Gene: POT1

25913
CMM10|GLM9|HPOT1
protection of telomeres 1
protein-coding
7q31.33
Ensembl:ENSG00000128513 MIM:606478 Vega:OTTHUMG00000157194 UniprotKB:Q9NUX5
NG_029232.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.811e-1 (AD)  1.860e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH70.886
C5orf150.876
SUZ120.875
SENP60.875
RARS20.872
UBXN40.871
MFSD80.871
ZNF1970.87
NMD30.87
CTDSPL20.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.516
OR4F29-0.485
PTGDR2-0.278
EPPIN-0.235
MMP23B-0.199
LCN1-0.197
HES5-0.185
OR4F16-0.185
MTRNR2L6-0.181
RNF223-0.18

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of POT1 mRNA"26330309
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Tetradecanoylphorbol Acetate] results in increased expression of POT1 mRNA"26330309
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [[Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA]"26330309
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [[Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA]"26330309
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of POT1 mRNA]"26330309
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of POT1 mRNA"26330309
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of POT1 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased methylation of POT1 promoter28329817
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of POT1 mRNA20106945
C006780bisphenol Abisphenol A affects the expression of POT1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of POT1 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of POT1 mRNA15336504
D019327Copper SulfateCopper Sulfate results in decreased expression of POT1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of POT1 mRNA25562108
C000944dicrotophosdicrotophos results in decreased expression of POT1 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of POT1 mRNA26924002
C024629dimethyl phthalatedimethyl phthalate results in increased expression of POT1 mRNA26924002
D004121Dimethyl Sulfoxide"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [[Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA]"26330309
D004121Dimethyl Sulfoxide"3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [[Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA]"26330309
D004121Dimethyl Sulfoxide[Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA26330309
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of POT1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of POT1 mRNA17555576
C544151jinfukangjinfukang results in decreased expression of POT1 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of POT1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of POT1 mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of POT1 mRNA26924002
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of POT1 mRNA25729387
D010936Plant ExtractsPlant Extracts results in increased expression of POT1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of POT1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of POT1 mRNA22079256
D013629TamoxifenTamoxifen affects the expression of POT1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of POT1 mRNA22574217
D013755Tetradecanoylphorbol Acetate"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Tetradecanoylphorbol Acetate] results in increased expression of POT1 mRNA"26330309
D013755Tetradecanoylphorbol Acetate"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of POT1 mRNA]"26330309
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of POT1 mRNA26330309
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of POT1 mRNA25729387
D014212Tretinoin"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [[Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA]"26330309
D014212Tretinoin"3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [[Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA]"26330309
D014212Tretinoin[Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA26330309
C057693troglitazonetroglitazone results in decreased expression of POT1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of POT1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of POT1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of POT1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12768206  15181449  15383534  15657433  16189514  17237768  
19287395  19651898  21044950  22763445  25172512  25416956  
25620558  26496610  
GO:0010521telomerase inhibitor activity-IBA21873635  
GO:0010521telomerase inhibitor activity-IDA15632080  
GO:0017151DEAD/H-box RNA helicase binding-IPI16030011  
GO:0042162telomeric DNA binding-IDA23685356  
GO:0043047single-stranded telomeric DNA binding-IDA15632080  17237767  
GO:0043047single-stranded telomeric DNA binding-IMP12768206  
GO:0061821telomeric D-loop binding-IDA19734539  
GO:0061849telomeric G-quadruplex DNA bindingNOTIDA19734539  
GO:0098505G-rich strand telomeric DNA binding-IBA21873635  
GO:0098505G-rich strand telomeric DNA binding-IDA17237768  21852327  22763445  
GO:19057738-hydroxy-2'-deoxyguanosine DNA binding-IDA19734539  
GO:1990955G-rich single-stranded DNA binding-IDA19734539  
GO ID GO Term Qualifier Evidence PubMed
GO:0007004telomere maintenance via telomerase-IDA12768206  
GO:0016233telomere capping-IBA21873635  
GO:0016233telomere capping-IGI17632522  
GO:0016233telomere capping-IMP15657433  
GO:0016233telomere capping-TAS17237768  
GO:0032202telomere assembly-IDA16043710  
GO:0032210regulation of telomere maintenance via telomerase-IBA21873635  
GO:0032210regulation of telomere maintenance via telomerase-IGI26586433  
GO:0032211negative regulation of telomere maintenance via telomerase-IGI15181449  
GO:0032211negative regulation of telomere maintenance via telomerase-TAS17237768  
GO:0032212positive regulation of telomere maintenance via telomerase-IDA17237768  
GO:0032212positive regulation of telomere maintenance via telomerase-IMP12768206  12781132  
GO:0032508DNA duplex unwinding-IDA16030011  
GO:0051096positive regulation of helicase activity-IDA16030011  
GO:0051973positive regulation of telomerase activity-IDA16043710  17237768  
GO:0051973positive regulation of telomerase activity-IMP15181449  
GO:0051974negative regulation of telomerase activity-IBA21873635  
GO:0051974negative regulation of telomerase activity-IDA15632080  
GO:0060383positive regulation of DNA strand elongation-IDA16043710  
GO:0061820telomeric D-loop disassembly-IGI22039056  
GO:0070200establishment of protein localization to telomere-IMP25589350  
GO:1905774regulation of DNA helicase activity-IDA19734539  
GO:1905776positive regulation of DNA helicase activity-IDA19734539  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric region-IDA12768206  
GO:0000783nuclear telomere cap complex-IBA21873635  
GO:0000783nuclear telomere cap complex-IDA16880378  
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0000784nuclear chromosome, telomeric region-IDA23685356  24270157  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0070187shelterin complex-IDA15383534  23685356  
GO:0070187shelterin complex-IMP21852327  
GO:0070187shelterin complex-TAS17237768  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-157579Telomere MaintenanceTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-171306Packaging Of Telomere EndsTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20056641Multiple genetic variants in telomere pathway genes and breast cancer risk. (2010 Jan)Shen JCancer Epidemiol Biomarkers Prev