Gene: TAS2R43

259289
T2R43|T2R52
taste 2 receptor member 43
protein-coding
12p13.2
Ensembl:ENSG00000255374 MIM:612668 Vega:OTTHUMG00000165352 UniprotKB:P59537
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.897e-1 (AD)  5.525e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR56A40.747
PRAMEF170.727
OR10K10.722
POU5F20.717
TAS2R300.713
IFNK0.712
MTRNR2L50.71
C9orf1310.709
PRDM140.705
OR9Q20.704

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLDND2-0.215
CHST8-0.206
SCGB3A1-0.2
CLEC11A-0.186
B9D2-0.185
MESP2-0.185
ACRV1-0.183
USP9Y-0.18
ZFY-0.18
RPS4Y1-0.175

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006457alloinalloin results in increased activity of TAS2R43 protein21629661
C006457alloinProbenecid inhibits the reaction [alloin results in increased activity of TAS2R43 protein]21629661
D019327Copper SulfateCopper Sulfate results in increased expression of TAS2R43 mRNA19549813
C568376MT19c compoundMT19c compound results in increased expression of TAS2R43 mRNA21781307
C046012pentanalpentanal results in decreased expression of TAS2R43 mRNA26079696
D011339ProbenecidProbenecid inhibits the reaction [alloin results in increased activity of TAS2R43 protein]21629661
D011339ProbenecidProbenecid results in decreased activity of TAS2R43 protein21629661
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TAS2R43 mRNA25895662
D018038Sodium SeleniteSodium Selenite results in decreased expression of TAS2R43 mRNA18175754
D014635Valproic AcidValproic Acid results in decreased methylation of TAS2R43 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IEA-  
GO:0008527taste receptor activity-IDA16720576  
GO:0033038bitter taste receptor activity-IBA21873635  
GO:0033038bitter taste receptor activity-IDA16720576  20022913  
GO ID GO Term Qualifier Evidence PubMed
GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste-IBA21873635  
GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste-IDA16720576  20022913  
GO:0007186G-protein coupled receptor signaling pathway-IC16720576  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IBA21873635  
GO:0016021integral component of membrane-IC16720576  20022913  
GO:0031514motile cilium-IDA19628819  
GO:0060170ciliary membrane-IEA-  
KEGG ID KEGG Term
hsa04742Taste transduction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-420499Class C/3 (Metabotropic glutamate/pheromone receptors)TAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29040583Taste receptor polymorphisms and male infertility. (2017 Nov 1)Gentiluomo MHum Reprod