Gene: PNKD

25953
BRP17|DYT8|FKSG19|FPD1|KIPP1184|MR-1|MR1|PDC|PKND1|PNKD1|TAHCCP2
paroxysmal nonkinesigenic dyskinesia
protein-coding
2q35
Ensembl:ENSG00000127838 MIM:609023 Vega:OTTHUMG00000133110 UniprotKB:Q8N490
NG_017060.1
PubMed
0   ANCO-SNPs
CD|ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.883e-1 (AD)  5.049e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C6orf1360.962
ATP13A20.959
REEP20.957
MAPRE30.955
GPI0.953
FAIM20.952
C11orf680.952
SLC22A170.951
TOM10.95
OTUB10.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.69
OR4F29-0.644
TFPI2-0.455
RAI14-0.439
KLRB1-0.411
SGMS2-0.408
KCNJ15-0.395
REST-0.393
WWTR1-0.389
CST7-0.386

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of PNKD mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of PNKD mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PNKD gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents affects the expression of PNKD mRNA24449571
D001280AtrazineAtrazine results in increased expression of PNKD mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PNKD mRNA19770486|2222880
D004958EstradiolEstradiol results in increased expression of PNKD mRNA23019147
C006780bisphenol Abisphenol A affects the expression of PNKD mRNA25181051
C006780bisphenol Abisphenol A results in decreased methylation of PNKD gene28505145
D002104CadmiumCadmium results in decreased expression of PNKD mRNA24067728
C028031cadmium acetatecadmium acetate results in increased expression of PNKD mRNA12965115
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PNKD mRNA27339419
D002737ChloropreneChloroprene results in decreased expression of PNKD mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PNKD mRNA20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of PNKD mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PNKD mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of PNKD mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of PNKD mRNA23640034
C014347decitabinedecitabine affects the expression of PNKD mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PNKD mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PNKD mRNA21266533
D002945CisplatinCisplatin affects the expression of PNKD mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PNKD mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of PNKD mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of PNKD mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PNKD mRNA]19850644
D002117CalcitriolCalcitriol results in decreased expression of PNKD mRNA16002434
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PNKD mRNA20938992
D019833GenisteinESR1 promotes the reaction [Genistein results in decreased expression of PNKD protein]20884965
D019833GenisteinGenistein results in decreased expression of PNKD protein20884965
D005897GlafenineGlafenine results in decreased expression of PNKD mRNA24136188
D017313FenretinideFenretinide results in increased expression of PNKD mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of PNKD mRNA19376150
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PNKD mRNA27392435
C544151jinfukangjinfukang results in increased expression of PNKD mRNA27392435
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of PNKD mRNA16507785
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PNKD mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PNKD mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PNKD mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PNKD mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PNKD mRNA"25620056
D009532NickelNickel results in decreased expression of PNKD mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of PNKD mRNA22714537
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PNKD protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of PNKD mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of PNKD mRNA19270015
C006253pirinixic acidpirinixic acid results in increased expression of PNKD mRNA18301758
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PNKD mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of PNKD mRNA24780913
C010327salinomycinsalinomycin results in decreased expression of PNKD mRNA19682730
D018038Sodium SeleniteSodium Selenite results in increased expression of PNKD mRNA18175754
D013629TamoxifenTamoxifen affects the expression of PNKD mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PNKD mRNA21570461|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PNKD mRNA19465110|1977048
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PNKD mRNA28065790
D014212TretinoinTretinoin results in increased expression of PNKD mRNA23830798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PNKD mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of PNKD mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of PNKD gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PNKD mRNA23179753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PNKD gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PNKD mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of PNKD mRNA26682919
C088658zoledronic acidzoledronic acid results in increased expression of PNKD mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004416hydroxyacylglutathione hydrolase activity-IEA-  
GO:0005515protein binding-IPI25066297  25416956  25910212  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0019243methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione-IEA-  
GO:0032225regulation of synaptic transmission, dopaminergic-IEA-  
GO:0042053regulation of dopamine metabolic process-IEA-  
GO:0046929negative regulation of neurotransmitter secretion-IMP25730884  
GO:0050884neuromuscular process controlling posture-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005739mitochondrion-IDA-  
GO:0016020membrane-IDA22214848  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal