decreased expression of MXRA5 mRNA26485663
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MXRA5 mRNA20170705|2686566
D019833GenisteinGenistein results in decreased expression of MXRA5 mRNA26865667
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in increased expression of MXRA5 mRNA19192274
C492448ICG 001ICG 001 results in increased expression of MXRA5 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MXRA5 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MXRA5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MXRA5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MXRA5 mRNA28628672
D008727MethotrexateMethotrexate results in increased expression of MXRA5 mRNA19192274
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MXRA5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MXRA5 mRNA26272509
D010894PiroxicamPiroxicam results in increased expression of MXRA5 mRNA19192274
D011374ProgesteroneProgesterone results in decreased expression of MXRA5 mRNA23012394
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of MXRA5 mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of MXRA5 mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of MXRA5 mRNA19690047
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MXRA5 mRNA25351596
D012906SmokeSmoke results in decreased expression of MXRA5 mRNA20015843
C004648testosterone enanthatetestosterone enanthate affects the expression of MXRA5 mRNA17440010
D014212TretinoinTretinoin results in increased expression of MXRA5 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of MXRA5 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of MXRA5 mRNA19140230
D017973Tungsten CompoundsTungsten Compounds results in decreased expression of MXRA5 mRNA28666766
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MXRA5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MXRA5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MXRA5 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of MXRA5 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0071559response to transforming growth factor beta-IBA21873635  
GO:0071559response to transforming growth factor beta-IMP27599751  
GO ID GO Term Qualifier Evidence PubMed
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26406953Matrix-remodeling associated 5 as a novel tissue biomarker predicts poor prognosis in non-small cell lung cancers. (2015)He YCancer Biomark