Gene: NCR3

259197
1C7|CD337|LY117|MALS|NKp30
natural cytotoxicity triggering receptor 3
protein-coding
6p21.33
Ensembl:ENSG00000204475 MIM:611550 Vega:OTTHUMG00000031123 UniprotKB:O14931
NG_021176.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBM460.739
SLC36A20.666
KRT33A0.664
CRX0.651
FOLR30.65
DEC10.644
TPRX10.631
FOXA30.622
CXCL90.622
LILRA30.598

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNNM1-0.416
CLEC2L-0.416
CAMK1G-0.414
RBFOX1-0.41
ASIC2-0.409
VSTM5-0.406
SH3GL2-0.402
SV2B-0.401
SLITRK5-0.401
SCN1A-0.401

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of NCR3 mRNA26690555
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NCR3 mRNA16483693
C006780bisphenol Abisphenol A affects the methylation of NCR3 promoter27415467
C006780bisphenol Abisphenol A results in decreased expression of NCR3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of NCR3 promoter22457795
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of NCR3 mRNA24763279
C018021cobaltous chloridecobaltous chloride results in decreased expression of NCR3 mRNA24386269
D003300CopperCopper deficiency results in increased expression of NCR3 mRNA26033743
D016572CyclosporineCyclosporine results in increased expression of NCR320736080
D019422Dietary SucroseDietary Sucrose results in increased expression of NCR3 mRNA26033743
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of NCR3 mRNA24763279
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NCR3 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NCR3 mRNA23086925
D009173Mycophenolic AcidMycophenolic Acid results in decreased expression of NCR320736080
C506614PD 0325901PD 0325901 inhibits the reaction [IL15 protein results in increased expression of NCR3 protein]27563819
C506614PD 0325901PD 0325901 inhibits the reaction [IL2 protein results in increased expression of NCR3 protein]27563819
D016559TacrolimusTacrolimus results in increased expression of NCR320736080
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NCR3 mRNA25613284
D004786Toxic ActionsToxic Actions results in decreased expression of NCR3 protein18468695
D014212TretinoinTretinoin results in decreased expression of NCR3 protein17107666
D015032ZincZinc deficiency results in increased expression of NCR3 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18852879  19528259  21422170  21444796  22807449  24275655  
25315772  27754869  
GO:0042802identical protein binding-IPI21444796  22807449  24275655  
GO ID GO Term Qualifier Evidence PubMed
GO:0002429immune response-activating cell surface receptor signaling pathway-IBA21873635  
GO:0002429immune response-activating cell surface receptor signaling pathway-IDA18852879  
GO:0006954inflammatory response-NAS10941844  
GO:0006955immune response-NAS10941844  
GO:0008037cell recognition-TAS16304049  
GO:0030101natural killer cell activation-IBA21873635  
GO:0030101natural killer cell activation-IDA18852879  
GO:0045954positive regulation of natural killer cell mediated cytotoxicity-IBA21873635  
GO:0045954positive regulation of natural killer cell mediated cytotoxicity-IMP16304049  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS7590964  
KEGG ID KEGG Term
hsa04650Natural killer cell mediated cytotoxicity
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29577422NOTCH4 is a possible novel susceptibility gene for dilated cardiomyopathy in the Chinese population: A case-control study. (2018 Mar 26)Shi XJ Clin Lab Anal