Gene: MTHFD1L

25902
FTHFSDC1|MTC1THFS|dJ292B18.2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
protein-coding
6q25.1
Ensembl:ENSG00000120254 MIM:611427 Vega:OTTHUMG00000015828 UniprotKB:Q6UB35
NG_029185.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
3   
1.858e-1 (AD)  4.487e-1 (ND)   (Frontal_Cortex)
9.969e-2 (AD)  3.332e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6933598chr6:150938634 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POLR3C0.881
EAF10.876
IARS0.876
BZW20.874
NUP930.872
GFPT10.869
PSMA50.868
AAGAB0.868
CXorf40B0.867
GOLT1B0.864

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.428
RFTN2-0.39
HIGD1B-0.39
OR4F29-0.385
MTRNR2L9-0.384
MTRNR2L6-0.383
EYA2-0.375
MTRNR2L10-0.373
AKR1C3-0.371
P2RY14-0.356

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of MTHFD1L mRNA19041380
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of MTHFD1L mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of MTHFD1L mRNA"19095052
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTHFD1L mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTHFD1L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTHFD1L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTHFD1L mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MTHFD1L mRNA21420995|2570463
D000082AcetaminophenAcetaminophen results in increased expression of MTHFD1L mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MTHFD1L mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MTHFD1L mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MTHFD1L mRNA23630614
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MTHFD1L mRNA24449571
D001104ArbutinArbutin results in decreased expression of MTHFD1L mRNA17103032
D001151ArsenicArsenic affects the methylation of MTHFD1L gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of MTHFD1L mRNA22521957
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of MTHFD1L mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MTHFD1L mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MTHFD1L mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MTHFD1L mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MTHFD1L mRNA20064835
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MTHFD1L mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MTHFD1L mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MTHFD1L mRNA"19150397|2623829
D004958EstradiolEstradiol affects the expression of MTHFD1L mRNA23557687
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of MTHFD1L mRNA]24758408
D004958EstradiolEstradiol affects the expression of MTHFD1L mRNA22574217
D004958EstradiolEstradiol results in increased expression of MTHFD1L mRNA20106945|2475840
D001622BetaineBetaine inhibits the reaction [Copper deficiency affects the expression of MTHFD1L protein]25150618
D001622BetaineBetaine results in decreased expression of MTHFD1L mRNA26391144
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MTHFD1L mRNA28628672
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of MTHFD1L mRNA26496021
C018475butyraldehydebutyraldehyde results in decreased expression of MTHFD1L mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of MTHFD1L mRNA25979313
D002509CephaloridineCephaloridine results in increased expression of MTHFD1L mRNA18500788
D002737ChloropreneChloroprene results in increased expression of MTHFD1L mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFD1L mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MTHFD1L gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MTHFD1L mRNA27858113
D003033Coal TarCoal Tar results in decreased expression of MTHFD1L mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of MTHFD1L mRNA19320972
D003300CopperBetaine inhibits the reaction [Copper deficiency affects the expression of MTHFD1L protein]25150618
D003300CopperCopper deficiency affects the expression of MTHFD1L protein25150618
D019327Copper SulfateCopper Sulfate results in increased expression of MTHFD1L mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of MTHFD1L mRNA20106945|2556210
C014347decitabinedecitabine affects the expression of MTHFD1L mRNA23300844
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MTHFD1L mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MTHFD1L mRNA28628672
D002945CisplatinCisplatin affects the expression of MTHFD1L mRNA23300844
D002945CisplatinCisplatin results in decreased expression of MTHFD1L mRNA19561079|2759478
D002945CisplatinCisplatin results in decreased expression of MTHFD1L mRNA22023808
C118739entinostatentinostat results in decreased expression of MTHFD1L mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MTHFD1L protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MTHFD1L mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MTHFD1L mRNA23649840
D015025ZearalenoneZearalenone results in increased expression of MTHFD1L protein25058043
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFD1L mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MTHFD1L gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of MTHFD1L mRNA23649840
D017313FenretinideFenretinide results in increased expression of MTHFD1L mRNA28973697
C492448ICG 001ICG 001 results in increased expression of MTHFD1L mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MTHFD1L mRNA28628672
C051890irinotecanirinotecan analog results in decreased expression of MTHFD1L mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MTHFD1L mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MTHFD1L mRNA21889194|2290429
C410337K 7174K 7174 results in increased expression of MTHFD1L mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of MTHFD1L mRNA"24972896
D008627Mercuric ChlorideMercuric Chloride results in increased expression of MTHFD1L mRNA16507785
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFD1L mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MTHFD1L gene20938992
D008727MethotrexateMethotrexate results in increased expression of MTHFD1L mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MTHFD1L mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MTHFD1L mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTHFD1L mRNA"27188386
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of MTHFD1L protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MTHFD1L mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of MTHFD1L mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of MTHFD1L mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MTHFD1L mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MTHFD1L mRNA"25620056
D009532NickelNickel results in increased expression of MTHFD1L mRNA24768652|2558310
C000605331OTX015OTX015 results in decreased expression of MTHFD1L mRNA27388964
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MTHFD1L mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of MTHFD1L mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of MTHFD1L mRNA20880076
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of MTHFD1L mRNA19095052
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MTHFD1L protein26879310
D010656PhenylephrinePhenylephrine results in increased expression of MTHFD1L mRNA18158353
D010672PhenytoinPhenytoin results in increased expression of MTHFD1L mRNA20345932
C006253pirinixic acidpirinixic acid results in increased expression of MTHFD1L mRNA23811191
D011192Potassium DichromatePotassium Dichromate results in decreased expression of MTHFD1L protein23718831
D011374ProgesteroneProgesterone results in increased expression of MTHFD1L mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of MTHFD1L mRNA19690047
C059514resveratrolresveratrol results in increased expression of MTHFD1L protein25505154
D053260SootSoot results in increased expression of MTHFD1L mRNA26551751
D013629TamoxifenTamoxifen affects the expression of MTHFD1L mRNA17555576
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of MTHFD1L mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MTHFD1L mRNA20106945|2163298
D019284ThapsigarginThapsigargin results in increased expression of MTHFD1L mRNA22378314
D013853ThioacetamideThioacetamide results in increased expression of MTHFD1L mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MTHFD1L mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MTHFD1L mRNA25729387
D014212TretinoinTretinoin results in decreased expression of MTHFD1L mRNA23724009
D014212TretinoinTretinoin results in increased expression of MTHFD1L mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased expression of MTHFD1L mRNA25549359
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTHFD1L mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of MTHFD1L mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MTHFD1L mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MTHFD1L mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of MTHFD1L mRNA22378314
D014520UrethaneUrethane results in decreased expression of MTHFD1L mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MTHFD1L mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MTHFD1L mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of MTHFD1L gene29154799
D014635Valproic AcidValproic Acid affects the expression of MTHFD1L mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MTHFD1L gene25560391
C025643vinclozolinvinclozolin results in increased expression of MTHFD1L mRNA23869203
C029297vinylidene chloridevinylidene chloride results in increased expression of MTHFD1L mRNA26682919
C111237vorinostatvorinostat results in decreased expression of MTHFD1L mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004329formate-tetrahydrofolate ligase activity-IBA21873635  
GO:0004329formate-tetrahydrofolate ligase activity-IDA12937168  
GO:0004329formate-tetrahydrofolate ligase activity-TAS-  
GO:0004477methenyltetrahydrofolate cyclohydrolase activity-IBA21873635  
GO:0004488methylenetetrahydrofolate dehydrogenase (NADP+) activity-IBA21873635  
GO:0005524ATP binding-IDA16171773  
GO:0042803protein homodimerization activity-IDA16171773  
GO ID GO Term Qualifier Evidence PubMed
GO:0001843neural tube closure-ISS-  
GO:0006760folic acid-containing compound metabolic process-IDA12937168  
GO:0009113purine nucleobase biosynthetic process-IBA21873635  
GO:000925710-formyltetrahydrofolate biosynthetic process-IBA21873635  
GO:0015942formate metabolic process-IDA16171773  
GO:0035999tetrahydrofolate interconversion-IEA-  
GO:0046653tetrahydrofolate metabolic process-IDA12937168  
GO:0046655folic acid metabolic process-TAS-  
GO:0048702embryonic neurocranium morphogenesis-ISS-  
GO:0048703embryonic viscerocranium morphogenesis-ISS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA12937168  
GO:0005759mitochondrial matrix-TAS-  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
hsa00670One carbon pool by folate
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196757Metabolism of folate and pterinesTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22103680Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study. (2011 Nov 21)Wernimont SMBMC Med Genet
25809277Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome. (2015 Aug)Hubacek JAMol Biol Rep
22216278Large scale association analysis identifies three susceptibility loci for coronary artery disease. (2011)Saade SPLoS One