Gene: GALT

2592
-
galactose-1-phosphate uridylyltransferase
protein-coding
9p13.3
Ensembl:ENSG00000213930 MIM:606999 Vega:OTTHUMG00000019836 UniprotKB:P07902
NG_009029.2
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.530e-1 (AD)  3.434e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OBSL10.911
ABCB80.903
SNX210.889
RNF2150.88
ACAD90.879
PIGQ0.876
NDUFV10.876
TUBGCP20.875
KIAA0895L0.874
RMND5B0.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.663
OR4F29-0.612
PPBP-0.387
MTRNR2L6-0.38
KCNJ15-0.365
CNTF-0.362
CST7-0.354
TFPI2-0.353
KIAA0040-0.349
MTRNR2L9-0.348

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of GALT mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of GALT mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GALT mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GALT mRNA16483693
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [GALT gene mutant form results in increased susceptibility to Galactose]22773758
D001280AtrazineAtrazine results in increased expression of GALT mRNA22378314
C006780bisphenol Abisphenol A results in increased expression of GALT mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of GALT mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of GALT promoter22457795
C018021cobaltous chloridecobaltous chloride results in decreased expression of GALT mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of GALT mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of GALT mRNA18579281
D016572CyclosporineCyclosporine results in decreased expression of GALT mRNA20106945|2556210
C014347decitabinedecitabine affects the expression of GALT mRNA23300844
D003976DiazinonDiazinon results in increased methylation of GALT gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GALT mRNA21266533
D002945CisplatinCisplatin affects the expression of GALT mRNA23300844
D004121Dimethyl SulfoxideDimethyl Sulfoxide promotes the reaction [GALT gene mutant form results in increased susceptibility to Galactose]22773758
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of GALT mRNA25198161
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GALT mRNA17555576
D011345FenofibrateFenofibrate results in increased expression of GALT mRNA25572481
C039281furanfuran results in increased expression of GALT mRNA26194646
C039281furanfuran results in increased methylation of GALT gene22079235
D005690GalactoseAscorbic Acid inhibits the reaction [GALT gene mutant form results in increased susceptibility to Galactose]22773758
D005690GalactoseDimethyl Sulfoxide promotes the reaction [GALT gene mutant form results in increased susceptibility to Galactose]22773758
D005690GalactoseGALT gene mutant form affects the reaction [Galactose results in increased expression of GSTE7 mRNA]22773758
D005690GalactoseGALT gene mutant form promotes the reaction [Galactose results in increased expression of GSTD6 mRNA]22773758
D005690GalactoseGALT gene mutant form results in increased susceptibility to Galactose22773758
D005690Galactosemangostin inhibits the reaction [GALT gene mutant form results in increased susceptibility to Galactose]22773758
D005690GalactoseParaquat promotes the reaction [GALT gene mutant form results in increased susceptibility to Galactose]22773758
C544151jinfukangjinfukang results in increased expression of GALT mRNA27392435
D007854LeadLead results in decreased expression of GALT mRNA19921347
C021053mangostinmangostin inhibits the reaction [GALT gene mutant form results in increased susceptibility to Galactose]22773758
D008694MethamphetamineMethamphetamine results in increased expression of GALT mRNA26307267
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GALT mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GALT mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GALT mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GALT mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GALT mRNA"25620056
D010269ParaquatParaquat promotes the reaction [GALT gene mutant form results in increased susceptibility to Galactose]22773758
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of GALT mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GALT mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of GALT mRNA19429403
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GALT mRNA19710929
D011374ProgesteroneProgesterone results in decreased expression of GALT mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of GALT mRNA21278054
D012822Silicon DioxideSilicon Dioxide results in decreased expression of GALT mRNA25351596
D013311StreptozocinStreptozocin results in decreased expression of GALT mRNA25905778
C061133tamibarotenetamibarotene results in increased expression of GALT mRNA15498508
D013629TamoxifenTamoxifen affects the expression of GALT mRNA14699072
D013629TamoxifenTamoxifen affects the expression of GALT mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GALT mRNA21570461
D014204Trenbolone AcetateTrenbolone Acetate results in increased expression of GALT mRNA25198161
D014212TretinoinTretinoin results in increased expression of GALT mRNA15498508
D014520UrethaneUrethane results in decreased expression of GALT mRNA28818685
C034028vanadyl sulfatevanadyl sulfate results in decreased expression of GALT mRNA16330358
C029297vinylidene chloridevinylidene chloride results in decreased expression of GALT mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of GALT mRNA"25198161
D015032ZincZinc deficiency results in decreased expression of GALT mRNA12672911

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  25416956  25910212  26871637  
GO:0008108UDP-glucose:hexose-1-phosphate uridylyltransferase activity-EXP1897530  
GO:0008108UDP-glucose:hexose-1-phosphate uridylyltransferase activity-IDA27005423  
GO:0008270zinc ion binding-IDA27005423  
GO ID GO Term Qualifier Evidence PubMed
GO:0006011UDP-glucose metabolic process-IDA27005423  
GO:0006012galactose metabolic process-IDA27005423  
GO:0006258UDP-glucose catabolic process-IEA-  
GO:0019388galactose catabolic process-TAS-  
GO:0033499galactose catabolic process via UDP-galactose-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-IDA20605918  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00052Galactose metabolism
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-5609975Diseases associated with glycosylation precursor biosynthesisTAS
R-HSA-5609978Defective GALT can cause GalactosemiaTAS
R-HSA-70370Galactose catabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21537330Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT. (2011 Jul)Verschuere SLab Invest
7962282Determinants of basal follicle-stimulating hormone levels in premenopausal women. (1994 Oct)Cramer DWJ Clin Endocrinol Metab
18089596Heterozygosity for the classical galactosemia mutation does not affect ovarian reserve and menopausal age. (2007 Dec)Knauff EAReprod Sci