Gene: MYRIP

25924
SLAC2-C|SLAC2C
myosin VIIA and Rab interacting protein
protein-coding
3p22.1
Ensembl:ENSG00000170011 MIM:611790 Vega:OTTHUMG00000131392 UniprotKB:Q8NFW9
NC_000003.12
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.441e-1 (AD)  7.839e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1598994chr3:39934271 (GRCh38.p7)T>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs1599903chr3:39913575 (GRCh38.p7)A>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYTL20.816
KIF1B0.728
MBD20.701
NAB10.691
KIF5C0.678
CDYL0.674
EHBP10.672
CEP1200.661
VAMP70.659
RIMS20.656

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.458
OR4F5-0.45
PLA2G5-0.394
ARSF-0.355
NTSR2-0.334
RLBP1-0.331
GPR143-0.316
TLCD1-0.315
SLC22A6-0.315
EYA2-0.311

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MYRIP mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MYRIP mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of MYRIP mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MYRIP mRNA21641981|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MYRIP gene27153756
D001151ArsenicArsenic affects the methylation of MYRIP gene25304211
D001151ArsenicArsenic results in decreased expression of MYRIP mRNA19654921
C015001arsenitearsenite results in increased methylation of MYRIP promoter23974009
D001280AtrazineAtrazine results in increased expression of MYRIP mRNA23358194
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MYRIP mRNA21569818
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of MYRIP mRNA20660070
C006780bisphenol Abisphenol A results in increased expression of MYRIP mRNA25594700
C006780bisphenol Abisphenol A affects the expression of MYRIP mRNA25181051
D002737ChloropreneChloroprene results in increased expression of MYRIP mRNA23125180
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MYRIP mRNA]27941970
D004397FonofosFonofos results in increased methylation of MYRIP promoter22847954
D019833GenisteinGenistein results in increased methylation of MYRIP gene28505145
D017313FenretinideFenretinide results in decreased expression of MYRIP mRNA28973697
D007545IsoproterenolIsoproterenol results in increased expression of MYRIP mRNA20003209
D007657Ketone BodiesKetone Bodies results in decreased expression of MYRIP mRNA16807920
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MYRIP mRNA"20188158
C008493methylselenic acidmethylselenic acid results in decreased expression of MYRIP mRNA18548127
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of MYRIP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MYRIP mRNA"25554681
D009532NickelNickel results in decreased expression of MYRIP mRNA24768652|2558310
D010278ParathionParathion results in increased methylation of MYRIP promoter22847954
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MYRIP mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of MYRIP mRNA19084549
D010795Phthalic AcidsPhthalic Acids results in decreased expression of MYRIP mRNA15728792
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MYRIP mRNA19710929
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of MYRIP mRNA20660070
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of MYRIP mRNA"21514415
D017632Asbestos, Serpentine"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of MYRIP mRNA]"21514415
D012834SilverSilver results in decreased expression of MYRIP mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of MYRIP mRNA16322246
D053260SootSoot affects the expression of MYRIP mRNA26551751
D013629TamoxifenTamoxifen results in increased expression of MYRIP mRNA25123088
C012568terbufosterbufos results in increased methylation of MYRIP promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MYRIP mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MYRIP mRNA21570461
C009495titanium dioxidetitanium dioxide results in decreased expression of MYRIP mRNA23409001
C009495titanium dioxidetitanium dioxide results in increased expression of MYRIP mRNA27760801
C012589trichostatin Atrichostatin A results in increased expression of MYRIP mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of MYRIP mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of MYRIP mRNA24383497|2493525

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IBA21873635  
GO:0005515protein binding-IPI11964381  17827149  25416956  
GO:0008270zinc ion binding-NAS11964381  
GO:0017022myosin binding-IBA21873635  
GO:0017137Rab GTPase binding-IBA21873635  
GO:0051018protein kinase A binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IEA-  
GO:0032024positive regulation of insulin secretion-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000145exocyst-IEA-  
GO:0001750photoreceptor outer segment-IEA-  
GO:0030133transport vesicle-IEA-  
GO:0030864cortical actin cytoskeleton-IBA21873635  
GO:0031045dense core granule-ISS-  
GO:0042470melanosome-IEA-  
GO:0045202synapse-IEA-  
GO:0048471perinuclear region of cytoplasm-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-264876Insulin processingIEA
R-HSA-2980736Peptide hormone metabolismIEA
R-HSA-392499Metabolism of proteinsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal