Gene: GAP43

2596
B-50|PP46
growth associated protein 43
protein-coding
3q13.31
Ensembl:ENSG00000172020 MIM:162060 Vega:OTTHUMG00000133758 UniprotKB:P17677
NC_000003.12
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.524e-1 (AD)  3.583e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BASP10.956
BEX50.95
ATP6V1G20.95
SNAP250.948
TAGLN30.948
GNG30.948
PFN20.947
YWHAH0.945
CALM30.945
NAP1L50.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.658
OR4F29-0.614
REST-0.402
CNN2-0.397
RUNX3-0.395
MAGEA12-0.393
CSAG1-0.385
CDA-0.383
TGIF1-0.382
WDR38-0.38

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of GAP43 mRNA"26377693
C0365351,6-bis(cyclohexyloximinocarbonyl)hexane"1,6-bis(cyclohexyloximinocarbonyl)hexane inhibits the reaction [FGF2 protein results in increased phosphorylation of GAP43 protein]"9852580
C0365351,6-bis(cyclohexyloximinocarbonyl)hexane"1,6-bis(cyclohexyloximinocarbonyl)hexane inhibits the reaction [NCAM1 protein results in increased phosphorylation of GAP43 protein]"9852580
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in increased expression of GAP43 mRNA"21436126
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in increased expression of GAP43 protein"21436126
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GAP43 mRNA"21436126
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GAP43 protein"21436126
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GAP43 mRNA"15059925
C0259463-methyladenine3-methyladenine inhibits the reaction [sodium arsenite results in decreased expression of GAP43]25639566
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C5605976,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide"6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide inhibits the reaction [Scopolamine Hydrobromide results in decreased expression of GAP43 protein]"22096544
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]18375950
D020106AcrylamideAcrylamide results in decreased expression of GAP43 mRNA15749267|2895956
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GAP43 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in decreased expression of GAP43 mRNA11377751
D003913DextroamphetamineDextroamphetamine results in increased expression of GAP43 mRNA11377751
D016718Arachidonic AcidArachidonic Acid results in increased phosphorylation of GAP43 protein9852580
D001151ArsenicArsenic results in decreased expression of GAP43 mRNA19654921
D001151ArsenicArsenic results in decreased expression of GAP43 mRNA23600209
C006632arsenic trioxidearsenic trioxide results in decreased expression of GAP43 mRNA26705709
C030693AshwagandhaAshwagandha inhibits the reaction [Scopolamine Hydrobromide results in decreased expression of GAP43 protein]22096544
D001280AtrazineAtrazine results in increased expression of GAP43 mRNA22378314
C072763azamethiphosazamethiphos promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]28385489
C547126AZM551248AZM551248 results in increased expression of GAP43 mRNA22323515
C487081belinostatbelinostat results in increased expression of GAP43 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of GAP43 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GAP43 mRNA27195522
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of GAP43 mRNA17404688
C088060bisindolylmaleimidebisindolylmaleimide inhibits the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]18375950
C006780bisphenol Abisphenol A results in decreased expression of GAP43 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GAP43 gene28505145
D001786Blood Glucose[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of GAP43 protein27693381
D001905Botulinum ToxinsBotulinum Toxins results in increased expression of GAP43 protein8089707
C013418bromfenacoumbromfenacoum results in increased expression of GAP43 protein28903499
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of GAP43 mRNA20147733
D0200011-Butanol1-Butanol inhibits the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]18004999
D002104CadmiumCadmium results in decreased expression of GAP43 mRNA24376830
D002220CarbamazepineCarbamazepine affects the expression of GAP43 mRNA22634333
C010063carbonyl sulfidecarbonyl sulfide results in decreased expression of GAP43 mRNA19395590
C043211carvedilolcarvedilol results in decreased expression of GAP43 mRNA20359859
C043211carvedilolcarvedilol results in decreased expression of GAP43 protein20359859
C024714caryophyllenecaryophyllene results in increased expression of GAP43 protein27871898
D004390ChlorpyrifosChlorpyrifos results in increased expression of GAP43 mRNA27018022
D004390ChlorpyrifosChlorpyrifos affects the expression of GAP43 mRNA17452286
D004390ChlorpyrifosChlorpyrifos promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]28385489
D003010ClorgylineClorgyline results in decreased expression of GAP43 protein12480131
C018021cobaltous chlorideAcetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]18375950
C018021cobaltous chloridebisindolylmaleimide inhibits the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]18375950
C018021cobaltous chloridecobaltous chloride results in increased expression of GAP43 mRNA18375950
C018021cobaltous chloridecobaltous chloride results in increased phosphorylation of GAP43 protein18375950
C018021cobaltous chloridePRKCE protein promotes the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]18375950
C018021cobaltous chlorideZinc inhibits the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]18375950
D003042CocaineCocaine results in decreased expression of GAP43 mRNA12629581
D016578Crack CocaineCrack Cocaine results in increased expression of GAP43 mRNA12629581
D003520CyclophosphamideCyclophosphamide results in increased expression of GAP43 protein10536274|9486479
C037304cyhalothrincyhalothrin promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]28385489
D003561CytarabineCytarabine results in increased expression of GAP43 mRNA21198554
C010902decabromobiphenyl etherdecabromobiphenyl ether affects the expression of GAP43 protein18061678
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GAP43 protein25194327
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GAP43 protein18753049
D016190CarboplatinCarboplatin results in increased expression of GAP43 protein19435600
D003976DiazinonDiazinon results in increased expression of GAP43 mRNA17452286
D004026DieldrinDieldrin promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]28385489
D002117CalcitriolCalcitriol results in increased expression of GAP43 mRNA16002434
D004237DiuronDiuron results in decreased expression of GAP43 mRNA25152437
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]8774942
D007980LevodopaLevodopa results in increased expression of GAP43 protein25044243
C508214(E)-N1-((6-chloro-3-pyridyl)methyl)-N2-cyano-N1-methylacetamidine(E)-N1-((6-chloro-3-pyridyl)methyl)-N2-cyano-N1-methylacetamidine promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]28385489
C118739entinostatentinostat results in increased expression of GAP43 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
D000431EthanolEthanol results in decreased expression of GAP43 mRNA15940294
D000431EthanolThyroxine inhibits the reaction [Ethanol results in decreased expression of GAP43 mRNA]15940294
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GAP43 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GAP43 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GAP43 mRNA15834898|1735126
D015025ZearalenoneZearalenone results in decreased expression of GAP43 mRNA17557909
D005411Flame RetardantsFlame Retardants results in increased expression of GAP43 protein16451863|1855017
D005473FluoxetineFluoxetine results in decreased expression of GAP43 mRNA17950272
C061365flusilazoleflusilazole affects the expression of GAP43 mRNA22634333
D005690GalactoseGalactose results in decreased expression of GAP43 mRNA16707173
D005690GalactoseQuercetin inhibits the reaction [Galactose results in decreased expression of GAP43 mRNA]16707173
C081021Go 6976Go 6976 inhibits the reaction [isophthalate analog results in increased expression of GAP43 protein]23643828
D006533HeptachlorHeptachlor promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]28385489
D007099ImipramineImipramine results in decreased expression of GAP43 mRNA17950272
C059768isophthalateGo 6976 inhibits the reaction [isophthalate analog results in increased expression of GAP43 protein]23643828
C059768isophthalateisophthalate analog results in increased expression of GAP43 mRNA23643828
C059768isophthalateisophthalate analog results in increased expression of GAP43 protein23643828
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of GAP43 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GAP43 mRNA26752646
D007608Kainic AcidDizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]8774942
D007608Kainic AcidKainic Acid results in increased expression of GAP43 mRNA8774942
D007608Kainic AcidPentobarbital inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]8774942
C063302KN 62KN 62 inhibits the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]18004999
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of GAP43 mRNA12057914
D008148LovastatinLovastatin results in increased expression of GAP43 protein20694854
D008148LovastatinLovastatin results in increased expression of GAP43 protein20694854
D008468MeclizineMeclizine affects the expression of GAP43 protein12388792
D008535MegestrolMegestrol affects the expression of GAP43 protein12388792
D008550MelatoninMelatonin inhibits the reaction [Methamphetamine results in decreased expression of GAP43 protein]19409439
D008555MelittenMelitten results in increased phosphorylation of GAP43 protein9852580
D008694MethamphetamineMelatonin inhibits the reaction [Methamphetamine results in decreased expression of GAP43 protein]19409439
D008694MethamphetamineMethamphetamine results in decreased expression of GAP43 protein19409439
D008704MethazolamideMethazolamide affects the expression of GAP43 protein12388792
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA"23933227
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein"23933227
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]"23933227
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein]"23933227
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]"23933227
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein]"23933227
C005238mipafoxmipafox results in decreased expression of GAP43 protein27939611
C523799MRK 003MRK 003 results in decreased expression of GAP43 mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GAP43 mRNA"25554681
D009532NickelNickel affects the expression of GAP43 mRNA18812211
D009538Nicotine"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]"23933227
D009538Nicotine"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein]"23933227
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]"23933227
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein]"23933227
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of GAP43 protein"21704052
D010070OxalatesOxalates inhibits the reaction [NGF protein results in increased expression of GAP43 protein]21981408
C030110oxaliplatinoxaliplatin inhibits the reaction [NGF protein results in increased expression of GAP43 protein]21981408
D016877OxidantsOxidants results in increased expression of GAP43 mRNA18375950
D010100Oxygen[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of GAP43 protein27693381
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of GAP43 mRNA26272509
D010261ParaoxonParaoxon results in decreased expression of GAP43 protein27939611
D010269ParaquatParaquat results in increased expression of GAP43 mRNA18198484
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of GAP43 mRNA22866812
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of GAP43 mRNA26705709
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of GAP43 protein16451863|1855017
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of GAP43 mRNA19954255
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of GAP43 mRNA19954255
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of GAP43 protein modified form19954255
D010424PentobarbitalPentobarbital inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]8774942
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GAP43 protein19211617
C076994perfluorooctane sulfonic acid"[2,2',4,4'-tetrabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in increased expression of GAP43 mRNA"21436126
C076994perfluorooctane sulfonic acid"[2,2',4,4'-tetrabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in increased expression of GAP43 protein"21436126
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GAP43 protein25524167
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GAP43 mRNA21436126|2552416
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GAP43 protein21436126
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GAP43 protein19211617
D010622PhencyclidinePhencyclidine results in increased expression of GAP43 mRNA11377751
D010862PilocarpinePilocarpine results in decreased expression of GAP43 protein15191797
D010862PilocarpinePilocarpine results in increased expression of GAP43 mRNA16134595
C043435polylactic acid-polyglycolic acid copolymer"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]"23933227
C043435polylactic acid-polyglycolic acid copolymer"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein]"23933227
D011189Potassium Chloride1-Butanol inhibits the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]18004999
D011189Potassium ChlorideCAMK2D protein affects the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]18004999
D011189Potassium ChlorideKN 62 inhibits the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]18004999
D011189Potassium ChloridePLD2 protein affects the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]18004999
D011189Potassium ChloridePotassium Chloride results in increased expression of GAP43 mRNA18004999
D011189Potassium ChloridePotassium Chloride results in increased expression of GAP43 protein18004999
D011189Potassium ChlorideU 0126 inhibits the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]18004999
D011189Potassium ChlorideU 0126 inhibits the reaction [Potassium Chloride results in increased expression of GAP43 protein]18004999
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of GAP43 mRNA17404688
D011374ProgesteroneProgesterone inhibits the reaction [VPS54 mutant form results in increased expression of GAP43 mRNA]19693665
D011441PropylthiouracilPropylthiouracil results in increased expression of GAP43 mRNA24780913
C030984pyrenepyrene results in decreased expression of GAP43 mRNA22487263
D011794QuercetinQuercetin inhibits the reaction [Galactose results in decreased expression of GAP43 mRNA]16707173
C059514resveratrolresveratrol results in decreased expression of GAP43 mRNA12002526
C010327salinomycinsalinomycin results in decreased expression of GAP43 mRNA19682730
D012524SarinSarin results in decreased expression of GAP43 mRNA19522546
D012601Scopolamine Hydrobromide"6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide inhibits the reaction [Scopolamine Hydrobromide results in decreased expression of GAP43 protein]"22096544
D012601Scopolamine HydrobromideAshwagandha inhibits the reaction [Scopolamine Hydrobromide results in decreased expression of GAP43 protein]22096544
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of GAP43 protein22096544
C017947sodium arsenitesodium arsenite results in increased expression of GAP43 mRNA12016162
C017947sodium arsenite3-methyladenine inhibits the reaction [sodium arsenite results in decreased expression of GAP43]25639566
C017947sodium arsenitesodium arsenite results in decreased expression of GAP4325639566
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [NGF protein results in increased expression of GAP43 protein]27871898
D013467SulindacSulindac affects the expression of GAP43 protein12388792
D014284TriiodothyronineTriiodothyronine results in increased expression of GAP43 mRNA15708448
D014284TriiodothyronineTriiodothyronine results in increased expression of GAP43 protein15708448
D043343Testosterone PropionateTestosterone Propionate results in increased expression of GAP43 mRNA19427307
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GAP43 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GAP43 mRNA17942748
D019284ThapsigarginThapsigargin results in decreased expression of GAP43 mRNA22378314
D013974ThyroxineThyroxine inhibits the reaction [Ethanol results in decreased expression of GAP43 mRNA]15940294
D013974ThyroxineThyroxine results in increased expression of GAP43 mRNA15940294
D013974ThyroxineThyroxine results in decreased expression of GAP43 mRNA17403546
C009495titanium dioxidetitanium dioxide results in decreased expression of GAP43 mRNA19464567
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GAP43 mRNA20133372
D014212TretinoinTretinoin results in increased expression of GAP43 mRNA11027660|2193413
D014212TretinoinTretinoin results in increased expression of GAP43 protein16849523
D014212TretinoinTretinoin promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]28385489
D014212TretinoinTretinoin results in increased expression of GAP43 mRNA15708448
D014212TretinoinTretinoin results in increased expression of GAP43 protein15708448|1713047
C009524tributyl phosphatetributyl phosphate results in decreased expression of GAP43 mRNA27018022
D014236TrichlorfonTrichlorfon results in decreased expression of GAP43 protein27939611
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of GAP43 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of GAP43 mRNA15901671
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of GAP43 mRNA27146889
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GAP43 mRNA"25461749|2582660
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GAP43 mRNA"24717766
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in decreased expression of GAP43 mRNA27018022
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in decreased expression of GAP43 mRNA27146889
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in increased expression of GAP43 mRNA27146889
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in decreased expression of GAP43 mRNA24717766
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in decreased expression of GAP43 protein24717766
C046243tryptanthrinetryptanthrine results in increased expression of GAP43 mRNA23500671
D014415TunicamycinTunicamycin results in decreased expression of GAP43 mRNA22378314
C113580U 0126U 0126 inhibits the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]18004999
C113580U 0126U 0126 inhibits the reaction [Potassium Chloride results in increased expression of GAP43 protein]18004999
C022884undecaneundecane results in increased expression of GAP43 protein17337753
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GAP43 mRNA25979313|2607246
D014635Valproic AcidValproic Acid results in increased expression of GAP43 mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of GAP43 mRNA26072468
D014635Valproic AcidValproic Acid results in decreased expression of GAP43 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions affects the methylation of GAP43 gene25560391
D014700VerapamilVerapamil affects the expression of GAP43 protein12388792
D024483Vitamin K 3Vitamin K 3 analog results in increased expression of GAP43 mRNA19273458
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAP43 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of GAP43 mRNA26272509
D015032ZincZinc inhibits the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]18375950

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001786phosphatidylserine binding-IEA-  
GO:0005515protein binding-IPI9139733  
GO:0005516calmodulin binding-IBA21873635  
GO:0005516calmodulin binding-IEA-  
GO:0035727lysophosphatidic acid binding-IEA-  
GO:1901981phosphatidylinositol phosphate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway-TAS3272162  
GO:0009611response to wounding-TAS3272162  
GO:0010001glial cell differentiation-IEA-  
GO:0016198axon choice point recognition-IEA-  
GO:0040008regulation of growth-IEA-  
GO:0042246tissue regeneration-IEA-  
GO:0045165cell fate commitment-IEA-  
GO:0051489regulation of filopodium assembly-IDA14978216  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0014069postsynaptic density-IBA21873635  
GO:0030054cell junction-IEA-  
GO:0031527filopodium membrane-IDA14978216  
GO:0032584growth cone membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-422475Axon guidanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27003941Cigarette Smoke Delays Regeneration of the Olfactory Epithelium in Mice. (2016 Aug)Ueha RNeurotox Res