Gene: EEF1AKMT3

25895
FAM119B|METTL21B
EEF1A lysine methyltransferase 3
protein-coding
12q14.1
Ensembl:ENSG00000123427 MIM:615258 Vega:OTTHUMG00000170459 UniprotKB:Q96AZ1
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.431e-2 (AD)  7.874e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10877015chr12:57774005 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EEF1AKMT3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EEF1AKMT3 mRNA"27188386
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of EEF1AKMT3 mRNA28522335
D001151ArsenicArsenic affects the methylation of EEF1AKMT3 gene25304211
C044887beta-methylcholinebeta-methylcholine affects the expression of EEF1AKMT3 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of EEF1AKMT3 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of EEF1AKMT3 gene22576693
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EEF1AKMT3 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of EEF1AKMT3 mRNA26272509
D016572CyclosporineCyclosporine results in increased expression of EEF1AKMT3 mRNA27989131
D002945CisplatinCisplatin results in increased expression of EEF1AKMT3 mRNA19561079
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EEF1AKMT3 mRNA26752646
C045463leflunomideleflunomide results in decreased expression of EEF1AKMT3 mRNA28988120
D011794QuercetinQuercetin results in increased expression of EEF1AKMT3 mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in decreased expression of EEF1AKMT3 mRNA25351596
D018038Sodium SeleniteSodium Selenite results in decreased expression of EEF1AKMT3 mRNA18175754
D013849ThimerosalThimerosal results in decreased expression of EEF1AKMT3 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23349634  
GO:0008168methyltransferase activity-IDA28108655  
GO:0016279protein-lysine N-methyltransferase activity-IDA28108655  
GO:0031072heat shock protein binding-IPI23349634  
GO ID GO Term Qualifier Evidence PubMed
GO:0018022peptidyl-lysine methylation-IDA28108655  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA-  
GO:0005737cytoplasm-IDA23349634  28108655  
GO:0005813centrosome-IDA28108655  
GO:0032991protein-containing complex-IDA23349634  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal