Gene: SH2B1

25970
PSM|SH2B
SH2B adaptor protein 1
protein-coding
16p11.2
Ensembl:ENSG00000178188 MIM:608937 Vega:OTTHUMG00000176590 UniprotKB:Q9NRF2
NG_029706.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.854e-2 (AD)  4.869e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DEF80.951
DTX30.95
SCAP0.948
MEN10.948
TMUB20.942
PTPN230.941
USP200.939
MAPK8IP30.939
AP3D10.938
ATG4B0.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.713
OR4F29-0.667
TFPI2-0.409
C9orf135-0.368
CD48-0.361
KLRB1-0.352
ARHGEF35-0.351
AGTR1-0.35
C9orf153-0.348
PROK2-0.348

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SH2B1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SH2B1 mRNA"28973690
D001151ArsenicArsenic affects the methylation of SH2B1 gene25304211
C547126AZM551248AZM551248 results in decreased expression of SH2B1 mRNA22323515
C006780bisphenol Abisphenol A affects the expression of SH2B1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SH2B1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SH2B1 mRNA26079696
D002273CarcinogensCarcinogens results in decreased expression of SH2B1 mRNA22269147
D002994ClofibrateClofibrate results in decreased expression of SH2B1 mRNA17585979
D003300Copper[Thiosemicarbazones binds to Copper] which results in increased expression of SH2B1 protein20931265
D019327Copper SulfateCopper Sulfate results in decreased expression of SH2B1 mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SH2B1 mRNA]27941970
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of SH2B1 mRNA"27840820
D000431EthanolEthanol results in decreased expression of SH2B1 mRNA17920746
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SH2B1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SH2B1 mRNA17942748
C069837fullerene C60fullerene C60 results in increased expression of SH2B1 mRNA19167457
C045463leflunomideleflunomide results in decreased expression of SH2B1 mRNA28988120
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SH2B1 mRNA"20188158
C028007nickel monoxidenickel monoxide results in increased expression of SH2B1 mRNA19167457
D011192Potassium DichromatePotassium Dichromate results in increased expression of SH2B1 protein23718831
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SH2B1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SH2B1 mRNA17942748
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in increased expression of SH2B1 protein20931265
D014118Toxins, Biological"Toxins, Biological affects the expression of SH2B1 mRNA"19682533
D014520UrethaneUrethane results in increased expression of SH2B1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of SH2B1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005068transmembrane receptor protein tyrosine kinase adaptor activity-IBA21873635  
GO:0005515protein binding-IPI9742218  16273093  24396070  24658140  
GO:0035591signaling adaptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO:0007596blood coagulation-TAS-  
GO:0009967positive regulation of signal transduction-IEA-  
GO:0030032lamellipodium assembly-IEA-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0045840positive regulation of mitotic nuclear division-IEA-  
GO:2000278regulation of DNA biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
hsa04722Neurotrophin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1170546Prolactin receptor signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionIEA
R-HSA-168256Immune SystemTAS
R-HSA-2586552Signaling by LeptinIEA
R-HSA-982772Growth hormone receptor signalingTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23054017The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan. (2013 Jan)Yang CWMol Biol Rep
27530450Evidence for Association between SH2B1 Gene Variants and Glycated Hemoglobin in Nondiabetic European American Young Adults: The Add Health Study. (2016 Sep)Lange LAAnn Hum Genet