Gene: ASPM

259266
ASP|Calmbp1|MCPH5
abnormal spindle microtubule assembly
protein-coding
1q31.3
Ensembl:ENSG00000066279 MIM:605481 Vega:OTTHUMG00000036277 UniprotKB:Q8IZT6
NG_015867.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.362e-2 (AD)  8.543e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SETDB20.71
VPS13A0.706
CCDC390.696
DDI20.689
PARP110.683
CCDC140.679
TMEM161B0.677
CAPS20.673
ZNF5100.673
PPIP5K20.672

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLA2G5-0.419
BCL7C-0.401
AQP5-0.394
LYPD1-0.389
S100A14-0.38
S100A1-0.369
HORMAD2-0.358
PINLYP-0.356
PPP1R14B-0.356
RBP1-0.35

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ASPM mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ASPM mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ASPM mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ASPM mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ASPM mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ASPM mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ASPM mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ASPM mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of ASPM mRNA"20406850
C0213383-hydroxybenzo(a)pyrene3-hydroxybenzo(a)pyrene results in decreased expression of ASPM mRNA26238291
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ASPM mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ASPM mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ASPM mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ASPM mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ASPM mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of ASPM mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ASPM protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ASPM mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of ASPM mRNA21757418
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of ASPM mRNA"22863853
C006632arsenic trioxidearsenic trioxide results in increased expression of ASPM mRNA20458559
D001280AtrazineAtrazine results in decreased expression of ASPM mRNA22378314
D001379AzathioprineAzathioprine results in decreased expression of ASPM mRNA22623647
C547126AZM551248AZM551248 results in increased expression of ASPM mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ASPM mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ASPM mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ASPM mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ASPM mRNA"19150397|2001819
D004958EstradiolEstradiol results in increased expression of ASPM mRNA16474171|1831028
C006780bisphenol Abisphenol A affects the expression of ASPM mRNA19490990
C006780bisphenol Abisphenol A results in decreased expression of ASPM mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of ASPM mRNA16474171
C006780bisphenol Abisphenol A results in decreased expression of ASPM mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ASPM mRNA26079696
D002104CadmiumCadmium results in decreased expression of ASPM mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ASPM mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ASPM mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ASPM mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ASPM mRNA17484886
D004390ChlorpyrifosChlorpyrifos results in decreased expression of ASPM mRNA20350560
C022990chromic chloridechromic chloride results in increased expression of ASPM mRNA12128095
D003033Coal TarCoal Tar results in increased expression of ASPM mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of ASPM mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of ASPM mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of ASPM mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ASPM mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with ESR1 protein] results in increased expression of ASPM mRNA18310284
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of ASPM mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of ASPM mRNA19167446
D003375CoumestrolESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of ASPM mRNA]18310284
D003471CuprizoneCuprizone results in increased expression of ASPM mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ASPM mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of ASPM mRNA19770486
D000069439DasatinibDasatinib results in decreased expression of ASPM mRNA20579391
D003703DemecolcineDemecolcine results in decreased expression of ASPM mRNA23649840
D002945CisplatinCisplatin promotes the reaction [Piroxicam results in decreased expression of ASPM mRNA]21858171
D002945CisplatinCisplatin results in decreased expression of ASPM mRNA27594783
C000944dicrotophosdicrotophos results in decreased expression of ASPM mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ASPM mRNA24535843
D002117CalcitriolCalcitriol results in decreased expression of ASPM mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of ASPM mRNA21592394
C024629dimethyl phthalatedimethyl phthalate affects the expression of ASPM mRNA26924002
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ASPM protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ASPM mRNA22079256
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of ASPM mRNA24412560
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of ASPM mRNA24412560
D005485FlutamideFlutamide results in increased expression of ASPM mRNA24793618
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of ASPM mRNA24657277
D005557FormaldehydeFormaldehyde results in decreased expression of ASPM mRNA23649840
C039281furanfuran results in increased expression of ASPM mRNA25539665
C001277geldanamycingeldanamycin results in increased expression of ASPM mRNA26705709
D019833GenisteinGenistein affects the expression of ASPM mRNA18847459
D019833GenisteinGenistein results in increased expression of ASPM mRNA16474171
C492448ICG 001ICG 001 results in decreased expression of ASPM mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ASPM mRNA25613284
C544151jinfukangjinfukang results in increased expression of ASPM mRNA27392435
D048628KetolidesKetolides analog results in decreased expression of ASPM mRNA24967691
D007840LatexLatex analog results in increased expression of ASPM mRNA24768652
C045463leflunomideleflunomide results in decreased expression of ASPM mRNA28988120
D008154LucanthoneLucanthone results in decreased expression of ASPM mRNA21148553
D008694MethamphetamineMethamphetamine results in decreased expression of ASPM mRNA25290377
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of ASPM mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of ASPM mRNA24657277
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ASPM mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ASPM mRNA20061341
C004925methylmercuric chloridemethylmercuric chloride affects the expression of ASPM mRNA20864626
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ASPM mRNA24810058
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ASPM mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ASPM mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ASPM mRNA]"20230807
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ASPM mRNA26924002
D009151Mustard GasMustard Gas results in decreased expression of ASPM mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ASPM mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ASPM mRNA"25554681
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ASPM mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ASPM mRNA]"20230807
C570897NSC668394NSC668394 results in decreased expression of ASPM mRNA27137931
C016340o,p'-DDT"o,p'-DDT results in decreased expression of ASPM mRNA"18204070
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ASPM mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of ASPM mRNA25729387
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of ASPM mRNA25658374
D017239PaclitaxelPaclitaxel results in increased expression of ASPM mRNA17374387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ASPM mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of ASPM mRNA26705709
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of ASPM mRNA26678675
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ASPM mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of ASPM mRNA23091169
D048789PhytoestrogensPhytoestrogens results in increased expression of ASPM mRNA18310284
C006253pirinixic acidpirinixic acid results in increased expression of ASPM mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of ASPM mRNA]17950772
D010894PiroxicamCisplatin promotes the reaction [Piroxicam results in decreased expression of ASPM mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of ASPM mRNA21858171
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of ASPM mRNA21334430
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of ASPM mRNA16474171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ASPM mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ASPM mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of ASPM mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of ASPM mRNA23012394
D011374ProgesteroneProgesterone results in increased expression of ASPM mRNA18070364
C045950propiconazolepropiconazole results in increased expression of ASPM mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of ASPM mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of ASPM mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ASPM mRNA27029645
D011794QuercetinQuercetin results in decreased expression of ASPM mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of ASPM mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ASPM mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ASPM mRNA19073995
D012834SilverSilver results in decreased expression of ASPM mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of ASPM mRNA17998272
D018038Sodium SeleniteSodium Selenite results in decreased expression of ASPM mRNA24383545
D053260SootSoot results in increased expression of ASPM mRNA26551751
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of ASPM mRNA"26680231
D014284TriiodothyronineTriiodothyronine results in decreased expression of ASPM mRNA23397585
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of ASPM mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of ASPM mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ASPM mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ASPM mRNA26377647
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ASPM mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of ASPM mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of ASPM mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ASPM mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ASPM mRNA20133372
D024505TocopherolsTocopherols results in increased expression of ASPM mRNA17056531
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ASPM mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ASPM mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of ASPM mRNA"17951470
D014241TrichloroethyleneTrichloroethylene results in increased expression of ASPM mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of ASPM mRNA15901671
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ASPM mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ASPM mRNA26272509
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ASPM mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ASPM mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ASPM mRNA19140230
D014635Valproic AcidValproic Acid results in decreased expression of ASPM mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of ASPM mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ASPM gene25560391
D014750VincristineVincristine results in increased expression of ASPM mRNA17374387
C029297vinylidene chloridevinylidene chloride results in increased expression of ASPM mRNA26682919
D012256RiboflavinRiboflavin affects the expression of ASPM20848206
C111237vorinostatvorinostat results in decreased expression of ASPM mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of ASPM mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17353931  26496610  
GO:0005516calmodulin binding-IEA-  
GO:0019901protein kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001764neuron migration-IEA-  
GO:0002052positive regulation of neuroblast proliferation-IEA-  
GO:0007051spindle organization-IMP21044324  
GO:0007283spermatogenesis-IEA-  
GO:0008584male gonad development-IEA-  
GO:0021873forebrain neuroblast division-IEA-  
GO:0021987cerebral cortex development-IEA-  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0045769negative regulation of asymmetric cell division-IEA-  
GO:0048477oogenesis-IEA-  
GO:0048589developmental growth-IEA-  
GO:0051445regulation of meiotic cell cycle-IEA-  
GO:0051653spindle localization-IMP21044324  
GO:0051661maintenance of centrosome location-IEA-  
GO:0090263positive regulation of canonical Wnt signaling pathway-IEA-  
GO:0090306spindle assembly involved in meiosis-IEA-  
GO:0097150neuronal stem cell population maintenance-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA21044324  
GO:0005737cytoplasm-IEA-  
GO:0005813centrosome-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0030496midbody-IEA-  
GO:0036449microtubule minus-end-IDA21044324  
GO:0072687meiotic spindle-IEA-  
GO:0097431mitotic spindle pole-IDA15972725  21044324  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18541031The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. (2008 Jun 9)Zhang HBMC Med Genet