Gene: TRIM58

25893
BIA2
tripartite motif containing 58
protein-coding
1q44
Ensembl:ENSG00000162722 Vega:OTTHUMG00000040203 UniprotKB:Q8NG06
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.037e-1 (AD)  9.831e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNH10.807
FAM78B0.782
SCN8A0.775
KCNH50.772
NCR3LG10.767
PPM1E0.765
ARHGAP200.764
OR2W30.762
PCDHAC20.759
GRM50.758

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STON2-0.498
ROM1-0.494
NFIA-0.489
S100A1-0.483
COPZ2-0.478
TST-0.476
PHGDH-0.474
HEY2-0.472
TMEM176A-0.468
ACAA2-0.467

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001280AtrazineAtrazine results in increased expression of TRIM58 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of TRIM58 mRNA22323515
C006780bisphenol Abisphenol A results in decreased expression of TRIM58 mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of TRIM58 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of TRIM58 mRNA27523638
D003520CyclophosphamideCyclophosphamide results in increased expression of TRIM58 mRNA27281708
D016572CyclosporineCyclosporine results in decreased methylation of TRIM58 promoter27989131
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TRIM58 mRNA24810058
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TRIM58 mRNA23806026

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0008270zinc ion binding-IEA-  
GO:0045504dynein heavy chain binding-IEA-  
GO:0045505dynein intermediate chain binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-IEA-  
GO:0006511ubiquitin-dependent protein catabolic process-IEA-  
GO:0008150biological_process-ND-  
GO:0051865protein autoubiquitination-IEA-  
GO:0061931positive regulation of erythrocyte enucleation-IEA-  
GO:1902838regulation of nuclear migration along microtubule-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27926516Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma. (2017 Jan 10)Kajiura KOncotarget