Gene: AOC1

26
ABP|ABP1|DAO|DAO1|KAO
amine oxidase, copper containing 1
protein-coding
7q36.1
Ensembl:ENSG00000002726 MIM:104610 Vega:OTTHUMG00000158306 UniprotKB:P19801
NC_000007.14
PubMed
0   ANCO-SNPs
OD|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.113e-1 (AD)  9.679e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR2T70.47
PDHA20.406
GIF0.388
CLCA10.382
HOXB60.381
SBK30.373
MUC20.364
FAM3D0.347
SLC1A70.346
C22orf340.335

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL1-0.273
TRIM67-0.266
ACTA1-0.264
MYBPC2-0.244
ISM1-0.239
KLHL41-0.236
AGAP4-0.232
MYLPF-0.227
TNNI1-0.225
SLCO5A1-0.224

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00594AmilorideSmall Molecule2609-46-3ApprovedTarget
DB01373CalciumSmall Molecule7440-70-2Approved|NutraceuticalTarget
DB03608DiminazeneSmall Molecule536-71-0ExperimentalTarget
DB00594AmilorideSmall Molecule2609-46-3ApprovedEnzyme
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalEnzyme
DB00594AmilorideSmall Molecule2609-46-3ApprovedEnzyme
ID Drug Name Action PubMed
C5411312,2',3,3',4,4',5-heptachlorobiphenyl"2,2',3,3',4,4',5-heptachlorobiphenyl affects the expression of AOC1 mRNA"24050789
C0867582,4,5-trihydroxyphenylalanine quinone"2,4,5-trihydroxyphenylalanine quinone results in increased activity of AOC1 protein"12072962
C0867582,4,5-trihydroxyphenylalanine quinone"[AOC1 protein binds to AOC1 protein] which binds to 2,4,5-trihydroxyphenylalanine quinone"12072962
D000082AcetaminophenAcetaminophen results in decreased expression of AOC1 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of AOC1 mRNA17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Methotrexate results in increased activity of AOC1 protein]20885979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AOC1 protein20106945
D000584AmilorideAmiloride binds to AOC1 protein2217167
D000584AmilorideAmiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]8144586
D000584AmilorideAmiloride results in decreased activity of AOC1 protein8144586
D005680gamma-Aminobutyric AcidAOC1 protein results in increased abundance of gamma-Aminobutyric Acid1644166
D000499AllylamineAllylamine affects the expression of AOC1 mRNA15910882
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AOC1 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of AOC1 mRNA"22863853
D001280AtrazineAtrazine results in increased expression of AOC1 mRNA22982499
C547126AZM551248AZM551248 results in increased expression of AOC1 mRNA22323515
C013407benzamilbenzamil binds to AOC1 protein2217167
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AOC1 mRNA21569818|2222880
D004958EstradiolEstradiol results in increased expression of AOC1 mRNA15289156|1948475
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AOC1 mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AOC1 mRNA25993096
D002118CalciumAOC1 protein binds to Calcium12072962
D002737ChloropreneChloroprene results in decreased expression of AOC1 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AOC1 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of AOC1 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of AOC1 mRNA17585979
C018021cobaltous chloridecobaltous chloride binds to AOC1 protein16842785
D005576ColforsinColforsin results in increased activity of AOC1 protein2860926
D003300Copper[AOC1 protein binds to AOC1 protein] which binds to Copper12072962
D003300CopperCopper results in increased activity of AOC1 protein12072962
C029892cupric chloridecupric chloride results in increased activity of AOC1 protein16842785
D003474CurcuminCurcumin inhibits the reaction [Methotrexate results in increased activity of AOC1 protein]20885979
D003513CycloheximideCycloheximide inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]2860926
D003513CycloheximideCycloheximide inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]6218830
D003513CycloheximideCycloheximide inhibits the reaction [Terbutaline results in increased activity of AOC1 protein]2860926
D016572CyclosporineCyclosporine results in decreased expression of AOC1 mRNA20106945
D003609DactinomycinDactinomycin inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]2860926
D003609DactinomycinDactinomycin inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]6218830
D003609DactinomycinDactinomycin inhibits the reaction [Terbutaline results in increased activity of AOC1 protein]2860926
C021006diaminobutenediaminobutene results in decreased activity of AOC1 protein7492592
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of AOC1 mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of AOC1 mRNA15289156
D004837EpinephrineCycloheximide inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]2860926
D004837EpinephrineDactinomycin inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]2860926
D004837EpinephrineEpinephrine results in increased activity of AOC1 protein2860926
D004837EpinephrineTimolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]2860926
C039614ethylisopropylamilorideethylisopropylamiloride binds to AOC1 protein2217167
C039614ethylisopropylamilorideethylisopropylamiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]8144586
C039614ethylisopropylamilorideethylisopropylamiloride results in decreased activity of AOC1 protein8144586
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AOC1 mRNA20938992
D019833GenisteinGenistein results in increased expression of AOC1 mRNA15289156
C004380H 35-25H 35-25 inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]2860926
C010176halofuginonehalofuginone results in increased expression of AOC1 mRNA17180598
D006632HistamineAOC1 protein results in increased metabolism of Histamine12072962
D017313FenretinideFenretinide results in increased expression of AOC1 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of AOC1 mRNA17183730
D007545IsoproterenolCycloheximide inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]6218830
D007545IsoproterenolDactinomycin inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]6218830
D007545IsoproterenolH 35-25 inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]2860926
D007545IsoproterenolIsoproterenol results in increased activity of AOC1 protein2860926|6218830
D007545Isoproterenolpimagedine inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]6218830
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AOC1 mRNA20938992
D008727MethotrexateAOC1 protein affects the susceptibility to Methotrexate16217747
D008727MethotrexateAcetylcysteine inhibits the reaction [Methotrexate results in increased activity of AOC1 protein]20885979
D008727MethotrexateCurcumin inhibits the reaction [Methotrexate results in increased activity of AOC1 protein]20885979
D008727MethotrexateMethotrexate results in increased activity of AOC1 protein20885979
D009532NickelNickel results in increased expression of AOC1 mRNA24084258
C029938nickel sulfatenickel sulfate results in increased expression of AOC1 mRNA16780908
D010081OxazoloneOxazolone results in increased expression of AOC1 mRNA21893156
D010100OxygenOxygen deficiency results in increased expression of AOC1 mRNA16373842
D010100OxygenSimvastatin inhibits the reaction [Oxygen deficiency results in increased expression of AOC1 mRNA]16373842
C410127PCB 180PCB 180 affects the expression of AOC1 mRNA24050789
C023036perfluorooctanoic acid[perfluorooctanoic acid co-treated with PPARA] results in increased expression of AOC1 mRNA20118188
C047088phenylamilphenylamil binds to AOC1 protein2217167
C047088phenylamilphenylamil inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]8144586
C047088phenylamilphenylamil results in decreased activity of AOC1 protein8144586
C047088phenylamilphenylamil binds to AOC1 protein8144586
C004479pimagedinepimagedine results in decreased activity of AOC1 protein11445272
C004479pimagedinepimagedine inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]8144586
C004479pimagedinepimagedine results in decreased activity of AOC1 protein8144586
C004479pimagedinepimagedine inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]6218830
C006253pirinixic acidpirinixic acid results in increased expression of AOC1 mRNA19162173
D011700PutrescineAmiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]8144586
D011700PutrescineAOC1 protein results in increased degradation of Putrescine8144586
D011700PutrescineAOC1 protein results in increased metabolism of Putrescine12072962
D011700Putrescineethylisopropylamiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]8144586
D011700Putrescinephenylamil inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]8144586
D011700Putrescinepimagedine inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]8144586
D011700PutrescineAOC1 protein results in increased metabolism of Putrescine1644166
D011700PutrescineAOC1 protein results in increased degradation of Putrescine8144586
D019821SimvastatinSimvastatin inhibits the reaction [Oxygen deficiency results in increased expression of AOC1 mRNA]16373842
C009277sodium arsenatesodium arsenate results in decreased expression of AOC1 mRNA12727804
C017947sodium arsenitesodium arsenite results in decreased expression of AOC1 mRNA12727804
C017947sodium arsenitesodium arsenite results in increased expression of AOC1 mRNA24570342
C017947sodium arsenitesodium arsenite results in increased methylation of AOC1 gene24570342
C016104sodium bichromatesodium bichromate results in decreased expression of AOC1 mRNA24612858
D013095SpermidineSpermidine results in decreased expression of AOC1 protein1644166
C020404tele-methylhistamineAOC1 protein results in increased metabolism of tele-methylhistamine12072962
D013726TerbutalineCycloheximide inhibits the reaction [Terbutaline results in increased activity of AOC1 protein]2860926
D013726TerbutalineDactinomycin inhibits the reaction [Terbutaline results in increased activity of AOC1 protein]2860926
D013726TerbutalineTerbutaline results in increased activity of AOC1 protein2860926
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AOC1 mRNA21570461
D013806TheophyllineTheophylline results in decreased expression of AOC1 mRNA18951874
D013806TheophyllineTheophylline results in increased activity of AOC1 protein2860926
D013999TimololTimolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]2860926
C009495titanium dioxidetitanium dioxide results in decreased expression of AOC1 mRNA23557971
D014204Trenbolone AcetateTrenbolone Acetate affects the expression of AOC1 protein24072461
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of AOC1 mRNA19042947
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of AOC1 mRNA21893156
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of AOC1 mRNA26898711
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of AOC1 mRNA17183730
D014640VancomycinVancomycin results in decreased expression of AOC1 mRNA18930951

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005507copper ion binding-IBA21873635  
GO:0005507copper ion binding-IDA12072962  19764817  
GO:0005509calcium ion binding-IDA12072962  19764817  
GO:0008131primary amine oxidase activity-IBA21873635  
GO:0008131primary amine oxidase activity-IDA8144586  19764817  
GO:0008144drug binding-IDA2217167  8144586  
GO:0008201heparin binding-IDA12072962  19764817  
GO:0008270zinc ion binding-IDA12072962  
GO:0042803protein homodimerization activity-IPI19764817  
GO:0044877protein-containing complex binding-IDA19764817  
GO:0048038quinone binding-IDA12072962  19764817  
GO:0052597diamine oxidase activity-IBA21873635  
GO:0052597diamine oxidase activity-IDA8144586  9399025  12072962  16846222  
GO:0052598histamine oxidase activity-TAS-  
GO:0052599methylputrescine oxidase activity-IEA-  
GO:0052600propane-1,3-diamine oxidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006805xenobiotic metabolic process-TAS-  
GO:0009308amine metabolic process-IBA21873635  
GO:0009308amine metabolic process-IEA-  
GO:0035874cellular response to copper ion starvation-IDA9399025  
GO:0042493response to drug-IDA8144586  
GO:0043312neutrophil degranulation-TAS-  
GO:0046677response to antibiotic-IBA21873635  
GO:0046677response to antibiotic-IDA7626074  19764817  
GO:0055114oxidation-reduction process-IDA8144586  16846222  
GO:0071280cellular response to copper ion-IDA9399025  
GO:0071420cellular response to histamine-IDA12072962  
GO:0071504cellular response to heparin-TAS19764817  
GO:0097185cellular response to azide-IDA16846222  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA9399025  12072962  
GO:0005777peroxisome-NAS1356107  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA2217167  8144586  
GO:0005886plasma membrane-TAS-  
GO:0005923bicellular tight junction-ISS-  
GO:0035580specific granule lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
GO:0070062extracellular exosome-IDA21082674  
KEGG ID KEGG Term
hsa00330Arginine and proline metabolism
hsa00340Histidine metabolism
hsa00380Tryptophan metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29162499Metabolic strategies for the degradation of the neuromodulator agmatine in mammals. (2018 Apr)Benitez JMetabolism
27401969Recombinant human diamine oxidase activity is not inhibited by ethanol, acetaldehyde, disulfiram, diethyldithiocarbamate or cyanamide. (2016 Aug)Bartko JAlcohol
12914896Impaired emotional facial expression recognition in alcoholics, opiate dependence subjects, methadone maintained subjects and mixed alcohol-opiate antecedents subjects compared with normal controls. (2003 Aug 1)Kornreich CPsychiatry Res