Gene: AMBP

259
A1M|EDC1|HCP|HI30|IATIL|ITI|ITIL|ITILC|UTI
alpha-1-microglobulin/bikunin precursor
protein-coding
9q32
Ensembl:ENSG00000106927 MIM:176870 Vega:OTTHUMG00000020534 UniprotKB:P02760
NC_000009.12
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.501e-1 (AD)  7.086e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGA0.772
FGG0.754
FGB0.747
ORM10.669
APOH0.667
APOA20.654
HP0.646
ORM20.635
ALB0.632
GC0.612

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLD5-0.21
SPC24-0.201
PLSCR5-0.2
SP8-0.195
AVPR1B-0.192
NPSR1-0.192
SLC13A2-0.191
GPR45-0.189
PCDHA2-0.188
PRLHR-0.187

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00062Human Serum AlbuminBiotechDrug9048-46-8ApprovedTarget
ID Drug Name Action PubMed
C05440011-(dansylamino)undecanoic acid11-(dansylamino)undecanoic acid binds to AMBP protein16461020
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of AMBP mRNA25596134
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of AMBP mRNA20566314
C0271321-anilino-8-naphthalenesulfonate1-anilino-8-naphthalenesulfonate binds to AMBP protein16461020
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of AMBP mRNA"19692669
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMBP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMBP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMBP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMBP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMBP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMBP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMBP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMBP mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of AMBP mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of AMBP mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of AMBP mRNA18779383|2328805
D020106AcrylamideAcrylamide results in decreased expression of AMBP mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AMBP protein20106945
D016604Aflatoxin B1[Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of AMBP mRNA23288050
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AMBP mRNA23288050
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of AMBP protein"11276964
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of AMBP mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AMBP mRNA16483693
D000666Amphotericin BAmphotericin B results in increased expression of AMBP protein28321043
D000968Antimycin AAntimycin A results in decreased uptake of AMBP protein9019736
C006632arsenic trioxidearsenic trioxide results in increased expression of AMBP mRNA27829220
D001280Atrazine[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of AMBP mRNA16532367
C547126AZM551248AZM551248 results in decreased expression of AMBP mRNA22323515
C044946benazeprilbenazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]16303729
C044946benazeprilbenazepril results in decreased expression of AMBP protein16303729
C044946benazeprilLosartan promotes the reaction [benazepril results in decreased expression of AMBP protein]16303729
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of AMBP mRNA26377693
D053119BenzophenanthridinesBenzophenanthridines analog results in decreased expression of AMBP mRNA22120849
D004958EstradiolEstradiol results in increased expression of AMBP mRNA19484750
C006780bisphenol Abisphenol A affects the expression of AMBP mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of AMBP mRNA25181051
C032036bromobenzenebromobenzene results in increased expression of AMBP mRNA23288050
D019328Buthionine Sulfoximine[Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of AMBP mRNA23288050
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of AMBP mRNA18804290
D002104CadmiumAMBP protein binds to Cadmium23896426
D002104CadmiumCadmium affects the expression of AMBP protein25286916
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AMBP mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AMBP mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of AMBP mRNA17484886
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of AMBP mRNA24763279
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of AMBP mRNA25596134
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of AMBP mRNA18804290
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMBP mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of AMBP mRNA26272509
D003078ColchicineColchicine results in decreased uptake of AMBP protein9019736
D019327Copper SulfateCopper Sulfate results in decreased expression of AMBP mRNA19549813
C009160cyclonitecyclonite results in increased expression of AMBP mRNA25559034
D016572CyclosporineCyclosporine results in decreased expression of AMBP mRNA20106945|2556210
D002945CisplatinCisplatin results in decreased expression of AMBP mRNA27392435
D002945CisplatinCisplatin results in increased secretion of AMBP protein28885000
D004026DieldrinDieldrin results in decreased expression of AMBP mRNA23041725
D004041Dietary FatsDietary Fats results in decreased expression of AMBP mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of AMBP mRNA15171707
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in decreased expression of AMBP mRNA"27840820
D004237Diuron[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of AMBP mRNA16532367
D0192972,4-Dinitrophenol"2,4-Dinitrophenol results in decreased uptake of AMBP protein"9019736
D004317DoxorubicinDoxorubicin results in increased secretion of AMBP protein28885000
C118739entinostatentinostat results in increased expression of AMBP mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMBP mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of AMBP mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AMBP mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AMBP mRNA17942748
C039281furanfuran binds to AMBP protein22240984
C039281furanfuran results in decreased expression of AMBP mRNA15120968|2619464
D005688GalactosamineGalactosamine results in increased expression of AMBP mRNA18779383
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of AMBP mRNA24763279
D006418HemeHeme results in increased expression of AMBP mRNA22096585
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of AMBP mRNA20566314
D006632HistamineAMBP protein results in decreased secretion of Histamine9579392
D007052IbuprofenIbuprofen results in decreased expression of AMBP mRNA25596134
C028904isoproturon[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of AMBP mRNA16532367
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AMBP mRNA26752646
D019808Losartanbenazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]16303729
D019808LosartanLosartan promotes the reaction [benazepril results in decreased expression of AMBP protein]16303729
D019808LosartanLosartan results in decreased expression of AMBP protein16303729
D017997Leukotriene C4AMBP protein results in decreased secretion of Leukotriene C49579392
C042720mercuric bromidemercuric bromide results in increased expression of AMBP mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMBP mRNA"27188386
D008687MetforminMetformin results in decreased expression of AMBP mRNA25596134
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of AMBP mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AMBP mRNA23649840
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of AMBP mRNA12773770
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of AMBP mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AMBP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AMBP mRNA"25554681
D009532NickelAMBP protein binds to Nickel23896426
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of AMBP mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of AMBP mRNA23288050
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of AMBP mRNA27935865
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of AMBP mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AMBP protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AMBP mRNA18804290
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMBP mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of AMBP mRNA26272509
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of AMBP mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of AMBP mRNA20813756
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of AMBP mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of AMBP mRNA19690047
C005556propionaldehydepropionaldehyde results in decreased expression of AMBP mRNA26079696
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of AMBP mRNA22096585
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of AMBP mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of AMBP mRNA24516582
D053260SootSoot results in increased expression of AMBP mRNA26551751
D014284TriiodothyronineTriiodothyronine results in increased expression of AMBP mRNA17403546
D013629TamoxifenTamoxifen affects the expression of AMBP mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AMBP mRNA17884332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AMBP protein16083274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AMBP mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AMBP protein16083274
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AMBP mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AMBP mRNA28213091
D013853ThioacetamideThioacetamide results in increased expression of AMBP mRNA23288050
C009495titanium dioxidetitanium dioxide affects the expression of AMBP mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of AMBP mRNA27760801
D014212TretinoinTretinoin binds to AMBP protein16461020
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of AMBP mRNA]15363585
D014241TrichloroethyleneTrichloroethylene results in decreased expression of AMBP mRNA19448997
D014635Valproic AcidValproic Acid results in decreased expression of AMBP mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of AMBP gene25560391
C025643vinclozolinvinclozolin results in increased expression of AMBP mRNA23869203
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of AMBP mRNA27935865
D015032ZincAMBP protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004867serine-type endopeptidase inhibitor activity-TAS12817471  
GO:0005515protein binding-IPI16140784  16364318  25416956  
GO:0019855calcium channel inhibitor activity-NAS12817471  
GO:0019862IgA binding-IBA21873635  
GO:0019862IgA binding-IDA11877257  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IDA11877257  
GO:0042803protein homodimerization activity-IPI11883904  
GO:0046904calcium oxalate binding-NAS14516400  
GO ID GO Term Qualifier Evidence PubMed
GO:0006898receptor-mediated endocytosis-TAS-  
GO:0007155cell adhesion-NAS9570066  
GO:0007565female pregnancy-NAS10097787  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0016032viral process-IEA-  
GO:0018298protein-chromophore linkage-IEA-  
GO:0030163protein catabolic process-IEA-  
GO:0042167heme catabolic process-NAS11877257  
GO:0046329negative regulation of JNK cascade-TAS12817471  
GO:0050777negative regulation of immune response-NAS10097787  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS11877257  14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005886plasma membrane-IDA12817471  
GO:0009986cell surface-IEA-  
GO:0043231intracellular membrane-bounded organelle-IEA-  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2168880Scavenging of heme from plasmaTAS
R-HSA-2173782Binding and Uptake of Ligands by Scavenger ReceptorsTAS
R-HSA-5653656Vesicle-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10097903Characteristics and prognosis of normoalbuminuric type 1 diabetic patients. (1999 Mar)Poulsen PLDiabetes Care
22241138Can ambulatory blood pressure measurements substitute assessment of subclinical cardiovascular damage? (2012 Mar)Sehestedt TJ Hypertens
922265324-h blood pressure and autonomic function is related to albumin excretion within the normoalbuminuric range in IDDM patients. (1997 Jun)Poulsen PLDiabetologia
10634379No deleterious effects of tight blood glucose control on 24-hour ambulatory blood pressure in normoalbuminuric insulin-dependent diabetes mellitus patients. (2000 Jan)Poulsen PLJ Clin Endocrinol Metab
857373624-h blood pressure recordings in type I diabetic patients. (1995 Oct-Dec)Hansen KWJ Diabetes Complications
22120883Associations between transition-specific stress experience, nocturnal decline in ambulatory blood pressure, and C-reactive protein levels among transgender men. (2012 Jan-Feb)Dubois LZAm J Hum Biol