Gene: CLIC4

25932
CLIC4L|H1|MTCLIC|huH1|p64H1
chloride intracellular channel 4
protein-coding
1p36.11
Ensembl:ENSG00000169504 MIM:606536 Vega:OTTHUMG00000003327 UniprotKB:Q9Y696
NC_000001.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.867e-1 (AD)  6.427e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LITAF0.905
ATL30.899
CBFB0.895
TANC10.891
ITGB10.89
ACTL6A0.883
REEP30.882
MAGT10.878
BAZ1A0.876
SPATA130.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNQ4-0.538
ABCC12-0.536
CDH22-0.531
FBLN7-0.519
MARCH4-0.518
ADRA1D-0.511
NKX6-3-0.508
PIP5KL1-0.498
SLC7A4-0.495
SCRT1-0.489

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of CLIC4 mRNA"26377693
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CLIC4 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CLIC4 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of CLIC4 mRNA28959563
C430898AGN 194204AGN 194204 results in decreased expression of CLIC4 mRNA16339527
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of CLIC4 mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CLIC4 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of CLIC4 mRNA17258074
C015001arsenitearsenite results in increased expression of CLIC4 mRNA18191166
C547126AZM551248AZM551248 results in increased expression of CLIC4 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in increased expression of CLIC4 mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CLIC4 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CLIC4 mRNA19770486|2719552
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLIC4 mRNA21569818|2222880
D004958EstradiolEstradiol results in increased expression of CLIC4 mRNA20068009
C044887beta-methylcholinebeta-methylcholine affects the expression of CLIC4 mRNA21179406
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of CLIC4 mRNA15912405
C006780bisphenol Abisphenol A affects the expression of CLIC4 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CLIC4 mRNA28628672
C006780bisphenol Abisphenol A results in decreased methylation of CLIC4 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of CLIC4 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of CLIC4 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CLIC4 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of CLIC4 mRNA29097150
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CLIC4 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of CLIC4 mRNA26314263
D001761BleomycinBleomycin results in decreased expression of CLIC4 protein25933445
C515564bromovaninbromovanin results in increased expression of CLIC4 protein21419150
C018475butyraldehydebutyraldehyde results in increased expression of CLIC4 mRNA26079696
C459604candoxincandoxin results in increased expression of CLIC4 mRNA16309724
D002737ChloropreneChloroprene results in increased expression of CLIC4 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CLIC4 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of CLIC4 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of CLIC4 mRNA26314263
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CLIC4 mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of CLIC4 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in increased expression of CLIC4 mRNA15331540
D016572CyclosporineCyclosporine results in increased expression of CLIC4 mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CLIC4 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CLIC4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CLIC4 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CLIC4 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CLIC4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CLIC4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of CLIC4 mRNA27594783
D004041Dietary FatsDietary Fats results in decreased expression of CLIC4 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of CLIC4 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of CLIC4 mRNA]19030233
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of CLIC4 mRNA16314067
D004237DiuronDiuron results in decreased expression of CLIC4 mRNA25152437
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of CLIC4 mRNA"23811387
C118739entinostatentinostat results in increased expression of CLIC4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC4 mRNA"27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CLIC4 protein23301498
D000431EthanolEthanol affects the expression of CLIC4 mRNA24355176
D000431EthanolCLIC4 protein affects the susceptibility to Ethanol22239914
D000431EthanolEthanol results in increased expression of CLIC4 mRNA22239914
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CLIC4 mRNA29097150
D005419FlavonoidsFlavonoids results in decreased expression of CLIC4 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CLIC4 gene20938992
C056507gemcitabinegemcitabine results in increased expression of CLIC4 mRNA17039268
D019833GenisteinGenistein results in increased methylation of CLIC4 gene28505145
D005839GentamicinsGentamicins results in decreased expression of CLIC4 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of CLIC4 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of CLIC4 mRNA26191083
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of CLIC4 mRNA"26377693
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CLIC4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CLIC4 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CLIC4 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CLIC4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CLIC4 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CLIC4 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CLIC4 mRNA27392435
C410337K 7174K 7174 results in increased expression of CLIC4 mRNA24086573
D007657Ketone BodiesKetone Bodies results in decreased expression of CLIC4 mRNA16807920
C440499lipopolysaccharide, Escherichia coli O111 B4"CLIC4 protein inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IRF3 protein]"21469130
C440499lipopolysaccharide, Escherichia coli O111 B4"CLIC4 protein promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein]"21469130
C440499lipopolysaccharide, Escherichia coli O111 B4"CLIC4 protein promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]"21469130
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CLIC4 mRNA"21469130
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CLIC4 mRNA18192897
D008627Mercuric ChlorideMercuric Chloride affects the expression of CLIC4 mRNA20353558
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of CLIC4 protein10968996
D008694MethamphetamineMethamphetamine results in increased expression of CLIC4 mRNA19149911
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CLIC4 gene20938992
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of CLIC4 mRNA28349193
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CLIC4 mRNA28001369
C030957methylmercury IImethylmercury II results in increased expression of CLIC4 mRNA26314263
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CLIC4 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CLIC4 protein26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CLIC4 mRNA22776087
C063855microcystin RRmicrocystin RR results in increased expression of CLIC4 protein19111056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CLIC4 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of CLIC4 mRNA23811387
C017096n-butoxyethanoln-butoxyethanol results in increased expression of CLIC4 mRNA19812364
D009532NickelNickel results in increased expression of CLIC4 mRNA23195993
C029938nickel sulfatenickel sulfate results in increased expression of CLIC4 mRNA16314067
C007350nitrofennitrofen results in decreased expression of CLIC4 mRNA20638522
C464660obeticholic acidobeticholic acid results in increased expression of CLIC4 mRNA27939613
C025589ochratoxin Aochratoxin A metabolite results in increased expression of CLIC4 mRNA26314263
C025589ochratoxin Aochratoxin A results in increased expression of CLIC4 mRNA26314263
D000073878Palm OilPalm Oil results in decreased expression of CLIC4 mRNA18042831
D052638Particulate Matter[CLIC4 gene mutant form affects the susceptibility to Particulate Matter] which results in decreased expression of CLIC4 mRNA21222557|2122255
D010416PentachlorophenolPentachlorophenol results in increased expression of CLIC4 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CLIC4 protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of CLIC4 mRNA19159669
D010656PhenylephrinePhenylephrine results in increased expression of CLIC4 mRNA18158353
D011374ProgesteroneProgesterone results in decreased expression of CLIC4 mRNA18070364
C045950propiconazolepropiconazole results in increased expression of CLIC4 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of CLIC4 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CLIC4 mRNA27029645
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of CLIC4 mRNA16497877
C089032rimonabantrimonabant affects the expression of CLIC4 mRNA19030233
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of CLIC4 mRNA]19030233
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CLIC4 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of CLIC4 mRNA28595984
D012999SomanSoman results in increased expression of CLIC4 mRNA19281266
D053260SootSoot results in increased expression of CLIC4 mRNA26551751
D013311StreptozocinStreptozocin affects the expression of CLIC4 mRNA18583417
C004648testosterone enanthatetestosterone enanthate affects the expression of CLIC4 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLIC4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CLIC4 mRNA18796159
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CLIC4 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CLIC4 mRNA25613284
C011559tributyltintributyltin results in increased expression of CLIC4 mRNA26314263
D014241TrichloroethyleneTrichloroethylene results in decreased expression of CLIC4 mRNA19448997
C012589trichostatin Atrichostatin A affects the expression of CLIC4 mRNA28542535
C022884undecaneundecane results in increased expression of CLIC4 protein17337753
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CLIC4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CLIC4 mRNA23179753|2438349
D001335Vehicle Emissions[CLIC4 gene mutant form affects the susceptibility to Vehicle Emissions] which results in decreased expression of CLIC4 mRNA21222557|2122255
C111237vorinostatvorinostat results in increased expression of CLIC4 protein20543569
D015032ZincZinc deficiency results in increased expression of CLIC4 mRNA12672911

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005244voltage-gated ion channel activity-IEA-  
GO:0005254chloride channel activity-IBA21873635  
GO:0005515protein binding-IPI10793131  12163479  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IBA21873635  
GO:0001886endothelial cell morphogenesis-IEA-  
GO:0006821chloride transport-NAS10793131  
GO:0007035vacuolar acidification-IEA-  
GO:0009566fertilization-IEA-  
GO:0030154cell differentiation-TAS12163372  
GO:0030216keratinocyte differentiation-IMP17636002  
GO:0030336negative regulation of cell migration-IDA12163372  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0035088establishment or maintenance of apical/basal cell polarity-NAS14569596  
GO:0035264multicellular organism growth-IEA-  
GO:0048754branching morphogenesis of an epithelial tube-IEA-  
GO:0051493regulation of cytoskeleton organization-NAS14569596  
GO:0061299retina vasculature morphogenesis in camera-type eye-IEA-  
GO:0071277cellular response to calcium ion-IMP17636002  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA-  
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IDA10793131  14569596  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA14569596  
GO:0005813centrosome-IDA14569596  
GO:0005829cytosol-IDA10026142  19776349  
GO:0005886plasma membrane-IDA19776349  
GO:0005902microvillus-IDA14569596  
GO:0005911cell-cell junction-IDA14569596  
GO:0009986cell surface-IDA14569596  
GO:0015629actin cytoskeleton-TAS12163372  
GO:0015630microtubule cytoskeletoncolocalizes_withIDA14569596  
GO:0016363nuclear matrix-IDA14569596  
GO:0030496midbody-IDA14569596  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0034707chloride channel complex-IEA-  
GO:0045177apical part of cell-IDA14569596  
GO:0048471perinuclear region of cytoplasm-IDA14569596  
GO:0070062extracellular exosome-HDA19056867  20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22239914Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice. (2012 Jun)Bhandari PGenes Brain Behav